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    IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) [ Homo sapiens ]

    Gene ID: 3572, updated on 19-May-2012
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    Summary

    Official Symbol
    IL6STprovided by HGNC
    Official Full Name
    interleukin 6 signal transducer (gp130, oncostatin M receptor)provided by HGNC
    Primary source
    HGNC:6021
    See related
    Ensembl:ENSG00000134352; HPRD:02824; MIM:600694; Vega:OTTHUMG00000097043
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD130; GP130; CDW130; IL-6RB; DKFZp564F053
    Summary
    The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2010]
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    Genomic context

    Location :
    5q11.2
    Sequence :
    Chromosome: 5; NC_000005.9 (55230923..55290821, complement)
    See IL6ST in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein H1 (H) pseudogene Neighboring gene interleukin 31 receptor A Neighboring gene uncharacterized LOC441072 Neighboring gene ankyrin repeat domain 55 Neighboring gene ribosomal protein L17 pseudogene 22

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Role of the IL-6 classic- and trans-signaling pathways in corneal sterile inflammation and wound healing. Ebihara N, et al. Invest Ophthalmol Vis Sci, 2011. PMID 21989726.
    2. Lack of association of IL6R rs2228145 and IL6ST/gp130 rs2228044 gene polymorphisms with cardiovascular disease in patients with rheumatoid arthritis. López-Mejías R, et al. Tissue Antigens, 2011 Dec. PMID 21981268.
    3. IL-6 trans-signaling system in intra-amniotic inflammation, preterm birth, and preterm premature rupture of the membranes. Lee SY, et al. J Immunol, 2011 Mar 1. PMID 21282511.
    4. Interleukin-6 gene (-174 C/G ) and apolipoprotein E gene polymorphisms and the risk of Alzheimer disease in a Polish population. Klimkowicz-Mrowiec A, et al. Neurol Neurochir Pol, 2010 Nov-Dec. PMID 21225514.
    5. Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex. Lupardus PJ, et al. Structure, 2011 Jan 12. PMID 21220115.

