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    CASP3 caspase 3, apoptosis-related cysteine peptidase [ Homo sapiens ]

    Gene ID: 836, updated on 19-May-2012
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    Summary

    Official Symbol
    CASP3provided by HGNC
    Official Full Name
    caspase 3, apoptosis-related cysteine peptidaseprovided by HGNC
    Primary source
    HGNC:1504
    See related
    Ensembl:ENSG00000164305; HPRD:02799; MIM:600636; Vega:OTTHUMG00000133681
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPP32; SCA-1; CPP32B
    Summary
    This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    4q34
    Sequence :
    Chromosome: 4; NC_000004.11 (185548850..185570629, complement)
    See CASP3 in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene interferon regulatory factor 2 Neighboring gene GAR1 ribonucleoprotein homolog (yeast) pseudogene Neighboring gene coiled-coil domain containing 111 Neighboring gene MLF1 interacting protein Neighboring gene acyl-CoA synthetase long-chain family member 1 Neighboring gene proteoglycan 3 pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Knock down of heat shock protein 27 (HspB1) induces degradation of several putative client proteins. Gibert B, et al. PLoS One, 2012. PMID 22238643.
    2. Prostate apoptosis response 4 (Par-4), a novel substrate of caspase-3 during apoptosis activation. Chaudhry P, et al. Mol Cell Biol, 2012 Feb. PMID 22184067.
    3. Genetic variant in CASP3 affects promoter activity and risk of esophageal squamous cell carcinoma. Zhang Z, et al. Cancer Sci, 2012 Mar. PMID 22136337.
    4. Human coronavirus-induced neuronal programmed cell death is cyclophilin d dependent and potentially caspase dispensable. Favreau DJ, et al. J Virol, 2012 Jan. PMID 22013052.
    5. Small molecular anticancer agent SKLB703 induces apoptosis in human hepatocellular carcinoma cells via the mitochondrial apoptotic pathway invitro and inhibits tumor growth invivo. Xu YZ, et al. Cancer Lett, 2011 Dec 26. PMID 21944661.

    See all (737) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. CASP3 829 A>C polymorphism may highly affect the function of caspase-3 and play an important role in the development of ESCC in Chinese populations
      Title: Genetic variant in CASP3 affects promoter activity and risk of esophageal squamous cell carcinoma.
    2. andrographolide induces apoptosis via inhibiting NF-kappaB-induced bcl-2-mediated survival signaling and modulating p53-induced caspase-3-mediated proapoptotic signaling.
      Title: Andrographolide induces apoptosis in B16F-10 melanoma cells by inhibiting NF-κB-mediated bcl-2 activation and modulating p53-induced caspase-3 gene expression.
    3. Beclin-1 is depleted in Alzheimer's disease brain following caspase-3 cleavage.
      Title: Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain.
    4. identified a novel specific caspase-3 cleavage site in Par-4, and the cleaved fragment of Par-4 retains proapoptotic activity
      Title: Prostate apoptosis response 4 (Par-4), a novel substrate of caspase-3 during apoptosis activation.
    5. Data suggest a positive association of caspase-3 and diplotype analysis of caspase-5 to be associated with prostate cancer risk.
      Title: Association of caspases with an increased prostate cancer risk in north Indian population.
    6. Our results indicate that caspase expression in prostate malignant cells is reduced in a substantial number of patients and that such an alteration occurs in the premalignant stage.
      Title: Immunoreactivity to caspase-3, caspase-7, caspase-8, and caspase-9 forms is frequently lost in human prostate tumors.
    7. Abnormal expression of Ezh2, Runx3 and caspase-3 is associated with the development and progression of endometrioid adenocarcinoma.
      Title: [Expression and relationship of Ezh2, Runx3 and caspase-3 in endometrial adenocarcinoma].
    8. Dimethylformamide can induce apoptosis of cultured adult normal hepatocytes in vitro by reducing expression of Bax and Bcl2 and cleaving casp3.
      Title: [DMF-induced adult hepatocyte apoptosis and its effects on expression of Bcl-2, Bax and Caspase-3].
    9. Human coronavirus-induced neuronal programmed cell death required cyclophilin d but not caspase 3 caspase 9 activities.
      Title: Human coronavirus-induced neuronal programmed cell death is cyclophilin d dependent and potentially caspase dispensable.
    10. Thermo-chemotherapy has a stronger inhibitory effect than chemotherapy alone in lung tumor cell growth, probably through induction of ROS production and subsequent inhibition of Akt pathway activation and Caspase pathway-induced cancer cell apoptosis.
