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    PARP1 poly (ADP-ribose) polymerase 1 [ Homo sapiens ]

    Gene ID: 142, updated on 20-May-2012
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    Summary

    Official Symbol
    PARP1provided by HGNC
    Official Full Name
    poly (ADP-ribose) polymerase 1provided by HGNC
    Primary source
    HGNC:270
    Locus tag
    RP11-125A15.2
    See related
    Ensembl:ENSG00000143799; HPRD:01435; MIM:173870; Vega:OTTHUMG00000037556
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PARP; PPOL; ADPRT; ADPRT1; PARP-1; ADPRT 1; pADPRT-1
    Summary
    This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    1q41-q42
    Sequence :
    Chromosome: 1; NC_000001.10 (226548392..226595801, complement)
    See PARP1 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene Mix paired-like homeobox Neighboring gene lin-9 homolog (C. elegans) Neighboring gene ribosomal protein S3a pseudogene 7 Neighboring gene CDKN2A interacting protein N-terminal like pseudogene 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Adamson B, et al. Nat Cell Biol, 2012 Feb 19. PMID 22344029.
    2. Differential expression of PARP1 mRNA in leucocytes of patients with Down's syndrome. Salemi M, et al. J Genet, 2011 Dec. PMID 22227934.
    3. Cellular bioenergetics is regulated by PARP1 under resting conditions and during oxidative stress. Módis K, et al. Biochem Pharmacol, 2012 Mar 1. PMID 22198485.
    4. The role of microRNA-binding site polymorphisms in DNA repair genes as risk factors for bladder cancer and breast cancer and their impact on radiotherapy outcomes. Teo MT, et al. Carcinogenesis, 2012 Mar. PMID 22166496.
    5. Enhanced killing of cancer cells by poly(ADP-ribose) polymerase inhibitors and topoisomerase I inhibitors reflects poisoning of both enzymes. Patel AG, et al. J Biol Chem, 2012 Feb 3. PMID 22158865.

    See all (494) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Immunohistochemical staining intensities of PARP-1 and DNA-PK were determined (score 0-3) and expression levels were correlated with /glioblastoma multiforme patients overall survival.
      Title: Impact of PARP-1 and DNA-PK expression on survival in patients with glioblastoma multiforme.
    2. findings demonstrated an association with increased bladder cancer risk with PARP1 rs8679 while variant homozygotes of PARP1 rs8679 were also noted to have an increased breast cancer risk.
      Title: The role of microRNA-binding site polymorphisms in DNA repair genes as risk factors for bladder cancer and breast cancer and their impact on radiotherapy outcomes.
    3. Data show that RBMX accumulated at DNA lesions through multiple domains in a poly(ADP-ribose) polymerase 1-dependent manner and promoted HR by facilitating proper BRCA2 expression.
      Title: A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response.
    4. An expression level more than double the normal level is associated with a severe intellecual disability phenotype in patients with Down's syndrome.
      Title: Differential expression of PARP1 mRNA in leucocytes of patients with Down's syndrome.
    5. Reduced expression of PARP1 is associated with an impairment of CLL responsiveness to cell death.
      Title: A subset of chronic lymphocytic leukemia patients display reduced levels of PARP1 expression coupled with a defective irradiation-induced apoptosis.
    6. Constitutive aberrant expression of PARP-1 and RasGRP-1 ratio may act in concert to impair survival of lymphocytes in systemic lupus erythematosus patients.
      Title: Constitutive abnormal expression of RasGRP-1 isoforms and low expression of PARP-1 in patients with systemic lupus erythematosus.
    7. Data suggest the therapeutic use of cordycepin for the treatment of BRCA1-deficient breast cancers by inhibiting poly(ADP-ribose) polymerase.
      Title: Cordycepin blocks lung injury-associated inflammation and promotes BRCA1-deficient breast cancer cell killing by effectively inhibiting PARP.