    See all (165) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. results do not confirm an association of IL6R rs2228145 and IL6ST/gp130 rs2228044 polymorphisms with CV disease in RA.
      Title: Lack of association of IL6R rs2228145 and IL6ST/gp130 rs2228044 gene polymorphisms with cardiovascular disease in patients with rheumatoid arthritis.
    2. The IL-6 classic- and trans-signaling pathways have an important role in corneal sterile inflammation and wound healing.
      Title: Role of the IL-6 classic- and trans-signaling pathways in corneal sterile inflammation and wound healing.
    3. gp130 regulates interleukin 6 signalling as an antagonist in cerebrospinal fluid immediately after subarachnoid haemorrhage
      Title: Soluble gp130 regulatess interleukin-6 in cerebrospinal fluid after subarachnoid haemorrhage.
    4. The IL-6/gp130 signaling pathway is dierctly involved in amyloid-beta precursor protein (APP)-induced glial differentiation.
      Title: Amyloid-β precursor protein induces glial differentiation of neural progenitor cells by activation of the IL-6/gp130 signaling pathway.
    5. Gp130 is a modulator of fetal membrane matrix metalloprotease-9 release and is involved in IL-6 trans-signaling in preterm premature rupture of membranes and preterm birth.
      Title: IL-6 trans-signaling system in intra-amniotic inflammation, preterm birth, and preterm premature rupture of the membranes.
    6. Single-particle imaging of the gp130/Jak1 holocomplex shows Jak1 associated with the membrane proximal intracellular regions of gp130
      Title: Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex.
    7. Data suggest that increased plasma soluble gp130/soluble IL-6R/IL-6 ratio and reduced membrane transsignaling gp130 expression could contribute to decreased SOCS-3 expression and subsequent reduction in SOCS-3 antiinflammatory activity in preeclampsia.
      Title: Elevated maternal soluble Gp130 and IL-6 levels and reduced Gp130 and SOCS-3 expressions in women complicated with preeclampsia.
    8. IL-6 (-174 C/G) polymorphism is not a risk factor for late onset AD in a Polish population.
      Title: Interleukin-6 gene (-174 C/G ) and apolipoprotein E gene polymorphisms and the risk of Alzheimer disease in a Polish population.
    9. gp130 levels are increased in older subjects with metabolic syndrome; gp130 may have a role in insulin resistance
      Title: Plasma soluble gp130 levels are increased in older subjects with metabolic syndrome. The role of insulin resistance.
    10. This study suggested revealed interaction between LGALS1 and IL2Rbeta suggesting a role of these proteins in this autoimmune myasthenia gravis disease.
      Title: A novel galectin-1 and interleukin 2 receptor β haplotype is associated with autoimmune myasthenia gravis.
    Submit: New GeneRIF Correction See all (93)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_002175.2 NP_997704.1 PRKCD    BIND  PubMed PKC-delta interacts with gp130. This interaction was modelled on a demonstrated interaction between mouse PKC-delta and human gp130. 
    NP_002175.2 STAT3    BIND  PubMed gp130 interacts with an unspecified isoform of Stat3. 
    NP_002175.2 NP_005419.2 VAV1    BIND  PubMed Vav interacts with gp130. 
    NP_002175.2     BIND  PubMed The IL6-IL6R complex interacts with IL6ST (gp130) 
    P40189 P10275 AR    HPRD  PubMed  
    P40189 P50750 CDK9    HPRD  PubMed  
    P40189 P26441 CNTF    HPRD  PubMed  
    P40189 P26992 CNTFR    HPRD  PubMed  
    P40189 Q16619 CTF1    HPRD  PubMed  
    P40189 P04626 ERBB2    HPRD  PubMed  
    P40189 P21860 ERBB3    HPRD  PubMed  
    P40189 P08631 HCK    HPRD  PubMed  
    P40189 Q8NI17 IL31RA    HPRD  PubMed  
    P40189 P05231 IL6    HPRD  PubMed  
    P40189 P08887 IL6R    HPRD  PubMed  
    P40189 P40189 IL6ST    HPRD  PubMed  
    P40189 P23458 JAK1    HPRD  PubMed  
    P40189 P15018 LIF    HPRD  PubMed  
    P40189 P42702 LIFR    HPRD  PubMed  
    P40189 P13725 OSM    HPRD  PubMed  
    P40189 Q99650 OSMR    HPRD  PubMed  
    P40189 P48736 PIK3CG    HPRD  PubMed  
    P40189 Q03405 PLAUR    HPRD  PubMed  
    P40189 Q05655 PRKCD    HPRD  PubMed  
    P40189 Q06124 PTPN11    HPRD  PubMed  
    P40189 P29350 PTPN6    HPRD  PubMed  
    P40189 O14543 SOCS3    HPRD  PubMed  
    P40189 P40763 STAT3    HPRD  PubMed  
    P40189 Q04724 TLE1    HPRD  PubMed  
    P40189 P29597 TYK2    HPRD  PubMed  
    P40189 P15498 VAV1    HPRD  PubMed  
    BioGRID:109786 BioGRID:106862 AR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109786 BioGRID:107459 CDK9    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109786 BioGRID:107671 CNTFR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109786 BioGRID:108376 ERBB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109786 BioGRID:108377 ERBB3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109786 BioGRID:109142 GRB2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109786 BioGRID:109305 HCK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109786 BioGRID:109784 IL6R    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109786 BioGRID:109919 JAK1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109786 BioGRID:109920 JAK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109786 BioGRID:110165 LIFR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109786 BioGRID:114617 OSMR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109786 BioGRID:111313 PIK3R1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109786 BioGRID:111566 PRKCD    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109786 BioGRID:111745 PTPN11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109786 BioGRID:111742 PTPN6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109786 BioGRID:112361 SHC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109786 BioGRID:114488 SOCS3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109786 BioGRID:112651 STAT3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109786 BioGRID:112943 TLE1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:109786 BioGRID:113148 TYK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109786 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109786 BioGRID:113252 VAV1    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adipogenesis, organism-specific biosystem (from WikiPathways)
      Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
    • Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-6 Signaling Pathway, organism-specific biosystemInterleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M...
    • IL27-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL27-mediated signaling events, organism-specific biosystem
      IL27-mediated signaling events
    • IL6-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL6-mediated signaling events, organism-specific biosystem
      IL6-mediated signaling events
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interleukin-6 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-6 signaling, organism-specific biosystemInterleukin-6 (IL-6) is a pleiotropic cytokine with roles in processes including immune regulation, hematopoiesis, inflammation, oncogenesis, metabolic control and sleep. It is the founding member o...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
      MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red dashed lin...
    • Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
      Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ciliary neurotrophic factor receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ciliary neurotrophic factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    growth factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to growth factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    interleukin-27 receptor activity IC
    Inferred by Curator
    more info
    		 PubMed 
    contributes_to interleukin-6 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to interleukin-6 receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to interleukin-6 receptor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    contributes_to interleukin-6 receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to leukemia inhibitory factor receptor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    contributes_to oncostatin-M receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein homodimerization activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    JAK-STAT cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    ciliary neurotrophic factor-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytokine-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    interleukin-27-mediated signaling pathway IC
    Inferred by Curator
    more info
    		 PubMed 
    interleukin-27-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    interleukin-6-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    interleukin-6-mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    leukemia inhibitory factor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    negative regulation of interleukin-6-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of acute inflammatory response IC
    Inferred by Curator
    more info
    		 PubMed 
    positive regulation of adaptive immune response IC
    Inferred by Curator
    more info
    		 PubMed 
    positive regulation of anti-apoptosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    positive regulation of cardiac muscle hypertrophy TAS
    Traceable Author Statement
    more info
    		 PubMed 
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    positive regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of tyrosine phosphorylation of Stat1 protein IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of tyrosine phosphorylation of Stat3 protein IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation vascular endothelial growth factor production TAS
    Traceable Author Statement
    more info
    		 PubMed 
    reduction of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to cytokine stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to nutrient IEA
    Inferred from Electronic Annotation
    more info
    		  
