Sign in to NCBI

Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

    PARP1 poly (ADP-ribose) polymerase 1 [ Homo sapiens (human) ]

    Gene ID: 142, updated on 14-May-2013
    Official Symbol
    PARP1provided by HGNC
    Official Full Name
    poly (ADP-ribose) polymerase 1provided by HGNC
    Primary source
    HGNC:270
    Locus tag
    RP11-125A15.2
    See related
    Ensembl:ENSG00000143799; HPRD:01435; MIM:173870; Vega:OTTHUMG00000037556
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PARP; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT 1; pADPRT-1
    Summary
    This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
    Location :
    1q41-q42
    Sequence :
    Chromosome: 1; NC_000001.10 (226548392..226595801, complement)
    See PARP1 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene signal peptidase complex subunit 3-like Neighboring gene Y box binding protein 1 pseudogene 9 Neighboring gene ribosomal protein S3a pseudogene 7 Neighboring gene CDKN2A interacting protein N-terminal like pseudogene 1

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Tocotrienols promote apoptosis in human breast cancer cells by inducing poly(ADP-ribose) polymerase cleavage and inhibiting nuclear factor kappa-B activity. Loganathan R, et al. Cell Prolif, 2013 Apr. PMID 23510475.
    2. Distinct spatiotemporal patterns and PARP dependence of XRCC1 recruitment to single-strand break and base excision repair. Campalans A, et al. Nucleic Acids Res, 2013 Mar 1. PMID 23355608.
    3. Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair. Robu M, et al. Proc Natl Acad Sci U S A, 2013 Jan 29. PMID 23319653.
    4. Poly(ADP-ribose) polymerase 1 promotes transcriptional repression of integrated retroviruses. Bueno MT, et al. J Virol, 2013 Mar. PMID 23255787.
    5. Apoptotic DNA fragmentation may be a cooperative activity between caspase-activated deoxyribonuclease and the poly(ADP-ribose) polymerase-regulated DNAS1L3, an endoplasmic reticulum-localized endonuclease that translocates to the nucleus during apoptosis. Errami Y, et al. J Biol Chem, 2013 Feb 1. PMID 23229555.

    See all (586) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Apoptosis in breast cancer cells is induced by PARP cleavage following vitamin E treatment.
      Title: Tocotrienols promote apoptosis in human breast cancer cells by inducing poly(ADP-ribose) polymerase cleavage and inhibiting nuclear factor kappa-B activity.
    2. XRCC1 is recruited to single-strand break repair by PARP-1, responsible for the initial recognition of the break.
      Title: Distinct spatiotemporal patterns and PARP dependence of XRCC1 recruitment to single-strand break and base excision repair.
    3. binds to the C-terminal-100 amino acids of NEIL1
      Title: Coordination of DNA repair by NEIL1 and PARP-1: a possible link to aging.
    4. Data indicate that poly(ADP-ribose) polymerase-1 (PARP-1)collaborates with DNA-binding protein 2 (DDB2) to increase the efficiency of the lesion recognition step of global genomic subpathway of NER (GG-NER).
      Title: Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair.
    5. Studied expression of BAG-1 and PARP-1 in LSILs, HSILs and SCCs. Research suggests BAG-1 expression could contribute to the differentiation between LSIL and HSIL/SCC whereas PARP-1 could be useful to the differentiation between HSIL HPV-related and SCC.
      Title: Expression of BAG-1 and PARP-1 in precursor lesions and invasive cervical cancer associated with human papillomavirus (HPV).
    6. data indicate a novel role of PARP-1 in the transcriptional repression of integrated retroviruses
      Title: Poly(ADP-ribose) polymerase 1 promotes transcriptional repression of integrated retroviruses.
    7. Data from various thyroid cancer cell lines suggest that PARP inhibition increases NIS (sodium iodide symporter) gene expression through a particular modulation of transcriptional regulatory mechanisms (i.e., specific histone modifications).
      Title: The PARP inhibitor PJ34 modifies proliferation, NIS expression and epigenetic marks in thyroid cancer cell lines.
    8. level of PARP-1 protein nuclear expression is associated with the tumor site and heterogeneous across clinical specimens of colorectal cancers
      Title: Colorectal cancers differ in respect of PARP-1 protein expression.
    9. an association of the PARP-1 V 762A polymorphism with increased risk of cancer among Asians, but decreased risk of cancer among Caucasians, particularly of glioma
      Title: Association between PARP-1 V762A polymorphism and cancer susceptibility: a meta-analysis.
    10. Knocking down human PARP-1 decreases both the amount of amastigotes and trypomastigotes in cell culture, indicating that the effect would be mainly due to inhibition of human PARP-1.
      Title: Inhibition of poly(ADP-ribose) polymerase interferes with Trypanosoma cruzi infection and proliferation of the parasite.
    Submit: New GeneRIF Correction See all (345)

