Display Settings:

Format

Send to:

Choose Destination

NOS3 nitric oxide synthase 3 (endothelial cell) [ Homo sapiens (human) ]

Gene ID: 4846, updated on 19-Oct-2014
Official Symbol
NOS3provided by HGNC
Official Full Name
nitric oxide synthase 3 (endothelial cell)provided by HGNC
Primary source
HGNC:HGNC:7876
See related
Ensembl:ENSG00000164867; HPRD:01224; MIM:163729; Vega:OTTHUMG00000158343
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
eNOS; ECNOS
Summary
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
See NOS3 in Epigenomics, MapViewer
Location:
7q36
Exon count:
30
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 7 NC_000007.14 (150991056..151014944)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150688144..150711687)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene amine oxidase, copper containing 1 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 2 Neighboring gene autophagy related 9B Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 8 Neighboring gene acid-sensing (proton-gated) ion channel 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV gp120 and TNF-alpha synergistically reduce endothelial nitric oxide synthase (eNOS) expression and cause endothelial dysfunction via ICAM-1 PubMed
Envelope transmembrane glycoprotein gp41 env The amino terminus of HIV-1 gp41 induces nitric oxide synthase in human glial and astrocyte cultures and that causes the dysregulation of nitric oxide production PubMed
Nef nef HIV Nef significantly decreases endothelial NOS3 expression in the vessels and human pulmonary artery endothelial cells PubMed
Tat tat HIV-1 Tat induces the expression of NOS-2 and NOS-3 which appears to be a mechanism for regulating Tat-mediated degradation of IkappaBalpha and activation of NFkappaB PubMed
tat HIV-1 Tat protein significantly decreased endothelium-dependent vasorelaxation and eNOS mRNA and protein expression in endothelial cells of porcine coronary arteries, suggesting a role for Tat in coronary heart disease in HIV-infected patients PubMed