      Title: Involvement of Akt in synergistic effects of thermo-chemotherapy on human small cell lung cancer H446 cell apoptosis.
    Submit: New GeneRIF Correction See all (444)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Signal transducer and activator of transcription factor 1 (STAT1) partially regulates HIV-1 gp120/HCV E2-induced caspase 3 activity PubMed
    env The interaction of cell-associated HIV-1 gp120 with CXCR4-expressing target cells triggers apoptotic processes by activating caspase-9 and -3 PubMed
    env Induction of apoptosis in cell cultures through binding of HIV-1 gp120 or gp160 to CXCR4 involves protein kinase C, basic fibroblast growth factor, caspase-3, and the pro-apoptotic molecule Bax PubMed
    env The cytolytic process that takes place between primary uninfected CD4+ T cells and HIV-1 infected or HIV-1 gp120-expressing cells requires the activity of caspases such as ICE and CPP32 PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41-dependent apoptosis involves caspase-3-dependent mitochondrial depolarization and reactive oxygen species production; HIV-1 gp41-induced mitochondrial depolarization is inhibited by the protease inhibitor nelfinavir PubMed
    Nef nef Microarray and Western blot analyses have shown HIV-1 Nef-induced apoptosis in human brain microvascular endothelial cells requires the involvement of caspase-3 and caspase-9 PubMed
    nef Stable expression of HIV-1 Nef in CEM T cells activates caspase-3 and enhances apoptosis through mechanisms unrelated to Fas PubMed
    nef Stable expression of HIV-1 Nef in Jurkat T cells confers resistance to Fas-mediated apoptosis through inactivation of caspase-3 and caspase-8 PubMed
    Tat tat A p53 fusion protein with the HIV-1 Tat basic domain at its N terminus activates the expression of p21and downregulates the levels of caspase-3 and Bcl-2 PubMed
    tat HIV-1 Tat induces apoptosis through activation of caspase-3 PubMed
    Vpr vpr Overproduction of EEF2 blocks HIV-1 Vpr-induced cell death both in fission yeast and human cells, suppresses caspase 9 and caspase 3-mediated apoptosis induced by Vpr, and reduces cytochrome c release induced by Vpr PubMed
    vpr HIV-1 Vpr increases the activity of caspase-3 and caspase-9, but not of caspase-8 in human HeLa cells; Vpr-induced apoptosis can be inhibited by inhibitors of caspase-3 and caspase-9, but not by inhibitors of caspase-8 PubMed
    vpr HIV-1 Vpr-induced apoptosis through caspase activation and Smac release from mitochondria is dependent on G2 cell cycle arrest , but is lost in cells synchronized in G1/S PubMed
    vpr Through activation of the caspase 9 pathway, HIV-1 Vpr also activates caspase 3 PubMed
    Vpu vpu Levels of active caspase-3 are elevated in T cells as a result of HIV-1 Vpu-mediated inhibition of NF-kappa B activation PubMed
    retropepsin gag-pol HIV-1 protease directly cleaves and activates procaspase 8 in T cells which is associated with cleavage of BID, mitochondrial release of cytochrome c, activation of the downstream caspases 9 and 3, and cleavage of DFF and PARP PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_004337.2 NP_000035.2 AR    BIND  PubMed Androgen Receptor interacts with caspase 3. This interaction was modeled on a demonstrated interaction between human androgen receptor and caspase 3 from an unspecified species. 
    NP_004337.2 NP_001931.1 ATN1    BIND  PubMed Atrophin-1 interacts with caspase 3. This interaction was modeled on a demonstrated interaction between human atrophin-1 and caspase 3 from an unspecified species. 
    NP_004337.2 AAB33571.1 ATXN3    BIND  PubMed Ataxin-3 interacts with caspase 3. This interaction was modeled on a demonstrated interaction between human ataxin-3 and caspase 3 from an unspecified species. 
    NP_004337.2 NP_001156.1 BIRC3    BIND  PubMed cIAP2 exhibits E3 ubiquitin ligase activity towards Casp3. 
    NP_004337.2 NP_057336.1 BIRC6    BIND  PubMed BRUCE interacts with Casp-3. This interaction was modeled on a demonstrated interaction between mouse BRUCE and human Casp-3. 
    NP_004337.2 NP_002102.2 HTT    BIND  PubMed Huntingtin interacts with caspase 3. This interaction was modeled on a demonstrated interaction between human Huntingtin and caspase 3 from an unspecified species. 
