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FN1 fibronectin 1 [ Homo sapiens (human) ]

Gene ID: 2335, updated on 17-Apr-2014
Official Symbol
FN1provided by HGNC
Official Full Name
fibronectin 1provided by HGNC
Primary source
HGNC:3778
See related
Ensembl:ENSG00000115414; HPRD:00626; MIM:135600; Vega:OTTHUMG00000133054
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2
Summary
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Location :
2q34
Sequence :
Chromosome: 2; NC_000002.12 (215360454..215436167, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928103 Neighboring gene ATP-binding cassette, sub-family A (ABC1), member 12 Neighboring gene 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Neighboring gene uncharacterized LOC102724849 Neighboring gene long intergenic non-protein coding RNA 607 Neighboring gene uncharacterized LOC102724861

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Glomerulopathy with fibronectin deposits 2
MedGen: C1866075 OMIM: 601894 GeneReviews: Not available
not available
Plasma fibronectin deficiency
MedGen: C2675436 OMIM: 614101 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Env, gp160, envelope glycoprotein env HIV-1 gp160 and gp120 specifically recognize the C-terminal heparin-binding domain of fibronectin (Fn) and this binding inhibits the interaction of gp160/gp120 with soluble CD4 PubMed
Envelope surface glycoprotein gp120 env HIV-1 gp120 induces phosphorylation of fibronectin and enhances a physical association between fibronectin and Robo4 in human lymphatic endothelial cells PubMed
env Fibronectin, which is present in submandibular saliva, binds to HIV-1 gp120/160 and enhances the interaction of C1q with gp120/160 PubMed
env HIV-1 gp120 binds to fibronectin (FN) present on the surface of platelets; the specificity of this binding is confirmed by the inhibition obtained by pretreating platelets with anti-FN antibodies PubMed
Envelope transmembrane glycoprotein gp41 env Fibronectin (FN) binds to HIV-1 glycoproteins, including gp41 and gp120; preincubation with antibodies against FN abolishes this binding PubMed
Nef, p27 nef Exogenous HIV-1 Nef upregulates fibronectin (FN) expression in MT4 and H9 T-cell lines PubMed
Tat, p14 tat HIV-1 Tat competes with fibronectin for binding to integrins PubMed
tat Fibronectin modulates the effects of HIV-1 Tat on endothelial cells and murine Kaposi's sarcoma-like cells PubMed
tat HIV-1 Tat upregulates fibronectin expression in salivary gland cell lines, thymic epithelial cells, and glioblastoma cells PubMed
pol gag-pol The cell-associated protein fibronectin (A-chain) is specifically cleaved in vitro by HIV-1 protease PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
collagen binding NAS
Non-traceable Author Statement
more info
PubMed 
heparin binding NAS
Non-traceable Author Statement
more info
PubMed 
integrin binding IDA
Inferred from Direct Assay
more info
PubMed 
peptidase activator activity IEA
Inferred from Electronic Annotation
more info
 
protease binding IPI
Inferred from Physical Interaction
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acute-phase response IEA
Inferred from Electronic Annotation
more info
 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
blood coagulation TAS
Traceable Author Statement
more info
 
calcium-independent cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
cell-substrate junction assembly IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix disassembly TAS
Traceable Author Statement
more info
 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
leukocyte migration TAS
Traceable Author Statement
more info
 
peptide cross-linking IDA
Inferred from Direct Assay
more info
PubMed 
platelet activation TAS
Traceable Author Statement
more info
 
platelet degranulation TAS
Traceable Author Statement
more info
 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
response to wounding NAS
Non-traceable Author Statement
more info
PubMed 
substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
basement membrane IEA
Inferred from Electronic Annotation
more info
 
blood microparticle IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with extracellular matrix IDA
Inferred from Direct Assay
more info
 
colocalizes_with extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
fibrinogen complex IDA
Inferred from Direct Assay
more info
PubMed 
platelet alpha granule lumen TAS
Traceable Author Statement
more info
 
Preferred Names
fibronectin
Names
fibronectin
cold-insoluble globulin
migration-stimulating factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012196.1 RefSeqGene

    Range
    5001..80615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002026.2NP_002017.1  fibronectin isoform 3 preproprotein

