PLCG1 phospholipase C, gamma 1 [ Homo sapiens ]

Gene ID: 5335, updated on 19-May-2012

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Summary

Official Symbol: PLCG1provided by HGNC
Official Full Name: phospholipase C, gamma 1provided by HGNC
Primary source: HGNC:9065
Locus tag: RP3-511B24.2
See related: Ensembl:ENSG00000124181; HPRD:01398; MIM:172420; Vega:OTTHUMG00000033082
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PLC1; NCKAP3; PLC-II; PLC148; PLCgamma1
Summary: The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 20q12-q13.1

Sequence :: Chromosome: 20; NC_000020.10 (39766161..39804357)

See PLCG1 in Epigenomics, MapViewer

Chromosome 20 - NC_000020.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Translocation of PLC-gamma 1 to the cell membrane and the associated calcium signal were enhanced only in mast cells responding to EP3 prostaglandin E2 receptor agonist sulprostone.
Title: Distinct PGE2-responder and non-responder phenotypes in human mast cell populations: "all or nothing" enhancement of antigen-dependent mediator release.
our approach, which is applicable to any set of interval scale traits that is heritable and exhibits evidence of phenotypic clustering, identified three new loci in or near APOC1, BRAP, and PLCG1, which were associated with multiple phenotype domains.
Title: A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains.
parkin interacts with PLCgamma1, affecting PLCgamma1 steady state protein levels in human and murine models with manipulated parkin function and expression levels
Title: Parkin-mediated ubiquitination regulates phospholipase C-gamma1.
PLCgamma plays a key role in RhoGDI2-mediated cisplatin resistance and cell invasion in gastric cancer cells.
Title: PLCγ is required for RhoGDI2-mediated cisplatin resistance in gastric cancer.
PLC-gamma1, but not phospholipase C-beta3,is required for the migration of T cells in response to stromal cell-derived factor-1
Title: Stromal cell-derived factor-1 signaling via the CXCR4-TCR heterodimer requires phospholipase C-β3 and phospholipase C-γ1 for distinct cellular responses.
In cultured vascular smooth muscle cells, phospholipase Cgamma1 expression was required for platelet-derived growth factor-induced ERK1/2 nuclear translocation, Elk-1 phosphorylation, and subsequent repression of SM alpha-actin gene expression.
Title: A phospholipase Cγ1-activated pathway regulates transcription in human vascular smooth muscle cells.
The Epo/EpoR complex plays a critical role in the adhesion and migration of rat fibroblasts, and its functional inactivation is associated with PLC-gammal-dependent reduction of cell-matrix adhesion and this also affects cell migration.
Title: Downregulation of erythropoietin receptor by overexpression of phospholipase C-gamma 1 is critical for decrease on focal adhesion in transformed cells.
propose c-Cbl as an angiogenic suppressor protein where upon activation it uniquely modulates PLCgamma1 activation by ubiquitination and subsequently inhibits VEGF-driven angiogenesis
Title: c-Cbl inhibits angiogenesis and tumor growth by suppressing activation of PLCγ1.
Calcium-induced apoptosis in bladder cancer cells is delayed by HER1 receptor activation involving the Akt and PLCgamma signalling pathways.
Title: Calcium-induced apoptosis is delayed by HER1 receptor signalling through the Akt and PLCγ pathways in bladder cancer cells.
These studies suggest that Kaposi's sarcoma-associated herpesvirus has evolved to exploit ANG for its advantage via a so-far-unexplored PLC-gamma pathway for maintaining its latency.
Title: Kaposi's sarcoma-associated herpesvirus-induced angiogenin plays roles in latency via the phospholipase C gamma pathway: blocking angiogenin inhibits latent gene expression and induces the lytic cycle.

