PTK2B PTK2B protein tyrosine kinase 2 beta [ Homo sapiens ]

Gene ID: 2185, updated on 19-May-2012

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Summary

Official Symbol: PTK2Bprovided by HGNC
Official Full Name: PTK2B protein tyrosine kinase 2 betaprovided by HGNC
Primary source: HGNC:9612
See related: Ensembl:ENSG00000120899; HPRD:03131; MIM:601212; Vega:OTTHUMG00000102082
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PKB; PTK; CAKB; FAK2; PYK2; CADTK; FADK2; RAFTK
Summary: This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 8p21.1

Sequence :: Chromosome: 8; NC_000008.10 (27168999..27316908)

See PTK2B in Epigenomics, MapViewer

Chromosome 8 - NC_000008.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This is a review of recent developments in Protein kinase B/AKT and focal adhesion kinase signaling in cancer with the particular emphasis on the novel signaling pathways in which FAK is downstream of AKT. [review]
Title: Protein kinase B/AKT and focal adhesion kinase: two close signaling partners in cancer.
Results may suggest a new evidence of Pyk2 on promoting cisplatin resistance of HCC cells through preventing cell apoptosis, activation of AKT pathway and upregulation of drug resistant genes.
Title: The role of proline rich tyrosine kinase 2 (Pyk2) on cisplatin resistance in hepatocellular carcinoma.
ATP stimulates epithelial cell motility through Pyk2-mediated activation of the EGF receptor
Title: Extracellular ATP stimulates epithelial cell motility through Pyk2-mediated activation of the EGF receptor.
although staurosporine-mediated caspase activation and FAK cleavage was delayed in the mtp53-R 175H HOSCC cell line, caspase-8 activation and FAK dephosphorylation were induced by increasing the apoptotic stimulus.
Title: Delayed caspase-8 activation and enhanced integrin β1-activated FAK underpins anoikis in oesophageal carcinoma cells harbouring mt p53-R175H.
Activation of Pyk2 in the heart during heart failure may contribute to protection against arrhythmia.
Title: Role of Pyk2 in cardiac arrhythmogenesis.
downregulation of endogenous FIP200 protein in glioblastoma tumor cells, astrocytes, and brain microvessel endothelial cells promotes apoptosis, most likely due to the removal of a direct interaction of FIP200 with Pyk2 that inhibits Pyk2 activation
Title: Downregulation of FIP200 induces apoptosis of glioblastoma cells and microvascular endothelial cells by enhancing Pyk2 activity.
data provided new evidence of the underlying mechanism of Pyk2 in controlling cell motility of HCC cells through regulation of genes associated with EMT
Title: Proline-rich tyrosine kinase 2 (Pyk2) promotes cell motility of hepatocellular carcinoma through induction of epithelial to mesenchymal transition.
The results suggest a surprising finding that limited cell adhesion can enhance endothelial responsiveness to VEGF and demonstrate a novel role for Pyk2 in the adhesive regulation of angiogenesis.
Title: Decreased cell adhesion promotes angiogenesis in a Pyk2-dependent manner.
Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to monocilia
Title: Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to monocilia.
Both wild-type and internal tandem duplication (ITD)-FLT3 proteins co-immunoprecipitated with beta1 integrin and Pyk2 indicating the signal crosstalk between FLT3, beta1 integrin and Pyk2.
Title: FLT3/ ITD regulates leukaemia cell adhesion through α4β1 integrin and Pyk2 signalling.

