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    CD3E CD3e molecule, epsilon (CD3-TCR complex) [ Homo sapiens (human) ]

    Gene ID: 916, updated on 11-May-2013
    Official Symbol
    CD3Eprovided by HGNC
    Official Full Name
    CD3e molecule, epsilon (CD3-TCR complex)provided by HGNC
    Primary source
    HGNC:1674
    See related
    Ensembl:ENSG00000198851; HPRD:08923; MIM:186830; Vega:OTTHUMG00000166968
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    T3E; TCRE
    Summary
    The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
    Location :
    11q23
    Sequence :
    Chromosome: 11; NC_000011.9 (118175295..118186890)
    See CD3E in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene myelin protein zero-like 3 Neighboring gene myelin protein zero-like 2 Neighboring gene CD3d molecule, delta (CD3-TCR complex) Neighboring gene CD3g molecule, gamma (CD3-TCR complex)

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain. Gagnon E, et al. J Exp Med, 2012 Dec 17. PMID 23166358.
    2. Directly infected resting CD4+T cells can produce HIV Gag without spreading infection in a model of HIV latency. Pace MJ, et al. PLoS Pathog, 2012. PMID 22911005.
    3. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Udeshi ND, et al. Mol Cell Proteomics, 2012 May. PMID 22505724.
    4. Altered expression of the TCR signaling related genes CD3 and FcεRIγ in patients with aplastic anemia. Li B, et al. J Hematol Oncol, 2012 Mar 8. PMID 22401598.
    5. Tumor site immune markers associated with risk for subsequent basal cell carcinomas. Glaser R, et al. PLoS One, 2011. PMID 21980389.

    See all (116) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Local changes in the lipid composition of TCR microclusters render the CD3epsilon cytoplasmic domain accessible during early stages of T cell activation.
      Title: Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain.
    2. Altered expression of the TCR signaling related genes CD3 and FcepsilonRIgamma in patients with aplastic anemia.
      Title: Altered expression of the TCR signaling related genes CD3 and FcεRIγ in patients with aplastic anemia.
    3. Results show that levels of CD3epsilon, CD25, CD68, and ICAM-1 mRNA in BCC biopsies may predict risk for new basal cell carcinomas.
      Title: Tumor site immune markers associated with risk for subsequent basal cell carcinomas.
    4. Study characterized the expression pattern of CD3-gamma, -delta, -epsilon and -zeta chain genes from placenta, which contributes to further understanding of the features of T-cell immune status in placenta.
      Title: The expression pattern of CD3 chain genes in fetal/maternal interface.
    5. Data show that the expression pattern of the four CD3 chains was epsilon>zeta>delta>gamma in peripheral blood mononuclear cells from MM, while a gamma>epsilon>zeta>delta expression pattern was found in healthy controls.
      Title: Change in expression pattern of TCR-CD3 complex in patients with multiple myeloma.
    6. analysis of the transgenic integration site in immunodeficient tgepsilon26 human CD3epsilon transgenic mice
      Title: Identification of the transgenic integration site in immunodeficient tgε26 human CD3ε transgenic mice.
    7. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    8. Results suggest that generation of CD3varepsilon chain isoforms with different N-terminal sequence and pI is a general phenomenon.
      Title: N-terminal negatively charged residues in CD3varepsilon chains as a phylogenetically conserved trait potentially yielding isoforms with different isoelectric points: analysis of human CD3varepsilon chains.
    9. Results revealed that the human CD3 epsilon subunit forms a homodimer structure, which provide insight into our understanding of the molecular assembly of the CD3 molecular complex.
      Title: In vitro preparation and characterization of the human CD3 epsilon epsilon homodimer and CD3 epsilon gamma and CD3 epsilon delta heterodimers.
    10. Data show that anti-CD3 monoclonal antibody (MAb)-mediated chimpanzee T-cell activation is a function of the anti-CD3 MAb isotype and is not governed by Siglec expression.
      Title: The quality of chimpanzee T-cell activation and simian immunodeficiency virus/human immunodeficiency virus susceptibility achieved via antibody-mediated T-cell receptor/CD3 stimulation is a function of the anti-CD3 antibody isotype.
    Submit: New GeneRIF Correction See all (24)

