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    CCND1 cyclin D1 [ Homo sapiens ]

    Gene ID: 595, updated on 21-Feb-2012
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    Summary

    Official Symbol
    CCND1provided by HGNC
    Official Full Name
    cyclin D1provided by HGNC
    Primary source
    HGNC:1582
    See related
    Ensembl:ENSG00000110092; HPRD:01346; MIM:168461; Vega:OTTHUMG00000167877
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BCL1; PRAD1; U21B31; D11S287E
    Summary
    The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    11q13
    Sequence :
    Chromosome: 11; NC_000011.9 (69455873..69469242)
    See CCND1 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene interferon induced transmembrane protein 9 pseudogene Neighboring gene uncharacterized LOC100505834 Neighboring gene oral cancer overexpressed 1 Neighboring gene fibroblast growth factor 19

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. microRNA-365, down-regulated in colon cancer, inhibits cell cycle progression and promotes apoptosis of colon cancer cells by probably targeting Cyclin D1 and Bcl-2. Nie J, et al. Carcinogenesis, 2012 Jan. PMID 22072615.
    2. Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification. Dekanić A, et al. Diagn Pathol, 2011 Nov 3. PMID 22050898.
    3. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    4. [Prognostic value of the molecular markers cyclin D1 and P53 in patients with lung cancer]. Uchikov A, et al. Khirurgiia (Sofiia), 2010. PMID 21972713.
    5. Interaction of CCND1 genotype and smoking habit in Taiwan lung cancer patients. Hsia TC, et al. Anticancer Res, 2011 Oct. PMID 21965784.

    See all (856) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. study indicates that CCND1 rs9344 polymorphisms confer host susceptibility to cervical cancer. A allele possesses a relative protective effect probably through the cyclin D1b's inhibition on HPV carcinogenesis
      Title: CCND1 rs9344 polymorphisms are associated with the genetic susceptibility to cervical cancer in Chinese population.
    2. The A allele of the CCND1 G870A polymorphism may confer additional breast cancer risk when it comes to homozygosity and Chinese populations.
      Title: Cyclin D1 G870A polymorphism and breast cancer risk: a meta-analysis comprising 9,911 cases and 11,171 controls.
    3. microRNA-365, down-regulated in colon cancer, inhibits cell cycle progression and promotes apoptosis of colon cancer cells by probably targeting Cyclin D1 and Bcl-2.
      Title: microRNA-365, down-regulated in colon cancer, inhibits cell cycle progression and promotes apoptosis of colon cancer cells by probably targeting Cyclin D1 and Bcl-2.
    4. Apigenin increases CASP3 and CASP8 mRNA expression but decreases mTOR and CCND1 mRNA expression in HT29 cells.
      Title: Evaluation of the effects of the flavonoid apigenin on apoptotic pathway gene expression on the colon cancer cell line (HT29).
    5. Results suggested that the Cyclin D1 A870G polymorphism is associated with an increased risk of SGTs in the Chinese population. The Cyclin D1 AA genotype not only increased the risk of PA, but also increased the expression of Cyclin D1 in these tumors.
      Title: Cyclin D1 gene polymorphism, A870G, is associated with an increased risk of salivary gland tumors in the Chinese population.
    6. These results indicate that increased migration of MDA-MB-231 cells following cyclin D1 silencing can be mediated by Id1 and is linked to an increase in EMT markers.
      Title: Cyclin D1, Id1 and EMT in breast cancer.
    7. AP-1 activity and cyclin D1/E2F-1 expression in human embryo lung fibroblasts increased significantly after benzo(a)pyrene treatment.
      Title: [Activated protein 1-cyclin D1/E2F 1 pathways involved in cell cycle changes induced by benzo (a) pyrene].
    8. The aim of the present study was to explore and correlate membrane and nuclear EGFR and cyclin-D1 protein expression with EGFR gene status in colorectal carcinomas
      Title: Strong nuclear EGFR expression in colorectal carcinomas is associated with cyclin-D1 but not with gene EGFR amplification.
    9. significant relationship between nucleostemin and cyclin D1 expression in ovarian neoplasms
      Title: Clinical significance of nucleostemin expression and its correlation with cyclin D1 expression in malignant ovarian tumors.
    10. Cyclin D1 overexpression was observed in 47.7% of tumors in the young group and in 32.8% of controls. In the young group, protein overexpression correlated with diminished disease-free survival.
      Title: CCND1 amplification and protein overexpression in oral squamous cell carcinoma of young patients.
    Submit: New GeneRIF Correction See all (638)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Colorectal cancer, susceptibility to

    Genome-wide association study identifies five new breast cancer susceptibility loci.