Submit: New GeneRIF Correction See all (77)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells	PubMed
Envelope surface glycoprotein gp160, precursor	env	Pretreatment of cells with HIV-1 gp160 results in marked inhibition of tyrosine phosphorylation of p59(fyn), PLC-gamma1, ras activation, and TNF-alpha secretion in anti-CD3 mAb activated CD4+ T cells	PubMed
	env	HIV-1 gp160 disrupts the association between phospholipase C gamma-1 and phosphoinositide 3 kinase (PI3-kinase), and this effect is dependent on PI3-kinase activity	PubMed
Tat	tat	HIV-1 Tat induces release of calcium and TNF-alpha production, an effect mediated at least in part by activation of phospholipase C	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_002651.2	NP_009297.1	ABL1	BIND	PubMed	c-Abl interacts with PLC-gamma1. This interaction was modeled on a demonstrated interaction between human c-Abl and bovine PLCgamma1.
NP_002651.2	NP_004318.2	BCR	BIND	PubMed	BCR interacts with PLCgamma1. This interaction was modeled on a demonstrated interaction between BCR from an unspecified source and bovine PLCgamma1.
NP_002651.2	NP_005219.2	EGFR	BIND	PubMed	EGFR interacts with PLC-gamma. This interaction was modelled on a demonstrated interaction between human EGFR and bovine PLC-gamma.
NP_002651.2		FGFR1	BIND	PubMed	An unspecified isoform of FGFR1 interacts with PLC-gamma. This interaction was modeled on a demonstrated interaction between FGFR1 from an unspecified species and human PLC-gamma.
NP_002651.2	NP_000213.1	KIT	BIND	PubMed	Kit interacts with PLC-gamma. This interaction was modeled on a demonstrated interaction between mouse proteins.
NP_002651.2	NP_002600.1	PDGFRB	BIND	PubMed	Beta-PDGFR interacts with PLC-gamma 1. This interaction was modeled on a demonstrated interaction between human beta-PDGFR and PLC-gamma from bovine and unspecified sources.
NP_002651.2	NP_002600.1	PDGFRB	BIND	PubMed	Phosphorylated beta-PDGFR interacts with PLC-gamma. This interaction was modeled on a demonstrated interaction between human beta-PDGFR and bovine PLC-gamma.
NP_002651.2	NP_002600.1	PDGFRB	BIND	PubMed	Autophosphorylated PDGFR interacts with PLC-gamma. This interaction was modelled on a demonstrated interaction between human PDGFR and PLC-gamma from an unspecified species.
NP_002651.2	NP_002654.2	PLD2	BIND	PubMed	PLC-gamma1 interacts with PLD2. This interaction was modeled on a demonstrated interaction between PLC-gamma1 from an unspecified species and human PLD2.
NP_002651.2	NP_065681.1	RET	BIND	PubMed	RET9 phosphorylates PLC-gamma via its amino-terminal SH2 domain. This interaction was modelled on a demonstrated interaction between RET9 from human and PLC-gamma from cow.
NP_002651.2	NP_000314.1		BIND	PubMed	RET51 phosphorylates PLC-gamma via its amino-terminal SH2 domain. This interaction was modelled on a demonstrated interaction between RET51 from human and PLC-gamma from cow.
P19174	P00519	ABL1	HPRD	PubMed
P19174	Q99490	AGAP2	HPRD	PubMed
P19174	P30556	AGTR1	HPRD	PubMed
P19174	Q9UM73	ALK	HPRD	PubMed
P19174	RICS	ARHGAP32	HPRD	PubMed
P19174	Q12774	ARHGEF5	HPRD	PubMed
P19174	P30530	AXL	HPRD	PubMed
P19174	O95817	BAG3	HPRD	PubMed
P19174	P11274	BCR	HPRD	PubMed
P19174	Q8WV28	BLNK	HPRD	PubMed
P19174	Q06187	BTK	HPRD	PubMed
P19174	P22681	CBL	HPRD	PubMed
P19174	P20273	CD22	HPRD	PubMed
P19174	P10747	CD28	HPRD	PubMed
P19174	P25774	CTSS	HPRD	PubMed
P19174	O75553	DAB1	HPRD	PubMed
P19174	Q9UN19	DAPP1	HPRD	PubMed
P19174	Q08345	DDR1	HPRD	PubMed
P19174	Q13574	DGKZ	HPRD	PubMed
P19174	Q05193	DNM1	HPRD	PubMed
P19174	Q99704	DOK1	HPRD	PubMed
P19174	P68104	EEF1A1	HPRD	PubMed
P19174	P00533	EGFR	HPRD	PubMed
P19174	P19235	EPOR	HPRD	PubMed
P19174	P04626	ERBB2	HPRD	PubMed
P19174	P11362	FGFR1	HPRD	PubMed
P19174	P21802	FGFR2	HPRD	PubMed