    NP_004337.2 NP_004997.4 NDUFS1    BIND  PubMed NDUFS1 interacts with caspase-3. This interaction was modeled on a demonstrated interaction between human NDUSF1 and caspase-3 from an unspecified source. 
    NP_004337.2 NP_002490.1 NEO1    BIND  PubMed Neogenin interacts with Caspase 3. This interaction was modelled on a demonstrated interaction between human Neogenin and Caspase 3 from an unspecified species. 
    NP_004337.2 NP_001609.1 PARP1    BIND  PubMed PARP interacts with Caspase-3. This interaction was modeled on a demonstrated interaction between human PARP and caspase-3 from an unspecified source. 
    NP_004337.2 NP_057358.2 PLEKHO1    BIND  PubMed CKIP-1 is cleaved by CASP3 during the initiation of apoptosis. 
    NP_004337.2 NP_001158.2 XIAP    BIND  PubMed Caspase-3 interacts with XIAP. 
    NP_116786.1 NP_057336.1 BIRC6    BIND  PubMed BRUCE interacts with Casp-3. This interaction was modeled on a demonstrated interaction between mouse BRUCE and human Casp-3. 
    NP_116786.1 NP_003870.3 CFLAR    BIND  PubMed MRIT-alpha-1 interacts with YAMA. This interaction was modelled on a demonstrated interaction between human MRIT-alpha-1 and YAMA from an unspecified species. 
    NP_116786.1 NP_015557.1 PSEN1    BIND  PubMed PS1 interacts with caspase 3. This interaction was modeled on a demonstrated interaction between human PS1 and mouse caspase 3. 
    NP_116786.1 NP_000312.1 RB1    BIND  PubMed CASP3 (caspase-3) cleaves RB-1 (hRB) at the DEAD and DSID consensus sites to produce the p100, p68, p61 and p48 forms. 
    NP_116786.1 NP_001158.2 XIAP    BIND  PubMed XIAP interacts with Casp-3. 
    P42574 Q9UKV3 ACIN1    HPRD  PubMed  
    P42574 P35611 ADD1    HPRD  PubMed  
    P42574 O95831 AIFM1    HPRD  PubMed  
    P42574 O43823 AKAP8    HPRD  PubMed  
    P42574 P31749 AKT1    HPRD  PubMed  
    P42574 O14727 APAF1    HPRD  PubMed  
    P42574 P05067 APP    HPRD  PubMed  
    P42574 P10275 AR    HPRD  PubMed  
    P42574 P52566 ARHGDIB    HPRD  PubMed  
    P42574 P54259 ATN1    HPRD  PubMed  
    P42574 P51572 BCAP31    HPRD  PubMed  
    P42574 P56945 BCAR1    HPRD  PubMed  
    P42574 P10415 BCL2    HPRD  PubMed  
    P42574 P55957 BID    HPRD  PubMed  
    P42574 Q13490 BIRC2    HPRD  PubMed  
    P42574 Q13489 BIRC3    HPRD  PubMed  
    P42574 O15392 BIRC5    HPRD  PubMed  
    P42574 Q9NR09 BIRC6    HPRD  PubMed  
    P42574 Q96CA5 BIRC7    HPRD  PubMed  
    P42574 P54132 BLM    HPRD  PubMed  
    P42574 P51813 BMX    HPRD  PubMed  
    P42574 P38398 BRCA1    HPRD  PubMed  
    P42574 P27708 CAD    HPRD  PubMed  
    P42574 Q92851 CASP10    HPRD  PubMed  
    P42574 P42574 CASP3    HPRD  PubMed  
    P42574 P49662 CASP4    HPRD  PubMed  
    P42574 P55212 CASP6    HPRD  PubMed  
    P42574 Q14790 CASP8    HPRD  PubMed  
    P42574 P55211 CASP9    HPRD  PubMed  
    P42574 P20810 CAST    HPRD  PubMed  
    P42574 P30260 CDC27    HPRD  PubMed  
    P42574 P60953 CDC42    HPRD  PubMed  
    P42574 P12830 CDH1    HPRD  PubMed  
    P42574 Q9UQ88 CDK11A    HPRD  PubMed  
    P42574 P21127 CDK11B    HPRD  PubMed  
    P42574 P38936 CDKN1A    HPRD  PubMed  
    P42574 O15519 CFLAR    HPRD  PubMed  
    P42574 P35222 CTNNB1    HPRD  PubMed  
    P42574 P43146 DCC    HPRD  PubMed  
    P42574 Q14203 DCTN1    HPRD  PubMed  
    P42574 O75618 DEDD    HPRD  PubMed  
    P42574 O00273 DFFA    HPRD  PubMed  
    P42574 P32926 DSG3    HPRD  PubMed  