    See proteins identical to NP_002017.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon and an internal segment in the coding region, as compared to variant 1. Isoform 3 encoded by this variant thus lacks two internal segments, as compared to isoform 1.
    Source sequence(s)
    AI033037, AJ535086, BQ005645, BX640638, BX640731, BX640802, X02761
    Consensus CDS
    CCDS2399.1
    UniProtKB/Swiss-Prot
    P02751
    UniProtKB/TrEMBL
    Q6MZF4
    UniProtKB/TrEMBL
    Q6N084
    Related
    ENSP00000338200, OTTHUMP00000164055, ENST00000336916, OTTHUMT00000256669
    Conserved Domains (4) summary
    cd00061
    Location:559602
    Blast Score: 159
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:354401
    Blast Score: 229
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00063
    Location:19041984
    Blast Score: 196
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:20752147
    Blast Score: 111
    fn3; Fibronectin type III domain
  2. NM_054034.2NP_473375.2  fibronectin isoform 7 preproprotein

    See proteins identical to NP_473375.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks multiple 3' exons and has an alternate 3' end, as compared to variant 1. Isoform 7 encoded by this variant is much shorter and has a distinct C-terminus, as compared isoform 1.
    Source sequence(s)
    AJ276395, AJ535086, BX640608
    Consensus CDS
    CCDS46512.1
    UniProtKB/Swiss-Prot
    P02751
    Related
    ENSP00000398907, OTTHUMP00000206767, ENST00000426059, OTTHUMT00000337235
    Conserved Domains (2) summary
    cd00061
    Location:559602
    Blast Score: 134
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:354401
    Blast Score: 203
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
  3. NM_212474.1NP_997639.1  fibronectin isoform 6 preproprotein

    See proteins identical to NP_997639.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks two in-frame exons and an in-frame segment in the coding region, as compared to variant 1. Isoform 6 encoded by this variant thus lacks three internal segments, as compared to isoform 6.
    Source sequence(s)
    AI033037, AJ535086, AL832202, BQ005645, U60068, X02761
    Consensus CDS
    CCDS2400.1
    UniProtKB/Swiss-Prot
    P02751
    UniProtKB/TrEMBL
    Q9UQS6
    Related
    ENSP00000350534, OTTHUMP00000164056, ENST00000357867, OTTHUMT00000256670
    Conserved Domains (4) summary
    cd00061
    Location:559602
    Blast Score: 158
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:354401
    Blast Score: 227
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00063
    Location:18141894
    Blast Score: 195
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:19101968
    Blast Score: 106
    fn3; Fibronectin type III domain
  4. NM_212476.1NP_997641.1  fibronectin isoform 5 preproprotein

    See proteins identical to NP_997641.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two in-frame exons in the coding region, as compared to variant 1. Isoform 5 encoded by this variant thus lacks two internal segments, as compared to isoform 1.
    Source sequence(s)
    AI033037, AJ535086, BQ005645, BX640608, U60068, X02761
    Consensus CDS
    CCDS42813.1
    UniProtKB/Swiss-Prot
    P02751
    UniProtKB/TrEMBL
    Q9UQS6
    Related
    ENSP00000348285, OTTHUMP00000206766, ENST00000356005, OTTHUMT00000337234
    Conserved Domains (4) summary
    cd00061
    Location:559602
    Blast Score: 158
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:354401
    Blast Score: 228
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00063
    Location:18141894
    Blast Score: 195
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:20302088
    Blast Score: 106
    fn3; Fibronectin type III domain
  5. NM_212478.1NP_997643.1  fibronectin isoform 4 preproprotein

    See proteins identical to NP_997643.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon and two in-frame segments in the coding region, as compared to variant 1. Isoform 4 encoded by this variant thus lacks three internal segments, as compared to isoform 1.
    Source sequence(s)
    AI033037, AJ535086, BQ005645, BX640802, U60068, X02761
    Consensus CDS
    CCDS46510.1
    UniProtKB/Swiss-Prot
    P02751
    UniProtKB/TrEMBL
    Q6MZF4
    UniProtKB/TrEMBL
    Q9UQS6
    Related
    ENSP00000410422, OTTHUMP00000206762, ENST00000446046, OTTHUMT00000337229
    Conserved Domains (4) summary
    cd00061
    Location:559602
    Blast Score: 159
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:354401
    Blast Score: 229
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00063
    Location:19041984
    Blast Score: 196
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:20502122
    Blast Score: 111
    fn3; Fibronectin type III domain
  6. NM_212482.1NP_997647.1  fibronectin isoform 1 preproprotein

