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    HLA-A major histocompatibility complex, class I, A [ Homo sapiens (human) ]

    Gene ID: 3105, updated on 11-May-2013
    Official Symbol
    HLA-Aprovided by HGNC
    Official Full Name
    major histocompatibility complex, class I, Aprovided by HGNC
    Primary source
    HGNC:4931
    Locus tag
    DAQB-90C11.16-002
    See related
    Ensembl:ENSG00000206503; HPRD:00826; MIM:142800; Vega:OTTHUMG00000130501
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HLAA
    Summary
    HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]
    Location :
    6p21.3
    Sequence :
    Chromosome: 6; NC_000006.11 (29910247..29913661)
    See HLA-A in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene major histocompatibility complex, class I, U (pseudogene) Neighboring gene HLA complex group 4 pseudogene 5 Neighboring gene HLA complex group 4 pseudogene 4 Neighboring gene major histocompatibility complex, class I, W (pseudogene)

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Diagnostic utility of HFE variants in Spanish patients: association with HLA alleles and role in susceptibility to acute lymphoblastic leukemia. Rodríguez-López R, et al. Gene, 2013 Feb 1. PMID 23178241.
    2. T cells engineered with a T cell receptor against the prostate antigen TARP specifically kill HLA-A2+ prostate and breast cancer cells. Hillerdal V, et al. Proc Natl Acad Sci U S A, 2012 Sep 25. PMID 23019373.
    3. Molecular architecture of the MHC I peptide-loading complex: one tapasin molecule is essential and sufficient for antigen processing. Hulpke S, et al. FASEB J, 2012 Dec. PMID 22923333.
    4. HLA-A*0206 with TLR3 polymorphisms exerts more than additive effects in Stevens-Johnson syndrome with severe ocular surface complications. Ueta M, et al. PLoS One, 2012. PMID 22912896.
    5. Alternative peptide repertoire of HLA-E reveals a binding motif that is strikingly similar to HLA-A2. Lampen MH, et al. Mol Immunol, 2013 Jan. PMID 22898188.

    See all (1211) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data indicate that the peptide-loading complex (PLC) consists maximally of 2x tapasin-ERp57/MHC I per TAP complex, but one tapasin-ERp57/MHC I in the PLC is essential and sufficient for antigen processing.
      Title: Molecular architecture of the MHC I peptide-loading complex: one tapasin molecule is essential and sufficient for antigen processing.
    2. Results show evidence that HLA class I alleles might be important risk factors for dengue hemorrhagic fever in Brazilian patients.
      Title: HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil's population.
    3. MICA+ patients were more frequently human leukocyte antigen (HLA) sensitized and regrafted in kidney transplants.
      Title: Posttransplant major histocompatibility complex class I chain-related gene A antibodies and long-term graft outcomes in a multicenter cohort of 779 kidney transplant recipients.
    4. The HLA-A1 and HLA-A2 antigens and not specific single nucleotide variants shared by multiple alleles are responsible for the association with Epstein-Barr Virus.
      Title: HLA associations in classical Hodgkin lymphoma: EBV status matters.
    5. findings suggest that A*31:01 might be a multidrug hypersensitivity risk marker
      Title: HLA-A*31:01 and methotrexate-induced interstitial lung disease in Japanese rheumatoid arthritis patients: a multidrug hypersensitivity marker?
    6. Data suggest that multiplicative interactions of HLA-A and TLR3 gene might be required for the onset of Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with ocular complications.
      Title: HLA-A*0206 with TLR3 polymorphisms exerts more than additive effects in Stevens-Johnson syndrome with severe ocular surface complications.
    7. Risk of developing chronic lymphocytic leukemia is influenced by HLA-A class I variation.
      Title: Risk of developing chronic lymphocytic leukemia is influenced by HLA-A class I variation.
    8. The frequencies of the HFE SNPs in ALL pediatric patients were lower than those found in controls, whereas the HLA-A*24 allele was significantly overrepresented in the patients group. No HFE-HLA-A associations were found to modulate the ALL risk.
      Title: Diagnostic utility of HFE variants in Spanish patients: association with HLA alleles and role in susceptibility to acute lymphoblastic leukemia.
    9. Peptide containing QWNFAGIEAA is a potent Mycobacterium tuberculosis-specific cytotoxic T lymphocytes epitope in HLA-A24 allele.
      Title: Weak binder for MHC molecule is a potent Mycobacterium tuberculosis-specific CTL epitope in the context of HLA-A24 allele.
    10. when the HLA-B KIR-ligand motif is lacking, the HLA-A KIR-ligand might have a vicarious role in controlling the natural killer cell-mediated innate immune response
      Title: Possible KIR-driven genetic pressure on the genesis and maintenance of specific HLA-A,B haplotypes as functional genetic blocks.
    Submit: New GeneRIF Correction See all (319)