P19174	P22455	FGFR4	HPRD	PubMed
P19174	P17948	FLT1	HPRD	PubMed
P19174	P06241	FYN	HPRD	PubMed
P19174	Q13480	GAB1	HPRD	PubMed
P19174	Q9Y2X7	GIT1	HPRD	PubMed
P19174	P63244	GNB2L1	HPRD	PubMed
P19174	Q13588	GRAP	HPRD	PubMed
P19174	P62993	GRB2	HPRD	PubMed
P19174	Q05586	GRIN1	HPRD	PubMed
P19174	Q12879	GRIN2A	HPRD	PubMed
P19174	Q13224	GRIN2B	HPRD	PubMed
P19174	P32780	GTF2H1	HPRD	PubMed
P19174	P08631	HCK	HPRD	PubMed
P19174	O00145	INPP5D	HPRD	PubMed
P19174	P06213	INSR	HPRD	PubMed
P19174	Q9Y4H2	IRS2	HPRD	PubMed
P19174	Q08881	ITK	HPRD	PubMed
P19174	P35968	KDR	HPRD	PubMed
P19174	Q07666	KHDRBS1	HPRD	PubMed
P19174	P10721	KIT	HPRD	PubMed
P19174	O43561	LAT	HPRD	PubMed
P19174	Q9GZY6	LAT2	HPRD	PubMed
P19174	P06239	LCK	HPRD	PubMed
P19174	Q13094	LCP2	HPRD	PubMed
P19174	P42702	LIFR	HPRD	PubMed
P19174	P07948	LYN	HPRD	PubMed
P19174	P08581	MET	HPRD	PubMed
P19174	Q04912	MST1R	HPRD	PubMed
P19174	P16333	NCK1	HPRD	PubMed
P19174	P04629	NTRK1	HPRD	PubMed
P19174	Q16620	NTRK2	HPRD	PubMed
P19174	Q16288	NTRK3	HPRD	PubMed
P19174	Q13153	PAK1	HPRD	PubMed
P19174	P16234	PDGFRA	HPRD	PubMed
P19174	P09619	PDGFRB	HPRD	PubMed
P19174	P16284	PECAM1	HPRD	PubMed
P19174	Q13492	PICALM	HPRD	PubMed
P19174	Q00169	PITPNA	HPRD	PubMed
P19174	Q16513	PKN2	HPRD	PubMed
P19174	O14939	PLD2	HPRD	PubMed
P19174	Q15139	PRKD1	HPRD	PubMed
P19174	Q05397	PTK2	HPRD	PubMed
P19174	Q06124	PTPN11	HPRD	PubMed
P19174	Q12913	PTPRJ	HPRD	PubMed
P19174	P07949	RET	HPRD	PubMed
P19174	P61586	RHOA	HPRD	PubMed
P19174	Rho GTPase like protein ARHU	RHOU	HPRD	PubMed
P19174	P16581	SELE	HPRD	PubMed
P19174	Q9NP31	SH2D2A	HPRD	PubMed
P19174	P78314	SH3BP2	HPRD	PubMed
P19174	Q15464	SHB	HPRD	PubMed
P19174	P29353	SHC1	HPRD	PubMed
P19174	O60641	SNAP91	HPRD	PubMed
P19174	O14512	SOCS7	HPRD	PubMed
P19174	Q07889	SOS1	HPRD	PubMed
P19174	Q07890	SOS2	HPRD	PubMed
P19174	P12931	SRC	HPRD	PubMed
P19174	P43405	SYK	HPRD	PubMed
P19174	P17600	SYN1	HPRD	PubMed
P19174	P42680	TEC	HPRD	PubMed
P19174	Q13470	TNK1	HPRD	PubMed
P19174	Q13507	TRPC3	HPRD	PubMed
P19174	Q96QT4	TRPM7	HPRD	PubMed
P19174	P50607	TUB	HPRD	PubMed
P19174	O60763	USO1	HPRD	PubMed
P19174	P15498	VAV1	HPRD	PubMed
P19174	Q9UKW4	VAV3	HPRD	PubMed
P19174	P09327	VIL1	HPRD	PubMed
P19174	P42768	WAS	HPRD	PubMed
P19174	P43403	ZAP70	HPRD	PubMed
BioGRID:111351	BioGRID:106543	ABL1	BioGRID	PubMed	Reconstituted Complex
BioGRID:111351	BioGRID:106739	ALK	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:111351	BioGRID:115091	ARHGAP32	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111351	BioGRID:114618	ARHGEF2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111351	BioGRID:114907	BAG3	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111351	BioGRID:107265	CAMK2A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111351	BioGRID:107315	CBL	BioGRID	PubMed	Affinity Capture-Western; Far Western; Reconstituted Complex
BioGRID:111351	BioGRID:107371	CD22	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111351	BioGRID:114095	DGKZ	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111351	BioGRID:108131	DOK1	BioGRID	PubMed	Reconstituted Complex
BioGRID:111351	BioGRID:108237	EEF1A1	BioGRID	PubMed	Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid
BioGRID:111351	BioGRID:108276	EGFR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111351	BioGRID:108362	EPHB2	BioGRID	PubMed	Two-hybrid
BioGRID:111351	BioGRID:108371	EPOR	BioGRID	PubMed	PCA
BioGRID:111351	BioGRID:108376	ERBB2	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation
BioGRID:111351	BioGRID:108551	FGFR1	BioGRID	PubMed	Two-hybrid
	NP_002010.1	FLT1	BIND	PubMed	Flt-1 interacts with the amino terminal SH2 domain of PLC-gamma.
BioGRID:111351	BioGRID:108609	FLT1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:111351	BioGRID:108824	GAB1	BioGRID	PubMed	Affinity Capture-Western; Far Western