    8. model in which small molecule inhibitors convert PARP1 into a protein that potentiates the effects of topoisomerase I poisons by binding to damaged DNA and preventing its normal repair.
      Title: Enhanced killing of cancer cells by poly(ADP-ribose) polymerase inhibitors and topoisomerase I inhibitors reflects poisoning of both enzymes.
    9. This study evaluated the role of PARP1 in the regulation of cellular energetics in endothelial cells under resting conditions and during oxidative stress.
      Title: Cellular bioenergetics is regulated by PARP1 under resting conditions and during oxidative stress.
    10. FGF-ERK regulates PARP-1 activity during human embryonic stem cell neural differentiation.
      Title: Fibroblast growth factor regulates human neuroectoderm specification through ERK1/2-PARP-1 pathway.
    Submit: New GeneRIF Correction See all (292)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120 PubMed
    env Contact of CD4+ T cells with HIV-1 infected or HIV-1 gp120-expressing cells induces PARP hydrolysis, which leads to the cleavage of 116 kDa PARP into two fragments PubMed
    Nef nef Expression of HIV-1 Nef in human brain microvascular endothelial cells induces the cleavage of PARP protein, which is involved in DNA repair PubMed
    nef HIV-1 Nef enhances apoptosis in CD4+ T lymphoblastoid cell lines through mechanisms that include the cleavage of the caspase target poly(ADP-ribose) polymerase PubMed
    Tat tat The poly(A) site in the HIV-1 5'-LTR is occluded in a Tat-dependent manner, suggesting a role for Tat in regulating this nucleotide signal PubMed
    tat Poly(ADP-ribose) polymerase modifies HIV-1 Tat with poly(ADP-ribose), suggesting a role for this enzyme in the regulation of HIV-1 gene expression PubMed
    tat Purified recombinant HIV-1 Tat protein stimulates poly(ADP-ribose) polymerase in a dose dependent manner PubMed
    tat PARP1 negatively regulates HIV-1 transcription by directly competing with Tat-P-TEFb complex for binding to TAR RNA PubMed
    tat Treatment of primary human microvascular endothelial cells of lung origin with HIV-1 Tat caused cleavage of poly(A/DP)-ribose polymerase as a result of caspase activation PubMed
    tat HIV-1 Tat induces the cleavage of PARP and activation of apoptosis through a p56lck dependent mechanism PubMed
    Vpr vpr Recruitment of PARP-1 by HIV-1 Vpr-glucocorticoid receptor (GR) complex prevents its nuclear localization, which is necessary for Vpr to suppress NF-kappaB PubMed
    vpr HIV-1 Vpr induces apoptosis and the cleavage of ADPRT in a manner that is signaled through the DNA damage signaling protein ataxia telangiectasia Rad3-related protein (ATR) PubMed
    integrase gag-pol PARP has been described as a requirement for efficient HIV-1 integration, however a conflicting report indicates it is not essential for efficient lentivirus integration PubMed
    retropepsin gag-pol Inhibition of HIV-1 protease by saquinavir and leu3.a blocks PARP cleavage and protects cells from apoptosis and necrosis PubMed
    gag-pol HIV-1 protease directly cleaves and activates procaspase 8 in T cells, which is associated with cleavage of BID, mitochondrial release of cytochrome c, activation of the downstream caspases 9 and 3, and cleavage of DFF and PARP PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001609.1 NP_004337.2 CASP3    BIND  PubMed PARP interacts with Caspase-3. This interaction was modeled on a demonstrated interaction between human PARP and caspase-3 from an unspecified source. 
    NP_001609.1 NP_203125.1 CASP7    BIND  PubMed PARP interacts with caspase-7. This interaction was modelled on a demonstrated interaction between human PARP and fly drICE. 
    NP_001609.1 NP_005457.2 MED6    BIND  PubMed PARP-1 interacts with Med6. 
    NP_001609.1 NP_000955.1 RARA    BIND  PubMed PARP-1 interacts with RAR-alpha. 