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 inhibits CD3-induced Lck activation and cellular tyrosine phosphorylation, particularly of phosphoinositide-specific phospholipase C-gamma-1 PubMed
    env Binding of HIV-1 gp120 to the CD4 receptor molecule results in co-stimulation of CD3-induced T cell activation PubMed
    env HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells PubMed
    env HIV-1 gp120 induces CD4 association with lymphocyte surface molecules CD3, CD11a, CD27, CD45RA, CD45RB, CD45RO, CD49d, CD38, CD26, CD59, CD95 and class I MHC molecules PubMed
    env Treatment of CD4+ T cells with HIV-1 gp120 significantly increases CD4 association with CD3, CD45RA, CD45RB, CD59, CD38, CD26 and HLA class I, and decreases that with CD45RC PubMed
    Envelope transmembrane glycoprotein gp41 env Gp41 TMD co-localizes with the CD3-TCR complex and inhibits T-cell activation induced by antibodies to CD3 PubMed
    env HIV-1 gp41 peptide (amino acids 581-597) inhibits lymphoproliferation stimulated via the T-cell-activation molecules CD3, CD2, and CD28, as well as via direct stimulation mediated by phorbol ester combined with ionomycin PubMed
    Gag, Pr55 gag CD3/28-treated resting CD4+ T cells produce more HIV-1 Gag protein than untreated cells PubMed
    gag Synthetic peptides corresponding to amino acids 218-238 of the Capsid protein of HIV-1 Gag have been shown to inhibit in a dose dependent manner the induction of a specific antibody response to the sheep red cell (SRC) antigen through the T3-Ti complex PubMed
    gag Interferon-gamma can counteract the inhibitory effect of peptides based on the Capsid protein of HIV-1 Gag on antibody response to SRC PubMed
    gag Peptides corresponding to amino acids 218-238 of the Capsid protein of HIV-1 Gag inhibited anti-CD3-induced lymphoproliferation but did not directly affect anti-CD2 activation PubMed
    Nef, p27 nef HIV-1 Nef interacts with CD3 in living cells PubMed
    nef HIV-1 Nef impairs the generation of a CD3epsilon(+)CD5(+) CD1a(+) T cell differentiation precursor stage that initiates a D-J rearrangement of the TCRbeta locus PubMed
    nef HIV-1 nef alleles from the great majority of primate lentiviruses, including HIV-2, downregulate TCR-CD3 from infected T cells and thereby block their responsiveness to activation PubMed
    Tat, p14 tat HIV-1 Tat interacts with CD3 and CD28 to co-stimulate IL-2 and IL-8 expression PubMed
    Vpu, p16 vpu HIV-1 Vpu interacts with CD3 in living cells PubMed
    capsid gag Synthetic peptides corresponding to amino acids 218-238 of HIV-1 Capsid have been shown to inhibit in a dose dependent manner the induction of a specific antibody response to the sheep red cell (SRC) antigen through the T3-Ti complex PubMed
    gag Interferon-gamma can counteract the inhibitory effect of HIV-1 Capsid based peptides on antibody response to SRC PubMed
    gag Peptides corresponding to amino acids 218-238 of HIV-1 Capsid inhibited anti-CD3-induced lymphoproliferation but did not directly affect anti-CD2 activation PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    P07766 P04234 CD3D    HPRD  PubMed  
    P07766 O15446 CD3EAP    HPRD  PubMed  
    P07766 P09693 CD3G    HPRD  PubMed  
    P07766 P40259 CD79B    HPRD  PubMed  
    P07766 P06239 LCK    HPRD  PubMed  
    P07766 P16333 NCK1    HPRD  PubMed  
    P07766 O43639 NCK2    HPRD  PubMed  
    P07766 P19338 NCL    HPRD  PubMed  
    P07766 P27986 PIK3R1    HPRD  PubMed  
    P07766 Q9Y2R2 PTPN22    HPRD  PubMed  
    P07766 P29353 SHC1    HPRD  PubMed  
    P07766 P43405 SYK    HPRD  PubMed  
    P07766 Q02880 TOP2B    HPRD  PubMed  
    P07766 Q6PIZ9 TRAT1    HPRD  PubMed  
    P07766 Q13432 UNC119    HPRD  PubMed  
    P07766 P43403 ZAP70    HPRD  PubMed  
    P07766 T cell antigen receptor, beta     HPRD  PubMed  
    BioGRID:107354 BioGRID:107357 CD247    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107354 BioGRID:107390 CD38    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:107354 BioGRID:116060 CD3EAP    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107354 BioGRID:107355 CD3G    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107354 BioGRID:109921 JAK3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107354 BioGRID:117971 LAT    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107354 BioGRID:110124 LCK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107354 BioGRID:110770 NCK1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107354 BioGRID:114020 NCK2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107354 BioGRID:110771 NCL    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107354 BioGRID:111313 PIK3R1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107354 BioGRID:111314 PIK3R2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107354 BioGRID:117604 PTPN22    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107354 BioGRID:112717 SYK    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107354 BioGRID:113008 TOP2B    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107354 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107354 BioGRID:113367 ZAP70    BioGRID  PubMed Reconstituted Complex 
