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    TP53 tumor protein p53 [ Homo sapiens ]

    Gene ID: 7157, updated on 20-May-2012
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    Summary

    Official Symbol
    TP53provided by HGNC
    Official Full Name
    tumor protein p53provided by HGNC
    Primary source
    HGNC:11998
    See related
    Ensembl:ENSG00000141510; HPRD:01859; MIM:191170; Vega:OTTHUMG00000162125
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P53; LFS1; TRP53; FLJ92943
    Summary
    This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    17p13.1
    Sequence :
    Chromosome: 17; NC_000017.10 (7571720..7590863, complement)
    See TP53 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene sex hormone-binding globulin Neighboring gene spermidine/spermine N1-acetyltransferase family member 2 Neighboring gene ATPase, Na+/K+ transporting, beta 2 polypeptide Neighboring gene WD repeat containing, antisense to TP53 Neighboring gene ephrin-B3 Neighboring gene dynein, axonemal, heavy chain 2 Neighboring gene ribosomal protein L29 pseudogene 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Geranylgeranylacetone attenuates cisplatin-induced reductions in cell viability by suppressing the elevation of intracellular p53 content without heat shock protein induction. Hasegawa M, et al. Nagoya J Med Sci, 2012 Feb. PMID 22515118.
    2. CLCA2 as a p53-inducible senescence mediator. Tanikawa C, et al. Neoplasia, 2012 Feb. PMID 22431922.
    3. Mpg2 interacts and cooperates with Mpg1 to maintain yeast glycosylation. Muñoz-Centeno MC, et al. FEMS Yeast Res, 2012 Mar 14. PMID 22416758.
    4. Different mutation profiles associated to P53 accumulation in colorectal cancer. López I, et al. Gene, 2012 May 10. PMID 22373952.
    5. The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure. Adams CJ, et al. Proc Natl Acad Sci U S A, 2012 Mar 6. PMID 22362889.

    See all (5116) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The gene expressions of PCNA, c-erbB-2, and p53 gradually decreased with the increased distance from primary tumor (P < 0.05).
      Title: The expression of PCNA, c-erbB-2, p53, ER and PR as well as atypical hyperplasia in tissues nearby the breast cancer.
    2. Mutations and polymorphisms in TP53 gene are associated with colorectal cancer.
      Title: Mutations and polymorphisms in TP53 gene--an overview on the role in colorectal cancer.
    3. Regulation of Double Strand Break repair by EGFR involves both the NHEJ and HR pathway, and appears to occur in most tumor cell lines regardless of p53 and K-Ras mutation status.
      Title: In tumor cells regulation of DNA double strand break repair through EGF receptor involves both NHEJ and HR and is independent of p53 and K-Ras status.
    4. Of all the 3 single nucleotide polymorphisms evaluated, only p53 codon 248 (exon7) gene polymorphism has an implication for risk in bladder cancer in the North Indian population.
      Title: Association of p53 codon 248 (exon7) with urinary bladder cancer risk in the North Indian population.
    5. Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G(1) -modulated P53 activity.
      Title: Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G(1) -modulated P53 activity.
    6. Expression of p53 is increased in keratoacanthoma over hypertrophic lichen planus
      Title: Use of proliferation rate, p53 staining and perforating elastic fibers in distinguishing keratoacanthoma from hypertrophic lichen planus: a pilot study.
    7. miR-122 as an amplifier of the antiapoptotic Akt/p53 circuit
      Title: miR-122 regulates p53/Akt signalling and the chemotherapy-induced apoptosis in cutaneous T-cell lymphoma.
    8. The results show a possible interaction between PTPN22 and p53 codon 72 genetic polymorphisms regarding their effects on susceptibility to coronary artery disease.
      Title: Coronary artery disease: evidence of interaction between PTPN22 and p53 genetic polymorphisms.
    9. Histone deacetylase inhibitors enhance the anticancer activity of nutlin-3 and induce p53 hyperacetylation and downregulation of MDM2 and MDM4 gene expression.
      Title: Histone deacetylase inhibitors enhance the anticancer activity of nutlin-3 and induce p53 hyperacetylation and downregulation of MDM2 and MDM4 gene expression.
    10. role in ultraviolet A-induced cell death and G1 arrest in human dermal fibroblasts
      Title: Role of NF-κB-p53 crosstalk in ultraviolet A-induced cell death and G1 arrest in human dermal fibroblasts.
    Submit: New GeneRIF Correction See all (4038)
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    Phenotypes