    Leukemia/lymphoma, chronic B-cell

    Multiple myeloma

    von Hippel-Lindau disease, modification of

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef is implicated in the upregulation of Cyclin D1 in infected podocytes and may be involved in the pathogenesis of HIV-associated nephropathy PubMed
    Tat tat Treatment of human endothelial cells with HIV-1 Tat significantly upregulates Cyclin D1 PubMed
    tat Microarray analysis indicates HIV-1 Tat downregulates the expression of many proteins, including Cyclin PRAD1, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NC_000011.8 NP_001269.3 CHUK    BIND  PubMed IKK-alpha interacts with cyclin D1 promoter. 
    NC_000011.8 NP_004371.1 CREBBP    BIND  PubMed CBP interacts with cyclin D1 promoter. 
    NC_000011.8 NP_001895.1 CTNNB1    BIND  PubMed CTNNB1 (beta-catenin) interacts with the CCND1 promoter. 
    NC_000011.8 NP_000113.1 ERCC3    BIND  PubMed TFIIH interacts with Cyclin D1 promoter. 
    NC_000011.8 NP_000116.1 ESR1    BIND  PubMed ER-alpha interacts with cyclin D1 promoter. 
    NC_000011.8 NCOA3    BIND  PubMed AIB1 interacts with cyclin D1 promoter. 
    NC_000011.8 NP_000928.1 POLR2A    BIND  PubMed Pol II interacts with cyclin D1 promoter. 
    NC_000011.8 NP_068810.2 RELA    BIND  PubMed RELA (NF-kappaB p65 subunit) interacts with the CCND1 (Cyclin D1) promoter. 
    NP_444284.1 NP_009227.1 BRCA1    BIND  PubMed BRCA1 associates with Cyclin D1 
    NP_444284.1 NP_000066.1 CDK4    BIND  PubMed CCND1 (cyclin D1) interacts with CDK4. 
    NP_444284.1 NP_000066.1 CDK4    BIND  PubMed CDK4 interacts with Cyclin D1. This interaction was modelled on a demonstrated interaction between human CDK4 and Cyclin D1 from an unspecified species. 
    NP_444284.1 NP_001250.1 CDK6    BIND  PubMed CCND1 (cyclin D1) interacts with CDK6. 
    NP_444284.1 NP_000380.1 CDKN1A    BIND  PubMed Cyclin D1 interacts with p21. 
    NP_444284.1 NP_000380.1 CDKN1A    BIND  PubMed p21 interacts with cyclin D. 
    NP_444284.1 NP_000380.1 CDKN1A    BIND  PubMed CDKN1A (p21) interacts with CCND1 (cyclin D1). 
    NP_444284.1 NP_004055.1 CDKN1B    BIND  PubMed p27 interacts with cyclin D. 
    NP_444284.1 NP_001291.3 KLF6    BIND  PubMed KLF6 interacts with Cyclin D1. 
    NP_444284.1 NP_006212.1 PIN1    BIND  PubMed PIN1 interacts with Cyclin D1. This interaction was modelled on a demonstrated interaction between human PIN1 and Cyclin D1 from an unspecified species. 
    NP_444284.1 NP_000312.1 RB1    BIND  PubMed Rb interacts with Cyclin D1. This interaction was modelled on a demonstrated interaction between Cyclin D1 from mouse and Rb from human. 
    NP_444284.1 NP_620278.1 TAF1    BIND  PubMed TAFII250 interacts with Cyclin D1. This interaction was modelled on a demonstrated interaction between TAFII250 from human and Cyclin D1 from mouse. 
    NT_035113.6 NP_005929.1 FOXO4    BIND  PubMed MLLT7 (FOXO4) interacts with the CCND1 (Cyclin D1) promoter. This interaction was modelled on a demonstrated interaction between MLLT7 and CCND1 both from unspecified species. 
    P24385 O43823 AKAP8    HPRD  PubMed  
    P24385 P10275 AR    HPRD  PubMed  
    P24385 P38398 BRCA1    HPRD  PubMed  
    P24385 Calmodulin 1 CALM1    HPRD  PubMed  
    P24385 Cyclin D type binding protein 1 CCNDBP1    HPRD  PubMed  
    P24385 P11802 CDK4    HPRD  PubMed  
    P24385 Q00534 CDK6    HPRD  PubMed  
    P24385 P38936 CDKN1A    HPRD  PubMed  
    P24385 P46527 CDKN1B    HPRD  PubMed  
    P24385 P35222 CTNNB1    HPRD  PubMed  
    P24385 Q13618 CUL3    HPRD  PubMed  
    P24385 Cyclin D binding myb like transcription factor 1 DMTF1    HPRD  PubMed  
    P24385 Q09472 EP300    HPRD  PubMed  
    P24385 P03372 ESR1    HPRD  PubMed  
    P24385 P49841 GSK3B    HPRD  PubMed  
    P24385 O15379 HDAC3    HPRD  PubMed  
    P24385 Q9UII4 HERC5    HPRD  PubMed  
    P24385 P40305 IFI27    HPRD  PubMed  
    P24385 Q01101 INSM1    HPRD  PubMed  
    P24385 Q92831 KAT2B    HPRD  PubMed  
    P24385 Q7L590 MCM10    HPRD  PubMed  
    P24385 P10244 MYBL2    HPRD  PubMed  
    P24385 Q15788 NCOA1    HPRD  PubMed  
    P24385 Q9Y6Q9 NCOA3    HPRD  PubMed  
    P24385 Q9NQX5 NPDC1    HPRD  PubMed  
    P24385 O43929 ORC4    HPRD  PubMed  
    P24385 P12004 PCNA    HPRD  PubMed  
    P24385 P17612 PRKACA    HPRD  PubMed  
    P24385 P06400 RB1    HPRD  PubMed  
    P24385 P28749 RBL1    HPRD  PubMed  
    P24385 Q08999 RBL2    HPRD  PubMed  
    P24385 P62877 RBX1    HPRD  PubMed  
    P24385 P35251 RFC1    HPRD  PubMed  
    P24385 Q01196 RUNX1    HPRD  PubMed  
    P24385 P08047 SP1    HPRD  PubMed  
    P24385 P40763 STAT3    HPRD  PubMed  
    P24385 P21675 TAF1    HPRD  PubMed  
    P24385 P10827 THRA    HPRD  PubMed  
    P24385 P37243 THRB    HPRD  PubMed  
    P24385 P49815 TSC2    HPRD  PubMed  