    P42574 P19525 EIF2AK2    HPRD  PubMed  
    P42574 P05198 EIF2S1    HPRD  PubMed  
    P42574 O75822 EIF3J    HPRD  PubMed  
    P42574 P23588 EIF4B    HPRD  PubMed  
    P42574 P78344 EIF4G2    HPRD  PubMed  
    P42574 P06241 FYN    HPRD  PubMed  
    P42574 P15976 GATA1    HPRD  PubMed  
    P42574 Q08378 GOLGA3    HPRD  PubMed  
    P42574 Q9BQQ3 GORASP1    HPRD  PubMed  
    P42574 Q4V328 GRIPAP1    HPRD  PubMed  
    P42574 P06396 GSN    HPRD  PubMed  
    P42574 P10144 GZMB    HPRD  PubMed  
    P42574 P14317 HCLS1    HPRD  PubMed  
    P42574 O00291 HIP1    HPRD  PubMed  
    P42574 P09429 HMGB1    HPRD  PubMed  
    P42574 Q00839 HNRNPU    HPRD  PubMed  
    P42574 P10809 HSPD1    HPRD  PubMed  
    P42574 P61604 HSPE1    HPRD  PubMed  
    P42574 P42858 HTT    HPRD  PubMed  
    P42574 Q14005 IL16    HPRD  PubMed  
    P42574 Q14116 IL18    HPRD  PubMed  
    P42574 Q9Y2W7 KCNIP3    HPRD  PubMed  
    P42574 P05783 KRT18    HPRD  PubMed  
    P42574 P20700 LMNB1    HPRD  PubMed  
    P42574 P07948 LYN    HPRD  PubMed  
    P42574 Q92918 MAP4K1    HPRD  PubMed  
    P42574 Q9UPT6 MAPK8IP3    HPRD  PubMed  
    P42574 P10636 MAPT    HPRD  PubMed  
    P42574 Q07820 MCL1    HPRD  PubMed  
    P42574 Q00987 MDM2    HPRD  PubMed  
    P42574 O15151 MDM4    HPRD  PubMed  
    P42574 Q02078 MEF2A    HPRD  PubMed  
    P42574 P08581 MET    HPRD  PubMed  
    P42574 P40692 MLH1    HPRD  PubMed  
    P42574 P08590 MYL3    HPRD  PubMed  
    P42574 P46934 NEDD4    HPRD  PubMed  
    P42574 Q16236 NFE2L2    HPRD  PubMed  
    P42574 O60551 NMT2    HPRD  PubMed  
    P42574 Q13177 PAK2    HPRD  PubMed  
    P42574 Q86W56 PARG    HPRD  PubMed  
    P42574 Q9Y233 PDE10A    HPRD  PubMed  
    P42574 O76074 PDE5A    HPRD  PubMed  
    P42574 Q13492 PICALM    HPRD  PubMed  
    P42574 Q99755 PIP5K1A    HPRD  PubMed  
    P42574 Q16512 PKN1    HPRD  PubMed  
    P42574 Q16513 PKN2    HPRD  PubMed  
    P42574 P47712 PLA2G4A    HPRD  PubMed  
    P42574 Q08209 PPP3CA    HPRD  PubMed  
    P42574 Q04759 PRKCQ    HPRD  PubMed  
    P42574 Q05513 PRKCZ    HPRD  PubMed  
    P42574 P78527 PRKDC    HPRD  PubMed  
    P42574 P49768 PSEN1    HPRD  PubMed  
    P42574 P49810 PSEN2    HPRD  PubMed  
    P42574 O75475 PSIP1    HPRD  PubMed  
    P42574 P61289 PSME3    HPRD  PubMed  
    P42574 P26599 PTBP1    HPRD  PubMed  
    P42574 P06454 PTMA    HPRD  PubMed  
    P42574 P49023 PXN    HPRD  PubMed  
    P42574 Q15276 RABEP1    HPRD  PubMed  
    P42574 P63000 RAC1    HPRD  PubMed  
    P42574 Q06609 RAD51    HPRD  PubMed  
    P42574 P20936 RASA1    HPRD  PubMed  
    P42574 P06400 RB1    HPRD  PubMed  
    P42574 P35251 RFC1    HPRD  PubMed  
    P42574 Q13464 ROCK1    HPRD  PubMed  
    P42574 Q9NP81 SARS2    HPRD  PubMed  
    P42574 Q9H2G2 SLK    HPRD  PubMed  
    P42574 P08047 SP1    HPRD  PubMed  
    P42574 Q13813 SPTAN1    HPRD  PubMed  
    P42574 Q12772 SREBF2    HPRD  PubMed  
    P42574 P11831 SRF    HPRD  PubMed  
    P42574 O76094 SRP72    HPRD  PubMed  
    P42574 Q9Y6E0 STK24    HPRD  PubMed  
    P42574 Q13188 STK3    HPRD  PubMed  
    P42574 Q13043 STK4    HPRD  PubMed  
    P42574 P05549 TFAP2A    HPRD  PubMed  
    P42574 P21980 TGM2    HPRD  PubMed  
    P42574 P11387 TOP1    HPRD  PubMed  
    P42574 Q13077 TRAF1    HPRD  PubMed  
    P42574 Q13114 TRAF3    HPRD  PubMed  
    P42574 O95155 UBE4B    HPRD  PubMed  