    Review eQTL and phenotype association data in this region using PheGenI

    NHGRI GWAS Catalog

    show more
    Protein Gene Interaction Pubs
    Env, gp160, envelope glycoprotein env HIV-1 gp160-derived peptide p18 presented by H-2Dd class I major histocompatibility complex molecules is processed by angiotensin-1 converting enzyme (ACE) prior to T cell stimulation by the peptide p18 PubMed
    env Epitope Env37-46 from HIV-1 gp160 binds strongly to HLA-A3 molecules and forms very stable complexes PubMed
    Envelope surface glycoprotein gp120 env Conformational changes in HIV-1 gp120, including an enhanced expression of the V3 loop of gp120 and of epitopes that are exposed upon CD4 binding, are consistent with the formation of a multimolecular complex between HLA class I and gp120/160 PubMed
    env Treatment of CD4+ T cells with HIV-1 gp120 significantly increases CD4 association with CD3, CD45RA, CD45RB, CD59, CD38, CD26 and HLA class I, and decreases that with CD45RC PubMed
    Envelope transmembrane glycoprotein gp41 env Soluble HIV-1 gp41 enhancement effects on MHC class I and II antigen expression can be inhibited by soluble gp41-binding proteins of 45, 49 and 62 kD from human B cells PubMed
    env Soluble HIV-1 gp41 can selectively enhance MHC class I and II expression on human B cells, but does not increase expression of other cell surface antigens such as CD21 and CD54 (ICAM-1) PubMed
    env HIV-1 gp41 selectively enhances MHC class I, ICAM-1, IFN-alpha, IFN-beta, and IFN-omega expression in H9 cells PubMed
    Gag, Pr55 gag HIV-1 Gag virus-like particles efficiently activate human monocyte-derived dendritic cells (MDDC) and induce MDDC maturation with an associated increase in the surface expression of CD80, CD86 and MHC classes I and II PubMed
    gag The PTAP L-domains in the p6 domain of HIV-1 Gag regulates ubiquitination of Gag which controls MHC-I presentation and gag processing in the DRiP pathway. PubMed
    gag The degree of HIV-1 Nef-mediated HLA-A2 downregulation strongly influences recognition of virus-infected cells by the Gag-specific CD8+ cytotoxic T lymphocyte clone PubMed
    gag Protective HLA alleles have a true preference for HIV-1 Gag protein, while non-protective HLA alleles preferentially target HIV-1 Nef PubMed
    gag Targeting HIV-1 Gag into the defective ribosomal product pathway enhances MHC class I antigen presentation and CD8+ T cell activation PubMed
    gag The HIV-1 Gag 20-28 epitope binds strongly to HLA-A3 molecules and forms very stable complexes PubMed
    Nef, p27 nef Dominant active ARF1 (Q71L) potently stabilizes interactions among AP-1 mu1, HIV-1 Nef, and HLA-A2 and that the formation of a static complex sequesters necessary trafficking components PubMed
    nef -COP as a cellular cofactor is required for HIV-1 Nef-mediated HLA-A2, CD4, and CD8 downregulation PubMed
    nef The HIV-1 Nef highly conserved valine-glycine-phenylalanine amino acid triplet (VGF) motif, which links the acidic cluster and the proline-rich motif, is important for downregulation of CXCR4 and MHC-I PubMed
    nef HLA-A2 molecules with HLA-A cytoplasmic domains are more downregulated by HIV-1 Nef than those with HLA-B domains. There is no downregulation of HLA-A2 with HLA-C cytoplasmic domains by Nef PubMed
    nef Asp327 and Tyr320 of MHC-I, Asp123 of Nef, and Arg225, Arg393, Lys396, Arg211, and Arg246 of mu 1 are involved in a crucial three-way electrostatic network, which results in the Nef-MHC-I CD-mu 1 complex formation PubMed
    nef HIV-1 Nef with A84D, Y135F, and G140R mutation impairs to its ability to downregulate MHC-I PubMed
    nef Double (W13A/V16R) and triple (W13A/V16R/M20A) substitution mutants of HIV-1 Nef fail to downregulate MHC-I PubMed
    nef HIV-1 Nef-mediated downregulation of MHC-I requires Nef motif EEEE(65)-dependent binding to the sorting protein PACS-2, which targets Nef to the paranuclear region and enables Nef PXXP(75) to bind and activate a trans-Golgi network localized Src kinase PubMed
    nef Knocking down either AP-1 gamma, AP-1 mu1, or clathrin strongly inhibits Nef-induced downregulation of HLA-A2 PubMed
    nef HIV-1 Nef acidic (Glu62-65) and polyproline domains (Pro75/78) stabilize the interaction between the HLA-A2/Nef fusion protein and AP-1 mu1 PubMed
    nef Mutating three amino acids (Y320, A324, and D327) in the cytoplasmic tail of HLA-A2 abrogates Nef-induced downregulation of HLA-A2 through a failuer to recruit the mu1 or gamma subunits of AP-1 PubMed
    nef Knocking down AP-2 enhances Nef activity by causing increased delivery of HLA-A2 to a prelysosomal compartment PubMed
    nef Protective HLA alleles have a true preference for HIV-1 Gag protein, while non-protective HLA alleles preferentially target HIV-1 Nef PubMed
    nef In promonocytic cells, Nef/Hck recruits the ZAP-70 homolog Syk to downregulate MHC-I PubMed
    nef Nef/Hck complex recruits and phosphorylates the tyrosine kinase ZAP-70, which binds class I PI3K to trigger MHC-I downregulation in primary CD4+ T cells PubMed
    nef MHC-I is found in the Rab7(+) vesicles and targeted for degradation via the activity of the Nef-interacting protein, beta-COP PubMed
    nef HIV-1 Nef sequesters HLA-I A2 and colocalizes with CD63 and LAMP1 markers in late endosomes and lysosomes PubMed
    nef ARF6(T27N/Q67L) and RAB11(Q67L) mutants induce significant reversal of HLA-I A2 downregulation by HIV-1 Nef through redistributing HLA-I A2 from the perinuclear vesicles to the peripheral punctate vesicles at the plasma membrane PubMed
    nef Expression of HIV-1 Nef in human T cells inhibits HLA-A2 transport to the cell surface PubMed
    nef HIV-1 selectively downregulates HLA-A and HLA-B but does not significantly affect HLA-C or HLA-E, which allows HIV-infected cells to avoid NK cell-mediated lysis; this effect is likely mediated by the HIV-1 Nef protein PubMed
    nef HIV-1 Nef-induced downregulation of MHC-I expression and MHC-I targeting to the trans-Golgi network (TGN) require the binding of Nef to PACS-1, a molecule that controls the TGN localization of the cellular protein furin PubMed
    nef HIV-1 Nef downregulates expression of MHC-I by blocking transport of MHC-I molecules to the cell surface through a mechanism that requires phosphoinositide 3-kinase (PI 3-kinase) activity PubMed
    nef Interaction of HIV-1 Nef with the mu subunit of AP adaptor complexes requires the recognition of tyrosine-based sorting signals, which likely facilitates the connection between MHC I and the clathrin-dependent sorting machinery during MHC I downregulation PubMed
    nef A methionine residue at amino acid 20 in the alpha-helix domain of HIV-1 Nef is required for the ability of Nef to downregulate MHC-I expression but not for the downregulation of CD4 PubMed
    nef Four glutamic acids from position 62 to 65 in the SH3 domain of HIV-1 Nef bind to the cytoplasmic tail at position 320Y of MHC-I, and are required for the Nef-mediated downregulation of MHC-I from the cell surface PubMed
    nef HIV-1 Nef downregulates the expression of MHC-I at the surface of lymphoid, monocytic and epithelial cells, causing MHC-I molecules to be rapidly internalized, accumulated in endosomal vesicles and degraded PubMed
    nef Two distinct regions of HIV-1 Nef modulate MHC-I cell surface expression: an N-terminal alpha-helix (residues 17-26) and a proline-rich motif (residues 75-78) PubMed
    nef The ability of HIV-1 Nef to disrupt MHC-I trafficking and inhibit antigen presentation is regulated by the expression of the mu1 subunit of adaptor protein (AP) AP-1A, a cellular protein complex implicated in TGN to endolysosomal pathways PubMed
    nef The HIV-1 Nef 73-82 epitope binds strongly to HLA-A3 molecules and forms very stable complexes PubMed
    nef The N-terminal alpha helix (17-26), polyproline (72-78), acidic (62-65), and oligomerization (123) domains of HIV-1 Nef are required for Nef-mediated disruption of the transport of HLA-A2 to the cell surface and for Nef to coprecipitate with HLA-A2 PubMed
    nef Mutation of amino acid P78 in HIV-1 Nef affects downregulation of MHC-I molecules from the cell surface, but does not interfere with Nef binding to Src homology 3 (SH3) domains PubMed
    nef HIV-1 Nef induces drastic and moderate downregulation of CD4 and MHC-I in resting CD4(+) T lymphocytes, respectively, but markedly upregulates cell surface levels of the MHC-II invariant chain CD74 PubMed
    nef HIV-1 Nef has been observed to downregulate HLA-A2 on immature dendritic cells from two donors PubMed
    nef HIV-1 Nef-mediated downregulation of HLA class I suppresses the cytolytic activity of HIV-1-specific cytotoxic T-lymphocyte (CTL) clones PubMed
    nef Macrophage-tropic HIV-1 Nef downregulates expression of HLA-A2 on the surface of productively infected macrophages; point mutations in Nef at prolines P74 or P80 abrogate the downregulation of HLA-A2 PubMed
    nef Different levels of MHC-I modulation are induced by different HIV-1 Nef proteins derived from HIV-1 infected adults and children PubMed
    nef HIV-1 Nef downregulates MHC-I in Jurkat cells in a concentration-dependent manner PubMed
    nef HIV-1 Nef downregulates human MHC-I more efficiently than murine MHC-I molecules in HeLa cells, and Nef does not function efficiently in murine endothelial cells PubMed
    nef HIV-1 Nef alleles derived from perinatally infected children efficiently downregulate both CD4 and MHC-I in HeLa-CD4+ cells PubMed
    nef HIV-1 group N and group O Nef alleles only weakly downregulate CD4, CD28, and class I and II MHC molecules PubMed