    Z29078.1 CREB1    BIND  PubMed CREB interacts with CRE. 
    Z29078.1 EGFR    BIND  PubMed An unspecified isoform of EGFR binds to Cyclin D1 promoter. 
    Z29078.1 STAT3    BIND  PubMed An unspecified isoform of STAT3 binds to Cyclin D1 promoter. 
    BioGRID:107067 BioGRID:115561 AKAP8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107067 BioGRID:106862 AR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107067 BioGRID:111861 ARID4A    BioGRID  PubMed Biochemical Activity 
    BioGRID:107067 BioGRID:107140 BRCA1    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:107067 BioGRID:117117 CCNDBP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107067 BioGRID:107454 CDK4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107067 BioGRID:107456 CDK6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107067 BioGRID:107460 CDKN1A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107067 BioGRID:107461 CDKN1B    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107067 BioGRID:107462 CDKN1C    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107067 BioGRID:107463 CDKN2A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107067 BioGRID:107800 CRYAB    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity 
    BioGRID:107067 BioGRID:114032 CUL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107067 BioGRID:115159 CUL7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107067 BioGRID:108347 EP300    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107067 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107067 BioGRID:122890 FBXO31    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107067 BioGRID:117656 FBXO4    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107067 BioGRID:117655 FBXO5    BioGRID  PubMed Biochemical Activity 
    BioGRID:107067 BioGRID:117645 FBXW8    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107067 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:107067 BioGRID:109316 HDAC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107067 BioGRID:114368 HDAC3    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:107067 BioGRID:119365 HERC5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107067 BioGRID:109544 HSPA8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107067 BioGRID:109853 INSM1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107067 BioGRID:114375 KAT2B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107067 BioGRID:111580 MAPK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107067 BioGRID:111586 MAPK11    BioGRID  PubMed Biochemical Activity 
    BioGRID:107067 BioGRID:201633 Mybl2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107067 BioGRID:114200 NCOA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107067 BioGRID:113841 NCOA3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107067 BioGRID:110833 NEUROD1    BioGRID  PubMed Affinity Capture-Western; Phenotypic Suppression 
    BioGRID:107067 BioGRID:121167 NPDC1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107067 BioGRID:247534 Oaz1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107067 BioGRID:111142 PCNA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107067 BioGRID:115688 PRMT5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107067 BioGRID:111860 RB1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Phenotypic Suppression; Reconstituted Complex 
    BioGRID:107067 BioGRID:115301 RBX1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107067 BioGRID:111913 RFC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107067 BioGRID:112391 SKP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107067 BioGRID:112550 SP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107067 BioGRID:112651 STAT3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107067 BioGRID:112735 TAF1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107067 BioGRID:112923 THRA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107067 BioGRID:112924 THRB    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107067 BioGRID:113100 TSC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107067 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107067 BioGRID:125434 UHRF2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Far Western; Reconstituted Complex 
    BioGRID:107067 BioGRID:114553 USP2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:107067 BioGRID:122532 WDR77    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107067 BioGRID:113348 XPO1    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • ATF-2 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      ATF-2 transcription factor network, organism-specific biosystem
      ATF-2 transcription factor network
    • Acute myeloid leukemia, organism-specific biosystem (from KEGG)