    Review eQTL and phenotype association data in this region using PheGenI

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120 PubMed
    env Contact of CD4+ T cells with HIV-1 infected or HIV-1 gp120-expressing cells induces PARP hydrolysis, which leads to the cleavage of 116 kDa PARP into two fragments PubMed
    Nef, p27 nef HIV-1 Nef enhances apoptosis in CD4+ T lymphoblastoid cell lines through mechanisms that include the cleavage of the caspase target poly(ADP-ribose) polymerase PubMed
    nef Expression of HIV-1 Nef in human brain micro vascular endothelial cells induces the cleavage of PARP protein, which is involved in DNA repair PubMed
    Tat, p14 tat The levels of PARP1 protein are reduced after Caco-2 cells exposure to HIV-1 Tat compared with control PubMed
    tat PARP1 negatively regulates HIV-1 transcription by directly competing with Tat-P-TEFb complex for binding to TAR RNA PubMed
    tat HIV-1 Tat induces the cleavage of PARP and activation of apoptosis through a p56lck dependent mechanism PubMed
    tat Treatment of primary human microvascular endothelial cells of lung origin with HIV-1 Tat caused cleavage of poly(A/DP)-ribose polymerase as a result of caspase activation PubMed
    tat The poly(A) site in the HIV-1 5'-LTR is occluded in a Tat-dependent manner, suggesting a role for Tat in regulating this nucleotide signal PubMed
    tat Poly(ADP-ribose) polymerase modifies HIV-1 Tat with poly(ADP-ribose), suggesting a role for this enzyme in the regulation of HIV-1 gene expression PubMed
    tat Purified recombinant HIV-1 Tat protein stimulates poly(ADP-ribose) polymerase in a dose dependent manner PubMed
    Vpr, p15 vpr Recruitment of PARP-1 by HIV-1 Vpr-glucocorticoid receptor (GR) complex prevents its nuclear localization, which is necessary for Vpr to suppress NF-kappaB PubMed
    vpr HIV-1 Vpr induces apoptosis and the cleavage of ADPRT in a manner that is signaled through the DNA damage signaling protein ataxia telangiectasia Rad3-related protein (ATR) PubMed
    pol gag-pol Positional proteomics analysis identifies the cleavage of human poly (ADP-ribose) polymerase family, member 1 (PARP1) at amino acid residues 185-186 by the HIV-1 protease PubMed
    gag-pol Inhibition of HIV-1 protease by saquinavir and leu3.a blocks PARP cleavage and protects cells from apoptosis and necrosis PubMed
    gag-pol HIV-1 protease directly cleaves and activates procaspase 8 in T cells, which is associated with cleavage of BID, mitochondrial release of cytochrome c, activation of the downstream caspases 9 and 3, and cleavage of DFF and PARP PubMed
    gag-pol PARP has been described as a requirement for efficient HIV-1 integration, however a conflicting report indicates it is not essential for efficient lentivirus integration PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001609.1 NP_004337.2 CASP3    BIND  PubMed PARP interacts with Caspase-3. This interaction was modeled on a demonstrated interaction between human PARP and caspase-3 from an unspecified source. 
    NP_001609.1 NP_203125.1 CASP7    BIND  PubMed PARP interacts with caspase-7. This interaction was modelled on a demonstrated interaction between human PARP and fly drICE. 
    NP_001609.1 NP_005457.2 MED6    BIND  PubMed PARP-1 interacts with Med6. 
    NP_001609.1 NP_000955.1 RARA    BIND  PubMed PARP-1 interacts with RAR-alpha. 
    NP_001609.1 THRA    BIND  PubMed PARP-1 interacts with TR-alpha. This interaction was modeled on a demonstrated interaction between human PARP-1 and TR-alpha from an unspecified species. 
    NP_001609.1 NP_003277.1 TOP1    BIND  PubMed PARP-1 interacts with Topo I 
    NP_001609.1 NP_000544.1 WRN    BIND  PubMed WRN interacts with PARP1. 
    NP_001609.1 NC_000001.8     BIND  PubMed PARP-1 interacts with p-dio1. 
    NP_001609.1     BIND  PubMed PARP1 interacts with ADP-ribose. This interaction was modeled on a demonstrated interaction between PARP1 from Aplysia and ADP-ribose. 
    NP_001609.1     BIND  PubMed PARP-1 interacts with NAD+ 
    P09874 Q7Z2E3 APTX    HPRD  PubMed  
    P09874 P10415 BCL2    HPRD  PubMed  
    P09874 O43684 BUB3    HPRD  PubMed  
    P09874 P29466 CASP1    HPRD  PubMed  
    P09874 P38936 CDKN1A    HPRD  PubMed  
    P09874 P49450 CENPA    HPRD  PubMed  
    P09874 P07199 CENPB    HPRD  PubMed  
    P09874 P08311 CTSG    HPRD  PubMed  
    P09874 Q01094 E2F1    HPRD  PubMed  
    P09874 Q03468 ERCC6    HPRD  PubMed  
    P09874 P10144 GZMB    HPRD  PubMed  
    P09874 P49916 LIG3    HPRD  PubMed  
    P09874 O75586 MED6    HPRD  PubMed  
    P09874 P10244 MYBL2    HPRD  PubMed  
    P09874 P19338 NCL    HPRD  PubMed  
    P09874 Q14686 NCOA6    HPRD  PubMed  
    P09874 Q15843 NEDD8    HPRD  PubMed  
    P09874 P19838 NFKB1    HPRD  PubMed  
    P09874 P06748 NPM1    HPRD  PubMed  
    P09874 P09874 PARP1    HPRD  PubMed  
    P09874 Q9UGN5 PARP2    HPRD  PubMed  