    triglyceride mobilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    ciliary neurotrophic factor receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
    		  
    extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    interleukin-6 receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    oncostatin-M receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    interleukin-6 receptor subunit beta
    Names
    interleukin-6 receptor subunit beta
    CD130 antigen
    IL-6R subunit beta
    membrane glycoprotein 130
    IL-6 receptor subunit beta
    membrane glycoprotein gp130
    interleukin receptor beta chain
    oncostatin-M receptor subunit alpha
    gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190981.1 → NP_001177910.1  interleukin-6 receptor subunit beta isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
      Source sequence(s)
      AB102802, AC008914, AC016596, BQ013034, DA863210, DA877322
      Consensus CDS
      CCDS54856.1
      Related
      ENSP00000370694, ENST00000381294
      Conserved Domains (3) summary
      cd00063
      Location:222 – 321
      Blast Score: 167
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:24 – 114
      Blast Score: 330
      Lep_receptor_Ig; Ig-like C2-type domain
      cl12153
      Location:121 – 215
      Blast Score: 99
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    2. NM_002184.3 → NP_002175.2  interleukin-6 receptor subunit beta isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC008914, AC016596, BC117402, BQ013034, DA863210, M57230
      Consensus CDS
      CCDS3971.1
      UniProtKB/Swiss-Prot
      P40189
      UniProtKB/TrEMBL
      Q17RA0
      Related
      ENSP00000370698, OTTHUMP00000122545, ENST00000381298, OTTHUMT00000214146
      Conserved Domains (3) summary
      cd00063
      Location:222 – 321
      Blast Score: 167
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:24 – 114
      Blast Score: 331
      Lep_receptor_Ig; Ig-like C2-type domain
      cl12153
      Location:121 – 215
      Blast Score: 99
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    3. NM_175767.2 → NP_786943.1  interleukin-6 receptor subunit beta isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon, which results in a frameshift in the 3' coding region and a premature termination codon, compared to variant 1. The resulting isoform (2, also known as gp130-RAPS) has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AB015706, AB102802, AC008914, AC016596, BQ013034, DA863210, DA877322
      Consensus CDS
      CCDS47209.1
      UniProtKB/Swiss-Prot
      P40189
      Related
      ENSP00000370687, ENST00000381287
      Conserved Domains (3) summary
      cd00063
      Location:222 – 321
      Blast Score: 166
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:24 – 114
      Blast Score: 318
      Lep_receptor_Ig; Ig-like C2-type domain
      cl12153
      Location:121 – 215
      Blast Score: 96
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p5 Primary Assembly

      Range
      55230923..55290821, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      52204630..52264547, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC008857.6 (2688..62599) None
    genomic AC008914.7 (133965..139676) None
    genomic AC016596.6 (34412..69856) None
    genomic CH471123.1 EAW54936.1
      EAW54937.1
      EAW54938.1
    genomic EF064722.1 ABK41905.1
    genomic U70617.1 None
    mRNA AB015706.1 BAA78112.1
    mRNA AB074172.1 None
    mRNA AB102799.1 BAD89390.1
    mRNA AB102800.1 BAD89391.1
    mRNA AB102801.1 BAD89392.1
    mRNA AB102802.1 BAD89393.1
    mRNA AB102803.1 BAD89394.1
    mRNA AB102804.1 BAD89395.1
    mRNA AL049265.1 None
    mRNA AW015107.1 None
    mRNA BC071555.1 None
    mRNA BC117402.1 AAI17403.1
    mRNA BC117404.1 AAI17405.1
    mRNA BC143842.1 None
    mRNA BQ013034.1 None
    mRNA DA863210.1 None
    mRNA DA877322.1 None
    mRNA M57230.1 AAA59155.1
    mRNA S80479.1 AAB35921.1
    mRNA U58146.1 AAB63010.1
    other-genetic HQ258523.1 ADR83277.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15281 GenPept UniProtKB/TrEMBL:O15281
    P40189.2 GenPept UniProtKB/Swiss-Prot:P40189
    Q13514 GenPept UniProtKB/TrEMBL:Q13514
    Q17RA0 GenPept UniProtKB/TrEMBL:Q17RA0
    Q5FC02 GenPept UniProtKB/TrEMBL:Q5FC02
    Q5FC03 GenPept UniProtKB/TrEMBL:Q5FC03
    Q5FC05 GenPept UniProtKB/TrEMBL:Q5FC05
    Q5FC06 GenPept UniProtKB/TrEMBL:Q5FC06
    Q5FC07 GenPept UniProtKB/TrEMBL:Q5FC07
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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