      Acute myeloid leukemia, organism-specific biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
    • Acute myeloid leukemia, conserved biosystem (from KEGG)
      Acute myeloid leukemia, conserved biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
    • Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Bladder cancer, organism-specific biosystem (from KEGG)
      Bladder cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • Bladder cancer, conserved biosystem (from KEGG)
      Bladder cancer, conserved biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • C-MYB transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      C-MYB transcription factor network, organism-specific biosystem
      C-MYB transcription factor network
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
      Chronic myeloid leukemia, organism-specific biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Chronic myeloid leukemia, conserved biosystem (from KEGG)
      Chronic myeloid leukemia, conserved biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Colorectal cancer, organism-specific biosystem (from KEGG)
      Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Colorectal cancer, conserved biosystem (from KEGG)
      Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Coregulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
      Coregulation of Androgen receptor activity, organism-specific biosystem
      Coregulation of Androgen receptor activity
    • Cyclin D associated events in G1, organism-specific biosystem (from REACTOME)
      Cyclin D associated events in G1, organism-specific biosystemThree D-type cyclins are essential for progression from G1 to S-phase. These D cyclins bind to and activate both CDK4 and CDK6. The formation of all possible complexes between the D-type cyclins and...
    • DNA damage response (only ATM dependent), organism-specific biosystem (from WikiPathways)
      DNA damage response (only ATM dependent), organism-specific biosystemThis is the second pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and TP53) which are connected with the first DNA damage response pathway. In...
    • E-cadherin signaling in the nascent adherens junction, organism-specific biosystem (from Pathway Interaction Database)
      E-cadherin signaling in the nascent adherens junction, organism-specific biosystem
      E-cadherin signaling in the nascent adherens junction
    • Endometrial cancer, organism-specific biosystem (from KEGG)
      Endometrial cancer, organism-specific biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
    • Endometrial cancer, conserved biosystem (from KEGG)
      Endometrial cancer, conserved biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
    • ErbB signaling pathway, organism-specific biosystem (from WikiPathways)
      ErbB signaling pathway, organism-specific biosystemThe ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with ...
    • FOXM1 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      FOXM1 transcription factor network, organism-specific biosystem
      FOXM1 transcription factor network
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • G1 Phase, organism-specific biosystem (from REACTOME)
      G1 Phase, organism-specific biosystemEarly cell cycle progression in G1 is under the control of the D-type cyclins together with Cdk4 and Cdk6. An important target for these CDKs is the Retinoblastoma (Rb) protein, which when phosphoryl...
    • G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
      G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
    • Glioma, organism-specific biosystem (from KEGG)
      Glioma, organism-specific biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • Glioma, conserved biosystem (from KEGG)
      Glioma, conserved biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Melanoma, organism-specific biosystem (from KEGG)
      Melanoma, organism-specific biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • Melanoma, conserved biosystem (from KEGG)
      Melanoma, conserved biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
      Mitotic G1-G1/S phases, organism-specific biosystem
      Mitotic G1-G1/S phases
    • Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
      Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem
      Neurotrophic factor-mediated Trk receptor signaling
    • Non-small cell lung cancer, organism-specific biosystem (from KEGG)
      Non-small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
    • Non-small cell lung cancer, conserved biosystem (from KEGG)
      Non-small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
    • Notch signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Notch signaling pathway, organism-specific biosystem
      Notch signaling pathway
