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    IL1B interleukin 1, beta [ Homo sapiens ]

    Gene ID: 3553, updated on 20-May-2012
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    Summary

    Official Symbol
    IL1Bprovided by HGNC
    Official Full Name
    interleukin 1, betaprovided by HGNC
    Primary source
    HGNC:5992
    See related
    Ensembl:ENSG00000125538; HPRD:00985; MIM:147720; Vega:OTTHUMG00000131344
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IL-1; IL1F2; IL1-BETA
    Summary
    The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    2q14
    Sequence :
    Chromosome: 2; NC_000002.11 (113587337..113594356, complement)
    See IL1B in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene cytoskeleton associated protein 2-like Neighboring gene interleukin 1, alpha Neighboring gene X-linked inhibitor of apoptosis pseudogene Neighboring gene interleukin 37

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Association of IL-1β -511 polymorphism with severe veno-occlusive disease in pediatric-matched allogeneic hematopoietic stem cell transplantation. Elbahlawan L, et al. J Pediatr Hematol Oncol, 2012 Apr. PMID 22395218.
    2. Interleukin-1β causes synaptic hyperexcitability in multiple sclerosis. Rossi S, et al. Ann Neurol, 2012 Jan. PMID 22275254.
    3. Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome. Gringhuis SI, et al. Nat Immunol, 2012 Jan 22. PMID 22267217.
    4. Interleukin-1ß and interleukin-1 receptor accessory protein gene polymorphisms are associated with persistent hepatitis B virus infection. Kim SS, et al. Hepatogastroenterology, 2012 Jan-Feb. PMID 22251538.
    5. Polymorphisms in inflammasome' genes and susceptibility to HIV-1 infection. Pontillo A, et al. J Acquir Immune Defic Syndr, 2012 Feb 1. PMID 22227487.

    See all (1674) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. IL-1beta -511 polymorphism is associated with severe veno-occlusive disease in pediatric-matched allogeneic hematopoietic stem cell transplantation
      Title: Association of IL-1β -511 polymorphism with severe veno-occlusive disease in pediatric-matched allogeneic hematopoietic stem cell transplantation.
    2. The IL-1-polymorphism is associated with lower number of teeth in non-smokers with untreated periodontal disease
      Title: IL-1-polymorphism and severity of periodontal disease.
    3. IL-1beta induces dedifferentiation of articular chondrocytes by up-regulation of SIRT1 activity enhanced by both NAMPT and ERK signaling.
      Title: Nicotinamide phosphoribosyltransferase is essential for interleukin-1beta-mediated dedifferentiation of articular chondrocytes via SIRT1 and extracellular signal-regulated kinase (ERK) complex signaling.
    4. RANKL induced large resorption pits (10,876 +/- 2190mum(2)) whereas TNF-alpha/IL-1 and LIGHT generated smaller pits (respectively 1328 +/- 210 and 1267 +/- 173mum(2))
      Title: Depth and volume of resorption induced by osteoclasts generated in the presence of RANKL, TNF-alpha/IL-1 or LIGHT.
    5. Data suggest that c-kit is an important regulator of IL-1 receptor 1/IL-1beta signaling and effector functions in mast cells; such signaling is IL-relevant for IL-6 release.
      Title: C-Kit controls IL-1β-induced effector functions in HMC-cells.
    6. Low values of intracellular pH enhance the production of IL-1beta, at least in part, by stimulating the synthesis of its precursor.
      Title: Low extracellular pH stimulates the production of IL-1β by human monocytes.
    7. Association was not found for the effect of allele, genotype, composite genotype, and haplotypes of IL-1B+3954 polymorphism with periodontitis. Its utility as a risk marker in this population was not borne out by the study.
      Title: Allele, genotype, and composite genotype effects of IL-1A +4845 and IL-1B +3954 polymorphisms for chronic periodontitis in an Indian population.
    8. The genetic polymorphisms of IL-1ss-2023 C allele, IL- 1RAcP -8261 T allele and -8183 A allele are probable host factors for persistent HBV infection.
      Title: Interleukin-1ß and interleukin-1 receptor accessory protein gene polymorphisms are associated with persistent hepatitis B virus infection.
    9. IL1B is a modifier gene of cystic fibrosis disease.
      Title: Initial interrogation, confirmation and fine mapping of modifying genes: STAT3, IL1B and IFNGR1 determine cystic fibrosis disease manifestation.
    10. IL-1beta-induced CXCL10 protein expression in astrocytes was potentiated by co-exposure to alpha-synuclein
      Title: α-Synuclein potentiates interleukin-1β-induced CXCL10 expression in human A172 astrocytoma cells.
    Submit: New GeneRIF Correction See all (928)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Gastric cancer risk after H. pylori infection