    nef HIV-1 Nef disrupts antigen presentation by binding to MHC-I (HLA-A2) hypophosphorylated cytoplasmic tails in the endoplasmic reticulum; this Nef-MHC-I complex migrates normally into the Golgi apparatus but subsequently fails to arrive at the cell surface PubMed
    nef PxxP motifs in HIV-1 Nef induce the accumulation of CCR5 in a perinuclear compartment where both molecules co-localize with MHC-1 PubMed
    nef The HIV-1 Nef mutant NefAAAA, which cannot interact with the endosomal sorting protein PACS-1, increases the number of cells containing long and stable tubules, which allows the internalization of MHC-1 into the tubules from the cell surface PubMed
    nef Downregulation of MHC-I by HIV-1 Nef decreases the incorporation of MHC-I molecules into virions, but does not decrease virion infectivity PubMed
    nef Downregulation of major histocompatibility class I on human dendritic cells by HIV-1 Nef impairs antigen presentation to HIV-specific CD8+ T lymphocytes PubMed
    nef A dominant-negative mutant protein derived from Hck, (composed of the N-terminal region, SH2, and SH3 domains) interacts with HIV-1 Nef and inhibits Nef-induced downregulation of MHC class I PubMed
    nef Deletion of the 19 N-terminal amino acids including the myristoylation signal from HIV-1 Nef inhibits both MHC-I and CD4 downregulation while preserving most CTL, T-helper and B-cell epitopes PubMed
    Tat, p14 tat Four mutations (C27S, K51T, R55L, and G79A) on HIV-1 Tat result in the loss of the deleterious effects of Tat on the expression of MHC I, IL-2, and CD25 genes compared with wild-type Tat in Jurkat cells PubMed
    tat HIV-1 Tat upregulates MHC class I in monocyte-derived dendritic cells and CD8(+) T cells, thereby driving T cell-mediated immune responses PubMed
    tat HIV-1 Tat represses the MHC class I gene promoter by binding to and repressing TAFII250, a component of the general transcription factor TFIID, suggesting a mechanism for HIV-1 to downregulate MHC class I expression and avoid immune surveillance PubMed
    Vpu, p16 vpu HLA class I-associated immune responses have minor effects on Vpu variability, suggesting that Vpu conformation and function are preserved through many possible combinations of primary and secondary polymorphisms PubMed
    vpu Using antibodies specific to MHC class I A, B, and C molecules (clone W6/32), HIV-1 Vpu protein has been shown to downregulate the expression of MHC class I molecules on the surface of HIV-1 infected cells PubMed
    pol gag-pol The HIV-1 Pol 325-333 epitope binds strongly to HLA-A3 molecules and forms very stable complexes PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    NP_002107.3 NP_057857.2 nef    BIND  PubMed HLA-A interacts with Nef. 
    P01891 Q06481 APLP2    HPRD  PubMed  
    P01891 P61769 B2M    HPRD  PubMed  
    P01891 P51572 BCAP31    HPRD  PubMed  
    P01891 P27824 CANX    HPRD  PubMed  
    P01891 P01732 CD8A    HPRD  PubMed  
    P01891 P35659 DEK    HPRD  PubMed  
    P01891 Q9BUN8 DERL1    HPRD  PubMed  
    P01891 P04626 ERBB2    HPRD  PubMed  
    P01891 P01891 HLA-A    HPRD  PubMed  
    P01891 P43630 KIR3DL2    HPRD  PubMed  
    P01891 Q8NHL6 LILRB1    HPRD  PubMed  
    P01891 Q8N423 LILRB2    HPRD  PubMed  
    P01891 P43355 MAGEA1    HPRD  PubMed  
    P01891 P43358 MAGEA4    HPRD  PubMed  
    P01891 P30101 PDIA3    HPRD  PubMed  
    P01891 P10644 PRKAR1A    HPRD  PubMed  
    P01891 P17252 PRKCA    HPRD  PubMed  
    P01891 P12931 SRC    HPRD  PubMed  
    P01891 O15533 TAPBP    HPRD  PubMed  
    P01891 Ubiquitin B UBB    HPRD  PubMed  
    P01891 T cell antigen receptor, alpha     HPRD  PubMed  
    P01891 T cell antigen receptor, beta     HPRD  PubMed  
    P01892 NP_004334.1 CALR    BIND  PubMed CRT interacts with HLA-A2. This interaction was modeled on a demonstrated interaction between rabbit CRT and human HLA-A2. 
    BioGRID:109350 BioGRID:107044 B2M    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109350 BioGRID:115437 BCAP31    BioGRID  PubMed Affinity Capture-Western; FRET 
    BioGRID:109350 BioGRID:107262 CALR    BioGRID  PubMed Protein-peptide 
    BioGRID:109350 BioGRID:107363 CD8A    BioGRID  PubMed Co-crystal Structure; Reconstituted Complex 
    BioGRID:109350 BioGRID:107710 COPB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109350 BioGRID:116496 COPG1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109350 BioGRID:122559 DERL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109350 BioGRID:110013 KIR3DL2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109350 BioGRID:116070 LILRB1    BioGRID  PubMed Co-crystal Structure 
    BioGRID:109350 BioGRID:110185 LMAN1    BioGRID  PubMed Co-localization 
    BioGRID:109350 BioGRID:110274 MAGEA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109350 BioGRID:110277 MAGEA4    BioGRID  PubMed Co-crystal Structure; Protein-peptide 
    BioGRID:109350 BioGRID:122103 MMS19    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109350 BioGRID:111681 PSMD2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109350 BioGRID:118968 SEC61A1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109350 BioGRID:112651 STAT3    BioGRID  PubMed Two-hybrid 
    BioGRID:109350 BioGRID:124085 SYVN1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109350 BioGRID:112753 TAP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109350 BioGRID:112754 TAP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109350 BioGRID:112755 TAPBP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109350 BioGRID:112815 TRA    BioGRID  PubMed Co-crystal Structure 
    BioGRID:109350 BioGRID:117032 TRAM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109350 BioGRID:112817 TRB    BioGRID  PubMed Co-crystal Structure 
    BioGRID:109350 BioGRID:246933 Tap1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109350 BioGRID:246934 Tap2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109350 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109350 BioGRID:119555 UBE2J1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109350 BioGRID:121217 UGGT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109350 BioGRID:1205544 env    BioGRID  PubMed Affinity Capture-MS 
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      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Host Interactions of HIV factors, organism-specific biosystem (from REACTOME)
      Host Interactions of HIV factors, organism-specific biosystemLike all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewis...
    • IL12-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL12-mediated signaling events, organism-specific biosystem
      IL12-mediated signaling events
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Interferon alpha/beta signaling, organism-specific biosystem (from REACTOME)
      Interferon alpha/beta signaling, organism-specific biosystemType I interferons (IFNs) are composed of various genes including IFN alpha (IFNA), beta (IFNB), omega, epsilon, and kappa. In humans the IFNA genes are composed of more than 13 subfamily genes, wher...
    • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
      Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
    • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Nef mediated downregulation of MHC class I complex cell surface expression, organism-specific biosystem (from REACTOME)
      Nef mediated downregulation of MHC class I complex cell surface expression, organism-specific biosystemDown-regulation of MHC class I involves Nef-mediated connection in the endosomes between MHC-I's cytoplasmic tail and the phosphofurin acidic cluster sorting protein-1 (PACS-1)-dependent protein-sort...
    • Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters, organism-specific biosystem (from REACTOME)
      Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters, organism-specific biosystemThe maximal virulence of HIV-1 requires Nef, a virally encoded peripheral membrane protein. Nef binds to the adaptor protein (AP) complexes of coated vesicles, inducing an expansion of the endosomal ...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Proteasome Degradation, organism-specific biosystem (from WikiPathways)
      Proteasome Degradation, organism-specific biosystem
      Proteasome Degradation
    • TCR signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD8+ T cells, organism-specific biosystem
      TCR signaling in naive CD8+ T cells
    • The role of Nef in HIV-1 replication and disease pathogenesis, organism-specific biosystem (from REACTOME)
      The role of Nef in HIV-1 replication and disease pathogenesis, organism-specific biosystemThe HIV-1 Nef protein is a 27-kDa myristoylated protein that is abundantly produced during the early phase of viral replication cycle. It is highly conserved in all primate lentiviruses, suggesting t...
    • Type I diabetes mellitus, organism-specific biosystem (from KEGG)
      Type I diabetes mellitus, organism-specific biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
    • Type I diabetes mellitus, conserved biosystem (from KEGG)
      Type I diabetes mellitus, conserved biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
    • Viral carcinogenesis, organism-specific biosystem (from KEGG)
      Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral carcinogenesis, conserved biosystem (from KEGG)
      Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral myocarditis, organism-specific biosystem (from KEGG)
      Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...