BioGRID:111351	BioGRID:115181	GAB2	BioGRID	PubMed	Reconstituted Complex
BioGRID:111351	BioGRID:108957	GHR	BioGRID	PubMed	Reconstituted Complex
BioGRID:111351	BioGRID:118789	GIT1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111351	BioGRID:115671	GNB2L1	BioGRID	PubMed	Far Western
BioGRID:111351	BioGRID:109142	GRB2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111351	BioGRID:109189	GSN	BioGRID	PubMed	Reconstituted Complex
BioGRID:111351	BioGRID:114209	IRS2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111351	BioGRID:109907	ITK	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:111351	BioGRID:109992	KDR	BioGRID	PubMed	Reconstituted Complex
BioGRID:111351	BioGRID:115900	KHDRBS1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111351	BioGRID:110015	KIT	BioGRID	PubMed	Reconstituted Complex
	NP_055202.1	LAT	BIND	PubMed	LAT interacts with an unspecified isoform of PLC-gamma-1.
BioGRID:111351	BioGRID:117971	LAT	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation; Reconstituted Complex
BioGRID:111351	BioGRID:113301	LAT2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111351	BioGRID:110129	LCP2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111351	BioGRID:110236	LTK	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111351	BioGRID:110592	MST1R	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111351	BioGRID:110969	NTRK1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:111351	BioGRID:110970	NTRK2	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:111351	BioGRID:110971	NTRK3	BioGRID	PubMed	Reconstituted Complex
BioGRID:111351	BioGRID:111095	PAK1	BioGRID	PubMed	Reconstituted Complex
BioGRID:111351	BioGRID:111105	PARK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111351	BioGRID:111180	PDGFA	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111351	BioGRID:111182	PDGFRA	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111351	BioGRID:111185	PDGFRB	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111351	BioGRID:111201	PECAM1	BioGRID	PubMed	Far Western; Reconstituted Complex
BioGRID:111351	BioGRID:113902	PICALM	BioGRID	PubMed	Reconstituted Complex
BioGRID:111351	BioGRID:111572	PKN2	BioGRID	PubMed	Reconstituted Complex
BioGRID:111351	BioGRID:111354	PLD2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111351	BioGRID:111377	PLXNB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111351	BioGRID:117178	PLXNB2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111351	BioGRID:111573	PRKD1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111351	BioGRID:111719	PTK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111351	BioGRID:111759	PTPRJ	BioGRID	PubMed	Biochemical Activity
BioGRID:111351	BioGRID:111856	RASA1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111351	BioGRID:111911	RET	BioGRID	PubMed	Reconstituted Complex
BioGRID:111351	BioGRID:106880	RHOA	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
	NP_067028.1	RHOU	BIND	PubMed	Wrch-1 interacts with PLC-gamma. This interaction was modeled on a demonstrated interaction between human Wrch-1 and PLC-gamma from an unspecified species.
BioGRID:111351	BioGRID:112301	SELE	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111351	BioGRID:115336	SH2B3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111351	BioGRID:112350	SH3BP2	BioGRID	PubMed	Far Western; Reconstituted Complex
BioGRID:111351	BioGRID:112358	SHB	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111351	BioGRID:112361	SHC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111351	BioGRID:112537	SOS1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111351	BioGRID:112538	SOS2	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:111351	BioGRID:112592	SRC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111351	BioGRID:112717	SYK	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111351	BioGRID:115755	SYNCRIP	BioGRID	PubMed	Reconstituted Complex