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • CXCR4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CXCR4-mediated signaling events, organism-specific biosystem
      CXCR4-mediated signaling events
    • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
      Costimulation by the CD28 family, organism-specific biosystemOptimal activation of T-lymphocytes requires at least two signals. A primary one is delivered by the T-cell receptor (TCR) complex after antigen recognition and additional costimulatory signals are d...
    • Downstream TCR signaling, organism-specific biosystem (from REACTOME)
      Downstream TCR signaling, organism-specific biosystemChanges in gene expression are required for the T cell to gain full proliferative competence and to produce effector cytokines. Three transcription factors in particular have been found to play a key...
    • Downstream signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      Downstream signaling in naive CD8+ T cells, organism-specific biosystem
      Downstream signaling in naive CD8+ T cells
    • Generation of second messenger molecules, organism-specific biosystem (from REACTOME)
      Generation of second messenger molecules, organism-specific biosystemIn addition to serving as a scaffold via auto-phosphorylation, ZAP-70 also phosphorylates a restricted set of substrates following TCR stimulation - including LAT and SLP-76. These substrates have be...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • IL12 signaling mediated by STAT4, organism-specific biosystem (from Pathway Interaction Database)
      IL12 signaling mediated by STAT4, organism-specific biosystem
      IL12 signaling mediated by STAT4
    • IL12-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL12-mediated signaling events, organism-specific biosystem
      IL12-mediated signaling events
    • IL23-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL23-mediated signaling events, organism-specific biosystem
      IL23-mediated signaling events
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • PD-1 signaling, organism-specific biosystem (from REACTOME)
      PD-1 signaling, organism-specific biosystemThe Programmed cell death protein 1 (PD-1) is one of the negative regulators of TCR signaling. PD-1 may exert its effects on cell differentiation and survival directly by inhibiting early activation ...
    • Phosphorylation of CD3 and TCR zeta chains, organism-specific biosystem (from REACTOME)
      Phosphorylation of CD3 and TCR zeta chains, organism-specific biosystemPrior to T cell receptor (TCR) stimulation, CD4/CD8 associated Lck remains seperated from the TCR and is maintained in an inactive state by the action of Csk. Csk phosphorylates the negative regulato...
    • Primary immunodeficiency, organism-specific biosystem (from KEGG)
      Primary immunodeficiency, organism-specific biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
    • Primary immunodeficiency, conserved biosystem (from KEGG)
      Primary immunodeficiency, conserved biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
      T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • TCR Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TCR Signaling Pathway, organism-specific biosystemThe T-cell antigen receptor (TCR) complex is composed of a ligand-binding subunit, the ? and ? chains, and a signaling subunit, namely the CD3?, ? and ? chains and the TCR? chain. This complex partic...
    • TCR signaling, organism-specific biosystem (from REACTOME)
      TCR signaling, organism-specific biosystemThe TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen p...
    • TCR signaling in naive CD4+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD4+ T cells, organism-specific biosystem
      TCR signaling in naive CD4+ T cells
    • TCR signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD8+ T cells, organism-specific biosystem
      TCR signaling in naive CD8+ T cells
    • Translocation of ZAP-70 to Immunological synapse, organism-specific biosystem (from REACTOME)
      Translocation of ZAP-70 to Immunological synapse, organism-specific biosystemThe dual phosphorylated ITAMs recruit Syk kinase ZAP-70 via their tandem SH2 domains (step 4). ZAP-70 subsequently undergoes phosphorylation on multiple tyrosine residues for further activation. ZAP-...

