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    CCNE1 cyclin E1 [ Homo sapiens ]

    Gene ID: 898, updated on 21-Feb-2012
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    Summary

    Official Symbol
    CCNE1provided by HGNC
    Official Full Name
    cyclin E1provided by HGNC
    Primary source
    HGNC:1589
    See related
    Ensembl:ENSG00000105173; HPRD:00455; MIM:123837
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CCNE
    Summary
    The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    19q12
    Sequence :
    Chromosome: 19; NC_000019.9 (30302901..30315215)
    See CCNE1 in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family F (with FYVE domain) member 1 Neighboring gene chromosome 19 open reading frame 12 Neighboring gene peptidylprolyl isomerase A (cyclophilin A) pseudogene Neighboring gene ribosomal protein L9 pseudogene 32 Neighboring gene URI1, prefoldin-like chaperone

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor. Mori T, et al. Cell Cycle, 2011 Oct 1. PMID 21952639.
    2. Epstein-Barr virus Rta-mediated transactivation of p21 and 14-3-3σ arrests cells at the G1/S transition by reducing cyclin E/CDK2 activity. Huang SY, et al. J Gen Virol, 2012 Jan. PMID 21918011.
    3. Down-regulation of cyclin E1 expression by microRNA-195 accounts for interferon-β-induced inhibition of hepatic stellate cell proliferation. Sekiya Y, et al. J Cell Physiol, 2011 Oct. PMID 21792910.
    4. Hypoxia-inducible factor 1 is activated by dysregulated cyclin E during mammary epithelial morphogenesis. Sengupta T, et al. Mol Cell Biol, 2011 Sep. PMID 21746877.
    5. PI3K-dependent phosphorylation of Fbw7 modulates substrate degradation and activity. Schülein C, et al. FEBS Lett, 2011 Jul 21. PMID 21620836.