    See proteins identical to NP_997647.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI033037, AJ535086, BQ005645, BX640803, BX640875, BX640999, U60068
    Consensus CDS
    CCDS42814.1
    UniProtKB/Swiss-Prot
    P02751
    UniProtKB/TrEMBL
    Q6MZM7
    UniProtKB/TrEMBL
    Q9UQS6
    Related
    ENSP00000346839, OTTHUMP00000164053, ENST00000354785, OTTHUMT00000256667
    Conserved Domains (4) summary
    cd00061
    Location:559602
    Blast Score: 160
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:354401
    Blast Score: 230
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00063
    Location:19952075
    Blast Score: 195
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:22112269
    Blast Score: 106
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000002.12

    Range
    215360454..215436167, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246417.1XP_005246474.1  

    UniProtKB/Swiss-Prot
    P02751
    Related
    ENSP00000394423, OTTHUMP00000206760, ENST00000421182, OTTHUMT00000337226
    Conserved Domains (4) summary
    cd00061
    Location:559602
    Blast Score: 158
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:354401
    Blast Score: 227
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00063
    Location:18141894
    Blast Score: 195
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:19602032
    Blast Score: 112
    fn3; Fibronectin type III domain
  2. XM_005246412.1XP_005246469.1  

    Conserved Domains (4) summary
    cd00061
    Location:559602
    Blast Score: 158
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:354401
    Blast Score: 228
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00063
    Location:18141894
    Blast Score: 195
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:20052063
    Blast Score: 107
    fn3; Fibronectin type III domain
  3. XM_005246415.1XP_005246472.1  

    UniProtKB/Swiss-Prot
    P02751
    Related
    ENSP00000415018, OTTHUMP00000206763, ENST00000443816, OTTHUMT00000337230
    Conserved Domains (4) summary
    cd00061
    Location:559602
    Blast Score: 158
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:354401
    Blast Score: 228
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00063
    Location:18141894
    Blast Score: 195
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:19852057
    Blast Score: 112
    fn3; Fibronectin type III domain
  4. XM_005246414.1XP_005246471.1  

    Related
    ENSP00000265312, ENST00000346544
    Conserved Domains (3) summary
    cd00061
    Location:559602
    Blast Score: 158
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:354401
    Blast Score: 228
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00063
    Location:19041984
    Blast Score: 196
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  5. XM_005246409.1XP_005246466.1  

    Conserved Domains (4) summary
    cd00061
    Location:559602
    Blast Score: 159
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:354401
    Blast Score: 229
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00063
    Location:19041984
    Blast Score: 196
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:20952153
    Blast Score: 107
    fn3; Fibronectin type III domain
  6. XM_005246406.1XP_005246463.1  

    See proteins identical to XP_005246463.1

    UniProtKB/Swiss-Prot
    P02751
    Related
    ENSP00000352696, ENST00000359671
    Conserved Domains (4) summary
    cd00061
    Location:559602
    Blast Score: 159
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:354401
    Blast Score: 229
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00063
    Location:19041984
    Blast Score: 196
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:21202178
    Blast Score: 107
    fn3; Fibronectin type III domain
  7. XM_005246413.1XP_005246470.1  

    UniProtKB/Swiss-Prot
    P02751
    Related
    ENSP00000399538, OTTHUMP00000206765, ENST00000432072, OTTHUMT00000337233
    Conserved Domains (4) summary
    cd00061
    Location:559602
    Blast Score: 159
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:354401
    Blast Score: 228
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00063
    Location:19051985
    Blast Score: 195
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:20012059
    Blast Score: 106
    fn3; Fibronectin type III domain
  8. XM_005246405.1XP_005246462.1  

    Conserved Domains (4) summary
    cd00061
    Location:559602
    Blast Score: 159
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:354401
    Blast Score: 229
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00063
    Location:19051985
    Blast Score: 195
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:21212179
    Blast Score: 106
    fn3; Fibronectin type III domain
  9. XM_005246402.1XP_005246459.1  