    P42574 O60763 USO1    HPRD  PubMed  
    P42574 P15498 VAV1    HPRD  PubMed  
    P42574 P08670 VIM    HPRD  PubMed  
    P42574 P30291 WEE1    HPRD  PubMed  
    P42574 P98170 XIAP    HPRD  PubMed  
    P42574 P62258 YWHAE    HPRD  PubMed  
    BioGRID:107286 BioGRID:107068 BCL2    BioGRID  PubMed Biochemical Activity 
    BioGRID:107286 BioGRID:107106 BID    BioGRID  PubMed Biochemical Activity 
    BioGRID:107286 BioGRID:106826 BIRC2    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:107286 BioGRID:106827 BIRC3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107286 BioGRID:106829 BIRC5    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:107286 BioGRID:122670 BIRC7    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107286 BioGRID:107110 BLM    BioGRID  PubMed Biochemical Activity 
    BioGRID:107286 BioGRID:107128 BMX    BioGRID  PubMed Biochemical Activity 
    BioGRID:107286 BioGRID:114457 BTRC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107286 BioGRID:107293 CASP10    BioGRID  PubMed Biochemical Activity 
    BioGRID:107286 BioGRID:107285 CASP2    BioGRID  PubMed Biochemical Activity 
    BioGRID:107286 BioGRID:107286 CASP3    BioGRID  PubMed Co-crystal Structure 
    BioGRID:107286 BioGRID:107289 CASP6    BioGRID  PubMed Biochemical Activity 
    BioGRID:107286 BioGRID:107291 CASP8    BioGRID  PubMed Biochemical Activity 
    AAC51623.1 CFLAR    BIND  PubMed MRIT-beta-1 interacts with YAMA. This interaction was modelled on a demonstrated interaction between human MRIT-beta-1 and YAMA from an unspecified species. 
    BioGRID:107286 BioGRID:114364 CFLAR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107286 BioGRID:108332 CTTN    BioGRID  PubMed Biochemical Activity 
    BioGRID:107286 BioGRID:118809 DBNL    BioGRID  PubMed Biochemical Activity 
    BioGRID:107286 BioGRID:107998 DCC    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107286 BioGRID:116887 FBXW11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107286 BioGRID:119246 GMNN    BioGRID  PubMed Biochemical Activity 
    BioGRID:107286 BioGRID:122232 GORASP1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107286 BioGRID:121210 GRIPAP1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107286 BioGRID:109309 HCLS1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107286 BioGRID:117045 HEY2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107286 BioGRID:109547 HSPB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107286 BioGRID:109561 HSPD1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107286 BioGRID:109568 HSPE1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107286 BioGRID:114487 MAP3K14    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107286 BioGRID:110338 MCL1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107286 BioGRID:110799 NDUFS1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107286 BioGRID:114077 PARG    BioGRID  PubMed Biochemical Activity 
    BioGRID:107286 BioGRID:115301 RBX1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107286 BioGRID:111972 RNF2    BioGRID  PubMed Biochemical Activity 
    BioGRID:107286 BioGRID:112599 SREBF2    BioGRID  PubMed Biochemical Activity 
    BioGRID:107286 BioGRID:139860 SRP72    BioGRID  PubMed Biochemical Activity 
    BioGRID:107286 BioGRID:121453 THAP11    BioGRID  PubMed Two-hybrid 
    NP_116254.3 TNS4    BIND  PubMed Caspase-3 interacts with and cleaves cten. 