Submit: New GeneRIF Correction See all (104)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Engagement of the CCR5 and CXCR4 receptors by HIV-1 gp120 induces tyrosine phosphorylation of the protein tyrosine kinase Pyk2	PubMed
Nef	nef	HIV-1 Nef expression in human T cells upregulates the levels of RAFTK activity through the SDF-1alpha signaling pathway	PubMed
Tat	tat	HIV-1 Tat stimulates the tyrosine phosphorylation of RAFTK and its association with paxillin, an effect mediated by the basic (amino acids 46-60) and RGD-containing (amino acids 65-80) domains of Tat and linked to AIDS-related Kaposi's sarcoma	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_775268.1	AAC05508.1	SORBS2	BIND	PubMed	ArgBP2 interacts with Pyk2.
Q14289	Rho GTPase activating protein 10	ARHGAP21	HPRD	PubMed
Q14289	Q13017	ARHGAP5	HPRD	PubMed
Q14289	Q9ULH1	ASAP1	HPRD	PubMed
Q14289	O43150	ASAP2	HPRD	PubMed
Q14289	P56945	BCAR1	HPRD	PubMed
Q14289	P22681	CBL	HPRD	PubMed
Q14289	P51681	CCR5	HPRD	PubMed
Q14289	P46108	CRK	HPRD	PubMed
Q14289	Q92796	DLG3	HPRD	PubMed
Q14289	P78352	DLG4	HPRD	PubMed
Q14289	O95886	DLGAP3	HPRD	PubMed
Q14289	O43281	EFS	HPRD	PubMed
Q14289	P00533	EGFR	HPRD	PubMed
Q14289	P04626	ERBB2	HPRD	PubMed
Q14289	P21860	ERBB3	HPRD	PubMed
Q14289	Q01844	EWSR1	HPRD	PubMed
Q14289	P21802	FGFR2	HPRD	PubMed
Q14289	P22607	FGFR3	HPRD	PubMed
Q14289	P17948	FLT1	HPRD	PubMed
Q14289	P06241	FYN	HPRD	PubMed
Q14289	Q14344	GNA13	HPRD	PubMed
Q14289	P62993	GRB2	HPRD	PubMed
Q14289	Q12879	GRIN2A	HPRD	PubMed
Q14289	P06396	GSN	HPRD	PubMed
Q14289	P16871	IL7R	HPRD	PubMed
Q14289	P05107	ITGB2	HPRD	PubMed
Q14289	P05106	ITGB3	HPRD	PubMed
Q14289	P23458	JAK1	HPRD	PubMed
Q14289	O60674	JAK2	HPRD	PubMed
Q14289	P52333	JAK3	HPRD	PubMed
Q14289	P16389	KCNA2	HPRD	PubMed
Q14289	P06239	LCK	HPRD	PubMed
Q14289	O60711	LPXN	HPRD	PubMed
Q14289	P07948	LYN	HPRD	PubMed
Q14289	Q9Y6R4	MAP3K4	HPRD	PubMed
Q14289	P42679	MATK	HPRD	PubMed
Q14289	P43121	MCAM	HPRD	PubMed
Q14289	Q9UKX2	MYH2	HPRD	PubMed
Q14289	Q14511	NEDD9	HPRD	PubMed
Q14289	O15259	NPHP1	HPRD	PubMed
Q14289	Q8WUM4	PDCD6IP	HPRD	PubMed
Q14289	O15530	PDPK1	HPRD	PubMed
Q14289	P27986	PIK3R1	HPRD	PubMed
Q14289	O00562	PITPNM1	HPRD	PubMed
Q14289	Q9BZ72	PITPNM2	HPRD	PubMed
Q14289	Q9BZ71	PITPNM3	HPRD	PubMed
Q14289	Q05655	PRKCD	HPRD	PubMed
Q14289	Q05397	PTK2	HPRD	PubMed
Q14289	Q14289	PTK2B	HPRD	PubMed
Q14289	Q14289	PTK2B	HPRD	PubMed
Q14289	Q06124	PTPN11	HPRD	PubMed
Q14289	Q05209	PTPN12	HPRD	PubMed
Q14289	P29350	PTPN6	HPRD	PubMed
Q14289	P49023	PXN	HPRD	PubMed
Q14289	P20936	RASA1	HPRD	PubMed
Q14289	Q8TDY2	RB1CC1	HPRD	PubMed
Q14289	Q8N5H7	SH2D3C	HPRD	PubMed
Q14289	P29353	SHC1	HPRD	PubMed
Q14289	P11166	SLC2A1	HPRD	PubMed
Q14289	P37840	SNCA	HPRD	PubMed
Q14289	Arg binding protein 2	SORBS2	HPRD	PubMed
Q14289	P12931	SRC	HPRD	PubMed
Q14289	BCR downstream signaling 1	STAP1	HPRD	PubMed
Q14289	P40763	STAT3	HPRD	PubMed
Q14289	P43405	SYK	HPRD	PubMed
Q14289	HIC5	TGFB1I1	HPRD	PubMed
Q14289	Q9Y490	TLN1	HPRD	PubMed
Q14289	P15498	VAV1	HPRD	PubMed
Q14289	P43403	ZAP70	HPRD	PubMed
BioGRID:108480	BioGRID:114378	ASAP2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:108480	BioGRID:114934	BCAR1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108480	BioGRID:107315	CBL	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108480	BioGRID:117140	CD2AP	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108480	BioGRID:107998	DCC	BioGRID	PubMed	Reconstituted Complex
BioGRID:108480	BioGRID:108085	DLG3	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:108480	BioGRID:108086	DLG4	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:108480	BioGRID:108276	EGFR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108480	BioGRID:108376	ERBB2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108480	BioGRID:108431	EWSR1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:108480	BioGRID:108810	FYN	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:108480	BioGRID:118789	GIT1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108480	BioGRID:115914	GNA13	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108480	BioGRID:109142	GRB2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108480	BioGRID:109160	GRIN2A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108480	BioGRID:109189	GSN	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Two-hybrid
BioGRID:108480	BioGRID:109789	IL7R	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108480	BioGRID:109895	ITGB2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108480	BioGRID:109896	ITGB3	BioGRID	PubMed	Reconstituted Complex
BioGRID:108480	BioGRID:109919	JAK1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108480	BioGRID:109920	JAK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108480	BioGRID:109921	JAK3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108480	BioGRID:109940	KCNA2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108480	BioGRID:110124	LCK	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108480	BioGRID:114801	LPXN	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108480	BioGRID:110245	LYN	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108480	BioGRID:114445	MBD2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:108480	BioGRID:110816	NEDD9	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108480	BioGRID:110927	NPHP1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:108480	BioGRID:114965	PITPNM1	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:108480	BioGRID:121653	PITPNM2	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:108480	BioGRID:123636	PITPNM3	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:108480	BioGRID:111566	PRKCD	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108480	BioGRID:111700	PTEN	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108480	BioGRID:108480	PTK2B	BioGRID	PubMed	Biochemical Activity
BioGRID:108480	BioGRID:111745	PTPN11	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Far Western