    Markers

    Genotypes

    Homology

    Clone Names

    • FLJ26655

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    antigen processing and presentation of exogenous peptide antigen via MHC class I TAS
    Traceable Author Statement
    more info
    		  
    antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
    Traceable Author Statement
    more info
    		  
    antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent TAS
    Traceable Author Statement
    more info
    		  
    antigen processing and presentation of peptide antigen via MHC class I IEA
    Inferred from Electronic Annotation
    more info
    		  
    antigen processing and presentation of peptide antigen via MHC class I TAS
    Traceable Author Statement
    more info
    		  
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    detection of bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		  
    immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    immune response IMP
    Inferred from Mutant Phenotype
    more info
    		  
    immune response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    interferon-gamma-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    regulation of defense response to virus by virus TAS
    Traceable Author Statement
    more info
    		  
    regulation of immune response TAS
    Traceable Author Statement
    more info
    		  
    type I interferon-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    viral reproduction TAS
    Traceable Author Statement
    more info
    		  
    virus-host interaction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    ER to Golgi transport vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    MHC class I protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    early endosome membrane TAS
    Traceable Author Statement
    more info
    		  
    integral to lumenal side of endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    phagocytic vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    Preferred Names
    HLA class I histocompatibility antigen, A-1 alpha chain
    Names
    HLA class I histocompatibility antigen, A-1 alpha chain
    antigen presenting molecule
    leukocyte antigen class I-A
    MHC class I antigen HLA-A heavy chain

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029217.2 RefSeqGene

      Range
      5005..8420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001242758.1 → NP_001229687.1  HLA class I histocompatibility antigen, A-1 alpha chain precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the A*01:01:01:01 allele of the HLA-A gene, as represented in the alternate locus group ALT_REF_LOCI_2 of the reference genome and in the RefSeqGene NG_029217.
      Source sequence(s)
      AL645935, BC003069
      Consensus CDS
      CCDS34373.1
      UniProtKB/Swiss-Prot
      P30443
      UniProtKB/TrEMBL
      Q5SUL5
      Related
      ENSP00000366005, ENST00000376809
      Conserved Domains (2) summary
      cd07698
      Location:207 – 299
      Blast Score: 359
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:26 – 203
      Blast Score: 874
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    2. NM_002116.7 → NP_002107.3  HLA class I histocompatibility antigen, A-1 alpha chain precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the A*03:01:0:01 allele of the HLA-A gene, as represented in the assembled chromosome 6 in the primary assembly of the reference genome.
      Source sequence(s)
      AK313119, AL671277, BE875389, U32184
      Consensus CDS
      CCDS34373.1
      UniProtKB/TrEMBL
      B1PKY1
      UniProtKB/TrEMBL
      B2R7U3
      UniProtKB/Swiss-Prot
      P04439
      Conserved Domains (2) summary
      cd07698
      Location:207 – 299
      Blast Score: 358
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:26 – 203
      Blast Score: 902
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 ALT_REF_LOCI_1

    Genomic

    1. NT_167244.1 Reference GRCh37.p10 ALT_REF_LOCI_1

      Range
      1150133..1153548
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.2 Reference GRCh37.p10 ALT_REF_LOCI_2

      Range
      1421998..1425413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.1 Reference GRCh37.p10 ALT_REF_LOCI_3

      Range
      1150461..1207037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.1 Reference GRCh37.p10 ALT_REF_LOCI_4

      Range
      1149740..1206062
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.1

      Range
      1292227..1295564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003960039.1 → XP_003960088.1  

    2. XM_003960037.1 → XP_003960086.1  

    3. XM_003960036.1 → XP_003960085.1  

    4. XM_003960038.1 → XP_003960087.1  

    5. XM_003960035.1 → XP_003960084.1  

    6. XM_003960040.1 → XP_003960089.1  

    7. XM_003960041.1 → XP_003960090.1  

    8. XM_003960045.1 → XP_003960094.1  

    9. XM_003960043.1 → XP_003960092.1  

    10. XM_003960042.1 → XP_003960091.1  

    11. XM_003960044.1 → XP_003960093.1  

    Reference GRCh37.p10 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.1 Reference GRCh37.p10 ALT_REF_LOCI_6