Go to the HIV-1, Human Interaction Database

  • ACE Inhibitor Pathway, organism-specific biosystem (from WikiPathways)
    ACE Inhibitor Pathway, organism-specific biosystemThe core of this pathway was elucidated over a century ago and involves the conversion of angiotensinogen to angiotensin I (Ang I) by renin, its subsequent conversion to angiotensin II (Ang II) by an...
  • AGE/RAGE pathway, organism-specific biosystem (from WikiPathways)
    AGE/RAGE pathway, organism-specific biosystemAdvanced glycation end products (AGEs) are heterogeneous group of non-enzymatic malliard reaction products of aldose sugar with proteins and lipids. Formation of AGEs is an indicator of one of the ma...
  • Angiogenesis, organism-specific biosystem (from WikiPathways)
    Angiogenesis, organism-specific biosystemThis pathway is a concise and simplified version of the basic proteins involved in angiogenesis. The proces is regulated by hyopoxia, which results in the transcription of eg. VEGF1, FGF2, PDGFbeta, ...
  • Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
    Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem
    Angiopoietin receptor Tie2-mediated signaling
  • Arginine and proline metabolism, organism-specific biosystem (from KEGG)
    Arginine and proline metabolism, organism-specific biosystem
    Arginine and proline metabolism
  • Arginine and proline metabolism, conserved biosystem (from KEGG)
    Arginine and proline metabolism, conserved biosystem
    Arginine and proline metabolism
  • Calcium signaling pathway, organism-specific biosystem (from KEGG)
    Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Calcium signaling pathway, conserved biosystem (from KEGG)
    Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Corticotropin-releasing hormone, organism-specific biosystem (from WikiPathways)
    Corticotropin-releasing hormone, organism-specific biosystemCorticotropin-releasing hormone (CRH) is a neuropeptide secreted abundantly in the paraventricular nucleus of the hypothalamus, amygdala, cerebral cortex and cerebellum in the central nervous system ...
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Effects of nitric oxide, organism-specific biosystem (from WikiPathways)
    Effects of nitric oxide, organism-specific biosystemNO (Nitric oxide) is an important signalling molecule with vasodilatory and anti-inflammatory effects, indicating a postive role in reducing hypertension and cardiovascular disease. At the same time,...
  • Endothelin, organism-specific biosystem (from WikiPathways)
    Endothelin, organism-specific biosystemEndothelin-1 is a bicyclic 21 amino acid peptide, produced primarily in the endothelium. It is a potent stimulus of long-lasting and persistent vasoconstriction. It also has a role as a stimulus of i...
  • Estrogen signaling pathway, organism-specific biosystem (from KEGG)
    Estrogen signaling pathway, organism-specific biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
  • Estrogen signaling pathway, conserved biosystem (from KEGG)
    Estrogen signaling pathway, conserved biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
  • HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
    HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Latent infection of Homo sapiens with Mycobacterium tuberculosis, organism-specific biosystem (from REACTOME)
    Latent infection of Homo sapiens with Mycobacterium tuberculosis, organism-specific biosystemInfection by Mycobacterium tuberculosis (Mtb) is soon countered by the host's immune system, the organism is however almost never eradicated; ten per cent of infections will develop into "open tuberc...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of nitric oxide, organism-specific biosystem (from REACTOME)
    Metabolism of nitric oxide, organism-specific biosystemNitric oxide (NO), a multifunctional second messenger, is implicated in physiological functions in mammals that range from immune response and potentiation of synaptic transmission to dilation of blo...
  • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
    Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
  • NOSIP mediated eNOS trafficking, organism-specific biosystem (from REACTOME)
    NOSIP mediated eNOS trafficking, organism-specific biosystemeNOS-interacting protein (NOSIP) is a 34-kDa nucleocytoplasmic shuttling protein that binds to the COOH-terminal region (amino acids 366-486) of the eNOS oxygenase domain. This protein association p...
  • NOSTRIN mediated eNOS trafficking, organism-specific biosystem (from REACTOME)
    NOSTRIN mediated eNOS trafficking, organism-specific biosystemeNOS traffic inducer (NOSTRIN) is a novel 506-amino acid eNOS-interacting protein. Along with a decrease in eNOS activity, NOSTRIN causes translocation of eNOS from the plasma membrane to intracellu...
  • Nitric oxide stimulates guanylate cyclase, organism-specific biosystem (from REACTOME)
    Nitric oxide stimulates guanylate cyclase, organism-specific biosystemNitric Oxide (NO) inhibits smooth muscle cell proliferation and migration, oxidation of low-density lipoproteins, and platelet aggregation and adhesion. It can stimulate vasodilatation of the endothe...
  • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
    Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Oxytocin signaling pathway, conserved biosystem (from KEGG)
    Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Phagosomal maturation (early endosomal stage), organism-specific biosystem (from REACTOME)
    Phagosomal maturation (early endosomal stage), organism-specific biosystemAlveolar macrophages normally develop their phagosome along the endolysosomal pathway. However, after having internalized Mtb, this development is arrested at an early stage and only includes acidifi...
