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ATG16L2 autophagy related 16 like 2 [ Homo sapiens (human) ]

Gene ID: 89849, updated on 8-May-2016
Official Symbol
ATG16L2provided by HGNC
Official Full Name
autophagy related 16 like 2provided by HGNC
Primary source
HGNC:HGNC:25464
See related
Ensembl:ENSG00000168010 HPRD:10959; Vega:OTTHUMG00000167961
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WDR80; ATG16B
Orthologs
Location:
11q13.4
Exon count:
20
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (72814406..72842705)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (72525451..72553793)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene StAR related lipid transfer domain containing 10 Neighboring gene uncharacterized LOC105369380 Neighboring gene microRNA 4692 Neighboring gene FCH and double SH3 domains 2 Neighboring gene ribosomal protein L15 pseudogene 16 Neighboring gene uncharacterized LOC105369381

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.
NHGRI GWA Catalog
Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
High levels of additive and synergic antiretroviral activity are obtained by using antiretroviral compounds (T1249, 3TC, RAL, or IDV) in PM1 cells stably expressing anti-host shRNAs (IPO7, HSPD1, or ATG16) or anti-HIV shRNAs (Pol, RT, or Nef) PubMed
Knockdown of ATG16 autophagy related 16-like 2 (ATG16L2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef High levels of additive and synergic antiretroviral activity are obtained by using antiretroviral compounds (T1249, 3TC, RAL, or IDV) in PM1 cells stably expressing anti-host shRNAs (IPO7, HSPD1, or ATG16) or anti-HIV shRNAs (Pol, RT, or Nef) PubMed
Pol gag-pol High levels of additive and synergic antiretroviral activity are obtained by using antiretroviral compounds (T1249, 3TC, RAL, or IDV) in PM1 cells stably expressing anti-host shRNAs (IPO7, HSPD1, or ATG16) or anti-HIV shRNAs (Pol, RT, or Nef) PubMed
reverse transcriptase gag-pol High levels of additive and synergic antiretroviral activity are obtained by using antiretroviral compounds (T1249, 3TC, RAL, or IDV) in PM1 cells stably expressing anti-host shRNAs (IPO7, HSPD1, or ATG16) or anti-HIV shRNAs (Pol, RT, or Nef) PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ00012

Gene Ontology Provided by GOA

Process Evidence Code Pubs
autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
negative stranded viral RNA replication IBA
Inferred from Biological aspect of Ancestor
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
autophagosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
Preferred Names
autophagy-related protein 16-2
Names
APG16-like 2
ATG16 autophagy related 16-like 2
WD repeat-containing protein 80
autophagy related 16-like 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318766.1NP_001305695.1  autophagy-related protein 16-2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK090597, AL832974, AP002381, BC137489
    UniProtKB/Swiss-Prot
    Q8NAA4
    Conserved Domains (3) summary
    COG2319
    Location:218513
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:225513
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl21477
    Location:495
    FliJ; Flagellar FliJ protein
  2. NM_033388.1NP_203746.1  autophagy-related protein 16-2 isoform 1

    See identical proteins and their annotated locations for NP_203746.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK024423, AK090597, AL832974, BC036713, BC069189, BQ929430
    Consensus CDS
    CCDS31634.1
    UniProtKB/Swiss-Prot
    Q8NAA4
    UniProtKB/TrEMBL
    Q9H7Q5
    Related
    ENSP00000326340, OTTHUMP00000237478, ENST00000321297, OTTHUMT00000397305
    Conserved Domains (4) summary
    COG2319
    Location:324619
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:331619
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08614
    Location:14203
    ATG16; Autophagy protein 16 (ATG16)
    cl21477
    Location:110201
    FliJ; Flagellar FliJ protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    72814406..72842705
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274376.3XP_005274433.1  

    Conserved Domains (4) summary
    COG2319
    Location:324586
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:331588
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08614
    Location:14203
    ATG16; Autophagy protein 16 (ATG16)
    cl21477
    Location:110201
    FliJ; Flagellar FliJ protein
  2. XM_006718732.2XP_006718795.1  

    Conserved Domains (4) summary
    COG2319
    Location:303598
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:310598
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08614
    Location:14203
    ATG16; Autophagy protein 16 (ATG16)
    cl21477
    Location:110201
    FliJ; Flagellar FliJ protein
  3. XM_011545332.1XP_011543634.1  

    Conserved Domains (4) summary
    COG2319
    Location:286581
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:293581
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08614
    Location:14203
    ATG16; Autophagy protein 16 (ATG16)
    cl21477
    Location:110201
    FliJ; Flagellar FliJ protein
  4. XM_006718733.2XP_006718796.1  

    Conserved Domains (1) summary
    pfam08614
    Location:14203
    ATG16; Autophagy protein 16 (ATG16)
  5. XM_005274378.2XP_005274435.1  

    Conserved Domains (3) summary
    COG2319
    Location:218513
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:225513
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl21477
    Location:495
    FliJ; Flagellar FliJ protein
  6. XM_011545333.1XP_011543635.1  

    See identical proteins and their annotated locations for XP_011543635.1

    UniProtKB/Swiss-Prot
    Q8NAA4
    Conserved Domains (3) summary
    COG2319
    Location:218513
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:225513
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl21477
    Location:495
    FliJ; Flagellar FliJ protein
  7. XM_011545334.1XP_011543636.1  

    See identical proteins and their annotated locations for XP_011543636.1

    UniProtKB/Swiss-Prot
    Q8NAA4
    Conserved Domains (3) summary
    COG2319
    Location:218513
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:225513
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl21477
    Location:495
    FliJ; Flagellar FliJ protein
  8. XM_006718734.2XP_006718797.1  

    Conserved Domains (2) summary
    COG2319
    Location:64334
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:64334
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_950094.1 RNA Sequence

    Related
    ENST00000435507, OTTHUMT00000397307

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    72409218..72424444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)