    P09874 Q9Y6F1 PARP3    HPRD  PubMed  
    P09874 P12004 PCNA    HPRD  PubMed  
    P09874 P09884 POLA1    HPRD  PubMed  
    P09874 P14859 POU2F1    HPRD  PubMed  
    P09874 P78527 PRKDC    HPRD  PubMed  
    P09874 P10276 RARA    HPRD  PubMed  
    P09874 Q96PK6 RBM14    HPRD  PubMed  
    P09874 Q04206 RELA    HPRD  PubMed  
    P09874 P61247 RPS3A    HPRD  PubMed  
    P09874 P19793 RXRA    HPRD  PubMed  
    P09874 Q8WXA9 SREK1    HPRD  PubMed  
    P09874 Switch associated protein 70 SWAP70    HPRD  PubMed  
    P09874 P15884 TCF4    HPRD  PubMed  
    P09874 P04637 TP53    HPRD  PubMed  
    P09874 Q14191 WRN    HPRD  PubMed  
    P09874 P18887 XRCC1    HPRD  PubMed  
    P09874 P13010 XRCC5    HPRD  PubMed  
    P09874 P12956 XRCC6    HPRD  PubMed  
    P09874 OAZ ZNF423    HPRD  PubMed  
    BioGRID:106652 BioGRID:106823 AIRE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:128334 APLF    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106652 BioGRID:120191 APTX    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106652 BioGRID:106962 ATM    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106652 BioGRID:114342 BANF1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106652 BioGRID:107068 BCL2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106652 BioGRID:107116 BMI1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:107166 BUB1B    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106652 BioGRID:114621 BUB3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:120937 CAND1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:115760 CARM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:107284 CASP1    BioGRID  PubMed Biochemical Activity 
    BioGRID:106652 BioGRID:107286 CASP3    BioGRID  PubMed Biochemical Activity 
    BioGRID:106652 BioGRID:124228 CBX2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:114105 CBX4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:107380 CD86    BioGRID  PubMed Two-hybrid 
    BioGRID:106652 BioGRID:107452 CDK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:107458 CDK8    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:107460 CDKN1A    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:106652 BioGRID:107479 CEBPA    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:107487 CENPA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:107488 CENPB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:114929 CHD1L    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106652 BioGRID:120861 CHFR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:116183 COPS5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:107777 CREBBP    BioGRID  PubMed Biochemical Activity 
    BioGRID:106652 BioGRID:115906 CTCF    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-localization 
    BioGRID:106652 BioGRID:107880 CTNNB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:107888 CTSB    BioGRID  PubMed Biochemical Activity 
    BioGRID:106652 BioGRID:107891 CTSG    BioGRID  PubMed Biochemical Activity 
    BioGRID:106652 BioGRID:114625 DDX21    BioGRID  PubMed Co-fractionation 
    BioGRID:106652 BioGRID:108309 ELAVL1    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:106652 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:106652 BioGRID:108389 ERG    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106652 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106652 BioGRID:107208 FMNL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:108621 FN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:108597 FOXO1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:108901 GBAS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:109217 GTF2F1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:109259 GZMM    BioGRID  PubMed Biochemical Activity 
    BioGRID:106652 BioGRID:109268 H2AFX    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:114927 H2AFY    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:109272 H3F3A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:109316 HDAC2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:114368 HDAC3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:115083 HDAC9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:109318 HDGF    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106652 BioGRID:109514 HES1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106652 BioGRID:109338 HIF1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:109275 HIST1H1A    BioGRID  PubMed Biochemical Activity 