BioGRID:111351	BioGRID:114253	TNK1	BioGRID	PubMed	Reconstituted Complex
	Q13507	TRPC3	BIND	PubMed	PLCG1 interacts with TRPC3. This interaction was modelled on a demonstrated interaction between rat PLCG1 and human TRPC3.
BioGRID:111351	BioGRID:120177	TRPM7	BioGRID	PubMed	Reconstituted Complex
BioGRID:111351	BioGRID:113126	TUB	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111351	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:111351	BioGRID:113252	VAV1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111351	BioGRID:113293	WAS	BioGRID	PubMed	Reconstituted Complex
BioGRID:111351	BioGRID:113367	ZAP70	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
calcium ion binding	IEA Inferred from Electronic Annotation more info
hydrolase activity	IEA Inferred from Electronic Annotation more info
neurotrophin TRKA receptor binding	IPI Inferred from Physical Interaction more info	PubMed
phosphatidylinositol phospholipase C activity	IDA Inferred from Direct Assay more info	PubMed
phosphatidylinositol phospholipase C activity	TAS Traceable Author Statement more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein tyrosine kinase activity	TAS Traceable Author Statement more info
receptor signaling protein activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
T cell receptor signaling pathway	TAS Traceable Author Statement more info
activation of phospholipase C activity	TAS Traceable Author Statement more info
axon guidance	TAS Traceable Author Statement more info
blood coagulation	TAS Traceable Author Statement more info
cellular response to epidermal growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
cytokine-mediated signaling pathway	TAS Traceable Author Statement more info
epidermal growth factor receptor signaling pathway	TAS Traceable Author Statement more info
fibroblast growth factor receptor signaling pathway	TAS Traceable Author Statement more info
interspecies interaction between organisms	IEA Inferred from Electronic Annotation more info
intracellular signal transduction	IEA Inferred from Electronic Annotation more info
leukocyte migration	TAS Traceable Author Statement more info
lipid catabolic process	IEA Inferred from Electronic Annotation more info
nerve growth factor receptor signaling pathway	TAS Traceable Author Statement more info
phospholipid catabolic process	IEA Inferred from Electronic Annotation more info
positive regulation of angiogenesis	IDA Inferred from Direct Assay more info
positive regulation of blood vessel endothelial cell migration	IDA Inferred from Direct Assay more info
positive regulation of epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
signal transduction	NAS Non-traceable Author Statement more info	PubMed
signal transduction	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytosol	IDA Inferred from Direct Assay more info	PubMed
cytosol	TAS Traceable Author Statement more info
lamellipodium	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	TAS Traceable Author Statement more info
ruffle	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; PLC-148; PLC-gamma-1; phospholipase C-II; phospholipase C-148; phosphoinositidase C; phospholipase C-gamma-1; inositoltrisphosphohydrolase; phosphoinositide phospholipase C; phosphatidylinositol phospholipase C; triphosphoinositide phosphodiesterase; phosphoinositide phospholipase C-gamma-1; monophosphatidylinositol phosphodiesterase; 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; phospholipase C, gamma 1 (formerly subtype 148); 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1