    See all (218) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Epstein-Barr virus Rta-mediated transactivation of p21 and 14-3-3sigma arrests cells at the G1/S transition by reducing cyclin E/CDK2 activity.
      Title: Epstein-Barr virus Rta-mediated transactivation of p21 and 14-3-3σ arrests cells at the G1/S transition by reducing cyclin E/CDK2 activity.
    2. our fi ndings reveal a direct link between cyclin E and HIF-1 activities in mammary epithelial cells and implicate HIF-1 as a mediator of proliferation-independent phenotypes associated with high cyclin E expression in some human breast cancers.
      Title: Hypoxia-inducible factor 1 is activated by dysregulated cyclin E during mammary epithelial morphogenesis.
    3. IFN-beta down-regulates cyclin E1 and up-regulates p21 mRNA levels in hepatic stellate cell line LX-2.
      Title: Down-regulation of cyclin E1 expression by microRNA-195 accounts for interferon-β-induced inhibition of hepatic stellate cell proliferation.
    4. cyclin E and CDK2 genes are key physiological effectors of the c-ETS1 proto-oncogene. Furthermore, c-ETS1 is indispensable for the hepatotropic action of HBx in cell cycle deregulation.
      Title: c-ETS1 facilitates G1/S-phase transition by up-regulating cyclin E and CDK2 genes and cooperates with hepatitis B virus X protein for their deregulation.
    5. After treating of NB4 cells with As(2)O(3), P27(Kip1) and endogenous TGF-beta1 mRNA expressions were up-regulated, and cyclin E mRNA expression was down-regulated.
      Title: [P27(Kip1), cyclin E and endogenous TGF-beta1 changes in apoptosis of NB4 cells induced by As(2)O(3) and/or TGF-beta1 and their significance].
    6. cyclin E1 is repressed independent of effects on cyclin D1 in a 3D collagen environment and dependent on beta1 integrin interaction with collagen I, reducing proliferation of invasive breast cancer cells.
      Title: Three-dimensional collagen represses cyclin E1 via β1 integrin in invasive breast cancer cells.
    7. that the overexpression of p16 and Cyclin E are valuable factors predicting disease progression and metastatic potential of ovarian carcinoma
      Title: Significance of cell cycle regulatory proteins as malignant and prognostic biomarkers in ovarian epithelial tumors.
    8. Overexpression of cyclin E1 in osteosarcoma has potential prognostic and therapeutic implications.
      Title: Cyclin E1 is amplified and overexpressed in osteosarcoma.
    9. cyclin A was strongly associated with the expression of cyclin E in invasive ductal breast carcinoma
      Title: Expression of cell-cycle regulatory proteins BUBR1, MAD2, Aurora A, cyclin A and cyclin E in invasive ductal breast carcinomas.
    10. This study is the first to demonstrate that K(+) channels such as hEag1 are directly involved in the IGF-1-induced up-regulation of cyclin D1 and E expression in MCF-7 cells.
      Title: Regulation of IGF-1-dependent cyclin D1 and E expression by hEag1 channels in MCF-7 cells: the critical role of hEag1 channels in G1 phase progression.
    Submit: New GeneRIF Correction See all (119)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The V3 loop of HIV-1 gp120 induces G1 arrest in IL-2-dependent cell cycle progression by reducing cyclin E expression and phosphorylation of retinoblastoma protein (pRb) PubMed
    Nef nef HIV-1 Nef induces the downregulation of cyclin E expression in podocytes PubMed
    Tat tat HIV-1 Tat induces Cyclin E-associated cdk activity in lymphocytes, indicating Tat drives cells to the late G1 phase of the cell cycle PubMed
    tat HIV-1 Tat 41/44 peptide TAALS from the core domain of Tat inhibits Tat-mediated HIV-1 gene expression and replication by binding the Cdk2/Cyclin E complex and inhibiting the phosphorylation of serine 5 of RNAPII PubMed
    tat HIV-1 Tat induces a G1 arrest in cells of glial origin, leading to a downregulation of cyclin E-Cdk2 kinase activity and phosphorylation of Rb PubMed
    tat Cdk2/cyclin E stimulates Tat-dependent HIV-1 transcription PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001229.1 NP_361014.1 FBXW7    BIND  PubMed hCDC4 interacts with cyclin E. This interaction was modelled on a demonstrated interaction between human CDC4 and cyclin E from an unspecified species. 
    NP_476530.1 NP_060785.2 FBXW7    BIND  PubMed Phosphorylated cycE interacts with Fbw7. This interaction was modeled on a demonstrated interaction between cycE from human and Fbw7 from an unspecified species. 
    P24864 P10275 AR    HPRD  PubMed  
    P24864 P51587 BRCA2    HPRD  PubMed  
    P24864 Q8TDN4 CABLES1    HPRD  PubMed  
    P24864 Calmodulin 1 CALM1    HPRD  PubMed  
    P24864 P50991 CCT4    HPRD  PubMed  
    P24864 P30304 CDC25A    HPRD  PubMed  
    P24864 P06493 CDK1    HPRD  PubMed  
    P24864 P24941 CDK2    HPRD  PubMed  
    P24864 Q00526 CDK3    HPRD  PubMed  
    P24864 P38936 CDKN1A    HPRD  PubMed  
    P24864 P38432 COIL    HPRD  PubMed  
    P24864 Q13618 CUL3    HPRD  PubMed  
    P24864 Q969H0 FBXW7    HPRD  PubMed  
    P24864 P49841 GSK3B    HPRD  PubMed  
    P24864 Q9UII4 HERC5    HPRD  PubMed  
    P24864 P49959 MRE11A    HPRD  PubMed  
    P24864 P10244 MYBL2    HPRD  PubMed  
    P24864 O60934 NBN    HPRD  PubMed  
    P24864 Q13526 PIN1    HPRD  PubMed  
    P24864 P10644 PRKAR1A    HPRD  PubMed  
    P24864 P28749 RBL1    HPRD  PubMed  
    P24864 Q08999 RBL2    HPRD  PubMed  
    P24864 Q04864 REL    HPRD  PubMed  
    P24864 Q13309 SKP2    HPRD  PubMed  
    P24864 P51532 SMARCA4    HPRD  PubMed  
    P24864 Q92922 SMARCC1    HPRD  PubMed  
    P24864 Q6STE5 SMARCD3    HPRD  PubMed  
    BioGRID:107338 BioGRID:106862 AR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107338 BioGRID:111861 ARID4A    BioGRID  PubMed Biochemical Activity 
    BioGRID:107338 BioGRID:107140 BRCA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107338 BioGRID:115827 CCT2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107338 BioGRID:107428 CDC25A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107338 BioGRID:107420 CDK1    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:107338 BioGRID:107452 CDK2    BioGRID  PubMed Affinity Capture-Western; Co-purification; Reconstituted Complex 
    NP_000380.1 CDKN1A    BIND  PubMed p21 interacts with cyclin E. 
    NP_000380.1 CDKN1A    BIND  PubMed CDKN1A (p21) interacts with CCNE1 (cyclin E). 
    BioGRID:107338 BioGRID:107460 CDKN1A    BioGRID  PubMed Affinity Capture-Western 
    NP_004055.1 CDKN1B    BIND  PubMed p27 interacts with Cyc E. 
    NP_004055.1 CDKN1B    BIND  PubMed p27 interacts with cyclin E. 
    BioGRID:107338 BioGRID:107461 CDKN1B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107338 BioGRID:123555 CDT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107338 BioGRID:113815 COIL    BioGRID  PubMed Biochemical Activity 
    BioGRID:107338 BioGRID:114030 CUL3    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107338 BioGRID:198644 Cdk2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107338 BioGRID:108206 E2F4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107338 BioGRID:120581 FBXW7    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-crystal Structure 
    BioGRID:107338 BioGRID:108594 FOXM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107338 BioGRID:109187 GSK3B    BioGRID  PubMed Biochemical Activity 
