FN1 fibronectin 1 [ Homo sapiens ]

Gene ID: 2335, updated on 20-May-2012

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Summary

Official Symbol: FN1provided by HGNC
Official Full Name: fibronectin 1provided by HGNC
Primary source: HGNC:3778
See related: Ensembl:ENSG00000115414; HPRD:00626; MIM:135600; Vega:OTTHUMG00000133054
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2; DKFZp686H0342; DKFZp686I1370; DKFZp686F10164; DKFZp686O13149
Summary: This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 2q34

Sequence :: Chromosome: 2; NC_000002.11 (216225177..216300791, complement)

See FN1 in Epigenomics, MapViewer

Chromosome 2 - NC_000002.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We conclude that TGF-beta1 may both switch on and switch off migration stimulating factor (MSF) expression in a manner critically determined by the nature of the matrix substratum
Title: Bistable switch in migration stimulating factor expression: regulation by the concerted signalling of transforming growth factor-β1 and the extracellular matrix.
first step in such infections is a bond that forms between fibronectin-binding protein (FnBP) on Staphylococcus aureus and host proteins, such as fibronectin (Fn), that coat the surface of implants in vivo.
Title: Dissociation rate constants of human fibronectin binding to fibronectin-binding proteins on living Staphylococcus aureus isolated from clinical patients.
Fibronectin matrix assembly suppresses dispersal of glioblastoma cells
Title: Fibronectin matrix assembly suppresses dispersal of glioblastoma cells.
LigB could facilitate leptospirosis transmission by binding fibronectin and fibrinogen
Title: The multifunctional LigB adhesin binds homeostatic proteins with potential roles in cutaneous infection by pathogenic Leptospira interrogans.
Danshensu can protect from oxidative stress through inhibiting the expression of FN and Col-I induced by high glucose.
Title: [Effect of Danshensu on fibronectin and collagen-1 secretion induced by high glucose in human peritoneal mesothelial cells].
Fibronectin type III-like domains of neurofascin-186 protein mediate gliomedin binding and its clustering at the developing nodes of Ranvier
Title: Fibronectin type III-like domains of neurofascin-186 protein mediate gliomedin binding and its clustering at the developing nodes of Ranvier.
Leukocytospermia was associated with the alterations of terminal monosaccharide expression in human seminal fibronectin and alpha{1}-acid glycoprotein
Title: Fucose and sialic acid expressions in human seminal fibronectin and α{1} -acid glycoprotein associated with leukocytospermia of infertile men.
Data show that a molecular complex of fibronectin and aggrecan predicts response to lumbar ESI for radiculopathic back pain with HNP.
Title: Outcome of lumbar epidural steroid injection is predicted by assay of a complex of fibronectin and aggrecan from epidural lavage.
the extent of molecular unfolding that contributes to Fn fiber extension
Title: Contribution of unfolding and intermolecular architecture to fibronectin fiber extensibility.
Structural and functional analysis of the tandem beta-zipper interaction of a Streptococcal protein with human fibronectin
Title: Structural and functional analysis of the tandem β-zipper interaction of a Streptococcal protein with human fibronectin.

Submit: New GeneRIF Correction See all (216)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Glomerulopathy with fibronectin deposits 2