    NP_001609.1 THRA    BIND  PubMed PARP-1 interacts with TR-alpha. This interaction was modeled on a demonstrated interaction between human PARP-1 and TR-alpha from an unspecified species. 
    NP_001609.1 NP_003277.1 TOP1    BIND  PubMed PARP-1 interacts with Topo I 
    NP_001609.1 NP_000544.1 WRN    BIND  PubMed WRN interacts with PARP1. 
    NP_001609.1 NC_000001.8     BIND  PubMed PARP-1 interacts with p-dio1. 
    NP_001609.1     BIND  PubMed PARP1 interacts with ADP-ribose. This interaction was modeled on a demonstrated interaction between PARP1 from Aplysia and ADP-ribose. 
    NP_001609.1     BIND  PubMed PARP-1 interacts with NAD+ 
    P09874 Q7Z2E3 APTX    HPRD  PubMed  
    P09874 P10415 BCL2    HPRD  PubMed  
    P09874 O43684 BUB3    HPRD  PubMed  
    P09874 P29466 CASP1    HPRD  PubMed  
    P09874 P38936 CDKN1A    HPRD  PubMed  
    P09874 P49450 CENPA    HPRD  PubMed  
    P09874 P07199 CENPB    HPRD  PubMed  
    P09874 P08311 CTSG    HPRD  PubMed  
    P09874 Q01094 E2F1    HPRD  PubMed  
    P09874 Q03468 ERCC6    HPRD  PubMed  
    P09874 P10144 GZMB    HPRD  PubMed  
    P09874 P49916 LIG3    HPRD  PubMed  
    P09874 O75586 MED6    HPRD  PubMed  
    P09874 P10244 MYBL2    HPRD  PubMed  
    P09874 P19338 NCL    HPRD  PubMed  
    P09874 Q14686 NCOA6    HPRD  PubMed  
    P09874 Q15843 NEDD8    HPRD  PubMed  
    P09874 P19838 NFKB1    HPRD  PubMed  
    P09874 P06748 NPM1    HPRD  PubMed  
    P09874 P09874 PARP1    HPRD  PubMed  
    P09874 Q9UGN5 PARP2    HPRD  PubMed  
    P09874 Q9Y6F1 PARP3    HPRD  PubMed  
    P09874 P12004 PCNA    HPRD  PubMed  
    P09874 P09884 POLA1    HPRD  PubMed  
    P09874 P14859 POU2F1    HPRD  PubMed  
    P09874 P78527 PRKDC    HPRD  PubMed  
    P09874 P10276 RARA    HPRD  PubMed  
    P09874 Q96PK6 RBM14    HPRD  PubMed  
    P09874 Q04206 RELA    HPRD  PubMed  
    P09874 P61247 RPS3A    HPRD  PubMed  
    P09874 P19793 RXRA    HPRD  PubMed  
    P09874 Q8WXA9 SREK1    HPRD  PubMed  
    P09874 Switch associated protein 70 SWAP70    HPRD  PubMed  
    P09874 P15884 TCF4    HPRD  PubMed  
    P09874 P04637 TP53    HPRD  PubMed  
    P09874 Q14191 WRN    HPRD  PubMed  
    P09874 P18887 XRCC1    HPRD  PubMed  
    P09874 P13010 XRCC5    HPRD  PubMed  
    P09874 P12956 XRCC6    HPRD  PubMed  
    P09874 OAZ ZNF423    HPRD  PubMed  
    BioGRID:106652 BioGRID:106823 AIRE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:128334 APLF    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106652 BioGRID:120191 APTX    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106652 BioGRID:114342 BANF1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106652 BioGRID:107068 BCL2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106652 BioGRID:107116 BMI1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:107166 BUB1B    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106652 BioGRID:114621 BUB3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:115760 CARM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:107458 CDK8    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:107460 CDKN1A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:107487 CENPA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:107488 CENPB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:114929 CHD1L    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106652 BioGRID:107777 CREBBP    BioGRID  PubMed Biochemical Activity 
    BioGRID:106652 BioGRID:115906 CTCF    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-localization 
    BioGRID:106652 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:106652 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:108597 FOXO1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:108901 GBAS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:109217 GTF2F1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:109268 H2AFX    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:114927 H2AFY    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:109272 H3F3A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:109316 HDAC2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:114368 HDAC3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:115083 HDAC9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:109318 HDGF    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106652 BioGRID:109514 HES1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106652 BioGRID:109338 HIF1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:109275 HIST1H1A    BioGRID  PubMed Biochemical Activity 