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 stimulates monocytes to release TNF-alpha, IL-1 beta, IL-6, and granulocyte-macrophage-CSF, and this effect can be blocked with soluble CD4 PubMed
    env Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta PubMed
    env CD23 protein membrane expression is upregulated by HIV-1 gp120 and this upregulation induces the production of nitric oxide (NO) and IL-1beta PubMed
    env HIV-1 coat protein gp120 stimulates the release of interleukin-1beta from human neuroblastoma cells and causes cell death PubMed
    env HIV-1 gp120 increases the levels of prostaglandin E2 (PGE2) and IL-1 in human monocytes PubMed
    Envelope surface glycoprotein gp160, precursor env IL-1 and TNF-alpha production are induced by the treatment of cells with HIV-1 gp160 PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 stimulates microglial cell production of cytokines (TNF-alpha, IL-1beta, and IL-6) and chemokines (RANTES and MIP-1alpha) PubMed
    env HIV-1 gp41 or gp120 synthetic peptides induce the production of interleukin (IL)-1 and tumor necrosis factor (TNF); in contrast, gp41 or gp120 synthetic peptides are able to depress the production of interferon (IFN)-alpha, IFN-gamma, and IL-2 PubMed
    Nef nef Treatment of human monocyte-derived macrophages with soluble recombinant HIV-1 Nef (rNef) upregulates the transcription of genes for several inflammatory factors, including IL-1beta, which is released upon rNef treatment PubMed
    nef Expression of Nef from the brain-derived HIV-1 isolate YU-2 in astrocytes significantly upregulates IL-1beta expression PubMed
    Pr55(Gag) gag Stimulation of HIV-1 infected human adipocytes by TNF-alpha and IL-1beta increases the levels of HIV-1 Gag production PubMed
    Tat tat IL-1 stimulated NO production and iNOS mRNA expression are down-regulated by pretreatment with HIV-1 Tat-SOD fusion proteins in cultured chondrocytes PubMed
    tat HIV-1 Tat upregulates IL-1beta expression in a variety of cell types, including macrophages, astrocytes, microglial cells, and primary blood mononuclear cells (PBMCs) PubMed
    tat HIV-1 Tat downregulates IL-1beta expression in U937 cells through the inhibition of CD26 PubMed
    tat IL-1beta, TNF-alpha, and IFN-gamma synergize with HIV-1 Tat to promote in nude mice the development of angioproliferative Kaposi's sarcoma-like lesions PubMed
    retropepsin gag-pol HIV-1 protease cleaves pro-interleukin 1 beta (pro-IL-1 beta) in vitro at amino acid positions 23-24 and 98-99 PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P01584 P01023 A2M    HPRD  PubMed  
    P01584 P07550 ADRB2    HPRD  PubMed  
    P01584 P29466 CASP1    HPRD  PubMed  
    P01584 P49662 CASP4    HPRD  PubMed  
    P01584 P01584 IL1B    HPRD  PubMed  
    P01584 P14778 IL1R1    HPRD  PubMed  
    P01584 P27930 IL1R2    HPRD  PubMed  
    P01584 Q9NPH3 IL1RAP    HPRD  PubMed  
    P01584 P08253 MMP2    HPRD  PubMed  
    P01584 P24158 PRTN3    HPRD  PubMed  
    BioGRID:109769 BioGRID:109770 IL1R1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109769 BioGRID:117086 MAPK8IP2    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:109769 BioGRID:113182 UBE2N    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:109769 BioGRID:128116 ZNF675    BioGRID  PubMed Phenotypic Suppression 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • African trypanosomiasis, organism-specific biosystem (from KEGG)
      African trypanosomiasis, organism-specific biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
    • African trypanosomiasis, conserved biosystem (from KEGG)
      African trypanosomiasis, conserved biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
    • Alzheimer's disease, organism-specific biosystem (from KEGG)
      Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimer's disease, conserved biosystem (from KEGG)
      Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Amoebiasis, organism-specific biosystem (from KEGG)
      Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Amoebiasis, conserved biosystem (from KEGG)
      Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Cellular roles of Anthrax toxin, organism-specific biosystem (from Pathway Interaction Database)
      Cellular roles of Anthrax toxin, organism-specific biosystem
      Cellular roles of Anthrax toxin
    • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokines and Inflammatory Response, organism-specific biosystem (from WikiPathways)
      Cytokines and Inflammatory Response, organism-specific biosystemInflammation is a protective response to infection by the immune system that requires communication between different classes of immune cells to coordinate their actions. Acute inflammation is an imp...
    • Cytosolic DNA-sensing pathway, organism-specific biosystem (from KEGG)
      Cytosolic DNA-sensing pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
    • Cytosolic DNA-sensing pathway, conserved biosystem (from KEGG)
      Cytosolic DNA-sensing pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
    • Graft-versus-host disease, organism-specific biosystem (from KEGG)
      Graft-versus-host disease, organism-specific biosystemGraft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT) where immunocompetent donor T cells attack the genetically disparate host cells....