      Range
      1203025..1206454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.1 Reference GRCh37.p10 ALT_REF_LOCI_7

      Range
      1186802..1243012
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 PATCHES

    Genomic

    1. NW_003871063.1 Reference GRCh37.p10 PATCHES

      Range
      176394..179809
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p10 Primary Assembly

      Range
      29910247..29913661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      29655296..29712161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018917.1 Alternate CHM1_1.0

      Range
      29824500..29827912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic AB005048.1 BAA20881.1
    genomic AB023056.1 (61429..64370) None
    genomic AB032594.1 BAA84642.2
    genomic AB032595.1 BAA84643.2
    genomic AB032596.1 BAA84644.1
    genomic AB048347.1 BAB13367.1
    genomic AB073217.2 BAB71760.1
    genomic AB086838.2 BAC01135.1
    genomic AB087372.2 BAC02897.1
    genomic AB087509.2 BAC02737.1
    genomic AB088084.1 BAC54917.1
    genomic AB121736.2 BAD00981.2
    genomic AB167823.2 BAD12776.1
    genomic AB169980.2 BAD12841.1
    genomic AB176448.2 BAD15076.1
    genomic AB179716.2 BAD19045.1
    genomic AB179758.2 BAD20194.1
    genomic AB179827.2 BAD20210.1
    genomic AB179865.2 BAD20285.1
    genomic AB180086.2 BAD20462.1
    genomic AB180089.2 BAD20463.1
    genomic AB180660.2 BAD20748.1
    genomic AB182247.2 BAD23959.1
    genomic AB182588.2 BAD24849.2
    genomic AB183420.1 BAD27480.1
    genomic AB183518.1 BAD29714.1
    genomic AB185092.1 BAD30023.1
    genomic AB185093.1 BAD30024.1
    genomic AB187124.1 BAD36737.1
    genomic AB187509.1 BAD36754.1
    genomic AB196347.1 BAD77818.1
    genomic AB196429.1 BAD77941.1
    genomic AB196452.1 BAD77942.1
    genomic AB196453.1 BAD77943.1
    genomic AB202079.1 BAE78598.1
    genomic AB211246.1 BAD95617.1
    genomic AB211247.1 BAD95618.1
    genomic AB213259.1 BAD98466.1
    genomic AB213261.1 BAD98468.1
    genomic AB213377.1 BAD98499.1
    genomic AB213607.1 BAE48521.1
    genomic AB213609.1 BAE48522.1
    genomic AB218626.1 BAD99518.1
    genomic AB234290.1 BAE48523.1
    genomic AB234291.1 BAE48524.1
    genomic AB247457.1 BAE78472.1
    genomic AB247458.1 BAE78473.1
    genomic AB247459.1 BAE78474.1
    genomic AB249885.1 BAE79443.1
    genomic AB253623.1 BAE87033.1
    genomic AB255356.1 BAE93145.1
    genomic AB261694.1 BAE95333.1
    genomic AB292218.1 BAF46251.1
    genomic AB427093.1 BAG12800.1
    genomic AB429497.1 BAG15909.1
    genomic AB477101.1 BAH11159.1
    genomic ABBA01038038.1 (28168..39894) None
    genomic ABBA01038039.1 None
    genomic ABBA01038040.1 None
    genomic AF017309.1 AAB70275.1
    genomic AF017310.1 AAB70276.1
    genomic AF017311.1 AAB70277.2
    genomic AF017312.1 AAB70278.2
    genomic AF017313.1 AAB70279.2
    genomic AF030927.1 AAB87059.1
    genomic AF030928.1 AAB87059.1
    genomic AF039016.1 AAB92589.1
    genomic AF039017.1 AAB92589.1
    genomic AF055066.1 AAC24825.1
    genomic AF100667.1 AAC72736.1
    genomic AF106692.1 AAD19593.1
    genomic AF139767.1 AAD33859.1
    genomic AF144013.1 AAF74211.1
    genomic AF145773.1 AAD38680.1
    genomic AF145775.1 AAD38681.1
    genomic AF145777.1 AAD38682.1
    genomic AF145955.1 AAD38679.1
    genomic AF148862.1 AAD39980.1
    genomic AF255333.1 AAF70298.1
    genomic AF284443.1 AAK82978.1
    genomic AF287960.1 AAG27627.1
    genomic AF384666.1 AAK66558.1
    genomic AF439511.1 AAL32021.1
    genomic AF480841.1 AAL84893.1
    genomic AJ006020.1 CAA06807.1
    genomic AJ011125.1 None
    genomic AJ012384.1 CAB57318.1
    genomic AJ012472.1 CAA10037.1
    genomic AJ223972.3 CAA11708.1
    genomic AJ238151.1 CAB42000.1
    genomic AJ238362.1 CAB41636.1
    genomic AJ238412.1 CAB42826.1
    genomic AJ238523.1 CAB41999.1
    genomic AJ238524.1 CAB41888.1
    genomic AJ238608.1 CAB43622.1
    genomic AJ239035.1 CAB42827.1
    genomic AJ245567.1 CAB59722.1
    genomic AJ251541.2 CAB62907.2
    genomic AJ251621.1 CAB96998.1
    genomic AJ251960.2 CAB64340.2
    genomic AJ252283.1 CAB65736.1
    genomic AJ252284.1 CAB65737.1
    genomic AJ252285.1 CAB65738.1
    genomic AJ271225.1 CAB66898.1
    genomic AJ271340.1 CAB75703.1
    genomic AJ271626.1 CAB71333.1
    genomic AJ277792.1 CAB91544.1
    genomic AJ277793.1 CAB91545.2
    genomic AJ278305.2 CAB93537.1
    genomic AJ278501.1 CAB95730.1
    genomic AJ278667.1 CAB96870.1
    genomic AJ289156.1 CAB92284.1
    genomic AJ291697.1 CAC27240.2
    genomic AJ297476.1 CAC00689.1
    genomic AJ297499.1 CAC27241.1
    genomic AJ303359.3 CAC27518.1
    genomic AJ306634.1 CAC36395.1
    genomic AJ306733.1 CAC37336.1
    genomic AJ308423.1 CAC88116.1
    genomic AJ315641.1 CAC44381.1
    genomic AJ315642.1 CAC44382.1
    genomic AJ401085.1 CAC06086.1
    genomic AJ401086.1 CAC06087.1
    genomic AJ401087.1 CAC06088.1
    genomic AJ426561.1 CAD20188.1
    genomic AJ429615.1 CAD22452.1