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Adrenal cortical carcinoma

    Breast cancer

    Choroid plexus papilloma

    Colorectal cancer

    Hepatocellular carcinoma

    Li-Fraumeni-like syndrome

    Summary from GeneReviews: Go to GeneReviews

    Disease Characteristics
    Li-Fraumeni syndrome is a cancer predisposition syndrome associated with soft tissue sarcoma, osteosarcoma, pre-menopausal breast cancer, brain tumors, adrenocortical carcinoma (ACC), and a variety of other neoplasms. Two forms are recognized: classic Li-Fraumeni syndrome (LFS) and Li-Fraumeni-like (LFL) syndrome, which shares some, but not all of the features of LFS. Individuals with LFS are at increased risk of developing multiple primary cancers. Age-specific cancer risks have been calculated.
    Diagnosis Testing
    LFS is diagnosed in individuals meeting established clinical criteria. More than 70% of individuals diagnosed clinically have an identifiable disease-causing mutation in TP53, the only gene known to be associated with LFS.
    Genetic Counseling
    LFS is inherited in an autosomal dominant manner. The proportion of individuals with a de novo mutation is unknown. Offspring of an affected individual have a 50% chance of inheriting the disease-causing mutation. Predisposition testing for at-risk family members and prenatal testing for pregnancies at increased risk are possible for families in which the disease-causing mutation has been identified.
    References