    BioGRID:106652 BioGRID:109261 HIST1H1C    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:129111 HIST1H2BA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106652 BioGRID:113949 HIST1H3E    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106652 BioGRID:113960 HIST1H4C    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106652 BioGRID:113933 HIST2H2AA3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106652 BioGRID:109402 HMGA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106652 BioGRID:109457 HOXB7    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:106652 BioGRID:109538 HSPA2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:106652 BioGRID:116185 IMMT    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106652 BioGRID:116435 KLF8    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:106652 BioGRID:110168 LIG3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106652 BioGRID:113852 LZTR1    BioGRID  PubMed Two-hybrid 
    BioGRID:106652 BioGRID:111465 MED1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:114699 MED14    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:114830 MED17    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:114829 MED23    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:115196 MED24    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:115319 MED6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:114833 MED7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:121122 MEPCE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:110687 MYB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:110690 MYBL2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:250505 Mapk1    BioGRID  PubMed Biochemical Activity 
    BioGRID:106652 BioGRID:204968 Mapk13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:115246 NCAPD2    BioGRID  PubMed Affinity Capture-Western; Far Western 
    BioGRID:106652 BioGRID:122089 NCAPG    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:116691 NCOA6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:110815 NEDD8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:110845 NFATC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:110857 NFKB1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106652 BioGRID:110929 NPM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:110955 NRF1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106652 BioGRID:106652 PARP1    BioGRID  PubMed Biochemical Activity; Co-crystal Structure; Reconstituted Complex 
    BioGRID:106652 BioGRID:115350 PARP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:115351 PARP3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:111142 PCNA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:119624 PIAS4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:111418 POLA1    BioGRID  PubMed Affinity Capture-Western; Far Western 
    BioGRID:106652 BioGRID:117176 POLA2    BioGRID  PubMed Affinity Capture-Western; Far Western 
    BioGRID:106652 BioGRID:111419 POLB    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:111549 PRKAA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:111577 PRKDC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:109512 PRMT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:111719 PTK2    BioGRID  PubMed Co-fractionation 
    BioGRID:106652 BioGRID:197999 Parp2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:106652 BioGRID:111849 RARA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:115700 RBM14    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:111902 RELA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:123598 RNF146    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:106652 BioGRID:112103 RPS3A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:106652 BioGRID:116708 RRP1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:112171 RYK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:215383 Rrp1b    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:118930 SENP1    BioGRID  PubMed Biochemical Activity 
    BioGRID:106652 BioGRID:117594 SENP3    BioGRID  PubMed Biochemical Activity 
    BioGRID:106652 BioGRID:112478 SMARCA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:121244 SMARCAD1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106652 BioGRID:112550 SP1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:106652 BioGRID:126754 SREK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:106652 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:116367 SUPT16H    BioGRID  PubMed Biochemical Activity 
    BioGRID:106652 BioGRID:116707 SWAP70    BioGRID  PubMed Co-purification 
    BioGRID:106652 BioGRID:112747 TAF13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:112749 TAL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:112781 TCEA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:112795 TCF7L2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:119942 TERF2IP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:112923 THRA    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106652 BioGRID:115292 THRAP3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:112924 THRB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:113003 TOP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:113008 TOP2B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:115505 TOPORS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western; Far Western 