    • Graft-versus-host disease, conserved biosystem (from KEGG)
      Graft-versus-host disease, conserved biosystemGraft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (HSCT) where immunocompetent donor T cells attack the genetically disparate host cells....
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • IFN-gamma pathway, organism-specific biosystem (from Pathway Interaction Database)
      IFN-gamma pathway, organism-specific biosystem
      IFN-gamma pathway
    • IL-1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-1 Signaling Pathway, organism-specific biosystemThe interleukin 1 family of cytokines includes interleukin-1 alpha (IL1A), beta (IL1B) and the IL-1 receptor antagonist (IL1RN). These bind to the IL-1 receptor (IL1R1) as well as its decoy receptor,...
    • IL1-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL1-mediated signaling events, organism-specific biosystem
      IL1-mediated signaling events
    • IL12-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL12-mediated signaling events, organism-specific biosystem
      IL12-mediated signaling events
    • IL23-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL23-mediated signaling events, organism-specific biosystem
      IL23-mediated signaling events
    • IL27-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL27-mediated signaling events, organism-specific biosystem
      IL27-mediated signaling events
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Interleukin-1 processing, organism-specific biosystem (from REACTOME)
      Interleukin-1 processing, organism-specific biosystemThe IL-1 family of cytokines that interact with the Type 1 IL-1R include IL-1 Alpha (IL1A), IL-1 Beta (IL1B) and the IL-1 receptor antagonist protein (IL1RAP). IL1RAP is synthesized with a signal pep...
    • Interleukin-1 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-1 signaling, organism-specific biosystemInterleukin 1 (IL1) signals via Interleukin 1 receptor 1 (IL1R1), the only signaling-capable IL1 receptor. This is a single chain type 1 transmembrane protein comprising an extracellular ligand bindi...
    • Legionellosis, organism-specific biosystem (from KEGG)
      Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Legionellosis, conserved biosystem (from KEGG)
      Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Leishmaniasis, organism-specific biosystem (from KEGG)
      Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Leishmaniasis, conserved biosystem (from KEGG)
      Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Malaria, organism-specific biosystem (from KEGG)
      Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Malaria, conserved biosystem (from KEGG)
      Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Monoamine Transport, organism-specific biosystem (from WikiPathways)
      Monoamine Transport, organism-specific biosystem
      Monoamine Transport
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Pertussis, organism-specific biosystem (from KEGG)
      Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Pertussis, conserved biosystem (from KEGG)
      Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Prion diseases, organism-specific biosystem (from KEGG)
      Prion diseases, organism-specific biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
    • Prion diseases, conserved biosystem (from KEGG)
      Prion diseases, conserved biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
    • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
      Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Rheumatoid arthritis, conserved biosystem (from KEGG)
      Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Salmonella infection, organism-specific biosystem (from KEGG)
      Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Salmonella infection, conserved biosystem (from KEGG)
      Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Selenium Pathway, organism-specific biosystem (from WikiPathways)
      Selenium Pathway, organism-specific biosystem
      Selenium Pathway
    • Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
      Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
      Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Type I diabetes mellitus, organism-specific biosystem (from KEGG)
      Type I diabetes mellitus, organism-specific biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
    • Type I diabetes mellitus, conserved biosystem (from KEGG)
      Type I diabetes mellitus, conserved biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
    • Type II interferon signaling (IFNG), organism-specific biosystem (from WikiPathways)
      Type II interferon signaling (IFNG), organism-specific biosystemAdapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several ...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytokine activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    interleukin-1 receptor binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		  
    activation of MAPK activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    aging IEA
    Inferred from Electronic Annotation
    more info
    		  