  • Plasma membrane estrogen receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
    Plasma membrane estrogen receptor signaling, organism-specific biosystem
    Plasma membrane estrogen receptor signaling
  • Platelet activation, organism-specific biosystem (from KEGG)
    Platelet activation, organism-specific biosystemPlatelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by ad...
  • Platelet homeostasis, organism-specific biosystem (from REACTOME)
    Platelet homeostasis, organism-specific biosystemUnder normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in charact...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by VEGF, organism-specific biosystem (from REACTOME)
    Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
  • Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
    Signaling events mediated by VEGFR1 and VEGFR2
  • Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation, organism-specific biosystem (from REACTOME)
    Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation, organism-specific biosystemTetrahydrobiopterin (BH4) is an essential co-factor for the aromatic amino acid hydroxylases and glycerol ether monooxygenase and it regulates nitric oxide synthase (NOS) activity. Inherited BH4 defi...
  • Thromboxane A2 receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
    Thromboxane A2 receptor signaling, organism-specific biosystem
    Thromboxane A2 receptor signaling
  • VEGF signaling pathway, organism-specific biosystem (from KEGG)
    VEGF signaling pathway, organism-specific biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
  • VEGF signaling pathway, conserved biosystem (from KEGG)
    VEGF signaling pathway, conserved biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
  • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
    VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
  • VEGFR1 specific signals, organism-specific biosystem (from Pathway Interaction Database)
    VEGFR1 specific signals, organism-specific biosystem
    VEGFR1 specific signals
  • VEGFR2 mediated vascular permeability, organism-specific biosystem (from REACTOME)
    VEGFR2 mediated vascular permeability, organism-specific biosystemThe free radical nitric oxide (NO), produced by endothelial NO synthase (eNOS), is an important vasoactive substance in normal vascular biology and pathophysiology. It plays an important role in vasc...
  • Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem (from Pathway Interaction Database)
    Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem
    Validated transcriptional targets of AP1 family members Fra1 and Fra2
  • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
    cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
  • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
    cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
  • citrulline-nitric oxide cycle, organism-specific biosystem (from BIOCYC)
    citrulline-nitric oxide cycle, organism-specific biosystemNitric oxide (NO) plays an important role in cell signaling in the nervous system, and is implicated in synaptic plasticity. It also participates in the immunologic response to infection. In the vasc...
  • citrulline-nitric oxide cycle, conserved biosystem (from BIOCYC)
    citrulline-nitric oxide cycle, conserved biosystem|FRAME: NITRIC-OXIDE Nitric oxide| (NO) plays an important role in cell signaling in the nervous system, and is implicated in synaptic plasticity. It also participates in the immunologic response to ...
  • eNOS activation, organism-specific biosystem (from REACTOME)
    eNOS activation, organism-specific biosystemeNOS activity is regulated by numerous post-translational modifications including phosphorylation and acylation, which also modulate its interactions with other proteins and its subcellular localizat...
  • eNOS activation and regulation, organism-specific biosystem (from REACTOME)
    eNOS activation and regulation, organism-specific biosystemOriginally identified as endothelium-derived relaxing factor, eNOS derived NO is a critical signaling molecule in vascular homeostasis. It regulates blood pressure and vascular tone, and is involved...
  • superpathway of citrulline metabolism, organism-specific biosystem (from BIOCYC)
    superpathway of citrulline metabolism, organism-specific biosystem
    superpathway of citrulline metabolism
  • superpathway of citrulline metabolism, conserved biosystem (from BIOCYC)
    superpathway of citrulline metabolism, conserved biosystemGeneral Background |FRAME: L-CITRULLINE| is a non-standard amino acid that is not normally incorporated into proteins during protein synthesis. The name citrulline was coined in 1930 from |FRAME:TA...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
FMN binding NAS
Non-traceable Author Statement
more info
PubMed 
NADP binding NAS
Non-traceable Author Statement
more info
PubMed 
NADPH-hemoprotein reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
actin monomer binding IPI
Inferred from Physical Interaction
more info
PubMed 
arginine binding IDA
Inferred from Direct Assay
more info
PubMed 
cadmium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
flavin adenine dinucleotide binding NAS
Non-traceable Author Statement
more info
PubMed 
heme binding IDA
Inferred from Direct Assay
more info
PubMed 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
nitric-oxide synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tetrahydrobiopterin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
arginine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
blood coagulation TAS
Traceable Author Statement
more info
 
