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HLA-A major histocompatibility complex, class I, A [ Homo sapiens (human) ]

Gene ID: 3105, updated on 23-May-2016
Official Symbol
HLA-Aprovided by HGNC
Official Full Name
major histocompatibility complex, class I, Aprovided by HGNC
Primary source
HGNC:HGNC:4931
See related
Ensembl:ENSG00000206503 Ensembl:ENST00000376809 HPRD:00826; MIM:142800; Vega:OTTHUMG00000130501
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HLAA; Aw-33; Aw-74
Summary
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]
Location:
6p21.3
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (29942470..29945884)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (29910247..29913661)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene major histocompatibility complex, class I, U (pseudogene) Neighboring gene HLA complex group 4 pseudogene 5 Neighboring gene HLA complex group 4 pseudogene 4 Neighboring gene major histocompatibility complex, class I, W (pseudogene)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Carbamazepine response
MedGen: CN077964 GeneReviews: Not available
Compare labs
Susceptibility to severe cutaneous adverse reaction
MedGen: C1840548 OMIM: 608579 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy.
NHGRI GWA Catalog
A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.
NHGRI GWA Catalog
A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study.
NHGRI GWA Catalog
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
NHGRI GWA Catalog
Common genetic variation and the control of HIV-1 in humans.
NHGRI GWA Catalog
Genome-wide association study for serum complement C3 and C4 levels in healthy Chinese subjects.
NHGRI GWA Catalog
Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin.
NHGRI GWA Catalog
Genome-wide association study reveals multiple nasopharyngeal carcinoma-associated loci within the HLA region at chromosome 6p21.3.
NHGRI GWA Catalog
HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.
NHGRI GWA Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog
Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles.
NHGRI GWA Catalog
Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Asp asp Two ASP peptide sequences, ASP-YL9 (89YLYNSLLQL97) and ASP-TL10 (79TPNGSIFTTL88), show high binding affinity to HLA-A*02 and HLA-B*07 molecules, respectively PubMed
asp Antisense reading frame-derived cryptic epitopes from the gag, pol, and nef genes are inhibited by the predicted HLA-I alleles, and presented by HIV-1-infected CD8+ T-cells PubMed
asp Antisense reading frame-derived cryptic epitopes from the env gene are inhibited by the HLA-I alleles in CD8+ T-cells PubMed
Envelope surface glycoprotein gp120 env Conformational changes in HIV-1 gp120, including an enhanced expression of the V3 loop of gp120 and of epitopes that are exposed upon CD4 binding, are consistent with the formation of a multimolecular complex between HLA class I and gp120/160 PubMed
env Treatment of CD4+ T cells with HIV-1 gp120 significantly increases CD4 association with CD3, CD45RA, CD45RB, CD59, CD38, CD26 and HLA class I, and decreases that with CD45RC PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160-derived peptide p18 presented by H-2Dd class I major histocompatibility complex molecules is processed by angiotensin-1 converting enzyme (ACE) prior to T cell stimulation by the peptide p18 PubMed
env Epitope Env37-46 from HIV-1 gp160 binds strongly to HLA-A3 molecules and forms very stable complexes PubMed
Envelope transmembrane glycoprotein gp41 env Soluble HIV-1 gp41 enhancement effects on MHC class I and II antigen expression can be inhibited by soluble gp41-binding proteins of 45, 49 and 62 kD from human B cells PubMed
env Soluble HIV-1 gp41 can selectively enhance MHC class I and II expression on human B cells, but does not increase expression of other cell surface antigens such as CD21 and CD54 (ICAM-1) PubMed
env HIV-1 gp41 selectively enhances MHC class I, ICAM-1, IFN-alpha, IFN-beta, and IFN-omega expression in H9 cells PubMed
Nef nef Expression of HIV-1 Nef in human T cells inhibits HLA-A2 transport to the cell surface PubMed
nef HIV-1 Nef downregulates the expression of MHC-I at the surface of lymphoid, monocytic and epithelial cells, causing MHC-I molecules to be rapidly internalized, accumulated in endosomal vesicles and degraded PubMed
nef In promonocytic cells, Nef/Hck recruits the ZAP-70 homolog Syk to downregulate MHC-I PubMed
nef Nef/Hck complex recruits and phosphorylates the tyrosine kinase ZAP-70, which binds class I PI3K to trigger MHC-I downregulation in primary CD4+ T cells PubMed
nef HIV-1 Nef-mediated downregulation of MHC-I requires Nef motif EEEE(65)-dependent binding to the sorting protein PACS-2, which targets Nef to the paranuclear region and enables Nef PXXP(75) to bind and activate a trans-Golgi network localized Src kinase PubMed
nef Dominant active ARF1 (Q71L) potently stabilizes interactions among AP-1 mu1, HIV-1 Nef, and HLA-A2 and that the formation of a static complex sequesters necessary trafficking components PubMed
nef Knocking down either AP-1 gamma, AP-1 mu1, or clathrin strongly inhibits Nef-induced downregulation of HLA-A2 PubMed
nef beta-COP as a cellular cofactor is required for HIV-1 Nef-mediated HLA-A2, CD4, and CD8 downregulation PubMed
