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    IGF2R insulin-like growth factor 2 receptor [ Homo sapiens ]

    Gene ID: 3482, updated on 11-May-2012
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    Summary

    Official Symbol
    IGF2Rprovided by HGNC
    Official Full Name
    insulin-like growth factor 2 receptorprovided by HGNC
    Primary source
    HGNC:5467
    See related
    Ensembl:ENSG00000197081; HPRD:00928; MIM:147280; Vega:OTTHUMG00000015945
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MPR1; MPRI; CD222; CIMPR; M6P-R
    Summary
    The protein encoded by this gene is a receptor for both, insulin-like growth factor 2 (IGF2) and mannose 6-phosphate (M6P). The IGF2 and M6P binding sites are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of IGF2. While the mouse Igf2r gene shows exclusive expression from the maternal allele, imprinting of the human IGF2R gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele. [provided by RefSeq, Oct 2010]
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    Genomic context

    Location :
    6q26
    Sequence :
    Chromosome: 6; NC_000006.11 (160390131..160527583)
    See IGF2R in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene poly(A)-specific ribonuclease (PARN)-like domain containing 1 Neighboring gene MAS1 oncogene Neighboring gene calcium binding protein P22 pseudogene Neighboring gene solute carrier family 22 (organic cation transporter), member 1 Neighboring gene solute carrier family 22 (organic cation transporter), member 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Influence of placental mannose/n-acetyl glucosamine-binding proteins on the interaction of insulin and insulin-like growth factors with their receptors. Nedic O, et al. Biochemistry (Mosc), 2011 Sep. PMID 22082268.
    2. Glycosylation-independent binding to extracellular domains 11-13 of mannose-6-phosphate/insulin-like growth factor-2 receptor mediates the effects of soluble CREG on the phenotypic modulation of vascular smooth muscle cells. Han Y, et al. J Mol Cell Cardiol, 2011 Apr. PMID 21195083.
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    4. IGF2 actions on trophoblast in human placenta are regulated by the insulin-like growth factor 2 receptor, which can function as both a signaling and clearance receptor. Harris LK, et al. Biol Reprod, 2011 Mar. PMID 20980691.
    5. Insulin-like growth factor 2 receptor is an IFNgamma-inducible microglial protein that facilitates intracellular HIV replication: implications for HIV-induced neurocognitive disorders. Suh HS, et al. Am J Pathol, 2010 Nov. PMID 20889566.

    See all (133) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The placental lectins have no effect on the binding of IGF-II to IGF II Receptor.
      Title: Influence of placental mannose/n-acetyl glucosamine-binding proteins on the interaction of insulin and insulin-like growth factors with their receptors.
    2. Data suggest that soluble CREG protein can exert its biological function via glycosylation-independent binding to the extracellular domains 11-13 of cell surface M6P/IGF2R, modulating SMC phenotypic switching from contractile to proliferative.
      Title: Glycosylation-independent binding to extracellular domains 11-13 of mannose-6-phosphate/insulin-like growth factor-2 receptor mediates the effects of soluble CREG on the phenotypic modulation of vascular smooth muscle cells.
    3. Leu(27)IGF2 promoted mitogenesis and survival only in explants with intact IGF2R expression.
      Title: IGF2 actions on trophoblast in human placenta are regulated by the insulin-like growth factor 2 receptor, which can function as both a signaling and clearance receptor.
    4. HFE:CI-MPR binding was mediated through phosphorylated mannose residues on HFE
      Title: In vitro binding of HFE to the cation-independent mannose-6 phosphate receptor.
    5. M6P/IGF2R may be involved in HBV-associated hepatocarcinogenesis by the regulation of its expression level.
      Title: Genetic changes and expression of the mannose 6-phosphate/insulin-like growth factor II receptor gene in human hepatitis B virus-associated hepatocellular carcinoma.
    6. Results demonstrate a novel role for IGF2R as an IFNgamma-inducible microglial protein involved in regulation of HIV and chemokine expression.
      Title: Insulin-like growth factor 2 receptor is an IFNgamma-inducible microglial protein that facilitates intracellular HIV replication: implications for HIV-induced neurocognitive disorders.
    7. Results identified polymorphisms in IGF2R, IGF2, and near H19 that are associated with birth weight.
      Title: Association of birth weight with polymorphisms in the IGF2, H19, and IGF2R genes.
    8. Imprinting of IGF2R gene in human is polymorphic, with a minority of individuals showing exclusive expression from the maternal allele.
      Title: Functional polymorphism in the parental imprinting of the human IGF2R gene.
    9. IGF-2R gene polymorphisms are associated with the susceptibility and pathological development of hepatocellular carcinoma.
      Title: Relationship of insulin-like growth factors system gene polymorphisms with the susceptibility and pathological development of hepatocellular carcinoma.
    10. IGFIIR/M6PR is nutritionally regulated independently of IGF-II.
      Title: Circulating levels of insulin-like growth factor-II/mannose-6-phosphate receptor in obesity and type 2 diabetes.
    Submit: New GeneRIF Correction See all (76)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.