    genomic AJ430528.1 CAD23134.1
    genomic AJ431714.1 CAD24477.2
    genomic AJ437690.1 CAD26948.1
    genomic AJ437691.1 CAD26949.1
    genomic AJ457988.1 CAD30042.1
    genomic AJ457989.1 CAD30043.1
    genomic AJ506046.1 CAD44568.1
    genomic AJ506181.1 CAD45434.1
    genomic AJ506182.1 CAD45435.1
    genomic AJ506194.1 CAD44640.1
    genomic AJ506200.1 CAD44643.1
    genomic AJ507149.1 CAD45178.1
    genomic AJ507645.1 CAD48116.1
    genomic AJ507647.1 CAD48117.1
    genomic AJ532607.1 CAD58883.1
    genomic AJ532608.1 CAD58884.1
    genomic AJ537422.1 CAD60933.1
    genomic AJ537477.1 CAD61024.1
    genomic AJ537481.1 CAD61025.1
    genomic AJ538192.1 CAD61338.1
    genomic AJ538193.1 CAD61339.1
    genomic AJ538194.1 CAD61340.1
    genomic AJ538195.1 CAD61341.1
    genomic AJ538348.1 CAD61867.1
    genomic AJ544281.1 CAD66670.1
    genomic AJ544282.1 CAD66671.1
    genomic AJ544283.1 CAD66672.1
    genomic AJ544284.1 CAD66673.1
    genomic AJ544285.1 CAD66674.1
    genomic AJ544286.1 CAD66675.1
    genomic AJ550620.1 CAD79469.1
    genomic AJ550621.1 CAD79470.1
    genomic AJ555412.1 CAD87771.1
    genomic AJ555413.1 CAD87772.1
    genomic AJ564994.2 CAD92641.1
    genomic AJ566139.2 CAD97419.1
    genomic AJ575096.1 CAE00637.1
    genomic AJ575565.1 CAE01416.1
    genomic AJ579651.1 CAE22481.1
    genomic AJ579652.1 CAE22482.1
    genomic AJ579653.1 CAE22483.1
    genomic AJ580596.1 CAE45179.1
    genomic AJ581659.1 CAE46395.1
    genomic AJ581838.1 CAE46481.1
    genomic AJ581839.1 CAE46482.1
    genomic AJ583242.1 CAE47424.2
    genomic AJ604535.1 CAE53175.1
    genomic AJ606924.1 CAE54950.1
    genomic AJ606925.1 CAE54951.1
    genomic AJ616915.1 CAE84855.1
    genomic AJ619767.1 CAF03603.1
    genomic AJ620859.1 CAF06506.1
    genomic AJ621243.1 CAF18417.1
    genomic AJ626847.1 CAF25145.1
    genomic AJ629317.1 CAF33344.1
    genomic AJ629868.1 CAF33597.1
    genomic AJ629870.1 CAF33598.1
    genomic AJ633570.1 CAG17585.1
    genomic AJ634004.2 CAG23922.2
    genomic AJ634051.1 CAG23945.1
    genomic AJ634258.1 CAG24006.1
    genomic AJ697942.2 CAG27087.2
    genomic AJ704546.2 CAG28694.1
    genomic AJ717300.1 CAG30519.1
    genomic AJ748743.1 CAG38621.1
    genomic AJ829713.1 CAH25490.1
    genomic AJ844895.1 CAH59953.1
    genomic AJ844896.1 CAH59954.1
    genomic AJ865349.1 CAI26292.1
    genomic AJ867235.1 CAI29454.1
    genomic AJ870438.1 CAI34859.1
    genomic AJ871405.5 CAI39219.4
    genomic AJ876374.1 CAI45286.1
    genomic AJ877923.1 CAI47569.1
    genomic AJ878876.2 CAI48026.2
    genomic AJ878878.1 CAI48028.1
    genomic AJ878879.1 CAI48029.1
    genomic AJ889845.1 CAI64374.1
    genomic AJ890835.1 CAI68021.1
    genomic AJ965497.1 CAI84068.1
    genomic AJ971317.1 CAI96181.1
    genomic AJ972405.1 CAI99175.2
    genomic AL645935.7 (49329..52744) None
    genomic AL671277.5 (19930..23343) None
    genomic AL845454.6 (74478..77907) None
    genomic AM039954.1 CAJ01785.1
    genomic AM040196.1 CAJ09236.1
    genomic AM040715.2 CAJ13640.2
    genomic AM050155.1 CAJ18328.1
    genomic AM056023.1 CAJ20746.1
    genomic AM062639.1 CAJ21008.1
    genomic AM072344.1 CAJ21345.1
    genomic AM072964.1 CAJ26353.1
    genomic AM076769.1 CAJ28360.1
    genomic AM087469.1 CAJ32464.1
    genomic AM114060.2 CAJ34946.1
    genomic AM157679.2 CAJ43230.2
    genomic AM158088.1 CAJ43432.1
    genomic AM161452.1 CAJ44108.1
    genomic AM183219.1 CAJ66086.1
    genomic AM183220.1 CAJ66087.1
    genomic AM183561.1 CAJ70622.1
    genomic AM183562.1 CAJ70623.1
    genomic AM183783.1 CAJ70701.1
    genomic AM235885.1 CAJ84549.1
    genomic AM235886.1 CAJ84550.1
    genomic AM261460.1 CAK02800.1
    genomic AM268430.1 CAK29511.1
    genomic AM282701.1 CAK54969.1
    genomic AM286552.1 CAL15397.1
    genomic AM286801.1 CAL18290.1
    genomic AM295253.1 CAL29421.1
    genomic AM392319.1 CAL34150.1
    genomic AM408111.1 CAL59585.1
    genomic AM422607.1 CAM12702.1
    genomic AM423239.1 CAM28531.1
    genomic AM712907.1 CAN85194.1
    genomic AM906168.1 CAP20082.1
    genomic AMYH01016204.1 (44499..47911) None
    genomic AY038075.1 AAK71476.1
    genomic AY062909.1 AAL55399.1
    genomic AY125088.1 AAM77796.1
    genomic AY128674.1 AAN01238.1
    genomic AY128675.1 AAN01239.1
    genomic AY128676.1 AAN01240.1
    genomic AY128677.1 AAN01241.1
    genomic AY128678.1 AAN01242.1
    genomic AY134743.1 AAM95704.1
    genomic AY310505.1 AAP74975.1
    genomic AY323229.1 AAP88042.1
    genomic AY330170.1 AAQ24372.1
    genomic AY398747.1 AAR19361.1
    genomic AY509616.1 AAR99592.1
    genomic AY509617.1 AAR99593.1
    genomic AY561761.1 AAT68270.1
    genomic AY574934.1 AAS87370.1
    genomic AY619990.1 AAT41623.1
    genomic AY619991.1 AAT41624.1
    genomic AY619992.1 AAT41625.1
    genomic AY619993.1 AAT44889.1
    genomic AY619994.1 AAT44890.1
    genomic AY621108.1 AAT35595.1
    genomic AY621109.1 AAT35596.1
    genomic AY623048.1 AAT35597.1
    genomic AY623049.1 AAT35598.1