nef HIV-1 Nef clones from acute controllers display a lesser ability to downregulate CD4 and HLA class I from the cell surface, and a reduced ability to enhance virion infectivity compared to those from acute progressors PubMed
nef HIV-1 Nef clones obtained from chronic patients infected with HIV-1 subtypes A, B, C or D show a functional hierarchy of subtype B > A/D > C for Nef-mediated HLA class I downregulation PubMed
nef HLA supertypes such as HLA B*07, HLA B*58, HLA A*02 and HLA A*03 are most successful in restricting the amino acid positions of epitope dense regions of HIV-1 Nef, CA, and MA with low entropy and hydrophobic property PubMed
nef Protective HLA alleles have a true preference for HIV-1 Gag protein, while non-protective HLA alleles preferentially interact with HIV-1 Nef PubMed
nef HIV-1 Nef clones, isolated from plasma of elite controllers (EC) and chronic progressors (CP), show significantly lower HLA class I downregulation activity in EC than that in CP PubMed
nef Interaction of HIV-1 Nef with the mu subunit of AP adaptor complexes requires the recognition of tyrosine-based sorting signals, which likely facilitates the connection between MHC I and the clathrin-dependent sorting machinery during MHC I downregulation PubMed
nef Four glutamic acids from position 62 to 65 in the SH3 domain of HIV-1 Nef bind to the cytoplasmic tail at position 320Y of MHC-I, and are required for the Nef-mediated downregulation of MHC-I from the cell surface PubMed
nef HIV-1 selectively downregulates HLA-A and HLA-B but does not significantly affect HLA-C or HLA-E, which allows HIV-infected cells to avoid NK cell-mediated lysis; this effect is likely mediated by the HIV-1 Nef protein PubMed
nef The N-terminal alpha helix (17-26), polyproline (72-78), acidic (62-65), and oligomerization (123) domains of HIV-1 Nef are required for Nef-mediated disruption of the transport of HLA-A2 to the cell surface and for Nef to coprecipitate with HLA-A2 PubMed
nef The ability of HIV-1 Nef to disrupt MHC-I trafficking and inhibit antigen presentation is regulated by the expression of the mu1 subunit of adaptor protein (AP) AP-1A, a cellular protein complex implicated in TGN to endolysosomal pathways PubMed
nef Different levels of MHC-I modulation are induced by different HIV-1 Nef proteins derived from HIV-1 infected adults and children PubMed
nef The HIV-1 Nef highly conserved valine-glycine-phenylalanine amino acid triplet (VGF) motif, which links the acidic cluster and the proline-rich motif, is important for downregulation of CXCR4 and MHC-I PubMed
nef HLA-A2 molecules with HLA-A cytoplasmic domains are more downregulated by HIV-1 Nef than those with HLA-B domains. There is no downregulation of HLA-A2 with HLA-C cytoplasmic domains by Nef PubMed
nef Asp327 and Tyr320 of MHC-I, Asp123 of Nef, and Arg225, Arg393, Lys396, Arg211, and Arg246 of mu 1 are involved in a crucial three-way electrostatic network, which results in the Nef-MHC-I CD-mu 1 complex formation PubMed
nef HIV-1 Nef with A84D, Y135F, and G140R mutation impairs to its ability to downregulate MHC-I PubMed
nef Double (W13A/V16R) and triple (W13A/V16R/M20A) substitution mutants of HIV-1 Nef fail to downregulate MHC-I PubMed
nef HIV-1 Nef acidic (Glu62-65) and polyproline domains (Pro75/78) stabilize the interaction between the HLA-A2/Nef fusion protein and AP-1 mu1 PubMed
nef Mutating three amino acids (Y320, A324, and D327) in the cytoplasmic tail of HLA-A2 abrogates Nef-induced downregulation of HLA-A2 through a failuer to recruit the mu1 or gamma subunits of AP-1 PubMed
nef Knocking down AP-2 enhances Nef activity by causing increased delivery of HLA-A2 to a prelysosomal compartment PubMed
nef MHC-I is found in the Rab7(+) vesicles and targeted for degradation via the activity of the Nef-interacting protein, beta-COP PubMed
nef HIV-1 Nef sequesters HLA-I A2 and colocalizes with CD63 and LAMP1 markers in late endosomes and lysosomes PubMed
nef ARF6(T27N/Q67L) and RAB11(Q67L) mutants induce significant reversal of HLA-I A2 downregulation by HIV-1 Nef through redistributing HLA-I A2 from the perinuclear vesicles to the peripheral punctate vesicles at the plasma membrane PubMed
nef HIV-1 Nef-induced downregulation of MHC-I expression and MHC-I targeting to the trans-Golgi network (TGN) require the binding of Nef to PACS-1, a molecule that controls the TGN localization of the cellular protein furin PubMed
nef HIV-1 Nef downregulates expression of MHC-I by blocking transport of MHC-I molecules to the cell surface through a mechanism that requires phosphoinositide 3-kinase (PI 3-kinase) activity PubMed
nef A methionine residue at amino acid 20 in the alpha-helix domain of HIV-1 Nef is required for the ability of Nef to downregulate MHC-I expression but not for the downregulation of CD4 PubMed
nef Two distinct regions of HIV-1 Nef modulate MHC-I cell surface expression: an N-terminal alpha-helix (residues 17-26) and a proline-rich motif (residues 75-78) PubMed
nef The HIV-1 Nef 73-82 epitope binds strongly to HLA-A3 molecules and forms very stable complexes PubMed
nef Mutation of amino acid P78 in HIV-1 Nef affects downregulation of MHC-I molecules from the cell surface, but does not interfere with Nef binding to Src homology 3 (SH3) domains PubMed
nef HIV-1 Nef induces drastic and moderate downregulation of CD4 and MHC-I in resting CD4(+) T lymphocytes, respectively, but markedly upregulates cell surface levels of the MHC-II invariant chain CD74 PubMed