    Hepatocellular carcinoma

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_000867.1 NP_001900.1 CTSD    BIND  PubMed CTSD (CD) interacts with IGF2R (MPR300). 
    NP_000867.1 NP_005808.2 PLIN3    BIND  PubMed M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR). 
    NP_000867.1 NP_005808.2 PLIN3    BIND  PubMed M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR). 
    NP_000867.1 NP_005808.2 PLIN3    BIND  PubMed M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR). 
    NP_000867.1 NP_005808.2 PLIN3    BIND  PubMed M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR). 
    NP_000867.1 NP_005808.2 PLIN3    BIND  PubMed M6PRBP1 (TIP47) interacts with IGF2R (CI-MPR). 
    NP_000867.1 NP_005808.2 PLIN3    BIND  PubMed TIP47 interacts with CI-MPR. This interaction was modeled on a demostrated interaction between a modified synthetic peptide representing human TIP47 and CI-MPR from an unspecified species. 
    P11717 P20933 AGA    HPRD  PubMed  
    P11717 O75629 CREG1    HPRD  PubMed  
    P11717 P07339 CTSD    HPRD  PubMed  
    P11717 Q9UJY5 GGA1    HPRD  PubMed  
    P11717 Q9UJY4 GGA2    HPRD  PubMed  
    P11717 Q9NZ52 GGA3    HPRD  PubMed  
    P11717 P10144 GZMB    HPRD  PubMed  
    P11717 P01344 IGF2    HPRD  PubMed  
    P11717 P11717 IGF2R    HPRD  PubMed  
    P11717 Q6VY07 PACS1    HPRD  PubMed  
    P11717 P00749 PLAU    HPRD  PubMed  
    P11717 O60664 PLIN3    HPRD  PubMed  
    P11717 O76076 WISP2    HPRD  PubMed  
    X83699.1 USF1    BIND  PubMed An unspecified isoform of USF1 interacts with IGF2R promoter. 
    X83699.1 USF2    BIND  PubMed An unspecified isoform of USF2 interacts with IGF2R promoter. 
    BioGRID:109703 BioGRID:114332 CREG1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109703 BioGRID:111345 PLAUR    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109703 BioGRID:115520 PLIN3    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:109703 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109703 BioGRID:131884 USP50    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Clathrin derived vesicle budding, organism-specific biosystem (from REACTOME)
      Clathrin derived vesicle budding, organism-specific biosystemThere at least two classes of clathrin coated vesicles in cells, one predominantly Golgi-associated, involved in budding from the trans-Golgi network and the other at the plasma membrane. Here the cl...
    • Golgi Associated Vesicle Biogenesis, organism-specific biosystem (from REACTOME)
      Golgi Associated Vesicle Biogenesis, organism-specific biosystemProteins that have been synthesized, processed and sorted eventually reach the final steps of the secretory pathway. This pathway is responsible not only for proteins that are secreted from the cell ...
    • Lysosome, organism-specific biosystem (from KEGG)
      Lysosome, organism-specific biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
    • Lysosome, conserved biosystem (from KEGG)
      Lysosome, conserved biosystemLysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • trans-Golgi Network Vesicle Budding, organism-specific biosystem (from REACTOME)
      trans-Golgi Network Vesicle Budding, organism-specific biosystemAfter passing through the Golgi complex, secretory cargo is packaged into post-Golgi transport intermediates (post-Golgi), which translocate plus-end directed along microtubules to the plasma membran...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    glycoprotein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    insulin-like growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    insulin-like growth factor-activated receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    mannose binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphoprotein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    insulin-like growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    receptor-mediated endocytosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane fraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear envelope lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    trans-Golgi network transport vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    cation-independent mannose-6-phosphate receptor
    Names
    cation-independent mannose-6-phosphate receptor
    M6PR
    CI-MPR
    MPR 300
    M6P/IGF2R
    IGF-II receptor
    M6P/IGF2 receptor
    CI Man-6-P receptor
    300 kDa mannose 6-phosphate receptor
    insulin-like growth factor II receptor
    cation-independent mannose-6 phosphate receptor
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011785.1 RefSeqGene

      Range
      5001..142453
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000876.2 → NP_000867.2  cation-independent mannose-6-phosphate receptor precursor

      Status: REVIEWED

      Source sequence(s)
      J03528, Y00285
      Consensus CDS
      CCDS5273.1
      UniProtKB/Swiss-Prot
      P11717
      Related
      ENSP00000349437, OTTHUMP00000017536, ENST00000356956, OTTHUMT00000042931
      Conserved Domains (2) summary
      cd00062
      Location:1897 – 1942
      Blast Score: 183
      FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
      pfam00878
      Location:423 – 573
      Blast Score: 569
      CIMR; Cation-independent mannose-6-phosphate receptor repeat

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      160390131..160527583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      157860740..157998270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF069333.2 AAL04402.1
    genomic AF109291.1 AAF16870.1
    genomic AL035691.17 CAI19940.1
    genomic AL353625.5 CAH72014.1
    genomic AY293855.1 AAP37954.1
    genomic CH471051.2 EAW47607.1
    genomic X83701.1 CAA58674.1
    genomic X91880.1 None
    mRNA AB209668.1 BAD92905.1
    mRNA AK300848.1 BAG62499.1
    mRNA J03528.1 AAA59866.1
    mRNA Y00285.1 CAA68395.1
    other-genetic BC172256.1 AAI72256.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P11717.3 GenPept UniProtKB/Swiss-Prot:P11717
    Q59EZ3 GenPept UniProtKB/TrEMBL:Q59EZ3
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
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