NP_002651.2

EC 3.1.4.11

NP_877963.1

EC 3.1.4.11

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002660.2 → NP_002651.2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AB210028, AL110247, M34667

Consensus CDS

CCDS13313.1

UniProtKB/TrEMBL

A2A284

UniProtKB/Swiss-Prot

P19174

UniProtKB/TrEMBL

Q4LE43

UniProtKB/TrEMBL

Q9UFY1

Related

ENSP00000362369, ENST00000373272

Conserved Domains (9) summary

cd00174
Location:796 – 848
Blast Score: 179

SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...

pfam09279
Location:247 – 318
Blast Score: 86

efhand_like; Phosphoinositide-specific phospholipase C, efhand-like

cd00275
Location:1087 – 1211
Blast Score: 433

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd00821
Location:872 – 929
Blast Score: 94

PH; Pleckstrin homology (PH) domain

cd01248
Location:26 – 140
Blast Score: 241

PH_PLC; Phospholipase C (PLC) pleckstrin homology (PH) domain

cd08592
Location:319 – 454
Blast Score: 812

PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma

cd09932
Location:663 – 765
Blast Score: 522

SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma

cd10341
Location:545 – 649
Blast Score: 486

SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma

cl14615
Location:977 – 1057
Blast Score: 459

PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
NM_182811.1 → NP_877963.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.

Source sequence(s)

AB210028, M34667

Consensus CDS

CCDS13314.1

UniProtKB/Swiss-Prot

P19174

UniProtKB/TrEMBL

Q4LE43

Related

ENSP00000362368, OTTHUMP00000031787, ENST00000373271, OTTHUMT00000080514

Conserved Domains (9) summary

cd00174
Location:796 – 848
Blast Score: 179

SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...

pfam09279
Location:247 – 318
Blast Score: 86

efhand_like; Phosphoinositide-specific phospholipase C, efhand-like

cd00275
Location:1087 – 1211
Blast Score: 433

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd00821
Location:872 – 929
Blast Score: 94

PH; Pleckstrin homology (PH) domain

cd01248
Location:26 – 140
Blast Score: 241

PH_PLC; Phospholipase C (PLC) pleckstrin homology (PH) domain

cd08592
Location:319 – 454
Blast Score: 813

PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma

cd09932
Location:663 – 765
Blast Score: 522

SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma

cd10341
Location:545 – 649
Blast Score: 486

SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma

cl14615
Location:977 – 1057
Blast Score: 459

PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000020.10 Reference GRCh37.p5 Primary Assembly

Range

39766161..39804357

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000152.1 Alternate HuRef

Range

36504215..36542409

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL022394.3	CAA18537.1
		CAM28260.1
genomic	CH471077.2	EAW75989.1
		EAW75990.1
		EAW75991.1
		EAW75992.1
		EAW75993.1
genomic	DQ297143.1	ABB84466.1
genomic	U80983.1	AAB70663.1
mRNA	AB210028.1	BAE06110.1
mRNA	AF147391.1	None
mRNA	AK297370.1	BAG59815.1
mRNA	AK309606.1	None
mRNA	AL110247.1	CAB53696.1
mRNA	BC136466.1	AAI36467.1
mRNA	BC144136.1	AAI44137.1
mRNA	BX415739.2	None
mRNA	BX434193.2	None
mRNA	M34667.1	AAA36452.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P19174.1	GenPept	UniProtKB/Swiss-Prot:P19174
Q4LE43	GenPept	UniProtKB/TrEMBL:Q4LE43
Q6LC80	GenPept	UniProtKB/TrEMBL:Q6LC80
Q9UFY1	GenPept	UniProtKB/TrEMBL:Q9UFY1