nef HIV-1 Nef has been observed to downregulate HLA-A2 on immature dendritic cells from two donors PubMed
nef HIV-1 Nef-mediated downregulation of HLA class I suppresses the cytolytic activity of HIV-1-specific cytotoxic T-lymphocyte (CTL) clones PubMed
nef Macrophage-tropic HIV-1 Nef downregulates expression of HLA-A2 on the surface of productively infected macrophages; point mutations in Nef at prolines P74 or P80 abrogate the downregulation of HLA-A2 PubMed
nef HIV-1 Nef downregulates MHC-I in Jurkat cells in a concentration-dependent manner PubMed
nef HIV-1 Nef downregulates human MHC-I more efficiently than murine MHC-I molecules in HeLa cells, and Nef does not function efficiently in murine endothelial cells PubMed
nef HIV-1 Nef alleles derived from perinatally infected children efficiently downregulate both CD4 and MHC-I in HeLa-CD4+ cells PubMed
nef HIV-1 group N and group O Nef alleles only weakly downregulate CD4, CD28, and class I and II MHC molecules PubMed
nef HIV-1 Nef disrupts antigen presentation by binding to MHC-I (HLA-A2) hypophosphorylated cytoplasmic tails in the endoplasmic reticulum; this Nef-MHC-I complex migrates normally into the Golgi apparatus but subsequently fails to arrive at the cell surface PubMed
nef PxxP motifs in HIV-1 Nef induce the accumulation of CCR5 in a perinuclear compartment where both molecules co-localize with MHC-1 PubMed
nef The HIV-1 Nef mutant NefAAAA, which cannot interact with the endosomal sorting protein PACS-1, increases the number of cells containing long and stable tubules, which allows the internalization of MHC-1 into the tubules from the cell surface PubMed
nef Downregulation of MHC-I by HIV-1 Nef decreases the incorporation of MHC-I molecules into virions, but does not decrease virion infectivity PubMed
nef Downregulation of major histocompatibility class I on human dendritic cells by HIV-1 Nef impairs antigen presentation to HIV-specific CD8+ T lymphocytes PubMed
nef A dominant-negative mutant protein derived from Hck, (composed of the N-terminal region, SH2, and SH3 domains) interacts with HIV-1 Nef and inhibits Nef-induced downregulation of MHC class I PubMed
nef Deletion of the 19 N-terminal amino acids including the myristoylation signal from HIV-1 Nef inhibits both MHC-I and CD4 downregulation while preserving most CTL, T-helper and B-cell epitopes PubMed
Pol gag-pol The HIV-1 Pol 325-333 epitope binds strongly to HLA-A3 molecules and forms very stable complexes PubMed
Pr55(Gag) gag Protective HLA alleles have a true preference for HIV-1 Gag protein, while non-protective HLA alleles preferentially interact with HIV-1 Nef PubMed
gag The S40F mutation in HIV-1 p6 enhances MHC-I antigen presentation of Gag PubMed
gag HIV-1 Gag virus-like particles efficiently activate human monocyte-derived dendritic cells (MDDC) and induce MDDC maturation with an associated increase in the surface expression of CD80, CD86 and MHC classes I and II PubMed
gag The PTAP L-domains in the p6 domain of HIV-1 Gag regulates ubiquitination of Gag which controls MHC-I presentation and gag processing in the DRiP pathway. PubMed
gag The degree of HIV-1 Nef-mediated HLA-A2 downregulation strongly influences recognition of virus-infected cells by the Gag-specific CD8+ cytotoxic T lymphocyte clone PubMed
gag Targeting HIV-1 Gag into the defective ribosomal product pathway enhances MHC class I antigen presentation and CD8+ T cell activation PubMed
gag The HIV-1 Gag 20-28 epitope binds strongly to HLA-A3 molecules and forms very stable complexes PubMed
Tat tat Four mutations (C27S, K51T, R55L, and G79A) on HIV-1 Tat result in the loss of the deleterious effects of Tat on the expression of MHC I, IL-2, and CD25 genes compared with wild-type Tat in Jurkat cells PubMed
tat HIV-1 Tat upregulates MHC class I in monocyte-derived dendritic cells and CD8(+) T cells, thereby driving T cell-mediated immune responses PubMed
tat HIV-1 Tat represses the MHC class I gene promoter by binding to and repressing TAFII250, a component of the general transcription factor TFIID, suggesting a mechanism for HIV-1 to downregulate MHC class I expression and avoid immune surveillance PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of HLA-A (A-68 alpha chain) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
Vpu vpu Using antibodies specific to MHC class I A, B, and C molecules (clone W6/32), HIV-1 Vpu protein has been shown to downregulate the expression of MHC class I molecules on the surface of HIV-1 infected cells PubMed
vpu HLA class I-associated immune responses have minor effects on Vpu variability, suggesting that Vpu conformation and function are preserved through many possible combinations of primary and secondary polymorphisms PubMed
capsid gag HLA supertypes such as HLA B*07, HLA B*58, HLA A*02 and HLA A*03 are most successful in restricting the amino acid positions of epitope dense regions of HIV-1 Nef, CA, and MA with low entropy and hydrophobic property PubMed
matrix gag HLA supertypes such as HLA B*07, HLA B*58, HLA A*02 and HLA A*03 are most successful in restricting the amino acid positions of epitope dense regions of HIV-1 Nef, CA, and MA with low entropy and hydrophobic property PubMed
p6 gag The S40F mutation in HIV-1 p6 enhances MHC-I antigen presentation of Gag PubMed