    Markers

    Genotypes

    Homology

    Clone Names

    • FLJ18683

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    T cell receptor binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    receptor signaling complex scaffold activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    receptor signaling protein activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    transmembrane signaling receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    T cell activation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    T cell costimulation TAS
    Traceable Author Statement
    more info
    		  
    T cell receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    cell surface receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    negative regulation of smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative thymic T cell selection IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of T cell anergy IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of alpha-beta T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of interferon-gamma production IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of interleukin-2 biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of interleukin-4 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein complex assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    regulation of immune response TAS
    Traceable Author Statement
    more info
    		  
    response to nutrient IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal complex assembly TAS
    Traceable Author Statement
    more info
    		 PubMed 
    transmembrane receptor protein tyrosine kinase signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    T cell receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    T cell receptor complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    alpha-beta T cell receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    immunological synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    Preferred Names
    T-cell surface glycoprotein CD3 epsilon chain
    Names
    T-cell surface glycoprotein CD3 epsilon chain
    CD3-epsilon
    T-cell surface antigen T3/Leu-4 epsilon chain
    CD3e antigen, epsilon polypeptide (TiT3 complex)
    T-cell antigen receptor complex, epsilon subunit of T3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007383.1 RefSeqGene

      Range
      5001..16596
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_38

    mRNA and Protein(s)

    1. NM_000733.3 → NP_000724.1  T-cell surface glycoprotein CD3 epsilon chain precursor

      Status: REVIEWED

      Source sequence(s)
      AK292612, BC049847, BP366535
      Consensus CDS
      CCDS31685.1
      UniProtKB/Swiss-Prot
      P07766
      Related
      ENSP00000354566, OTTHUMP00000234559, ENST00000361763, OTTHUMT00000392120
      Conserved Domains (2) summary
      smart00077
      Location:185 – 205
      Blast Score: 84
      ITAM; Immunoreceptor tyrosine-based activation motif
      cd07692
      Location:36 – 117
      Blast Score: 213
      Ig_CD3_epsilon; Immunoglobulin (Ig)-like domain of CD3 epsilon chain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p10 Primary Assembly

      Range
      118175295..118186890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      114108889..114120482
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018922.1 Alternate CHM1_1.0

      Range
      118038954..118050549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01039714.1 (14987..26580) None
    genomic AMYH01004067.1 (399548..411143) None
    genomic AP001582.4 (17747..29185) None
    genomic CH471065.1 EAW67360.1
      EAW67361.1
      EAW67362.1
      EAW67363.1
      EAW67364.1
    genomic M23323.1 AAA52295.1
    mRNA AK292612.1 BAF85301.1
    mRNA AK301255.1 BAG62822.1
    mRNA AK311641.1 None
    mRNA BC049847.1 AAH49847.1
    mRNA BI910359.1 None
    mRNA BP366535.1 None
    mRNA X03884.1 CAA27516.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07766.2 GenPept UniProtKB/Swiss-Prot:P07766

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
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      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • ClinVar
        Related medical variations
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • GAP
        GAP Links
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        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
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      • GTR
        GTR associated with a gene
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • MedGen
        Related information in MedGen
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • SNP: VarView
        Related Clinical SNP
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

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