BioGRID:108480	BioGRID:111746	PTPN12	BioGRID	PubMed	Biochemical Activity
BioGRID:108480	BioGRID:111742	PTPN6	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:108480	BioGRID:111787	PXN	BioGRID	PubMed	Affinity Capture-Western; Far Western; Reconstituted Complex
BioGRID:108480	BioGRID:111856	RASA1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:108480	BioGRID:115160	RB1CC1	BioGRID	PubMed	Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex; Two-hybrid
BioGRID:108480	BioGRID:112404	SLC2A1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108480	BioGRID:114362	SOCS2	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:108480	BioGRID:114488	SOCS3	BioGRID	PubMed	Two-hybrid
BioGRID:108480	BioGRID:115831	SORBS1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108480	BioGRID:114047	SORBS2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:108480	BioGRID:112592	SRC	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:108480	BioGRID:112717	SYK	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108480	BioGRID:112899	TGFB1I1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:108480	BioGRID:112949	TLN1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108480	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:108480	BioGRID:113252	VAV1	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
3-phosphoinositide-dependent protein kinase binding	IEA Inferred from Electronic Annotation more info
ATP binding	IEA Inferred from Electronic Annotation more info
binding	IEA Inferred from Electronic Annotation more info
non-membrane spanning protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
protein tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed
signal transducer activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
MAPK cascade	IEA Inferred from Electronic Annotation more info
actin filament organization	IEA Inferred from Electronic Annotation more info
activation of Janus kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
activation of Rac GTPase activity	IEA Inferred from Electronic Annotation more info
apoptotic process	TAS Traceable Author Statement more info	PubMed
blood vessel endothelial cell migration	IEA Inferred from Electronic Annotation more info
bone resorption	ISS Inferred from Sequence or Structural Similarity more info
cell differentiation	IEA Inferred from Electronic Annotation more info
cell surface receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to retinoic acid	IMP Inferred from Mutant Phenotype more info	PubMed
chemokine-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
elevation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
focal adhesion assembly	IEA Inferred from Electronic Annotation more info
glial cell proliferation	IEA Inferred from Electronic Annotation more info
integrin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
marginal zone B cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of bone mineralization	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of myeloid cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
oocyte maturation	IEA Inferred from Electronic Annotation more info
peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of B cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of JUN kinase activity	IEA Inferred from Electronic Annotation more info
positive regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of anti-apoptosis	IEA Inferred from Electronic Annotation more info
positive regulation of cell growth	IEA Inferred from Electronic Annotation more info
positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info
positive regulation of phosphatidylinositol 3-kinase activity	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
positive regulation of translation	IEA Inferred from Electronic Annotation more info
protein autophosphorylation	TAS Traceable Author Statement more info	PubMed
protein complex assembly	TAS Traceable Author Statement more info	PubMed
protein phosphorylation	TAS Traceable Author Statement more info	PubMed
regulation of actin cytoskeleton reorganization	ISS Inferred from Sequence or Structural Similarity more info
regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of establishment of cell polarity	ISS Inferred from Sequence or Structural Similarity more info
regulation of inositol trisphosphate biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
regulation of macrophage chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
regulation of release of sequestered calcium ion into cytosol	ISS Inferred from Sequence or Structural Similarity more info
response to cAMP	IEA Inferred from Electronic Annotation more info
response to calcium ion	IEA Inferred from Electronic Annotation more info
response to cocaine	IEA Inferred from Electronic Annotation more info
response to drug	IEA Inferred from Electronic Annotation more info
response to ethanol	IEA Inferred from Electronic Annotation more info
response to glucose stimulus	IEA Inferred from Electronic Annotation more info
response to hormone stimulus	IEA Inferred from Electronic Annotation more info
response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
response to hypoxia	IEA Inferred from Electronic Annotation more info
response to lithium ion	IEA Inferred from Electronic Annotation more info
response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
response to organic nitrogen	IEA Inferred from Electronic Annotation more info
response to osmotic stress	IEA Inferred from Electronic Annotation more info
response to stress	TAS Traceable Author Statement more info	PubMed
signal complex assembly	IEA Inferred from Electronic Annotation more info
signal transduction	NAS Non-traceable Author Statement more info	PubMed
sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
stress fiber assembly	IEA Inferred from Electronic Annotation more info
tumor necrosis factor-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info