    BioGRID:107338 BioGRID:119365 HERC5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107338 BioGRID:111105 PARK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107338 BioGRID:111868 RBL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107338 BioGRID:111869 RBL2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107338 BioGRID:120102 RRN3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107338 BioGRID:117017 SF3B1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107338 BioGRID:112393 SKP2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107338 BioGRID:112479 SMARCA2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107338 BioGRID:112481 SMARCA4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107338 BioGRID:112482 SMARCB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107338 BioGRID:112483 SMARCC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107338 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107338 BioGRID:125434 UHRF2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Far Western; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • BARD1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      BARD1 signaling events, organism-specific biosystem
      BARD1 signaling events
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
      Cell Cycle Checkpoints, organism-specific biosystemA hallmark of the human cell cycle in normal somatic cells is its precision. This remarkable fidelity is achieved by a number of signal transduction pathways, known as checkpoints, which monitor cell...
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystem (from REACTOME)
      Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystemCyclin A:Cdk2 plays a key role in S phase entry by phosphorylation of proteins including Cdh1, Rb, p21 and p27. During G1 phase of the cell cycle, cyclin A is synthesized and associates with Cdk2. Af...
    • Cyclin E associated events during G1/S transition, organism-specific biosystem (from REACTOME)
      Cyclin E associated events during G1/S transition, organism-specific biosystemThe transition from the G1 to S phase is controlled by the Cyclin E:Cdk2 complexes. As the Cyclin E:Cdk2 complexes are formed, the Cdk2 is phosphorylated by the Wee1 and Myt1 kinases. This phosphor...
    • E2F mediated regulation of DNA replication, organism-specific biosystem (from REACTOME)
      E2F mediated regulation of DNA replication, organism-specific biosystemProgression through G1 and G1 to S-phase transition that initiates DNA synthesis involve many complexes that are regulated by Rb:E2F pathway. Rb:E2F pathway plays a key role in gene expression regul...
    • E2F transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      E2F transcription factor network, organism-specific biosystem
      E2F transcription factor network
    • G0 and Early G1, organism-specific biosystem (from REACTOME)
      G0 and Early G1, organism-specific biosystemIn G0 and early G1 in quiescent cells, p130 (RBL2) bound to E2F4 or E2F5 and either DP1 or DP2, associates with the MuvB complex, forming an evolutionarily conserved DREAM complex, that represses tr...
    • G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
      G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
    • G1/S DNA Damage Checkpoints, organism-specific biosystem (from REACTOME)
      G1/S DNA Damage Checkpoints, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding ...
    • G1/S Transition, organism-specific biosystem (from REACTOME)
      G1/S Transition, organism-specific biosystemCyclin E - Cdk2 complexes control the transition from G1 into S-phase. In this case, the binding of p21Cip1/Waf1 or p27kip1 is inhibitory. Important substrates for Cyclin E - Cdk2 complexes include p...
    • G1/S-Specific Transcription, organism-specific biosystem (from REACTOME)
      G1/S-Specific Transcription, organism-specific biosystemThe E2F family of transcription factors regulate the transition from the G1 to the S phase in the cell cycle. E2F activity is regulated by members of the retinoblastoma protein (pRb) family, resulti...
    • Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
      Mitotic G1-G1/S phases, organism-specific biosystem
      Mitotic G1-G1/S phases
    • Oocyte meiosis, organism-specific biosystem (from KEGG)
      Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Oocyte meiosis, conserved biosystem (from KEGG)
      Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • PLK3 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      PLK3 signaling events, organism-specific biosystem
      PLK3 signaling events
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes, organism-specific biosystem (from REACTOME)
      Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes, organism-specific biosystemThe G1/S transition is facilitated by Cyclin E:Cdk2-mediated phoshorylation of proteins including Rb and Cyclin Kinase Inhibitors (CKIs).
    • Prostate cancer, organism-specific biosystem (from KEGG)
      Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Prostate cancer, conserved biosystem (from KEGG)
      Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Regulation of retinoblastoma protein, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of retinoblastoma protein, organism-specific biosystem
      Regulation of retinoblastoma protein
    • S Phase, organism-specific biosystem (from REACTOME)
      S Phase, organism-specific biosystemDNA synthesis occurs in the S phase, or the synthesis phase, of the cell cycle. The cell duplicates its hereditary material, and two copies of the chromosome are formed. As DNA replication continu...
    • SCF(Skp2)-mediated degradation of p27/p21, organism-specific biosystem (from REACTOME)
      SCF(Skp2)-mediated degradation of p27/p21, organism-specific biosystemDuring G1, the activity of cyclin-dependent kinases (CDKs) is kept in check by the CDK inhibitors (CKIs) p27 and p21, thereby preventing premature entry into S phase (see Guardavaccaro and Pagano, 20...
    • Signaling events mediated by PRL, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by PRL, organism-specific biosystem
      Signaling events mediated by PRL
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • mTOR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      mTOR signaling pathway, organism-specific biosystem
      mTOR signaling pathway
    • miRNAs involved in DDR, organism-specific biosystem (from WikiPathways)
      miRNAs involved in DDR, organism-specific biosystemMicroRNA clusters involved in de DNA damage response. Genes they regulated and genes that regulate them. All genes presented in this pathway can also be found in the pathway "DNA damage response(Homo...
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53-Dependent G1 DNA Damage Response, organism-specific biosystem (from REACTOME)
      p53-Dependent G1 DNA Damage Response, organism-specific biosystemMost of the damage-induced modifications of p53 are dependent on the ATM kinase. The first link between ATM and p53 was predicted based on the earlier studies that showed that AT cells exhibit a redu...
    • p53-Dependent G1/S DNA damage checkpoint, organism-specific biosystem (from REACTOME)
      p53-Dependent G1/S DNA damage checkpoint, organism-specific biosystemThe arrest at G1/S checkpoint is mediated by the action of a widely known tumor suppressor protein, p53. Loss of p53 functions, as a result of mutations in cancer prevent the G1/S checkpoint (Kuerbi...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    androgen receptor binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    cyclin-dependent protein kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription coactivator activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    DNA-dependent DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    G1/S transition of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    Wnt receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    androgen receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    antral ovarian follicle growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to nutrient IEA
    Inferred from Electronic Annotation
    more info
    		  