    BioGRID:106652 BioGRID:109261 HIST1H1C    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:129111 HIST1H2BA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106652 BioGRID:113949 HIST1H3E    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106652 BioGRID:113960 HIST1H4C    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106652 BioGRID:113933 HIST2H2AA3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106652 BioGRID:109402 HMGA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106652 BioGRID:109457 HOXB7    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:106652 BioGRID:109538 HSPA2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:106652 BioGRID:116185 IMMT    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106652 BioGRID:109883 ITGA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:115114 KIAA0101    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:116435 KLF8    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:106652 BioGRID:110168 LIG3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106652 BioGRID:113852 LZTR1    BioGRID  PubMed Two-hybrid 
    BioGRID:106652 BioGRID:110358 MDM2    BioGRID  PubMed Co-localization 
    BioGRID:106652 BioGRID:111465 MED1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:114699 MED14    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:114830 MED17    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:114829 MED23    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:115196 MED24    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:115319 MED6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:114833 MED7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:121122 MEPCE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:110687 MYB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:110690 MYBL2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:250505 Mapk1    BioGRID  PubMed Biochemical Activity 
    BioGRID:106652 BioGRID:204968 Mapk13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:115246 NCAPD2    BioGRID  PubMed Affinity Capture-Western; Far Western 
    BioGRID:106652 BioGRID:122089 NCAPG    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:116691 NCOA6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:110815 NEDD8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:110845 NFATC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:110857 NFKB1    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:106652 BioGRID:110913 NOTCH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:110929 NPM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:110955 NRF1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106652 BioGRID:201823 Npm1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:1777029 ORF50    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:106652 PARP1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Reconstituted Complex 
    BioGRID:106652 BioGRID:115350 PARP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:115351 PARP3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:111142 PCNA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:111260 PGR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:119624 PIAS4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:116440 PNKP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:111418 POLA1    BioGRID  PubMed Affinity Capture-Western; Far Western 
    BioGRID:106652 BioGRID:117176 POLA2    BioGRID  PubMed Affinity Capture-Western; Far Western 
    BioGRID:106652 BioGRID:111419 POLB    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:111549 PRKAA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:159585 PRKACB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:111577 PRKDC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:109512 PRMT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:111719 PTK2    BioGRID  PubMed Co-fractionation 
    BioGRID:106652 BioGRID:197999 Parp2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:106652 BioGRID:111849 RARA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:115700 RBM14    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:111902 RELA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:123598 RNF146    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:106652 BioGRID:112055 RPL11    BioGRID  PubMed Co-localization 
    BioGRID:106652 BioGRID:112045 RPL5    BioGRID  PubMed Co-localization 
    BioGRID:106652 BioGRID:112103 RPS3A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106652 BioGRID:116708 RRP1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:112171 RYK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:215383 Rrp1b    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:118930 SENP1    BioGRID  PubMed Biochemical Activity 
    BioGRID:106652 BioGRID:117594 SENP3    BioGRID  PubMed Biochemical Activity 
    BioGRID:106652 BioGRID:112478 SMARCA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:121244 SMARCAD1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106652 BioGRID:112550 SP1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:106652 BioGRID:126754 SREK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-MS; Biochemical Activity; Reconstituted Complex 