MIM: 601894

HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Fibronectin, which is present in submandibular saliva, binds to HIV-1 gp120/160 and enhances the interaction of C1q with gp120/160	PubMed
	env	HIV-1 gp120 binds to fibronectin (FN) present on the surface of platelets; the specificity of this binding is confirmed by the inhibition obtained by pretreating platelets with anti-FN antibodies	PubMed
Envelope surface glycoprotein gp160, precursor	env	HIV-1 gp160 and gp120 specifically recognize the C-terminal heparin-binding domain of fibronectin (Fn) and this binding inhibits the interaction of gp160/gp120 with soluble CD4	PubMed
Envelope transmembrane glycoprotein gp41	env	Fibronectin (FN) binds to HIV-1 glycoproteins, including gp41 and gp120; preincubation with antibodies against FN abolishes this binding	PubMed
Nef	nef	Exogenous HIV-1 Nef upregulates fibronectin (FN) expression in MT4 and H9 T-cell lines	PubMed
Tat	tat	HIV-1 Tat competes with fibronectin for binding to integrins	PubMed
	tat	Fibronectin modulates the effects of HIV-1 Tat on endothelial cells and murine Kaposi's sarcoma-like cells	PubMed
	tat	HIV-1 Tat upregulates fibronectin expression in salivary gland cell lines, thymic epithelial cells, and glioblastoma cells	PubMed
retropepsin	gag-pol	The cell-associated protein fibronectin (A-chain) is specifically cleaved in vitro by HIV-1 protease	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_002017.1	NP_000542.1	VHL	BIND	PubMed	pVHL interacts with fibronectin 1
NP_002017.1	AAC83709.1		BIND	PubMed	NSP4 interacts with Fibronectin.
NP_002017.1			BIND	PubMed	FN interacts with Integrin alpha-8 beta-1
NP_002017.1			BIND	PubMed	FN interacts with Integrin alpha-IIb beta-3
NP_002017.1			BIND	PubMed	FN interacts with Integrin alpha-v beta-1
NP_002017.1			BIND	PubMed	FN interacts with Integrin alpha-v beta-3
NP_002017.1			BIND	PubMed	FN interacts with Integrin alpha-v beta-6
NP_002017.1			BIND	PubMed	FN interacts with Integrin alpha-5 beta-1
P02751	O75173	ADAMTS4	HPRD	PubMed
P02751	P02760	AMBP	HPRD	PubMed
P02751	P02743	APCS	HPRD	PubMed
P02751	P02745	C1QA	HPRD	PubMed
P02751	Collagen, type XIII, alpha 1	COL13A1	HPRD	PubMed
P02751	P02452	COL1A1	HPRD	PubMed
P02751	P08123	COL1A2	HPRD	PubMed
P02751	P02458	COL2A1	HPRD	PubMed
P02751	P02462	COL4A1	HPRD	PubMed
P02751	P08572	COL4A2	HPRD	PubMed
P02751	Q01955	COL4A3	HPRD	PubMed
P02751	P53420	COL4A4	HPRD	PubMed
P02751	P29400	COL4A5	HPRD	PubMed
P02751	Q14031	COL4A6	HPRD	PubMed
P02751	P12110	COL6A2	HPRD	PubMed
P02751	Q02388	COL7A1	HPRD	PubMed
P02751	P49747	COMP	HPRD	PubMed
P02751	P02741	CRP	HPRD	PubMed
P02751	P07339	CTSD	HPRD	PubMed
P02751	P48061	CXCL12	HPRD	PubMed
P02751	P07585	DCN	HPRD	PubMed
P02751	P00488	F13A1	HPRD	PubMed
P02751	P48023	FASLG	HPRD	PubMed
P02751	P23142	FBLN1	HPRD	PubMed
P02751	P98095	FBLN2	HPRD	PubMed
P02751	P19883	FST	HPRD	PubMed
P02751	O95633	FSTL3	HPRD	PubMed
P02751	Q8NCL4	GALNT6	HPRD	PubMed
P02751	P06396	GSN	HPRD	PubMed
P02751	P14210	HGF	HPRD	PubMed
P02751	P17936	IGFBP3	HPRD	PubMed
P02751	P24593	IGFBP5	HPRD	PubMed
P02751	P26006	ITGA3	HPRD	PubMed
P02751	P13612	ITGA4	HPRD	PubMed
P02751	P08648	ITGA5	HPRD	PubMed
P02751	P53708	ITGA8	HPRD	PubMed
P02751	P05556	ITGB1	HPRD	PubMed
P02751	P05106	ITGB3	HPRD	PubMed
P02751	P18564	ITGB6	HPRD	PubMed
P02751	P26010	ITGB7	HPRD	PubMed
P02751	P07288	KLK3	HPRD	PubMed
P02751	Q9GZZ8	LACRT	HPRD	PubMed
P02751	Q08380	LGALS3BP	HPRD	PubMed
P02751	P08519	LPA	HPRD	PubMed
P02751	P02750	LRG1	HPRD	PubMed
P02751	Q14766	LTBP1	HPRD	PubMed
P02751	P20916	MAG	HPRD	PubMed
P02751	O00339	MATN2	HPRD	PubMed
P02751	Q16819	MEP1A	HPRD	PubMed
P02751	Q16820	MEP1B	HPRD	PubMed
P02751	Q16674	MIA	HPRD	PubMed
P02751	P14780	MMP9	HPRD	PubMed
P02751	Q99972	MYOC	HPRD	PubMed
P02751	P48745	NOV	HPRD	PubMed
P02751	P21589	NT5E	HPRD	PubMed
P02751	P98161	PKD1	HPRD	PubMed