    anti-apoptosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cell-cell signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cellular response to drug IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    cellular response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    		  
    cellular response to organic substance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    chronic inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytokine-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    elevation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		  
    embryo implantation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    hyaluronan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    inflammatory response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    inflammatory response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    interleukin-1 beta production IEA
    Inferred from Electronic Annotation
    more info
    		  
    leukocyte migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    lipopolysaccharide-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		  
    memory IEA
    Inferred from Electronic Annotation
    more info
    		  
    monocyte aggregation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    negative regulation of adiponectin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    negative regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of glucose transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    negative regulation of glutamate secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    negative regulation of lipid catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of lipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    neutrophil chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    ovulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of I-kappaB kinase/NF-kappaB cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of JUN kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of NF-kappaB import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of T cell mediated immunity IC
    Inferred by Curator
    more info
    		 PubMed 
    positive regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of calcidiol 1-monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of cell adhesion molecule production NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of chemokine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of fever generation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of granulocyte macrophage colony-stimulating factor production IDA
    Inferred from Direct Assay
    more info
    		  
    positive regulation of heterotypic cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of heterotypic cell-cell adhesion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    positive regulation of histone acetylation NAS
    Non-traceable Author Statement
    more info
    		  
    positive regulation of histone phosphorylation NAS
    Non-traceable Author Statement
    more info
    		  
    positive regulation of interferon-gamma production IDA
    Inferred from Direct Assay
    more info
    		  
    positive regulation of interleukin-2 biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of interleukin-6 biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of interleukin-6 production TAS
    Traceable Author Statement
    more info
    		 PubMed 
    positive regulation of interleukin-8 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of lipid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    positive regulation of membrane protein ectodomain proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of monocyte chemotactic protein-1 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of myosin light chain kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of nitric oxide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of prostaglandin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of protein export from nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    positive regulation of sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of vascular endothelial growth factor receptor signaling pathway IC
    Inferred by Curator
    more info
    		 PubMed 
    positive regulation vascular endothelial growth factor production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation vascular endothelial growth factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein kinase B signaling cascade IMP
    Inferred from Mutant Phenotype
    more info
    		  
    regulation of I-kappaB kinase/NF-kappaB cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of insulin secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to ATP IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to L-ascorbic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to estradiol stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to gamma radiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to glucocorticoid stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to heat IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to morphine IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to nutrient IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to organic nitrogen IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to ozone IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to vitamin D IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequestering of triglyceride IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    smooth muscle adaptation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    social behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    wound healing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
    		  
    extracellular space IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    secretory granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    interleukin-1 beta
    Names
    interleukin-1 beta
    IL-1 beta
    catabolin
    preinterleukin 1 beta
    pro-interleukin-1-beta
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008851.1 RefSeqGene

      Range
      5001..12020
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000576.2 → NP_000567.1  interleukin-1 beta proprotein

      Status: REVIEWED

      Source sequence(s)
      M15330
      Consensus CDS
      CCDS2102.1
      UniProtKB/Swiss-Prot
      P01584
      Related
      ENSP00000263341, OTTHUMP00000162031, ENST00000263341, OTTHUMT00000254125
      Conserved Domains (2) summary
      cd00100
      Location:123 – 265
      Blast Score: 557
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
      pfam02394
      Location:1 – 92
      Blast Score: 359
      IL1_propep; Interleukin-1 propeptide

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      113587337..113594356, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      106041964..106048983, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC079753.7 AAX88888.1
    genomic AY137079.1 AAM88883.1
    genomic BN000002.1 CAD29872.1
    genomic CH471217.1 EAW73605.1
      EAW73606.1
      EAW73607.1
    genomic JA104597.1 CCA63968.1
    genomic M15840.1 AAA74137.1
    genomic X04500.1 CAA28185.1
    genomic X52430.1 None
    genomic X52431.1 None
    mRNA AB451494.1 BAG70308.1
    mRNA AF043335.1 AAC03536.1
    mRNA AK313983.1 None
    mRNA BC008678.1 AAH08678.1
    mRNA BT007213.1 AAP35877.1
    mRNA CR407679.1 CAG28607.1
    mRNA K02770.1 AAA36106.1
    mRNA M15330.1 AAA59135.1
    mRNA M54933.1 AAA59136.1
    mRNA X02532.1 CAA26372.1
    mRNA X56087.1 CAA39567.1
    other-genetic DQ890673.2 ABM81599.1
    other-genetic DQ893854.2 ABM84780.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43645 GenPept UniProtKB/TrEMBL:O43645
    P01584.2 GenPept UniProtKB/Swiss-Prot:P01584
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
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