    BioGRID:106652 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:116367 SUPT16H    BioGRID  PubMed Biochemical Activity 
    BioGRID:106652 BioGRID:116707 SWAP70    BioGRID  PubMed Co-purification 
    BioGRID:106652 BioGRID:112747 TAF13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:112749 TAL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:112781 TCEA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:112795 TCF7L2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:119942 TERF2IP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:112923 THRA    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106652 BioGRID:115292 THRAP3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:112924 THRB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:113003 TOP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:113008 TOP2B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:115505 TOPORS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western; Co-localization; Far Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:115457 TRIM28    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:117177 TRIM29    BioGRID  PubMed Two-hybrid 
    BioGRID:106652 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106652 BioGRID:113177 UBE2I    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106652 BioGRID:113237 USF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:121651 USP36    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:113255 VCAM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:113269 VHL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:113306 WHSC1    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:106652 BioGRID:113323 WRN    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:113349 XRCC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106652 BioGRID:113353 XRCC5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:106652 BioGRID:108822 XRCC6    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:106652 BioGRID:113366 YWHAZ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:113498 ZBTB16    BioGRID  PubMed Biochemical Activity 
    BioGRID:106652 BioGRID:128736 ZBTB9    BioGRID  PubMed Two-hybrid 
    BioGRID:106652 BioGRID:116718 ZNF423    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    • BER complex, organism-specific biosystem (from KEGG)
      BER complex, organism-specific biosystemStructural complex; Genetic information processing; Repair system
    • BER complex, conserved biosystem (from KEGG)
      BER complex, conserved biosystemStructural complex; Genetic information processing; Repair system
    • Base excision repair, organism-specific biosystem (from KEGG)
      Base excision repair, organism-specific biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
    • Base excision repair, conserved biosystem (from KEGG)
      Base excision repair, conserved biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
    • Caspase cascade in apoptosis, organism-specific biosystem (from Pathway Interaction Database)
      Caspase cascade in apoptosis, organism-specific biosystem
      Caspase cascade in apoptosis
    • Downregulation of SMAD2/3:SMAD4 transcriptional activity, organism-specific biosystem (from REACTOME)
      Downregulation of SMAD2/3:SMAD4 transcriptional activity, organism-specific biosystemTranscriptional activity of SMAD2/3:SMAD4 heterotrimer can be inhibited by formation of a complex with SKI or SKIL (SNO), where SKI or SKIL recruit NCOR and possibly other transcriptional repressors ...
    • FAS pathway and Stress induction of HSP regulation, organism-specific biosystem (from WikiPathways)
      FAS pathway and Stress induction of HSP regulation, organism-specific biosystemThis pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
      NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • Notch-mediated HES/HEY network, organism-specific biosystem (from Pathway Interaction Database)
      Notch-mediated HES/HEY network, organism-specific biosystem
      Notch-mediated HES/HEY network
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by TGF-beta Receptor Complex, organism-specific biosystem (from REACTOME)
      Signaling by TGF-beta Receptor Complex, organism-specific biosystemThe TGF-beta/BMP pathway incorporates several signaling pathways that share most, but not all, components of a central signal transduction engine. The general signaling scheme is rather simple: upon ...
    • Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, organism-specific biosystem (from REACTOME)
      Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, organism-specific biosystemIn the nucleus, SMAD2/3:SMAD4 heterotrimer complex acts as a transcriptional regulator. The activity of SMAD2/3 complex is regulated both positively and negatively by association with other transcrip...