Component	Evidence Code	Pubs
axon	IEA Inferred from Electronic Annotation more info
cell cortex	IEA Inferred from Electronic Annotation more info
cell junction	IEA Inferred from Electronic Annotation more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoskeleton	IEA Inferred from Electronic Annotation more info
cytosol	TAS Traceable Author Statement more info
focal adhesion	IDA Inferred from Direct Assay more info	PubMed
growth cone	IEA Inferred from Electronic Annotation more info
lamellipodium	IDA Inferred from Direct Assay more info	PubMed
membrane raft	IEA Inferred from Electronic Annotation more info
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IEA Inferred from Electronic Annotation more info
postsynaptic density	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: protein-tyrosine kinase 2-beta

Names: protein-tyrosine kinase 2-beta; FADK 2; CAK-beta; protein kinase B; focal adhesion kinase 2; cell adhesion kinase beta; proline-rich tyrosine kinase 2; calcium-dependent tyrosine kinase; related adhesion focal tyrosine kinase; calcium-regulated non-receptor proline-rich tyrosine kinase

NP_004094.3

EC 2.7.10.2

NP_775266.1

EC 2.7.10.2

NP_775267.1

EC 2.7.10.2

NP_775268.1

EC 2.7.10.2

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029510.1 RefSeqGene

Range

5001..152910

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_004103.4 → NP_004094.3 protein-tyrosine kinase 2-beta isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode isoform a.