Go to the HIV-1, Human Interaction Database

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    Type I diabetes mellitus, organism-specific biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
  • Type I diabetes mellitus, conserved biosystem (from KEGG)
    Type I diabetes mellitus, conserved biosystemType I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-pre...
  • Viral carcinogenesis, organism-specific biosystem (from KEGG)
    Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • Viral carcinogenesis, conserved biosystem (from KEGG)
    Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
  • Viral myocarditis, organism-specific biosystem (from KEGG)
    Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ26655

Gene Ontology Provided by GOA

Function Evidence Code Pubs
T cell receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
TAP binding IDA
Inferred from Direct Assay
more info
PubMed 
beta-2-microglobulin binding IC
Inferred by Curator
more info
PubMed 
beta-2-microglobulin binding IDA
Inferred from Direct Assay
more info
PubMed 
beta-2-microglobulin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
beta-2-microglobulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
peptide antigen binding IDA
Inferred from Direct Assay
more info
PubMed 
peptide antigen binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptide antigen binding ISS
Inferred from Sequence or Structural Similarity
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
antibacterial humoral response IDA
Inferred from Direct Assay
more info
PubMed 
antigen processing and presentation IBA
Inferred from Biological aspect of Ancestor
more info
 
antigen processing and presentation of endogenous peptide antigen via MHC class I IDA
Inferred from Direct Assay
more info
PubMed 
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IDA
Inferred from Direct Assay
more info
PubMed 
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
Traceable Author Statement
more info
 