P02751	P51888	PRELP	HPRD	PubMed
P02751	O75400	PRPF40A	HPRD	PubMed
P02751	Q06141	REG3A	HPRD	PubMed
P02751	P11684	SCGB1A1	HPRD	PubMed
P02751	P34741	SDC2	HPRD	PubMed
P02751	P12757	SKIL	HPRD	PubMed
P02751	Q13485	SMAD4	HPRD	PubMed
P02751	O15198	SMAD9	HPRD	PubMed
P02751	P09486	SPARC	HPRD	PubMed
P02751	P20366	TAC1	HPRD	PubMed
P02751	Q15582	TGFBI	HPRD	PubMed
P02751	P21980	TGM2	HPRD	PubMed
P02751	P07996	THBS1	HPRD	PubMed
P02751	Q8IU80	TMPRSS6	HPRD	PubMed
P02751	P24821	TNC	HPRD	PubMed
P02751	O00300	TNFRSF11B	HPRD	PubMed
P02751	P16473	TSHR	HPRD	PubMed
P02751	P40337	VHL	HPRD	PubMed
BioGRID:108621	BioGRID:106757	AMBP	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108621	BioGRID:106822	APCS	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108621	BioGRID:112221	ATXN7	BioGRID	PubMed	Two-hybrid
BioGRID:108621	BioGRID:107173	C1QA	BioGRID	PubMed	Reconstituted Complex
BioGRID:108621	BioGRID:107398	CD44	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:108621	BioGRID:107691	COL7A1	BioGRID	PubMed	Reconstituted Complex
BioGRID:108621	BioGRID:107791	CRP	BioGRID	PubMed	Reconstituted Complex
BioGRID:108621	BioGRID:112288	CXCL12	BioGRID	PubMed	Reconstituted Complex
BioGRID:108621	BioGRID:108276	EGFR	BioGRID	PubMed	PCA
BioGRID:108621	BioGRID:108460	F13A1	BioGRID	PubMed	Reconstituted Complex
BioGRID:108621	BioGRID:106852	FASLG	BioGRID	PubMed	Reconstituted Complex
BioGRID:108621	BioGRID:108486	FBLN1	BioGRID	PubMed	Reconstituted Complex
BioGRID:108621	BioGRID:108493	FBLN2	BioGRID	PubMed	Reconstituted Complex
BioGRID:108621	BioGRID:109142	GRB2	BioGRID	PubMed	Two-hybrid
BioGRID:108621	BioGRID:109189	GSN	BioGRID	PubMed	Reconstituted Complex
BioGRID:108621	BioGRID:109571	HSPG2	BioGRID	PubMed	Reconstituted Complex
BioGRID:108621	BioGRID:109707	IGFBP3	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:108621	BioGRID:109884	ITGA5	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:108621	BioGRID:109900	ITGB6	BioGRID	PubMed	Reconstituted Complex
BioGRID:108621	BioGRID:109901	ITGB7	BioGRID	PubMed	Affinity Capture-Western
BioGRID:108621	BioGRID:124659	LACRT	BioGRID	PubMed	Reconstituted Complex
BioGRID:108621	BioGRID:110202	LPA	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:108621	BioGRID:110387	MEP1A	BioGRID	PubMed	Biochemical Activity
BioGRID:108621	BioGRID:110388	MEP1B	BioGRID	PubMed	Biochemical Activity
BioGRID:108621	BioGRID:113834	MIA	BioGRID	PubMed	Reconstituted Complex
BioGRID:108621	BioGRID:110736	MYOC	BioGRID	PubMed	Reconstituted Complex
BioGRID:108621	BioGRID:110918	NOV	BioGRID	PubMed	Reconstituted Complex
BioGRID:108621	BioGRID:111327	PKD1	BioGRID	PubMed	Reconstituted Complex
BioGRID:108621	BioGRID:111343	PLAT	BioGRID	PubMed	Reconstituted Complex
BioGRID:108621	BioGRID:111356	PLG	BioGRID	PubMed	Reconstituted Complex
BioGRID:108621	BioGRID:111103	REG3A	BioGRID	PubMed	Reconstituted Complex
BioGRID:108621	BioGRID:112285	SDC2	BioGRID	PubMed	Reconstituted Complex
	NP_003004.1	SFRP2	BIND	PubMed	SFRP2 interacts with an unspecified isoform of FN1 (FN). This interaction was modeled on a demonstrated interaction between canine SFRP2 and human FN1.
BioGRID:108621	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108621	BioGRID:112903	TGFBI	BioGRID	PubMed	Reconstituted Complex
BioGRID:108621	BioGRID:112910	TGM2	BioGRID	PubMed	Reconstituted Complex
BioGRID:108621	BioGRID:109602	TNC	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:108621	BioGRID:121756	TRIB3	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:108621	BioGRID:113104	TSHR	BioGRID	PubMed	Reconstituted Complex
BioGRID:108621	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108621	BioGRID:113269	VHL	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:108621	BioGRID:1205544	env	BioGRID	PubMed	Reconstituted Complex
	AAA26632.1		BIND	PubMed	FNBPA interacts with an unspecified isoform of FN1 (fibronectin).