    BioGRID:107286 BioGRID:113039 TRAF3    BioGRID  PubMed Biochemical Activity 
    BioGRID:107286 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:107286 BioGRID:114173 USO1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107286 BioGRID:106828 XIAP    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Activation of DNA fragmentation factor, organism-specific biosystem (from REACTOME)
      Activation of DNA fragmentation factor, organism-specific biosystemDNA fragmentation in response to apoptotic signals is achieved, in part, through the activity of apoptotic nucleases, termed DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) (reviewed ...
    • Activation of caspases through apoptosome-mediated cleavage, organism-specific biosystem (from REACTOME)
      Activation of caspases through apoptosome-mediated cleavage, organism-specific biosystemProcaspase-3 and 7 are cleaved by the apoptosome.
    • Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem"Integrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligand...
    • Alzheimer's disease, organism-specific biosystem (from KEGG)
      Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimer's disease, conserved biosystem (from KEGG)
      Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Amoebiasis, organism-specific biosystem (from KEGG)
      Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Amoebiasis, conserved biosystem (from KEGG)
      Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Amyotrophic lateral sclerosis (ALS), conserved biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), conserved biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis Modulation by HSP70, organism-specific biosystem (from WikiPathways)
      Apoptosis Modulation by HSP70, organism-specific biosystem
      Apoptosis Modulation by HSP70
    • Apoptosis induced DNA fragmentation, organism-specific biosystem (from REACTOME)
      Apoptosis induced DNA fragmentation, organism-specific biosystemDNA fragmentation in response to apoptotic signals is achieved through the activity of two apoptotic nucleases, termed DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease...
    • Apoptotic cleavage of cell adhesion proteins, organism-specific biosystem (from REACTOME)
      Apoptotic cleavage of cell adhesion proteins, organism-specific biosystemApoptotic cells show dramatic rearrangements of tight junctions, adherens junctions, and desmosomes (Abreu et al., 2000). Desmosome-specific members of the cadherin superfamily of cell adhesion mole...
    • Apoptotic cleavage of cellular proteins, organism-specific biosystem (from REACTOME)
      Apoptotic cleavage of cellular proteins, organism-specific biosystemApoptotic cell death is achieved by the caspase-mediatedcleavage of various vital proteins. Among caspase targets are proteins such as E-cadherin, Beta-catenin, alpha fodrin, GAS2, FADK, alpha adduc...
    • Apoptotic execution phase, organism-specific biosystem (from REACTOME)
      Apoptotic execution phase, organism-specific biosystemIn the execution phase of apoptosis, effector caspases cleave vital cellular proteins leading to the morphological changes that characterize apoptosis. These changes include destruction of the nucle...
    • Apoptotic factor-mediated response, organism-specific biosystem (from REACTOME)
      Apoptotic factor-mediated response, organism-specific biosystemIn response to apoptotic signals, mitochondrial proteins are released into the cytosol and activate both caspase-dependent and -independent cell death pathways. Cytochrome c induces apoptosome form...
    • Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
      Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem
      Calcineurin-regulated NFAT-dependent transcription in lymphocytes
    • Caspase cascade in apoptosis, organism-specific biosystem (from Pathway Interaction Database)
      Caspase cascade in apoptosis, organism-specific biosystem
      Caspase cascade in apoptosis
    • Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystem (from REACTOME)
      Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystemCaspase-mediated cleavage of a number of proteins in the cortical actin network ( ) microfilament system and others involved in maintenance of the cytoskeletal architecture (vimentin, or Gas2 and ...
    • Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem (from REACTOME)
      Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystemp75NTR is a key regulator of neuronal apoptosis, both during development and after injury. Apoptosis is triggered by binding of either mature neurotrophin or proneurotrophin (proNGF, proBDNF). ProNG...
    • Colorectal cancer, organism-specific biosystem (from KEGG)
      Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Colorectal cancer, conserved biosystem (from KEGG)
      Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Cytochrome c-mediated apoptotic response, organism-specific biosystem (from REACTOME)
      Cytochrome c-mediated apoptotic response, organism-specific biosystemUpon its release from the mitochondrial intermembrane space, Cytochrome c binds to and causes a conformational change in the cytoplasmic protein Apaf1. This conformational change allows the Cytochrom...
    • Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystem (from KEGG)
      Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystemTwo major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA)....
    • Epithelial cell signaling in Helicobacter pylori infection, conserved biosystem (from KEGG)
      Epithelial cell signaling in Helicobacter pylori infection, conserved biosystemTwo major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA)....
    • FAS (CD95) signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      FAS (CD95) signaling pathway, organism-specific biosystem
      FAS (CD95) signaling pathway
    • FAS pathway and Stress induction of HSP regulation, organism-specific biosystem (from WikiPathways)
      FAS pathway and Stress induction of HSP regulation, organism-specific biosystemThis pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].
    • HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem (from Pathway Interaction Database)
      HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem
      HIV-1 Nef: Negative effector of Fas and TNF-alpha
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Huntington's disease, organism-specific biosystem (from KEGG)
      Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Huntington's disease, conserved biosystem (from KEGG)
      Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-6 Signaling Pathway, organism-specific biosystemInterleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M...
    • Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
      Intrinsic Pathway for Apoptosis, organism-specific biosystemThe intrinsic (Bcl-2 inhibitable or mitochondrial) pathway of apoptosis functions in response to various types of intracellular stress including growth factor withdrawal, DNA damage, unfolding stress...
    • LPA receptor mediated events, organism-specific biosystem (from Pathway Interaction Database)
      LPA receptor mediated events, organism-specific biosystem
      LPA receptor mediated events
    • Legionellosis, organism-specific biosystem (from KEGG)
      Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Legionellosis, conserved biosystem (from KEGG)
      Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • NADE modulates death signalling, organism-specific biosystem (from REACTOME)
      NADE modulates death signalling, organism-specific biosystemNADE protein (p75NTR-associated cell death executor) may induce cell death upon NGF binding, but not BDNF, NT3, or NT4/5 binding, to p75NTR. The NADE-dependent apoptosis is modulated by the 14-3-3-ep...
    • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Parkinson's disease, organism-specific biosystem (from KEGG)
      Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic neurons in the substantia nigra. Mutations in alpha-synuclein, UCHL...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Pertussis, organism-specific biosystem (from KEGG)
      Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Pertussis, conserved biosystem (from KEGG)
      Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Regulation of Apoptosis, organism-specific biosystem (from REACTOME)
      Regulation of Apoptosis, organism-specific biosystemA regulated balance between cell survival and apoptosis is essential for normal development and homeostasis of multicellular organisms (see Matsuzawa, 2001). Defects in control of this balance may...
    • Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
      Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem
      Role of Calcineurin-dependent NFAT signaling in lymphocytes
    • Role of DCC in regulating apoptosis, organism-specific biosystem (from REACTOME)
      Role of DCC in regulating apoptosis, organism-specific biosystemIn the presence of Netrin1, DCC and UNC5 generate attractive and repulsive signals to growing axons. In the absence of Netrin-1, DCC induces cell death signaling initiated via caspase cleavage of DCC...
    • SMAC binds to IAPs, organism-specific biosystem (from REACTOME)
      SMAC binds to IAPs, organism-specific biosystemSMAC binds to the XIAP:caspase complexes.
    • SMAC-mediated apoptotic response, organism-specific biosystem (from REACTOME)
      SMAC-mediated apoptotic response, organism-specific biosystemOnce released from the mitochondria, SMAC binds to IAP family proteins displacing them from Caspase:IAP complexes liberating the active caspases.
    • SMAC-mediated dissociation of IAP:caspase complexes, organism-specific biosystem (from REACTOME)
      SMAC-mediated dissociation of IAP:caspase complexes, organism-specific biosystemSmac/DIABLO regulates IAP function. Residues 56â??59 of Smac/DIABLO are homologous to the amino-terminal motif that is used by caspase-9 to bind to the BIR3 domain of XIAP. Binding of Smac/DIABLO to...
    • Serotonergic synapse, organism-specific biosystem (from KEGG)
      Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Hippo, organism-specific biosystem (from REACTOME)
      Signaling by Hippo, organism-specific biosystemHuman Hippo signaling is a network of reactions that regulates cell proliferation and apoptosis, centered on a three-step kinase cascade. The cascade was discovered by analysis of Drosophila mutation...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Stimulation of the cell death response by PAK-2p34, organism-specific biosystem (from REACTOME)
      Stimulation of the cell death response by PAK-2p34, organism-specific biosystemIn response to stress signals, the p21-activated protein kinase PAK-2 stimulates a cell death response characterized by increased cell rounding and apoptotic chromatin condensation (see Jakobi et al...