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent TAS
Traceable Author Statement
more info
 
antigen processing and presentation of peptide antigen via MHC class I TAS
Traceable Author Statement
more info
 
defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
PubMed 
detection of bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune response NAS
Non-traceable Author Statement
more info
PubMed 
interferon-gamma-mediated signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of CD8-positive, alpha-beta T cell activation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of CD8-positive, alpha-beta T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of T cell cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of T cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interferon-gamma production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of memory T cell activation IDA
Inferred from Direct Assay
more info
PubMed 
protection from natural killer cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
PubMed 
NOT protection from natural killer cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of defense response to virus by virus TAS
Traceable Author Statement
more info
 
regulation of immune response TAS
Traceable Author Statement
more info
 
type I interferon signaling pathway TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
ER to Golgi transport vesicle membrane TAS
Traceable Author Statement
more info
 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
Golgi medial cisterna IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
MHC class I protein complex IDA
Inferred from Direct Assay
more info
PubMed 
MHC class I protein complex ISS
Inferred from Sequence or Structural Similarity
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
early endosome membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum exit site IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of lumenal side of endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic vesicle membrane TAS
Traceable Author Statement
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
HLA class I histocompatibility antigen, A-1 alpha chain
Names
HLA class I histocompatibility antigen, A-30 alpha chain
HLA class I histocompatibility antigen, A-33 alpha chain
HLA class I histocompatibility antigen, A-74 alpha chain
MHC class I antigen A*30
MHC class I antigen A*33
MHC class I antigen A*74
MHC class I antigen HLA-A heavy chain
antigen presenting molecule
leukocyte antigen class I-A

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029217.2 RefSeqGene

    Range
    5005..8420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001242758.1NP_001229687.1  HLA class I histocompatibility antigen, A-1 alpha chain precursor

    See identical proteins and their annotated locations for NP_001229687.1

    Status: REVIEWED

    Source sequence(s)
    AL645935, BC003069
    UniProtKB/Swiss-Prot
    P30443
    UniProtKB/TrEMBL
    Q5SUL5
    Conserved Domains (3) summary
    cd07698
    Location:207299
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam06623
    Location:336364
    MHC_I_C; MHC_I C-terminus
    pfam00129
    Location:25203
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
  2. NM_002116.7NP_002107.3  HLA class I histocompatibility antigen, A-1 alpha chain precursor

    See identical proteins and their annotated locations for NP_002107.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the A*03:01:0:01 allele of the HLA-A gene, as represented in the assembled chromosome 6 in the primary assembly of the reference genome.
    Source sequence(s)
    AK313119, AL671277, BE875389, U32184
    Consensus CDS
    CCDS34373.1
    UniProtKB/Swiss-Prot
    P04439
    UniProtKB/TrEMBL
    B1PKY1, B2R7U3
    Related
    ENSP00000366005, ENST00000376809
    Conserved Domains (3) summary
    cd07698
    Location:207299
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam06623
    Location:336364
    MHC_I_C; MHC_I C-terminus
    pfam00129
    Location:25203
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    29942470..29945884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p2 ALT_REF_LOCI_1

    Range
    1200217..1203632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p2 ALT_REF_LOCI_2

    Range
    1421892..1425307
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p2 ALT_REF_LOCI_3

    Range
    1198023..1201452
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p2 ALT_REF_LOCI_4

    Range
    1197012..1200442
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p2 ALT_REF_LOCI_5

    Range
    1286642..1289974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011548124.1XP_011546426.1  

    Conserved Domains (3) summary
    cd07698
    Location:204296
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam06623
    Location:333361
    MHC_I_C; MHC_I C-terminus
    pfam00129
    Location:22200
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
  2. XM_005275331.2XP_005275388.1  

    Conserved Domains (3) summary
    cd07698
    Location:204296
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam06623
    Location:333361
    MHC_I_C; MHC_I C-terminus
    pfam00129
    Location:22200
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RNA

  1. XR_430999.1 RNA Sequence

Reference GRCh38.p2 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p2 ALT_REF_LOCI_6

    Range
    1197429..1200858
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p2 ALT_REF_LOCI_7

    Range
    1240284..1243714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    29857559..29915772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)