Function	Evidence Code	Pubs
collagen binding	NAS Non-traceable Author Statement more info	PubMed
extracellular matrix structural constituent	NAS Non-traceable Author Statement more info
heparin binding	NAS Non-traceable Author Statement more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acute-phase response	IEA Inferred from Electronic Annotation more info
angiogenesis	IEA Inferred from Electronic Annotation more info
blood coagulation	TAS Traceable Author Statement more info
cell adhesion	NAS Non-traceable Author Statement more info	PubMed
cell migration	NAS Non-traceable Author Statement more info
leukocyte migration	TAS Traceable Author Statement more info
peptide cross-linking	IDA Inferred from Direct Assay more info	PubMed
platelet activation	TAS Traceable Author Statement more info
platelet degranulation	TAS Traceable Author Statement more info
regulation of cell shape	IEA Inferred from Electronic Annotation more info
response to wounding	NAS Non-traceable Author Statement more info	PubMed
substrate adhesion-dependent cell spreading	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
endoplasmic reticulum-Golgi intermediate compartment	IDA Inferred from Direct Assay more info	PubMed
extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with extracellular matrix	IDA Inferred from Direct Assay more info
colocalizes_with extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info
extracellular region	NAS Non-traceable Author Statement more info	PubMed
extracellular region	TAS Traceable Author Statement more info
extracellular space	IDA Inferred from Direct Assay more info
fibrinogen complex	IDA Inferred from Direct Assay more info	PubMed
platelet alpha granule lumen	TAS Traceable Author Statement more info
proteinaceous extracellular matrix	NAS Non-traceable Author Statement more info

General protein information

Preferred Names: fibronectin

Names: fibronectin; cold-insoluble globulin; migration-stimulating factor

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012196.1 RefSeqGene

Range

5001..80615

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002026.2 → NP_002017.1 fibronectin isoform 3 preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an in-frame exon and an internal segment in the coding region, as compared to variant 1. Isoform 3 encoded by this variant thus lacks two internal segments, as compared to isoform 1.