    Multiple malignancy syndrome

    Nasopharyngeal carcinoma

    Osteosarcoma

    Pancreatic cancer

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env p38 MAPK-mediated p53 phosphorylation on serine 46 contributes to apoptosis induced by the HIV-1 envelope glycoprotein complex (gp120/gp41) PubMed
    env Syncytial apoptosis mediated by the fusion of cells expressing HIV-1 gp120 with cells expressing the CD4/CXCR4 receptor/coreceptor complex causes phosphorylation of p53 on serine 15 and Bax upregulation PubMed
    env HIV-1 gp120 is potentially cytotoxic to human cells through the induction of p53, which may eventually lead to induction of apoptosis PubMed
    Nef nef HIV-1 Nef binds directly to tumor suppressor protein p53; an N-terminal 57-residue fragment of Nef (Nef 1-57) contains the p53-binding domain PubMed
    nef Assays with phage-displayed Nef from HIV-1 NL4-3 have been used to identify a series of guanidine alkaloid-based inhibitors of Nef interactions with p53, actin, and p56(lck) PubMed
    Tat tat When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA PubMed
    tat Supernatants from HIV-1 Tat-transfected monocytoid cells induces p53 expression in neurons, indicating a role for Tat in the neuropathogenesis of HIV-1 PubMed
    tat HIV-1 Tat inhibits p53-responsive transcription by binding to histone acetyltransferases and repressing the acetylation of p53 on residue Lys-320, alluding to a mechanism whereby Tat may impair p53 functions, thus favoring the establishment of neoplasia PubMed
    tat HIV-1 Tat and p53 cooperate in the activation of HIV-1 gene expression in SaOS2 cells PubMed
    tat Wild-type p53 is a potent inhibitor of HIV-1 Tat transactivation of the HIV-1 LTR promoter in Jurkat T cells and Hep3B cells PubMed
    tat HIV-1 Tat downregulates the expression of p53, suggesting a mechanism for HIV-1-mediated transformation of infected cells PubMed
    tat HIV-1 Tat binds to p53, an interaction mediated by the basic region of Tat (amino acids 49-57) and the acidic O2 domain of p53 (amino acids 341-354 PubMed
    Vpr vpr HIV-1 Vpr inhibits the interaction of p53 and Rad51 in chromatin fractions, as observed under irradiation-induced DNA double-strand breaks PubMed
    vpr Activation of p21/Waf1/Cip1 by HIV-1 Vpr appears to be regulated by p53 PubMed
    vpr Results from GST pull-down assays show the association of Vpr with p53 in extracts containing Sp1, suggesting the physical interaction of Vpr with Sp1 and p53 could modulate transcriptional activity of p21 PubMed
    vpr HIV-1 Vpr can neutralize inhibitory effects of the human homologue of yeast Rad23 protein A (hHR23A) on p53, thereby activating p53 transcriptional activity PubMed
    vpr Overexpression of p53 decreases the level of activation of the viral LTR promoter by HIV-1 Vpr PubMed
    vpr HIV-1 Vpr interacts with p53 in a complex with the transcription factor Sp1 that modulates viral gene transcription from the HIV-1 LTR promoter PubMed
    reverse transcriptase gag-pol Tumor suppressor protein p53 displays 3' --> 5' exonuclease activity, and interaction of p53 with HIV-1 reverse transcriptase (RT) can provide a proofreading function for HIV-1 RT PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    CAA42633.1 NP_001179.1 BAK1    BIND  PubMed Mitochondrial p53-P72 interacts with Bak. 
    NC_000017.9 NP_001697.2 BCL6    BIND  PubMed BCL6 interacts with the p53 promoter region. 
    NP_000537.2 NP_001632.2 APEX1    BIND  PubMed p53 interacts with Ref-1. 
    NP_000537.2 NP_001665.1 ATF3    BIND  PubMed An unspecified isoform of ATF3 interacts with p53. 
    NP_000537.2 NP_000042.2 ATM    BIND  PubMed ATM phosphorylates p53 at serine 15. 
    NP_000537.2 NP_000042.2 ATM    BIND  PubMed ATM phosphorylates p53 at Ser15. 
    NP_000537.2 NP_000042.2 ATM    BIND  PubMed ATM phosphorylates p53 at serine 15. 
    NP_000537.2 ATM    BIND  PubMed An unspecified isoform of ATM interacts with and phosphorylates p53. This interaction was modeled on a demonstrated interaction between human ATM and p53 from an unspecified species. 
    NP_000537.2 NP_001175.1 ATR    BIND  PubMed ATR interacts with TP53 (p53). 
    NP_000537.2 NP_003591.2 AURKA    BIND  PubMed p53 interacts with STK15. 
    NP_000537.2 NP_001179.1 BAK1    BIND  PubMed Mitochondrial p53-R72 interacts with Bak. 
    NP_000537.2 NP_000456.1 BARD1    BIND  PubMed TP53 (p53) interacts with BARD1. 
    NP_000537.2 AY217036.1 BAX    BIND  PubMed p53 interacts with Bax. 
