LAMP1 lysosomal-associated membrane protein 1 [Homo sapiens] - Gene

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Summary

Official Symbol: LAMP1provided by HGNC
Official Full Name: lysosomal-associated membrane protein 1provided by HGNC
Primary source: HGNC:6499
See related: Ensembl:ENSG00000185896; HPRD:01076; MIM:153330; Vega:OTTHUMG00000017380
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LAMPA; CD107a; LGP120
Summary: The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 13q34

Sequence :: Chromosome: 13; NC_000013.10 (113951469..113977741)

See LAMP1 in Epigenomics, MapViewer

Chromosome 13 - NC_000013.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

nucleolin and LAMP-1 have a role in promoting infection of human monocytes by Francisella tularensis
Title: Nucleolin, a shuttle protein promoting infection of human monocytes by Francisella tularensis.
Human full-length amelogenin increases the proliferation of mesenchymal stem cells by interaction with LAMP1 through the MAPK-ERK signaling pathway.
Title: Effects of human full-length amelogenin on the proliferation of human mesenchymal stem cells derived from bone marrow.
Immunohistochemistry studies showed EGBs to exhibit pronounced reactivity to antibodies against lysosome-associated membrane proteins (LAMP)-1 and LAMP-2, and the lysosomal enzyme cathepsin D.
Title: Distribution of lysosome-associated membrane proteins-1 and -2, and cathepsin D in eosinophilic granular bodies: possible relationship to cyst development in pilocytic astrocytomas.
Data show that The cell surface expression levels of (ICAM)-2 and -3 on the apoptotic cells were markedly lower, while those of calnexin, calreticulin, and (LAMP)-1 and -2 were significantly higher compared to non-apoptotic cells.
Title: Altered expression of glycoproteins on the cell surface of Jurkat cells during etoposide-induced apoptosis: shedding and intracellular translocation of glycoproteins.
Most Hassal's corpuscules in thymoma were negative for LAMPs, but positive in normal thymus. Both lymphocytes and epithelial cells in pathological thymus showed higher intensity for LAMP-2 compared with LAMP-1.
Title: Differential expression of LAMPs and ubiquitin in human thymus.
Despite its abundance, LAMP-1 is not essential, but LAMP-2 may be partially important for the Salmonella-containing vacuolar membrane.
Title: Effects of lysosomal membrane protein depletion on the Salmonella-containing vacuole.
the activation-induced degranulation of Fas ligand has distinct requirements and involves different mechanisms than those of the granule markers CD63 and CD107a/Lamp-1
Title: Distinct requirements for activation-induced cell surface expression of preformed Fas/CD95 ligand and cytolytic granule markers in T cells.
CD107a expression may be a sensitive marker for the cytotoxic activity determination
Title: Relationship between CD107a expression and cytotoxic activity.
Data show that cells lacking either LAMP-1 or LAMP-2 alone formed phagosomes that gradually acquired microbicidal activity and curtailed bacterial growth, but LAMP-1 and LAMP-2 double-deficient cells failed to kill engulfed Neisseria gonorrhoeae.
Title: Arrested maturation of Neisseria-containing phagosomes in the absence of the lysosome-associated membrane proteins, LAMP-1 and LAMP-2.
Data identify CD13, CD107a, and CD164 as novel basophil-activation antigens.
Title: Identification of CD13, CD107a, and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-dependent upregulation.

Submit: New GeneRIF Correction See all (19)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
capsid	gag	In human macrophages, HIV-1 Capsid (p24) co-localizes with MHC II (HLA-DR), CD63, and Lamp1 in MHC II compartments	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
P11279	Q9BXS5	AP1M1	HPRD	PubMed
P11279	Q96CW1	AP2M1	HPRD	PubMed
BioGRID:110110	BioGRID:129222	SVIP	BioGRID	PubMed	Co-localization
BioGRID:110110	BioGRID:112983	TNFAIP3	BioGRID	PubMed	Co-fractionation
BioGRID:110110	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Process	Evidence Code	Pubs
autophagic cell death	IEA Inferred from Electronic Annotation more info
autophagy	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
dendrite	IEA Inferred from Electronic Annotation more info
endosome membrane	IEA Inferred from Electronic Annotation more info
external side of plasma membrane	IEA Inferred from Electronic Annotation more info
integral to plasma membrane	TAS Traceable Author Statement more info	PubMed
lamellar body	IEA Inferred from Electronic Annotation more info
late endosome	IDA Inferred from Direct Assay more info	PubMed
lysosomal membrane	IEA Inferred from Electronic Annotation more info
lysosome	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with lysosome	IDA Inferred from Direct Assay more info	PubMed
melanosome	IEA Inferred from Electronic Annotation more info
membrane fraction	TAS Traceable Author Statement more info	PubMed
multivesicular body	IEA Inferred from Electronic Annotation more info
neuronal cell body	IEA Inferred from Electronic Annotation more info
sarcolemma	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: lysosome-associated membrane glycoprotein 1

Names: lysosome-associated membrane glycoprotein 1; LAMP-1; CD107 antigen-like family member A; lysosome-associated membrane protein 1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005561.3 → NP_005552.3 lysosome-associated membrane glycoprotein 1 precursor

Status: REVIEWED

Source sequence(s)

BC025335, BU849686, DB462451

Consensus CDS

CCDS41909.1

UniProtKB/Swiss-Prot

P11279

Related

ENSP00000333298, OTTHUMP00000018748, ENST00000332556, OTTHUMT00000045876

Conserved Domains (1) summary

pfam01299
Location:111 – 417
Blast Score: 976

Lamp; Lysosome-associated membrane glycoprotein (Lamp)

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000013.10 Reference GRCh37.p5 Primary Assembly

Range

113951469..113977741

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000145.1 Alternate HuRef

Range

94390382..94416378

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL136221.38	CAI13797.1
genomic	CH471085.1	EAX09202.1
		EAX09203.1
mRNA	AB209319.1	BAD92556.1
mRNA	AK092398.1	BAG52545.1
mRNA	AK301584.1	BAG63075.1
mRNA	BC006345.2	AAH06345.2
mRNA	BC007845.2	AAH07845.2
mRNA	BC021288.2	AAH21288.1
mRNA	BC025335.1	None
mRNA	BC093044.1	AAH93044.1
mRNA	BU849686.1	None
mRNA	DB462451.1	None
mRNA	J03263.1	AAA59524.1
mRNA	J04182.1	AAA60382.1
other-genetic	DQ892614.2	ABM83540.1
other-genetic	DQ895854.2	ABM86780.1