    genomic AY796420.1 AAW73085.1
    genomic AY834199.1 AAW22618.1
    genomic AY836150.1 AAW30165.1
    genomic AY847001.1 AAW30168.1
    genomic AY862874.1 AAW57895.1
    genomic AY897620.1 AAX14022.1
    genomic AY904343.1 AAX07135.1
    genomic AY918166.1 AAX18627.1
    genomic AY918167.1 AAX18628.1
    genomic AY973958.1 AAX94767.1
    genomic AY973959.1 AAX94768.1
    genomic BA000025.2 BAB63400.1
    genomic BX005091.7 (2000..31915) None
    genomic BX284699.4 (12814..39108) None
    genomic BX927141.7 (88826..125405) None
    genomic CH471081.1 EAX03240.1
      EAX03241.1
      EAX03242.1
      EAX03243.1
      EAX03244.1
      EAX03245.1
      EAX03246.1
    genomic CR382333.7 (18397..21736) None
    genomic CR388220.8 (100084..103422) None
    genomic CR759762.5 None
    genomic CR759913.4 (44313..47637) None
    genomic D50458.1 BAA09049.1
    genomic D82930.2 BAA11635.1
    genomic DQ072942.1 AAY85375.1
    genomic DQ188808.1 ABA29233.1
    genomic DQ188809.1 ABA29234.1
    genomic DQ188810.1 ABA29235.1
    genomic DQ188811.1 ABA29236.1
    genomic DQ343835.1 ABC70993.1
    genomic DQ409216.1 ABD75333.1
    genomic DQ409217.1 ABD75334.1
    genomic DQ455021.1 ABE27973.1
    genomic DQ455022.1 ABE27974.1
    genomic DQ465608.1 ABF58773.1
    genomic DQ465609.1 ABF58774.1
    genomic DQ465611.1 ABF58775.1
    genomic DQ465612.1 ABF58776.1
    genomic DQ473291.1 ABF18977.1
    genomic DQ473292.1 ABF18978.1
    genomic DQ485722.1 ABF47209.1
    genomic DQ485737.1 ABF29706.1
    genomic DQ494174.1 ABF54961.1
    genomic DQ523225.1 ABF67610.1
    genomic DQ525626.1 ABF71073.1
    genomic DQ530236.1 ABF71714.1
    genomic DQ535036.1 ABF93214.1
    genomic DQ645957.1 ABG54312.1
    genomic DQ648004.1 ABG43097.1
    genomic DQ648005.1 ABG43098.1
    genomic DQ780570.1 ABG79047.1
    genomic DQ782333.1 ABG91056.1
    genomic DQ872509.1 ABI31649.1
    genomic DQ885885.1 ABI64161.1
    genomic DQ905958.1 ABI34469.1
    genomic EF050037.1 ABK41349.1
    genomic EF062307.2 ABK60080.2
    genomic EF078984.1 ABK56694.1
    genomic EF088204.1 ABK97607.1
    genomic EF092416.1 ABL09832.1
    genomic EF173479.1 ABM53023.1
    genomic EF370118.1 ABN45878.1
    genomic EF495117.1 ABP01670.1
    genomic EF591031.1 ABR08289.1
    genomic EF656472.1 ABS18723.1
    genomic EU146151.1 ABV66222.1
    genomic EU185511.1 ABW38319.1
    genomic EU189866.2 ABW70165.2
    genomic EU330464.1 ABY21173.1
    genomic EU445484.1 ACA35004.1
    genomic EU734549.1 ACG49999.1
    genomic FJ174581.1 ACI15742.1
    genomic FJ464340.1 ACJ71678.1
    genomic FJ594661.1 ACU02151.1
    genomic FJ792530.1 ACN91039.1
    genomic FJ797355.1 ACN89842.1
    genomic FJ797359.1 ACN89846.1
    genomic FJ976710.1 ACS12755.1
    genomic FN806794.2 None
    genomic FN908396.2 CBM43069.1
    genomic FR675935.1 CBW44123.1
    genomic GQ215661.1 ADE18745.1
    genomic GQ254328.1 ADE73117.1
    genomic GQ373161.1 ACU46618.1
    genomic GQ449609.1 ACV89431.1
    genomic HM021736.1 ADI24356.1
    genomic HM021756.1 ADI24376.1
    genomic K02883.1 AAA98727.1
    genomic L47206.1 AAF24937.1
    genomic L48341.1 AAF25960.1
    genomic L77702.1 AAA98118.1
    genomic L78918.1 AAB05976.1
    genomic M15497.1 AAA59611.1
    genomic M15634.1 AAA59615.1
    genomic M19670.1 AAA03683.2
    genomic M20139.1 AAA59838.1
    genomic M20179.1 AAA59839.1
    genomic M24043.1 AAA59652.1
    genomic M30578.1 AAA59613.1
    genomic M64742.1 AAA03662.1
    genomic U02934.1 AAA76607.1
    genomic U02935.2 AAA76608.2
    genomic U02936.1 AAA76609.1
    genomic U03861.1 AAA03602.1
    genomic U03862.1 AAA03603.1
    genomic U03863.1 AAA03604.1
    genomic U41844.1 AAA84994.1
    genomic U70863.1 AAB16923.1
    genomic U88250.1 AAB48494.1
    genomic U89946.1 AAB82079.1
    genomic U89947.1 AAB82080.1
    genomic U90139.1 AAB48628.1
    genomic U90178.1 AAB82081.1
    genomic U90179.1 AAB82082.1
    genomic X00492.1 CAA25162.1
    genomic X03070.1 CAB56605.1
    genomic X03071.1 CAB56606.1
    genomic X55710.1 CAA39243.1
    genomic X82161.1 CAA57654.1
    genomic Y09218.1 CAA70419.1
    genomic Y10695.1 CAA71701.1
    genomic Y12469.1 CAA73072.1
    genomic Y12470.1 CAA73073.1
    genomic Y17000.1 CAA76574.1
    genomic Y17001.1 CAA76575.1
    genomic Y17291.1 CAC27119.1
    genomic Y17292.1 CAC27120.1
    genomic Z72422.1 CAA96532.1
    genomic Z72423.1 CAA96533.1
    genomic Z93949.1 CAB07989.1
    genomic Z97027.1 CAB09723.1
    genomic Z97370.1 CAB10671.1
    mRNA AB209117.1 BAD92354.1
    mRNA AF008933.1 AAB66704.1
    mRNA AF012766.1 AAB70187.1
    mRNA AF012767.1 AAB70188.1
    mRNA AF015930.1 AAB66582.1
    mRNA AF036921.1 AAD02067.1
    mRNA AF116214.1 AAD05568.1
    mRNA AF116215.1 AAD05569.1
    mRNA AF140506.1 AAD32673.1
    mRNA AF165065.1 AAF25781.1
    mRNA AF217561.1 AAF28734.1
    mRNA AF287958.1 AAG27625.1
    mRNA AF287959.1 AAG27626.1
    mRNA AF305699.2 AAG30922.2
    mRNA AJ000661.1 CAA04209.1