    • Pancreatic cancer, organism-specific biosystem (from KEGG)
      Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pancreatic cancer, conserved biosystem (from KEGG)
      Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Presenilin action in Notch and Wnt signaling, organism-specific biosystem (from Pathway Interaction Database)
      Presenilin action in Notch and Wnt signaling, organism-specific biosystem
      Presenilin action in Notch and Wnt signaling
    • Prostate cancer, organism-specific biosystem (from KEGG)
      Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Prostate cancer, conserved biosystem (from KEGG)
      Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Regulation of Telomerase, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of Telomerase, organism-specific biosystem
      Regulation of Telomerase
    • Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem
      Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    • S Phase, organism-specific biosystem (from REACTOME)
      S Phase, organism-specific biosystemDNA synthesis occurs in the S phase, or the synthesis phase, of the cell cycle. The cell duplicates its hereditary material, and two copies of the chromosome are formed. As DNA replication continu...
    • Signaling events mediated by focal adhesion kinase, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by focal adhesion kinase, organism-specific biosystem
      Signaling events mediated by focal adhesion kinase
    • Signaling mediated by p38-gamma and p38-delta, organism-specific biosystem (from Pathway Interaction Database)
      Signaling mediated by p38-gamma and p38-delta, organism-specific biosystem
      Signaling mediated by p38-gamma and p38-delta
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • Thyroid cancer, organism-specific biosystem (from KEGG)
      Thyroid cancer, organism-specific biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
    • Thyroid cancer, conserved biosystem (from KEGG)
      Thyroid cancer, conserved biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
    • Trk receptor signaling mediated by PI3K and PLC-gamma, organism-specific biosystem (from Pathway Interaction Database)
      Trk receptor signaling mediated by PI3K and PLC-gamma, organism-specific biosystem
      Trk receptor signaling mediated by PI3K and PLC-gamma
    • Ubiquitin-dependent degradation of Cyclin D, organism-specific biosystem (from REACTOME)
      Ubiquitin-dependent degradation of Cyclin D, organism-specific biosystemCyclin D turnover is regulated by ubiquitination and proteasomal degradation which are positively regulated by cyclin D phosphorylation on threonine-286 (Diehl et al., 1997).
    • Ubiquitin-dependent degradation of Cyclin D1, organism-specific biosystem (from REACTOME)
      Ubiquitin-dependent degradation of Cyclin D1, organism-specific biosystemAfter the Cyclin D serves the role of mediating reactions by Cdk4 and Cdk6, it is shuttled to the cytoplasm and degraded in a ubiquitin-dependent manner. Whether Cdk4 and Cdk6 are truly redundant is...
    • Validated targets of C-MYC transcriptional repression, organism-specific biosystem (from Pathway Interaction Database)
      Validated targets of C-MYC transcriptional repression, organism-specific biosystem
      Validated targets of C-MYC transcriptional repression
    • Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem (from Pathway Interaction Database)
      Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem
      Validated transcriptional targets of AP1 family members Fra1 and Fra2
    • Viral myocarditis, organism-specific biosystem (from KEGG)
      Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...
    • Wnt Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
    • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluri...
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • miRNAs involved in DDR, organism-specific biosystem (from WikiPathways)
      miRNAs involved in DDR, organism-specific biosystemMicroRNA clusters involved in de DNA damage response. Genes they regulated and genes that regulate them. All genes presented in this pathway can also be found in the pathway "DNA damage response(Homo...
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cyclin-dependent protein kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    G1 phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Leydig cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    S phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    canonical Wnt receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to organic substance IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum unfolded protein response IEA
    Inferred from Electronic Annotation
    more info
    		  
    fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    lactation IEA
    Inferred from Electronic Annotation
    more info
    		  
    liver development IEA
    Inferred from Electronic Annotation
    more info
    		  
    mammary gland alveolus development IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    mitotic cell cycle G1/S transition DNA damage checkpoint IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of Wnt receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    organ regeneration IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of cyclin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of mammary gland epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    re-entry into mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to UV-A IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to X-ray IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to corticosterone stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to drug IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    response to estrogen stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to iron ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to magnesium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to organic nitrogen IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to vitamin E IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cyclin-dependent protein kinase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    intracellular IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    G1/S-specific cyclin-D1
    Names
    G1/S-specific cyclin-D1
    BCL-1 oncogene
    PRAD1 oncogene
    B-cell CLL/lymphoma 1
    G1/S-specific cyclin D1
    B-cell lymphoma 1 protein
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007375.1 RefSeqGene

      Range
      5001..18370
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_053056.2 → NP_444284.1  G1/S-specific cyclin-D1

      Status: REVIEWED

      Source sequence(s)
      AP001888, BC001501, BM796500, X59798
      Consensus CDS
      CCDS8191.1
      UniProtKB/Swiss-Prot
      P24385
      UniProtKB/TrEMBL
      Q6FI00
      Related
      ENSP00000227507, OTTHUMP00000237144, ENST00000227507, OTTHUMT00000396775
      Conserved Domains (2) summary
      cd00043
      Location:56 – 145
      Blast Score: 138
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
      cl00050
      Location:156 – 269
      Blast Score: 131
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      69455873..69469242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      65748357..65761725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF511593.2 AAM34300.2
    genomic AP001824.5 None
    genomic AP001888.4 (12951..15749) None
    genomic CH471076.1 EAW74746.1
      EAW74747.1
      EAW74748.1
    genomic L09054.1 AAA36481.1
    genomic Z29078.1 CAA82318.1
    mRNA AB075505.1 None
    mRNA AK299044.1 BAG61118.1
    mRNA AK313136.1 BAG35955.1
    mRNA AY830112.1 AAV91344.1
    mRNA BC000076.2 AAH00076.1
    mRNA BC001501.2 AAH01501.1
    mRNA BC014078.2 AAH14078.1
    mRNA BC023620.2 AAH23620.1
    mRNA BC025302.1 AAH25302.1
    mRNA BM796500.1 None
    mRNA BT019844.1 AAV38647.1
    mRNA BT019845.1 AAV38648.1
    mRNA CR536538.1 CAG38775.1
    mRNA CR542099.1 CAG46896.1
    mRNA M64349.1 AAA52136.1
    mRNA M73554.1 AAA58392.1
    mRNA M74092.1 None
    mRNA S71637.1 None
    mRNA X59798.1 CAA42470.1
    other-genetic AM393193.1 CAL38071.1
    other-genetic AM393430.1 CAL38308.1
    other-genetic AM393593.1 CAL38470.1
    other-genetic DQ891848.2 ABM82774.1
    other-genetic DQ895038.2 ABM85964.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P24385.1 GenPept UniProtKB/Swiss-Prot:P24385
    Q14092 GenPept UniProtKB/TrEMBL:Q14092
    Q5MGB2 GenPept UniProtKB/TrEMBL:Q5MGB2
    Q6FI00 GenPept UniProtKB/TrEMBL:Q6FI00
    Q9H014 GenPept UniProtKB/TrEMBL:Q9H014
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

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