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    CD3E CD3e molecule, epsilon (CD3-TCR complex) [ Homo sapiens ]

    Gene ID: 916, updated on 19-May-2012
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    Summary

    Official Symbol
    CD3Eprovided by HGNC
    Official Full Name
    CD3e molecule, epsilon (CD3-TCR complex)provided by HGNC
    Primary source
    HGNC:1674
    See related
    Ensembl:ENSG00000198851; HPRD:08923; MIM:186830; Vega:OTTHUMG00000166968
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    T3E; TCRE; FLJ18683
    Summary
    The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    11q23
    Sequence :
    Chromosome: 11; NC_000011.9 (118175295..118186890)
    See CD3E in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene myelin protein zero-like 3 Neighboring gene myelin protein zero-like 2 Neighboring gene CD3d molecule, delta (CD3-TCR complex) Neighboring gene CD3g molecule, gamma (CD3-TCR complex)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Tumor site immune markers associated with risk for subsequent basal cell carcinomas. Glaser R, et al. PLoS One, 2011. PMID 21980389.
    2. The expression pattern of CD3 chain genes in fetal/maternal interface. Lu X, et al. Hematology, 2011 May. PMID 21669059.
    3. Change in expression pattern of TCR-CD3 complex in patients with multiple myeloma. Li Y, et al. Hematology, 2011 May. PMID 21669053.
    4. Identification of the transgenic integration site in immunodeficient tgε26 human CD3ε transgenic mice. Ohigashi I, et al. PLoS One, 2010 Dec 22. PMID 21203507.
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Bailey SD, et al. Diabetes Care, 2010 Oct. PMID 20628086.

    See all (98) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Results show that levels of CD3epsilon, CD25, CD68, and ICAM-1 mRNA in BCC biopsies may predict risk for new basal cell carcinomas.
      Title: Tumor site immune markers associated with risk for subsequent basal cell carcinomas.
    2. Study characterized the expression pattern of CD3-gamma, -delta, -epsilon and -zeta chain genes from placenta, which contributes to further understanding of the features of T-cell immune status in placenta.
      Title: The expression pattern of CD3 chain genes in fetal/maternal interface.
    3. Data show that the expression pattern of the four CD3 chains was epsilon>zeta>delta>gamma in peripheral blood mononuclear cells from MM, while a gamma>epsilon>zeta>delta expression pattern was found in healthy controls.
      Title: Change in expression pattern of TCR-CD3 complex in patients with multiple myeloma.
    4. analysis of the transgenic integration site in immunodeficient tgepsilon26 human CD3epsilon transgenic mice
      Title: Identification of the transgenic integration site in immunodeficient tgε26 human CD3ε transgenic mice.
    5. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    6. Results suggest that generation of CD3varepsilon chain isoforms with different N-terminal sequence and pI is a general phenomenon.
      Title: N-terminal negatively charged residues in CD3varepsilon chains as a phylogenetically conserved trait potentially yielding isoforms with different isoelectric points: analysis of human CD3varepsilon chains.
    7. Results revealed that the human CD3 epsilon subunit forms a homodimer structure, which provide insight into our understanding of the molecular assembly of the CD3 molecular complex.
      Title: In vitro preparation and characterization of the human CD3 epsilon epsilon homodimer and CD3 epsilon gamma and CD3 epsilon delta heterodimers.
    8. Data show that anti-CD3 monoclonal antibody (MAb)-mediated chimpanzee T-cell activation is a function of the anti-CD3 MAb isotype and is not governed by Siglec expression.
      Title: The quality of chimpanzee T-cell activation and simian immunodeficiency virus/human immunodeficiency virus susceptibility achieved via antibody-mediated T-cell receptor/CD3 stimulation is a function of the anti-CD3 antibody isotype.
    9. In lung adenocarcinoma patients, significant decreases of MFI values for CD3epsilon, but not CD3zeta, were found in CD4+T and CD8+T cells from pleural effusion compared to peripheral blood and in peripheral blood of patients compared to healthy donors.
      Title: Lung carcinomas do not induce T-cell apoptosis via the Fas/Fas ligand pathway but down-regulate CD3 epsilon expression.
    10. Data show that Nck forms a complex with an atypical PxxDY motif of the CD3epsilon tail, which encompasses Tyr166 within the activation motif and a T-cell receptor endocytosis signal.
      Title: Structural and functional evidence that Nck interaction with CD3epsilon regulates T-cell receptor activity.
    Submit: New GeneRIF Correction See all (22)
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    Phenotypes

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Immunodeficiency due to defect in CD3-epsilon

    Severe combined immunodeficiency, T cell-negative, B-cell/natural killer-cell positive