Source sequence(s)

AI033037, AJ535086, BQ005645, BX640638, BX640731, BX640802, X02761

Consensus CDS

CCDS2399.1

UniProtKB/Swiss-Prot

P02751

UniProtKB/TrEMBL

Q6MZF4

UniProtKB/TrEMBL

Q6N084

Related

ENSP00000338200, OTTHUMP00000164055, ENST00000336916, OTTHUMT00000256669

Conserved Domains (5) summary

cd00061
Location:559 – 602
Blast Score: 147

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00062
Location:354 – 401
Blast Score: 211

FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...

cd00063
Location:1449 – 1531
Blast Score: 156

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl00063
Location:311 – 341
Blast Score: 110

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cl00065
Location:619 – 688
Blast Score: 145

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_054034.2 → NP_473375.2 fibronectin isoform 7 preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks multiple 3' exons and has an alternate 3' end, as compared to variant 1. Isoform 7 encoded by this variant is much shorter and has a distinct C-terminus, as compared isoform 1.

Source sequence(s)

AJ276395, AJ535086, BX640608

Consensus CDS

CCDS46512.1

UniProtKB/TrEMBL

E9PG29

UniProtKB/Swiss-Prot

P02751

Related

ENSP00000398907, OTTHUMP00000206767, ENST00000426059, OTTHUMT00000337235

Conserved Domains (3) summary

cd00061
Location:559 – 602
Blast Score: 122

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00062
Location:354 – 401
Blast Score: 185

FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...

cl00063
Location:523 – 560
Blast Score: 139

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
NM_212474.1 → NP_997639.1 fibronectin isoform 6 preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks two in-frame exons and an in-frame segment in the coding region, as compared to variant 1. Isoform 6 encoded by this variant thus lacks three internal segments, as compared to isoform 6.

Source sequence(s)

AI033037, AJ535086, AL832202, BQ005645, U60068, X02761

Consensus CDS

CCDS2400.1

UniProtKB/Swiss-Prot

P02751

UniProtKB/TrEMBL

Q9UQS6

Related

ENSP00000350534, OTTHUMP00000164056, ENST00000357867, OTTHUMT00000256670

Conserved Domains (5) summary

cd00061
Location:559 – 602
Blast Score: 146

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00062
Location:354 – 401
Blast Score: 209

FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...

cd00063
Location:1449 – 1531
Blast Score: 156

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl00063
Location:311 – 341
Blast Score: 109

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cl00065
Location:619 – 688
Blast Score: 145

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_212476.1 → NP_997641.1 fibronectin isoform 5 preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks two in-frame exons in the coding region, as compared to variant 1. Isoform 5 encoded by this variant thus lacks two internal segments, as compared to isoform 1.

Source sequence(s)

AI033037, AJ535086, BQ005645, BX640608, U60068, X02761

Consensus CDS

CCDS42813.1

UniProtKB/Swiss-Prot

P02751

UniProtKB/TrEMBL

Q9UQS6

Related

ENSP00000348285, OTTHUMP00000206766, ENST00000356005, OTTHUMT00000337234

Conserved Domains (5) summary

cd00061
Location:559 – 602
Blast Score: 147

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00062
Location:354 – 401
Blast Score: 210

FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...

cd00063
Location:1449 – 1531
Blast Score: 156

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl00063
Location:311 – 341
Blast Score: 109

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cl00065
Location:619 – 688
Blast Score: 145

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_212478.1 → NP_997643.1 fibronectin isoform 4 preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an in-frame exon and two in-frame segments in the coding region, as compared to variant 1. Isoform 4 encoded by this variant thus lacks three internal segments, as compared to isoform 1.