    BioGRID:106652 BioGRID:115457 TRIM28    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:117177 TRIM29    BioGRID  PubMed Two-hybrid 
    BioGRID:106652 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:106652 BioGRID:113237 USF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106652 BioGRID:121651 USP36    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:113269 VHL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106652 BioGRID:113349 XRCC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:106652 BioGRID:113353 XRCC5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:108822 XRCC6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:106652 BioGRID:128736 ZBTB9    BioGRID  PubMed Two-hybrid 
    BioGRID:106652 BioGRID:116718 ZNF423    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the PARP1 gene: The PARP1 gene is conserved in , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NAD+ ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein N-terminus binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transferase activity, transferring glycosyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA damage response, detection of DNA damage IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA repair TAS
    Traceable Author Statement
    more info
    		 PubMed 
    base-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein ADP-ribosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein autoprocessing IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein poly-ADP-ribosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of growth rate IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    poly [ADP-ribose] polymerase 1
    Names
    poly [ADP-ribose] polymerase 1
    poly(ADP-ribose) polymerase
    poly(ADP-ribose) synthetase
    poly[ADP-ribose] synthase 1
    poly(ADP-ribosyl)transferase
    ADP-ribosyltransferase NAD(+)
    NAD(+) ADP-ribosyltransferase 1
    poly (ADP-ribose) polymerase family, member 1
    ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)
    NP_001609.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001618.3 → NP_001609.2  poly [ADP-ribose] polymerase 1

      Status: REVIEWED

      Source sequence(s)
      AK225654, BC037545, DB097441, J03473
      Consensus CDS
      CCDS1554.1
      UniProtKB/Swiss-Prot
      P09874
      Related
      ENSP00000355759, OTTHUMP00000035663, ENST00000366794, OTTHUMT00000091519
      Conserved Domains (6) summary
      cd01437
      Location:662 – 997
      Blast Score: 1289
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      cd08001
      Location:543 – 645
      Blast Score: 466
      WGR_PARP1_like; WGR domain of poly(ADP-ribose) polymerase 1 and similar proteins
      PLN03123
      Location:6 – 997
      Blast Score: 2007
      PLN03123; poly [ADP-ribose] polymerase; Provisional
      pfam00645
      Location:12 – 90
      Blast Score: 310
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam08063
      Location:279 – 332
      Blast Score: 249
      PADR1; PADR1 (NUC008) domain
      cl00038
      Location:388 – 461
      Blast Score: 92
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      226548392..226595801, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      197065678..197113094, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF524947.1 AAM75364.1
    genomic AL359704.9 CAH70215.1
      CAH70216.1
      CAH70217.1
    genomic AL359742.15 CAI12102.1
    genomic CH471098.1 EAW69783.1
      EAW69784.1
      EAW69785.1
    genomic HD117904.1 CBX74363.1
    genomic M29786.1 AAA51663.1
    genomic M60436.1 AAA60000.1
    genomic X16674.1 CAA34663.1
    genomic X56140.1 CAA39606.1
    mRNA AF401218.1 AAL02174.1
    mRNA AK125650.1 None
    mRNA AK225654.1 None
    mRNA AK303340.1 BAG64403.1
    mRNA AK312339.1 BAG35260.1
    mRNA BC008660.1 None
    mRNA BC014206.2 AAH14206.1
    mRNA BC018620.1 AAH18620.1
    mRNA BC021045.1 None
    mRNA BC037545.1 AAH37545.1
    mRNA DB097441.1 None
    mRNA J03473.1 AAB59447.1
    mRNA M17081.1 AAA51599.1
    mRNA M18112.1 AAA60137.1
    mRNA M32721.1 AAA60155.1
    other-genetic DQ891636.2 ABM82562.1
    other-genetic DQ894826.2 ABM85752.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09874.4 GenPept UniProtKB/Swiss-Prot:P09874
    Q05D33 GenPept UniProtKB/TrEMBL:Q05D33
    Q6PJL0 GenPept UniProtKB/TrEMBL:Q6PJL0
    Q96P95 GenPept UniProtKB/TrEMBL:Q96P95
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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