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 inhibits CD3-induced Lck activation and cellular tyrosine phosphorylation, particularly of phosphoinositide-specific phospholipase C-gamma-1 PubMed
    env Binding of HIV-1 gp120 to the CD4 receptor molecule results in co-stimulation of CD3-induced T cell activation PubMed
    env HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells PubMed
    env HIV-1 gp120 induces CD4 association with lymphocyte surface molecules CD3, CD11a, CD27, CD45RA, CD45RB, CD45RO, CD49d, CD38, CD26, CD59, CD95 and class I MHC molecules PubMed
    env Treatment of CD4+ T cells with HIV-1 gp120 significantly increases CD4 association with CD3, CD45RA, CD45RB, CD59, CD38, CD26 and HLA class I, and decreases that with CD45RC PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 peptide (amino acids 581-597) inhibits lymphoproliferation stimulated via the T-cell-activation molecules CD3, CD2, and CD28, as well as via direct stimulation mediated by phorbol ester combined with ionomycin PubMed
    Nef nef HIV-1 nef alleles from the great majority of primate lentiviruses, including HIV-2, downregulate TCR-CD3 from infected T cells and thereby block their responsiveness to activation PubMed
    Tat tat HIV-1 Tat interacts with CD3 and CD28 to co-stimulate IL-2 and IL-8 expression PubMed
    capsid gag Synthetic peptides corresponding to amino acids 218-238 of HIV-1 Capsid have been shown to inhibit in a dose dependent manner the induction of a specific antibody response to the sheep red cell (SRC) antigen through the T3-Ti complex PubMed
    gag Interferon-gamma can counteract the inhibitory effect of HIV-1 Capsid based peptides on antibody response to SRC PubMed
    gag Peptides corresponding to amino acids 218-238 of HIV-1 Capsid inhibited anti-CD3-induced lymphoproliferation but did not directly affect anti-CD2 activation PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P07766 P04234 CD3D    HPRD  PubMed  
    P07766 O15446 CD3EAP    HPRD  PubMed  
    P07766 P09693 CD3G    HPRD  PubMed  
    P07766 P40259 CD79B    HPRD  PubMed  
    P07766 P06239 LCK    HPRD  PubMed  
    P07766 P16333 NCK1    HPRD  PubMed  
    P07766 O43639 NCK2    HPRD  PubMed  
    P07766 P19338 NCL    HPRD  PubMed  
    P07766 P27986 PIK3R1    HPRD  PubMed  
    P07766 Q9Y2R2 PTPN22    HPRD  PubMed  
    P07766 P29353 SHC1    HPRD  PubMed  
    P07766 P43405 SYK    HPRD  PubMed  
    P07766 Q02880 TOP2B    HPRD  PubMed  
    P07766 Q6PIZ9 TRAT1    HPRD  PubMed  
    P07766 Q13432 UNC119    HPRD  PubMed  
    P07766 P43403 ZAP70    HPRD  PubMed  
    P07766 T cell antigen receptor, beta     HPRD  PubMed  
    BioGRID:107354 BioGRID:116060 CD3EAP    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107354 BioGRID:107355 CD3G    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107354 BioGRID:109921 JAK3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107354 BioGRID:110770 NCK1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107354 BioGRID:114020 NCK2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107354 BioGRID:110771 NCL    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107354 BioGRID:111313 PIK3R1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107354 BioGRID:112717 SYK    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107354 BioGRID:113008 TOP2B    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107354 BioGRID:113367 ZAP70    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • CXCR4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CXCR4-mediated signaling events, organism-specific biosystem
      CXCR4-mediated signaling events
    • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
      Costimulation by the CD28 family, organism-specific biosystemOptimal activation of T-lymphocytes requires at least two signals. A primary one is delivered by the T-cell receptor (TCR) complex after antigen recognition and additional costimulatory signals are d...
    • Downstream TCR signaling, organism-specific biosystem (from REACTOME)
      Downstream TCR signaling, organism-specific biosystemChanges in gene expression are required for the T cell to gain full proliferative competence and to produce effector cytokines. Three transcription factors in particular have been found to play a key...
    • Downstream signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      Downstream signaling in naive CD8+ T cells, organism-specific biosystem
      Downstream signaling in naive CD8+ T cells
    • Generation of second messenger molecules, organism-specific biosystem (from REACTOME)
      Generation of second messenger molecules, organism-specific biosystemIn addition to serving as a scaffold via auto-phosphorylation, ZAP-70 also phosphorylates a restricted set of substrates following TCR stimulation - including LAT and SLP-76. These substrates have be...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • IL12 signaling mediated by STAT4, organism-specific biosystem (from Pathway Interaction Database)
      IL12 signaling mediated by STAT4, organism-specific biosystem
      IL12 signaling mediated by STAT4
    • IL12-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL12-mediated signaling events, organism-specific biosystem
      IL12-mediated signaling events
    • IL23-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL23-mediated signaling events, organism-specific biosystem
      IL23-mediated signaling events
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • PD-1 signaling, organism-specific biosystem (from REACTOME)
      PD-1 signaling, organism-specific biosystemThe Programmed cell death protein 1 (PD-1) is one of the negative regulators of TCR signaling. PD-1 may exert its effects on cell differentiation and survival directly by inhibiting early activation ...
    • Phosphorylation of CD3 and TCR zeta chains, organism-specific biosystem (from REACTOME)
      Phosphorylation of CD3 and TCR zeta chains, organism-specific biosystemPrior to T cell receptor (TCR) stimulation, CD4/CD8 associated Lck remains seperated from the TCR and is maintained in an inactive state by the action of Csk. Csk phosphorylates the negative regulato...
    • Primary immunodeficiency, organism-specific biosystem (from KEGG)
      Primary immunodeficiency, organism-specific biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
    • Primary immunodeficiency, conserved biosystem (from KEGG)
      Primary immunodeficiency, conserved biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
    • T Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      T Cell Receptor Signaling Pathway, organism-specific biosystem
      T Cell Receptor Signaling Pathway
    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
      T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • TCR signaling, organism-specific biosystem (from REACTOME)
      TCR signaling, organism-specific biosystemThe TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen p...
    • TCR signaling in naive CD4+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD4+ T cells, organism-specific biosystem
      TCR signaling in naive CD4+ T cells
    • TCR signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD8+ T cells, organism-specific biosystem
      TCR signaling in naive CD8+ T cells
    • Translocation of ZAP-70 to Immunological synapse, organism-specific biosystem (from REACTOME)
      Translocation of ZAP-70 to Immunological synapse, organism-specific biosystemThe dual phosphorylated ITAMs recruit Syk kinase ZAP-70 via their tandem SH2 domains (step 4). ZAP-70 subsequently undergoes phosphorylation on multiple tyrosine residues for further activation. ZAP-...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    T cell receptor binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    receptor signaling complex scaffold activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    receptor signaling protein activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    transmembrane signaling receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    T cell activation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    T cell costimulation TAS
    Traceable Author Statement
    more info
    		  