Source sequence(s)

AI033037, AJ535086, BQ005645, BX640802, U60068, X02761

Consensus CDS

CCDS46510.1

UniProtKB/Swiss-Prot

P02751

UniProtKB/TrEMBL

Q6MZF4

UniProtKB/TrEMBL

Q9UQS6

Related

ENSP00000410422, OTTHUMP00000206762, ENST00000446046, OTTHUMT00000337229

Conserved Domains (5) summary

cd00061
Location:559 – 602
Blast Score: 147

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00062
Location:354 – 401
Blast Score: 210

FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...

cd00063
Location:1449 – 1531
Blast Score: 156

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl00063
Location:311 – 341
Blast Score: 109

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cl00065
Location:619 – 688
Blast Score: 145

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_212482.1 → NP_997647.1 fibronectin isoform 1 preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AI033037, AJ535086, BQ005645, BX640803, BX640875, BX640999, U60068

Consensus CDS

CCDS42814.1

UniProtKB/Swiss-Prot

P02751

UniProtKB/TrEMBL

Q6MZM7

UniProtKB/TrEMBL

Q9UQS6

Related

ENSP00000346839, OTTHUMP00000164053, ENST00000354785, OTTHUMT00000256667

Conserved Domains (5) summary

cd00061
Location:559 – 602
Blast Score: 148

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00062
Location:354 – 401
Blast Score: 212

FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...

cd00063
Location:1540 – 1622
Blast Score: 156

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl00063
Location:311 – 341
Blast Score: 110

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cl00065
Location:619 – 688
Blast Score: 145

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000002.11 Reference GRCh37.p5 Primary Assembly

Range

216225177..216300791, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000134.1 Alternate HuRef

Range

208082209..208158070, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_212475.1: Suppressed sequence