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NAD+ ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NAD+ ADP-ribosyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    protein N-terminus binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA damage response, detection of DNA damage IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA repair TAS
    Traceable Author Statement
    more info
    		 PubMed 
    base-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		  
    gene expression TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    		  
    protein ADP-ribosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein autoprocessing IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein poly-ADP-ribosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of growth rate IEA
    Inferred from Electronic Annotation
    more info
    		  
    telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    		 PubMed 
    transcription initiation from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    		  
    transcription, DNA-dependent TAS
    Traceable Author Statement
    more info
    		  
    transforming growth factor beta receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		  
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Preferred Names
    poly [ADP-ribose] polymerase 1
    Names
    poly [ADP-ribose] polymerase 1
    poly(ADP-ribose) polymerase
    poly(ADP-ribose) synthetase
    poly[ADP-ribose] synthase 1
    poly(ADP-ribosyl)transferase
    ADP-ribosyltransferase NAD(+)
    NAD(+) ADP-ribosyltransferase 1
    poly (ADP-ribose) polymerase family, member 1
    ADP-ribosyltransferase diphtheria toxin-like 1
    ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)
    NP_001609.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001618.3 → NP_001609.2  poly [ADP-ribose] polymerase 1

      Status: REVIEWED

      Source sequence(s)
      AK225654, BC037545, DB097441, J03473
      Consensus CDS
      CCDS1554.1
      UniProtKB/Swiss-Prot
      P09874
      Related
      ENSP00000355759, OTTHUMP00000035663, ENST00000366794, OTTHUMT00000091519
      Conserved Domains (6) summary
      cd01437
      Location:662 – 997
      Blast Score: 1289
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      cd08001
      Location:543 – 645
      Blast Score: 466
      WGR_PARP1_like; WGR domain of poly(ADP-ribose) polymerase 1 and similar proteins
      PLN03123
      Location:6 – 997
      Blast Score: 2007
      PLN03123; poly [ADP-ribose] polymerase; Provisional
      pfam00645
      Location:12 – 90
      Blast Score: 310
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam08063
      Location:279 – 332
      Blast Score: 249
      PADR1; PADR1 (NUC008) domain
      pfam00533
      Location:388 – 461
      Blast Score: 92
      BRCT; BRCA1 C Terminus (BRCT) domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p10 Primary Assembly

      Range
      226548392..226595801, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      197065678..197113094, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018912.1 Alternate CHM1_1.0

      Range
      233343826..233391238, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01009640.1 (6099..53515) None
    genomic AF524947.1 AAM75364.1
    genomic AL359704.9 (146579..169501) None
    genomic AL359742.15 (61710..86196) None
    genomic AMYH01001779.1 (70806..118218) None
    genomic CH471098.1 EAW69783.1
      EAW69784.1
      EAW69785.1
    genomic HD117904.1 CBX74363.1
    genomic M29786.1 AAA51663.1
    genomic M60436.1 AAA60000.1
    genomic X16674.1 CAA34663.1
    genomic X56140.1 CAA39606.1
    mRNA AF401218.1 AAL02174.1
    mRNA AK125650.1 None
    mRNA AK225654.1 None
    mRNA AK303340.1 BAG64403.1
    mRNA AK312339.1 BAG35260.1
    mRNA BC008660.1 None
    mRNA BC014206.2 AAH14206.1
    mRNA BC018620.1 AAH18620.1
    mRNA BC021045.1 None
    mRNA BC037545.1 AAH37545.1
    mRNA DB097441.1 None
    mRNA J03473.1 AAB59447.1
    mRNA M17081.1 AAA51599.1
    mRNA M18112.1 AAA60137.1
    mRNA M32721.1 AAA60155.1
    other-genetic DQ891636.2 ABM82562.1
    other-genetic DQ894826.2 ABM85752.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09874.4 GenPept UniProtKB/Swiss-Prot:P09874

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioAssay, by Gene target
        PubChem BioAssays done on the Gene target
      • BioAssay, by Protein Target
        BioAssay, by Protein Target
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...