    mRNA AJ001269.1 CAA04643.1
    mRNA AJ001274.1 CAA04647.1
    mRNA AJ249241.1 CAB56838.1
    mRNA AJ290394.2 CAC27416.2
    mRNA AJ580771.1 CAE45340.1
    mRNA AK125608.1 BAC86217.1
    mRNA AK130165.1 None
    mRNA AK296091.1 BAG58845.1
    mRNA AK301014.1 BAG62631.1
    mRNA AK301019.1 BAG62636.1
    mRNA AK301282.1 BAG62841.1
    mRNA AK304472.1 BAG65286.1
    mRNA AK313119.1 BAG35940.1
    mRNA AK316195.1 BAH14566.1
    mRNA AL566368.3 None
    mRNA AY191309.1 AAO20853.1
    mRNA AY191310.1 AAO20854.1
    mRNA AY225407.1 AAO43992.1
    mRNA AY365426.1 AAQ64634.1
    mRNA AY786585.1 AAV53343.1
    mRNA AY786586.1 AAV53344.1
    mRNA AY786587.1 AAV53345.1
    mRNA AY786588.1 None
    mRNA AY856830.1 AAX51797.1
    mRNA BC003069.2 AAH03069.1
    mRNA BC008611.1 AAH08611.1
    mRNA BC019236.2 AAH19236.1
    mRNA BE875389.1 None
    mRNA D14350.1 BAA03279.1
    mRNA D14351.1 BAA03280.1
    mRNA D14354.1 BAA03282.1
    mRNA D16841.1 BAA04117.1
    mRNA D16842.1 BAA04118.1
    mRNA D16843.1 BAA04119.1
    mRNA D26550.1 BAA05549.1
    mRNA D32129.1 BAA06855.1
    mRNA D32130.1 BAA06856.1
    mRNA D32131.1 BAA06857.1
    mRNA D38525.1 BAA07530.1
    mRNA D50068.1 BAA08783.1
    mRNA D83515.1 BAA11935.1
    mRNA D83516.1 BAA11936.1
    mRNA DQ327718.1 ABC55710.1
    mRNA DQ327719.1 ABC55711.1
    mRNA DQ327720.1 ABC55712.1
    mRNA DQ327721.1 ABC55713.1
    mRNA DQ327722.1 ABC55714.1
    mRNA DQ336693.1 ABC59610.1
    mRNA DQ336694.1 ABC59611.1
    mRNA DQ336695.1 ABC59612.1
    mRNA JQ313909.1 AFH41801.1
    mRNA L18898.1 AAA17012.1
    mRNA L76936.1 AAB59614.2
    mRNA M11887.1 AAA52656.1
    mRNA M12377.1 AAA17889.1
    mRNA M12758.1 AAA59598.1
    mRNA M23739.1 AAB47873.1
    mRNA M24042.1 AAA59653.1
    mRNA M24095.1 AAA59655.1
    mRNA M27537.1 AAA36227.1
    mRNA M27538.1 AAA59636.1
    mRNA M27539.1 AAA59637.1
    mRNA M27971.1 AAA59602.1
    mRNA M32321.1 AAA36234.1
    mRNA M64740.1 AAA59600.1
    mRNA M84375.1 AAA59599.1
    mRNA M84377.1 AAA59603.1
    mRNA M84378.1 AAA59604.1
    mRNA M84379.1 AAA59606.1
    mRNA M86404.1 None
    mRNA M98453.1 AAA35991.1
    mRNA U03697.1 AAA03720.1
    mRNA U03754.1 AAC04322.1
    mRNA U03907.1 AAA03605.1
    mRNA U07161.1 AAA80569.1
    mRNA U18930.1 AAA87076.1
    mRNA U25971.1 AAA73518.1
    mRNA U32184.1 AAB63980.1
    mRNA U36914.1 AAA80238.1
    mRNA U41057.1 AAB41292.1
    mRNA U43334.1 AAA87570.1
    mRNA U43335.1 AAA87571.1
    mRNA U43336.1 AAA87572.1
    mRNA U45480.1 AAB38491.1
    mRNA U50574.1 AAB60406.1
    mRNA U52429.1 AAB08574.1
    mRNA U56825.1 AAB17465.1
    mRNA U83415.1 AAB53373.1
    mRNA X02457.1 CAA26297.1
    mRNA X13111.1 CAA31503.1
    mRNA X13112.1 CAA31504.1
    mRNA X57954.1 CAA41022.1
    mRNA X60108.1 CAA42702.1
    mRNA X60764.1 CAB56609.1
    mRNA X61700.1 CAA43869.1
    mRNA X61703.1 CAA43872.1
    mRNA X61704.1 CAA43873.1
    mRNA X61711.1 CAA43880.1
    mRNA X91399.1 CAA62745.1
    mRNA X94566.1 None
    mRNA X94567.1 None
    mRNA X94568.1 None
    mRNA X94570.1 None
    mRNA X94572.1 None
    mRNA X94573.1 None
    mRNA X96638.1 CAA65442.1
    mRNA X96724.1 CAA65501.1
    mRNA X97802.1 CAA66389.1
    mRNA Y08275.1 CAA69599.1
    mRNA Y11441.1 CAA72245.1
    mRNA Y13028.1 CAA73473.1
    mRNA Y13267.1 CAA73716.1
    mRNA Y17224.1 CAB38056.1
      CAB38057.1
    mRNA Z23071.1 CAA80612.1
    mRNA Z27120.1 CAA81644.1
    mRNA Z46633.1 CAA86602.1
    other-genetic DQ891760.2 ABM82686.1
    other-genetic EU176622.1 ABW03423.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P01891.4 GenPept UniProtKB/Swiss-Prot:P01891
    P01892.1 GenPept UniProtKB/Swiss-Prot:P01892
    P04439.2 GenPept UniProtKB/Swiss-Prot:P04439
    P05534.2 GenPept UniProtKB/Swiss-Prot:P05534
    P10314.2 GenPept UniProtKB/Swiss-Prot:P10314
    P10316.2 GenPept UniProtKB/Swiss-Prot:P10316
    P13746.1 GenPept UniProtKB/Swiss-Prot:P13746
    P16189.2 GenPept UniProtKB/Swiss-Prot:P16189
    P18462.1 GenPept UniProtKB/Swiss-Prot:P18462
    P30443.1 GenPept UniProtKB/Swiss-Prot:P30443
    P30447.1 GenPept UniProtKB/Swiss-Prot:P30447
    P30450.2 GenPept UniProtKB/Swiss-Prot:P30450
    P30453.1 GenPept UniProtKB/Swiss-Prot:P30453
    P30455.1 GenPept UniProtKB/Swiss-Prot:P30455
    P30456.1 GenPept UniProtKB/Swiss-Prot:P30456
    P30457.1 GenPept UniProtKB/Swiss-Prot:P30457
    P30512.2 GenPept UniProtKB/Swiss-Prot:P30512
    Q09160.1 GenPept UniProtKB/Swiss-Prot:Q09160

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • Books
        Links between Entrez Gene and 'Books' are established if a GeneID is explicitly referenced in a book.
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • ClinVar
        Related medical variations
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • MedGen
        Related information in MedGen
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • SNP: VarView
        Related Clinical SNP
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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