    • Syndecan-2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Syndecan-2-mediated signaling events, organism-specific biosystem
      Syndecan-2-mediated signaling events
    • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Viral myocarditis, organism-specific biosystem (from KEGG)
      Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
      p75 NTR receptor-mediated signalling, organism-specific biosystemBesides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a ...
    • p75(NTR)-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
      p75(NTR)-mediated signaling, organism-specific biosystem
      p75(NTR)-mediated signaling

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    cyclin-dependent protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cysteine-type endopeptidase activity TAS
    Traceable Author Statement
    more info
    		  
    peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    B cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA fragmentation involved in apoptotic nuclear change TAS
    Traceable Author Statement
    more info
    		  
    T cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c TAS
    Traceable Author Statement
    more info
    		  
    apoptotic process TAS
    Traceable Author Statement
    more info
    		  
    cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular component disassembly involved in apoptosis TAS
    Traceable Author Statement
    more info
    		  
    heart development IEA
    Inferred from Electronic Annotation
    more info
    		  
    induction of apoptosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    induction of apoptosis by extracellular signals TAS
    Traceable Author Statement
    more info
    		 PubMed 
    induction of apoptosis by intracellular signals TAS
    Traceable Author Statement
    more info
    		  
    induction of apoptosis by oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    induction of apoptosis via death domain receptors IEA
    Inferred from Electronic Annotation
    more info
    		  
    keratinocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of activated T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    negative regulation of cyclin-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    nerve growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    nuclear fragmentation involved in apoptotic nuclear change IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of neuron apoptosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    		  
    release of cytochrome c from mitochondria IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to UV IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to tumor necrosis factor TAS
    Traceable Author Statement
    more info
    		 PubMed 
    response to wounding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sensory perception of sound IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    caspase-3
    Names
    caspase-3
    Yama
    CASP-3
    CPP-32
    apopain
    procaspase3
    protein Yama
    PARP cleavage protease
    cysteine protease CPP32
    SREBP cleavage activity 1
    caspase 3, apoptosis-related cysteine protease
    NP_004337.2
    NP_116786.1
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004346.3 → NP_004337.2  caspase-3 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha) represents the longer transcript.
      Source sequence(s)
      AU127028, BC016926, BU753483
      Consensus CDS
      CCDS3836.1
      UniProtKB/Swiss-Prot
      P42574
      Related
      ENSP00000311032, OTTHUMP00000165052, ENST00000308394, OTTHUMT00000257885
      Conserved Domains (1) summary
      cd00032
      Location:37 – 275
      Blast Score: 805
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    2. NM_032991.2 → NP_116786.1  caspase-3 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta) differs in the 5' UTR, compared to variant alpha.
      Source sequence(s)
      AU127028, BC016926, BU753483
      Consensus CDS
      CCDS3836.1
      UniProtKB/Swiss-Prot
      P42574
      Related
      ENSP00000428929, OTTHUMP00000165054, ENST00000523916, OTTHUMT00000257887
      Conserved Domains (1) summary
      cd00032
      Location:37 – 275
      Blast Score: 805
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p5 Primary Assembly

      Range
      185548850..185570629, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      181303305..181324956, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC073932.4 (47710..48216) None
    genomic AC079257.7 (1997..23269) None
    genomic AY219866.1 AAO25654.1
    genomic CH471056.2 EAX04673.1
      EAX04674.1
      EAX04675.1
      EAX04676.1
    genomic CQ786438.1 CAG17895.1
    genomic GM887507.1 CAV28500.1
    genomic HI179110.1 CBX53863.1
    genomic HI179112.1 CBX53864.1
    mRNA AJ413269.1 CAC88866.1
    mRNA AK291337.1 BAF84026.1
    mRNA AU127028.1 None
    mRNA AU133051.1 None
    mRNA BC016926.2 AAH16926.1
    mRNA BU753483.1 None
    mRNA BX647609.1 CAI46084.1
    mRNA U13737.1 AAA65015.1
    mRNA U13738.1 AAB60355.1
    mRNA U26943.1 AAA74929.1
    other-genetic DQ891543.2 ABM82469.1
    other-genetic DQ894731.2 ABM85657.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42574.2 GenPept UniProtKB/Swiss-Prot:P42574
    Q5HYI3 GenPept UniProtKB/TrEMBL:Q5HYI3
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

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