    Conserved Domains (4) summary
    cd00061
    Location:559602
    Blast Score: 159
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:354401
    Blast Score: 229
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00063
    Location:19952075
    Blast Score: 195
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:21412213
    Blast Score: 112
    fn3; Fibronectin type III domain
  10. XM_005246400.1XP_005246457.1  

    UniProtKB/Swiss-Prot
    P02751
    Related
    ENSP00000323534, OTTHUMP00000164054, ENST00000323926, OTTHUMT00000256668
    Conserved Domains (4) summary
    cd00061
    Location:559602
    Blast Score: 160
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:354401
    Blast Score: 230
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00063
    Location:19952075
    Blast Score: 195
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:21662238
    Blast Score: 112
    fn3; Fibronectin type III domain
  11. XM_005246416.1XP_005246473.1  

    Conserved Domains (3) summary
    cd00061
    Location:559602
    Blast Score: 158
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:354401
    Blast Score: 228
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00063
    Location:18141894
    Blast Score: 196
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  12. XM_005246404.1XP_005246461.1  

    Conserved Domains (4) summary
    cd00061
    Location:559602
    Blast Score: 160
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:354401
    Blast Score: 230
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00063
    Location:19041984
    Blast Score: 196
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:21202178
    Blast Score: 107
    fn3; Fibronectin type III domain
  13. XM_005246411.1XP_005246468.1  

    Conserved Domains (4) summary
    cd00061
    Location:559602
    Blast Score: 159
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:354401
    Blast Score: 229
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00063
    Location:19051985
    Blast Score: 195
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:20012059
    Blast Score: 106
    fn3; Fibronectin type III domain
  14. XM_005246410.1XP_005246467.1  

    Conserved Domains (4) summary
    cd00061
    Location:559602
    Blast Score: 159
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:354401
    Blast Score: 229
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00063
    Location:19051985
    Blast Score: 195
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:20512123
    Blast Score: 111
    fn3; Fibronectin type III domain
  15. XM_005246408.1XP_005246465.1  

    Conserved Domains (4) summary
    cd00061
    Location:559602
    Blast Score: 160
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:354401
    Blast Score: 229
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00063
    Location:19051985
    Blast Score: 195
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:20762148
    Blast Score: 111
    fn3; Fibronectin type III domain
  16. XM_005246403.1XP_005246460.1  

    Conserved Domains (4) summary
    cd00061
    Location:559602
    Blast Score: 160
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:354401
    Blast Score: 229
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00063
    Location:19051985
    Blast Score: 195
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:21212179
    Blast Score: 107
    fn3; Fibronectin type III domain
  17. XM_005246407.1XP_005246464.1  

    Conserved Domains (4) summary
    cd00061
    Location:559602
    Blast Score: 160
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:354401
    Blast Score: 229
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00063
    Location:19952075
    Blast Score: 195
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:20912149
    Blast Score: 107
    fn3; Fibronectin type III domain
  18. XM_005246401.1XP_005246458.1  

    Conserved Domains (4) summary
    cd00061
    Location:559602
    Blast Score: 160
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:354401
    Blast Score: 230
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00063
    Location:19952075
    Blast Score: 195
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:21412213
    Blast Score: 112
    fn3; Fibronectin type III domain
  19. XM_005246398.1XP_005246455.1  

    Conserved Domains (4) summary
    cd00061
    Location:559602
    Blast Score: 160
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:354401
    Blast Score: 230
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00063
    Location:19952075
    Blast Score: 196
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:21862244
    Blast Score: 107
    fn3; Fibronectin type III domain
  20. XM_005246399.1XP_005246456.1  

    Conserved Domains (4) summary
    cd00061
    Location:559602
    Blast Score: 160
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:354401
    Blast Score: 230
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00063
    Location:19952075
    Blast Score: 195
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:21662238
    Blast Score: 112
    fn3; Fibronectin type III domain
  21. XM_005246397.1XP_005246454.1  

    Conserved Domains (4) summary
    cd00061
    Location:559602
    Blast Score: 160
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:354401
    Blast Score: 230
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00063
    Location:19952075
    Blast Score: 196
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:22112269
    Blast Score: 107
    fn3; Fibronectin type III domain

Alternate HuRef

Genomic

  1. AC_000134.1 Alternate HuRef

    Range
    208082209..208158070, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    216231077..216306650, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_212475.1: Suppressed sequence

    Description
    NM_212475.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

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