    T cell differentiation in thymus IEA
    Inferred from Electronic Annotation
    more info
    		  
    T cell receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    cell surface receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    induction of apoptosis by extracellular signals IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative thymic T cell selection IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of T cell anergy IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of alpha-beta T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of interferon-gamma production IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of interleukin-2 biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of interleukin-4 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein complex assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    regulation of immune response TAS
    Traceable Author Statement
    more info
    		  
    response to nutrient IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal complex assembly TAS
    Traceable Author Statement
    more info
    		 PubMed 
    transmembrane receptor protein tyrosine kinase signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    T cell receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    T cell receptor complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    alpha-beta T cell receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    immunological synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    T-cell surface glycoprotein CD3 epsilon chain
    Names
    T-cell surface glycoprotein CD3 epsilon chain
    CD3-epsilon
    T-cell surface antigen T3/Leu-4 epsilon chain
    CD3e antigen, epsilon polypeptide (TiT3 complex)
    T-cell antigen receptor complex, epsilon subunit of T3
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007383.1 RefSeqGene

      Range
      5001..16596
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_38

    mRNA and Protein(s)

    1. NM_000733.3 → NP_000724.1  T-cell surface glycoprotein CD3 epsilon chain precursor

      Status: REVIEWED

      Source sequence(s)
      AK292612, BC049847, BP366535
      Consensus CDS
      CCDS31685.1
      UniProtKB/Swiss-Prot
      P07766
      Related
      ENSP00000354566, OTTHUMP00000234559, ENST00000361763, OTTHUMT00000392120
      Conserved Domains (2) summary
      smart00077
      Location:185 – 205
      Blast Score: 84
      ITAM; Immunoreceptor tyrosine-based activation motif
      cd07692
      Location:36 – 117
      Blast Score: 213
      Ig_CD3_epsilon; Immunoglobulin (Ig)-like domain of CD3 epsilon chain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      118175295..118186890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      114108889..114120482
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AP001582.4 (17746..29184) None
    genomic CH471065.1 EAW67360.1
      EAW67361.1
      EAW67362.1
      EAW67363.1
      EAW67364.1
    genomic M23323.1 AAA52295.1
    mRNA AK292612.1 BAF85301.1
    mRNA AK301255.1 BAG62822.1
    mRNA AK311641.1 None
    mRNA BC049847.1 AAH49847.1
    mRNA BI910359.1 None
    mRNA BP366535.1 None
    mRNA X03884.1 CAA27516.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07766.2 GenPept UniProtKB/Swiss-Prot:P07766
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

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