blood vessel remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
interaction with host TAS
Traceable Author Statement
more info
 
lipopolysaccharide-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
lung development IEA
Inferred from Electronic Annotation
more info
 
mitochondrion organization ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of muscle hyperplasia ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of platelet activation NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
nitric oxide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
nitric oxide mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
nitric oxide metabolic process TAS
Traceable Author Statement
more info
 
ovulation from ovarian follicle IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
phagosome maturation TAS
Traceable Author Statement
more info
 
positive regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of guanylate cyclase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of guanylate cyclase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of vasodilation NAS
Non-traceable Author Statement
more info
PubMed 
regulation of blood pressure NAS
Non-traceable Author Statement
more info
PubMed 
regulation of blood vessel size ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of blood vessel size NAS
Non-traceable Author Statement
more info
PubMed 
regulation of nitric-oxide synthase activity TAS
Traceable Author Statement
more info
 
regulation of sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
regulation of systemic arterial blood pressure by endothelin IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of the force of heart contraction by chemical signal IEA
Inferred from Electronic Annotation
more info
 
response to fluid shear stress IEP
Inferred from Expression Pattern
more info
PubMed 
response to heat NAS
Non-traceable Author Statement
more info
PubMed 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
smooth muscle hyperplasia ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
caveola IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
nitric oxide synthase, endothelial
Names
nitric oxide synthase, endothelial
cNOS
EC-NOS
NOSIII
NOS type III
endothelial NOS
constitutive NOS
nitric oxide synthase 3 transcript variant eNOS-delta20
nitric oxide synthase 3 transcript variant eNOS-delta21
nitric oxide synthase 3 transcript variant eNOS-delta20-21
NP_000594.2
NP_001153581.1
NP_001153582.1
NP_001153583.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011992.1 

    Range
    4998..28541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000603.4NP_000594.2  nitric oxide synthase, endothelial isoform 1

    See proteins identical to NP_000594.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI082109, BC063294, DA859819
    Consensus CDS
    CCDS5912.1
    UniProtKB/Swiss-Prot
    P29474
    Related
    ENSP00000297494, OTTHUMP00000212826, ENST00000297494, OTTHUMT00000350750
    Conserved Domains (4) summary
    COG0369
    Location:5121159
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    cd00795
    Location:68480
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    pfam00258
    Location:522698
    Flavodoxin_1; Flavodoxin
    cl06868
    Location:7621164
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
  2. NM_001160109.1NP_001153581.1  nitric oxide synthase, endothelial isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as eNOS13A, uses an alternate 3' exon and poly-adenylation site, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC063294, DQ256129
    UniProtKB/TrEMBL
    A0S0A6
    UniProtKB/Swiss-Prot
    P29474
    Conserved Domains (2) summary
    cd00795
    Location:68480
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    pfam00258
    Location:522584
    Flavodoxin_1; Flavodoxin
  3. NM_001160110.1NP_001153582.1  nitric oxide synthase, endothelial isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as eNOS13B, uses an alternate 3' exon and poly-adenylation site, compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC063294, DQ256130
    Consensus CDS
    CCDS55183.1
    UniProtKB/Swiss-Prot
    P29474
    Related
    ENSP00000420551, OTTHUMP00000213185, ENST00000467517, OTTHUMT00000351551
    Conserved Domains (2) summary
    cd00795
    Location:68480
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    pfam00258
    Location:522593
    Flavodoxin_1; Flavodoxin
  4. NM_001160111.1NP_001153583.1  nitric oxide synthase, endothelial isoform 4

    See proteins identical to NP_001153583.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as eNOS13C, uses an alternate 3' exon and poly-adenylation site, compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    DQ256131
    Consensus CDS
    CCDS55182.1
    UniProtKB/Swiss-Prot
    P29474
    Related
    ENSP00000420215, OTTHUMP00000213184, ENST00000484524, OTTHUMT00000351550
    Conserved Domains (2) summary
    cd00795
    Location:68480
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    pfam00258
    Location:522589
    Flavodoxin_1; Flavodoxin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000007.14 

    Range
    150991056..151014944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006716000.1XP_006716063.1  

    See proteins identical to XP_006716063.1

    UniProtKB/Swiss-Prot
    P29474
    Conserved Domains (4) summary
    COG0369
    Location:5121159
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    cd00795
    Location:68480
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    pfam00258
    Location:522698
    Flavodoxin_1; Flavodoxin
    cl06868
    Location:7621164
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
  2. XM_006716002.1XP_006716065.1  

    Conserved Domains (2) summary
    cd00795
    Location:68480
    NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
    pfam00258
    Location:522698
    Flavodoxin_1; Flavodoxin
  3. XM_006716001.1XP_006716064.1  

    UniProtKB/TrEMBL
    E7ESA7
    Related
    ENSP00000417143, OTTHUMP00000213183, ENST00000461406, OTTHUMT00000351548
    Conserved Domains (4) summary
    COG0369
    Location:306953
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    pfam00258
    Location:316492
    Flavodoxin_1; Flavodoxin
    cl00254
    Location:1274
    NOS_oxygenase; Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an ...
    cl06868
    Location:556958
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

Alternate HuRef

Genomic

  1. AC_000139.1 

    Range
    144500690..144524025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 

    Range
    150696541..150720093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)