Description

NM_212475.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC012462.5	AAX76513.1
genomic	AC073284.5	AAY24063.1
genomic	CH471063.1	EAW70530.1
		EAW70531.1
		EAW70532.1
		EAW70533.1
		EAW70534.1
		EAW70535.1
		EAW70536.1
		EAW70537.1
		EAW70538.1
		EAW70539.1
		EAW70540.1
		EAW70541.1
		EAW70542.1
		EAW70543.1
		EAW70544.1
		EAW70545.1
		EAW70546.1
		EAW70547.1
		EAW70548.1
genomic	M12549.1	AAA58483.1
genomic	M15801.1	AAA53376.1
genomic	M18179.1	AAA52461.1
genomic	X07717.1	CAB52437.1
genomic	X07718.1	CAB52436.1
mRNA	AB191261.1	BAD52437.1
mRNA	AB209287.1	BAD92524.1
mRNA	AB209840.1	BAD93077.1
mRNA	AF130095.1	AAG35520.1
mRNA	AF312399.1	AAG30571.1
mRNA	AI033037.1	None
mRNA	AJ276395.1	CAC20427.1
mRNA	AJ320525.1	CAC86914.1
mRNA	AJ320526.1	CAC86915.1
mRNA	AJ320527.1	CAC86916.1
mRNA	AJ535086.1	CAD59389.1
mRNA	AK026737.1	None
mRNA	AK094153.1	None
mRNA	AK297733.1	BAG60083.1
mRNA	AK300216.1	BAG61984.1
mRNA	AK300246.1	BAG62013.1
mRNA	AK300458.1	BAG62178.1
mRNA	AK316350.1	BAH14721.1
mRNA	AL832202.1	CAD91166.1
mRNA	AL832771.1	None
mRNA	BC005858.2	AAH05858.2
mRNA	BC016875.2	AAH16875.1
mRNA	BC078656.1	None
mRNA	BC100030.1	None
mRNA	BC117176.1	AAI17177.1
mRNA	BC143754.1	AAI43755.1
mRNA	BC143763.1	AAI43764.1
mRNA	BQ005645.1	None
mRNA	BT006856.1	AAP35502.1
mRNA	BX537590.1	CAD97791.1
mRNA	BX538017.1	CAD97964.1
mRNA	BX538018.1	CAD97965.1
mRNA	BX538045.1	CAD97984.1
mRNA	BX640608.1	CAE45714.1
mRNA	BX640638.1	CAE45786.1
mRNA	BX640731.1	CAE45847.1
mRNA	BX640802.1	CAE45885.1
mRNA	BX640803.1	None
mRNA	BX640875.1	CAE45932.1
mRNA	BX640920.1	CAE45958.1
mRNA	BX640999.1	CAE46002.1
mRNA	BX641150.1	None
mRNA	BX649182.1	CAE46200.1
mRNA	CR749281.1	CAH18136.1
mRNA	CR749316.1	CAH18171.1
mRNA	CR749317.1	CAH18172.1
mRNA	CR749666.1	CAH18457.1
mRNA	CR936623.1	CAI56766.1
mRNA	EF550130.1	ABR68534.1
mRNA	EF550131.1	ABR68535.1
mRNA	EF550132.1	ABR68536.1
mRNA	EF550133.1	ABR68537.1
mRNA	EF550134.1	ABR68538.1
mRNA	EF550135.1	ABR68539.1
mRNA	M10905.1	AAA52462.1
mRNA	M14059.1	AAA52463.1
mRNA	M14060.1	AAA52464.1
mRNA	M27589.1	AAA52465.1
mRNA	M27590.1	AAA52466.1
mRNA	U41724.1	AAD00013.1
mRNA	U41850.1	AAD00014.1
mRNA	U42404.1	AAD00015.1
mRNA	U42455.1	AAD09448.1
mRNA	U42456.1	AAD09449.1
mRNA	U42457.1	AAD04751.1
mRNA	U42458.1	AAD09450.1
mRNA	U42592.1	AAD00017.1
mRNA	U42593.1	AAD00018.1
mRNA	U42594.1	AAD00019.1
mRNA	U60067.1	AAD11500.1
mRNA	U60068.1	AAD10853.1
mRNA	X02761.1	CAA26536.1
mRNA	AJ849445.1	CAH60958.1
other-genetic	EU831936.1	ACE87377.1
other-genetic	EU832031.1	ACE86693.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
O95608	GenPept	UniProtKB/TrEMBL:O95608
O95617	GenPept	UniProtKB/TrEMBL:O95617
P02751.4	GenPept	UniProtKB/Swiss-Prot:P02751
Q14327	GenPept	UniProtKB/TrEMBL:Q14327
Q14328	GenPept	UniProtKB/TrEMBL:Q14328
Q53S27	GenPept	UniProtKB/TrEMBL:Q53S27
Q564H7	GenPept	UniProtKB/TrEMBL:Q564H7
Q59G22	GenPept	UniProtKB/TrEMBL:Q59G22
Q5CZ99	GenPept	UniProtKB/TrEMBL:Q5CZ99
Q68CX6	GenPept	UniProtKB/TrEMBL:Q68CX6
Q6MZF4	GenPept	UniProtKB/TrEMBL:Q6MZF4
Q6MZM7	GenPept	UniProtKB/TrEMBL:Q6MZM7
Q6N084	GenPept	UniProtKB/TrEMBL:Q6N084
Q6PJE5	GenPept	UniProtKB/TrEMBL:Q6PJE5
Q7L553	GenPept	UniProtKB/TrEMBL:Q7L553
Q7Z391	GenPept	UniProtKB/TrEMBL:Q7Z391
Q9H382	GenPept	UniProtKB/TrEMBL:Q9H382
Q9UQS6	GenPept	UniProtKB/TrEMBL:Q9UQS6