Source sequence(s)

AF311103, AL120380, AW130888, BC036651, U33284, U43522

Consensus CDS

CCDS6057.1

UniProtKB/Swiss-Prot

Q14289

Conserved Domains (5) summary

cd05056
Location:418 – 687
Blast Score: 1328

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

pfam03623
Location:870 – 1008
Blast Score: 612

Focal_AT; Focal adhesion targeting region

smart00219
Location:448 – 679
Blast Score: 916

TyrKc; Tyrosine kinase, catalytic domain

smart00295
Location:41 – 254
Blast Score: 344

B41; Band 4.1 homologues

pfam00373
Location:145 – 254
Blast Score: 167

FERM_M; FERM central domain
NM_173174.2 → NP_775266.1 protein-tyrosine kinase 2-beta isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, and 3 all encode isoform a.

Source sequence(s)

AC124649, AL120380, AW130888, BC036651, BM712234, BQ009032, U33284

Consensus CDS

CCDS6057.1

UniProtKB/Swiss-Prot

Q14289

Related

ENSP00000380638, OTTHUMP00000128275, ENST00000397501, OTTHUMT00000219916

Conserved Domains (5) summary

cd05056
Location:418 – 687
Blast Score: 1328

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

pfam03623
Location:870 – 1008
Blast Score: 612

Focal_AT; Focal adhesion targeting region

smart00219
Location:448 – 679
Blast Score: 916

TyrKc; Tyrosine kinase, catalytic domain

smart00295
Location:41 – 254
Blast Score: 344

B41; Band 4.1 homologues

pfam00373
Location:145 – 254
Blast Score: 167

FERM_M; FERM central domain
NM_173175.2 → NP_775267.1 protein-tyrosine kinase 2-beta isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1, resulting in a shorter isoform (b) compared to isoform a.

Source sequence(s)

AF311103, AL120380, AW130888, BC036651, U33284

Consensus CDS

CCDS6058.1

UniProtKB/Swiss-Prot

Q14289

Related

ENSP00000391995, ENST00000420218

Conserved Domains (5) summary

cd05056
Location:418 – 687
Blast Score: 1328

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

pfam03623
Location:828 – 966
Blast Score: 612

Focal_AT; Focal adhesion targeting region

smart00219
Location:448 – 679
Blast Score: 915

TyrKc; Tyrosine kinase, catalytic domain

smart00295
Location:41 – 254
Blast Score: 343

B41; Band 4.1 homologues

pfam00373
Location:145 – 254
Blast Score: 166

FERM_M; FERM central domain
NM_173176.2 → NP_775268.1 protein-tyrosine kinase 2-beta isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode isoform a.

Source sequence(s)

AF311103, AL120380, AW130888, BC042599, DA773624, U33284

Consensus CDS

CCDS6057.1

UniProtKB/Swiss-Prot

Q14289

Related

ENSP00000332816, OTTHUMP00000225229, ENST00000346049, OTTHUMT00000376116

Conserved Domains (5) summary

cd05056
Location:418 – 687
Blast Score: 1328

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

pfam03623
Location:870 – 1008
Blast Score: 612

Focal_AT; Focal adhesion targeting region

smart00219
Location:448 – 679
Blast Score: 916

TyrKc; Tyrosine kinase, catalytic domain

smart00295
Location:41 – 254
Blast Score: 344

B41; Band 4.1 homologues

pfam00373
Location:145 – 254
Blast Score: 167

FERM_M; FERM central domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000008.10 Reference GRCh37.p5 Primary Assembly

Range

27168999..27316908

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000140.1 Alternate HuRef

Range

25714123..25861970

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC010856.12 (8636..27311)	None
genomic	AC124649.6 (130037..191003)	None
genomic	AF311103.5 (7429..69268)	None
genomic	CH471080.2	EAW63553.1
		EAW63554.1
		EAW63555.1
		EAW63556.1
mRNA	AB209085.1	BAD92322.1
mRNA	AK128371.1	BAC87404.1
mRNA	AL120380.1	None
mRNA	AW130888.1	None
mRNA	AY429564.1	None
mRNA	BC036651.2	AAH36651.1
mRNA	BC042599.2	AAH42599.1
mRNA	BF796371.1	None
mRNA	BM712234.1	None
mRNA	BQ009032.1	None
mRNA	D45853.1	BAA08289.1
mRNA	DA773624.1	None
mRNA	L49207.1	AAB47217.1
mRNA	U33284.1	AAC50203.1
mRNA	U43522.1	AAC05330.1
mRNA	DQ590775.1	None