    liver development IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    organ regeneration IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of transcription, DNA-dependent NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of cyclin-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of transcription involved in G1/S phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    response to corticosterone stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to cytokine stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to drug IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to estradiol stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to methylmercury IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to organic nitrogen IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to progesterone stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to purine-containing compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to vitamin E IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    cyclin-dependent protein kinase holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus NAS
    Non-traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    G1/S-specific cyclin-E1
    Names
    G1/S-specific cyclin-E1
    cyclin Es
    cyclin Et
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001238.2 → NP_001229.1  G1/S-specific cyclin-E1

      Status: REVIEWED

      Source sequence(s)
      AK291549, BC035498
      Consensus CDS
      CCDS12419.1
      UniProtKB/Swiss-Prot
      P24864
      Related
      ENSP00000262643, ENST00000262643
      Conserved Domains (3) summary
      cd00043
      Location:144 – 234
      Blast Score: 189
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
      COG5024
      Location:30 – 242
      Blast Score: 261
      COG5024; Cyclin [Cell division and chromosome partitioning]
      cl00050
      Location:293 – 363
      Blast Score: 106
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      30302901..30315215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      26814506..26826846
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

     

    1. NM_057182.1: Suppressed sequence

      Description
      NM_057182.1: This RefSeq was suppressed due to concerns that it is 5' partial.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC008798.10 (38008..50326) None
    genomic AF518727.1 AAM54043.1
    genomic L48996.1 None
    genomic X95406.1 CAA64687.1
      CAA64688.1
    mRNA AK291549.1 BAF84238.1
    mRNA AU137789.1 None
    mRNA BC035498.2 AAH35498.1
    mRNA BE645164.1 None
    mRNA M73812.1 None
    mRNA M74093.1 None
    other-genetic DQ893383.2 ABM84309.1
    other-genetic DQ896703.2 ABM87702.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P24864.2 GenPept UniProtKB/Swiss-Prot:P24864
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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