    NP_000537.2 NC_000019.8 BAX    BIND  PubMed p53 interacts with bax promoter. 
    NP_000537.2 U17193.1 BAX    BIND  PubMed p53 interacts with the Bax promoter. 
    NP_000537.2 NP_612815.1 BCL2L1    BIND  PubMed Bcl-xl interacts with p53. 
    NP_000537.2 NP_000048.1 BLM    BIND  PubMed BLM interacts with p53. This interaction was modeled on a demonstrated interaction between BLM and p53 both from African green monkey. 
    NP_000537.2 NP_000048.1 BLM    BIND  PubMed BLM interacts with p53. 
    NP_000537.2 NP_000048.1 BLM    BIND  PubMed p53 interacts with BLM. 
    NP_000537.2 NT_023666.17 BNIP3L    BIND  PubMed p53 interacts with Bnip3L. 
    NP_000537.2 NP_009227.1 BRCA1    BIND  PubMed BRCA1 physically associates with p53 and stimulates its transcriptional activity 
    NP_000537.2 NP_009235.1 BRCA1    BIND  PubMed BRCA1a interacts with p53. 
    NP_000537.2 NP_954592.1 CARM1    BIND  PubMed CARM1 interacts with p53. This interaction was modeled on a demonstrated interaction between mouse CARM1 and human p53. 
    NP_000537.2 AY497474.1 CDC25C    BIND  PubMed p53 interacts with the cdc25c promoter. 
    NP_000537.2 NC_000006.9 CDKN1A    BIND  PubMed p53 interacts with p21 promoter. 
    NP_000537.2 NC_000006.9 CDKN1A    BIND  PubMed p53 interacts with p21 promoter. 
    NP_000537.2 NC_000006.9 CDKN1A    BIND  PubMed p53 interacts with the p21 promoter. 
    NP_000537.2 NC_000006.9 CDKN1A    BIND  PubMed TP53 (p53) interacts with the CDKN1A (p21) promoter. 
    NP_000537.2 U24170.1 CDKN1A    BIND  PubMed p53 interacts with the p21 promoter. 
    NP_000537.2 NP_001868.2 CR2    BIND  PubMed P53 interacts with CR2. 
    NP_000537.2 NP_004371.1 CREBBP    BIND  PubMed p53 interacts with CBP. This interaction was modeled on a demonstrated interaction between human p53 and CBP from an unspecified species. 
    NP_000537.2 NP_055904.1 CUL9    BIND  PubMed Parc interacts with p53 
    NP_000537.2 NP_004387.1 DDX5    BIND  PubMed p68 interacts with p53. 
    NP_000537.2 NP_055577.1 DHCR24    BIND  PubMed Seladin-1 interacts with p53. 
    NP_000537.2 NP_001420.1 EP300    BIND  PubMed p300 interacts with p53. This interaction was modeled on a demonstrated interaction between p300 from an unspecified species and human p53. 
    NP_000537.2 NP_001420.2 EP300    BIND  PubMed p300 interacts with and acetylates p53. This interaction was modeled on a demonstrated interaction between p300 from an unspecified species and human p53. 
    NP_000537.2 NP_001420.2 EP300    BIND  PubMed p300 interacts with p53 
    NP_000537.2 NP_000113.1 ERCC3    BIND  PubMed p53 interacts with ERCC3. This interaction was modeled on a demonstrated interaction between human p53 and ERCC3 from an unspecified species. 
    NP_000537.2 NP_000116.1 ESR1    BIND  PubMed P53 interacts with ER-alpha. 
    NP_000537.2 FOXO3    BIND  PubMed Foxo3a interacts with p53. 
    NP_000537.2 NP_004480.1 GPS2    BIND  PubMed p53 interacts with AMF1 
    NP_000537.2 NP_002084.2 GSK3B    BIND  PubMed p53 interacts with GSK3-beta. 
    NP_000537.2 NP_751919.1 HCVgp1    BIND  PubMed HCV core protein interacts with p53 
    NP_000537.2 NP_751919.1 HCVgp1    BIND  PubMed Hepatitis C virus core protein interacts with human p53. 
    NP_000537.2 NP_751927.1 HCVgp1    BIND  PubMed NS5A interacts with p53. 
    NP_000537.2 NP_751927.1 HCVgp1    BIND  PubMed p53 interacts with the Hepatitis C virus protein NS5A. 
    NP_000537.2 NP_803144.1 HCVgp1    BIND  PubMed NS3 interacts with p53. 
    NP_000537.2 NP_001521.1 HIF1A    BIND  PubMed HIF-1alpha interacts with p53 
    NP_000537.2 NP_001521.1 HIF1A    BIND  PubMed p53 interacts with HIF-1 alpha. 
    NP_000537.2 NP_851397.1 HIF1A    BIND  PubMed p53 interacts with HIF-1 alpha. 
    NP_000537.2 NP_073577.2 HIPK2    BIND  PubMed HIPK2 does not interact directly with tumour suppressor protein p53 but enhances p53 activity and p53 expression or stability 
    NP_000537.2 NP_002119.1 HMGB1    BIND  PubMed p53 interacts with HMG-1. 
    NP_000537.2 HSPA8    BIND  PubMed Hsc70 interacts with p53. 
    NP_000537.2 HSPA8    BIND  PubMed p53 interacts with an unspecified isoform of Hsc70. This interaction was modeled on a demonstrated interaction between human p53 and bovine Hsc70. 
    NP_000537.2 NP_002102.2 HTT    BIND  PubMed p53 interacts with htt. This interaction was modeled on a demonstrated interaction between p53 from human and htt from an unspecified species. 
    NP_000537.2 NP_002102.3 HTT    BIND  PubMed Htt interacts with TP53(p53). 
    NP_000537.2 NP_113584.3 HUWE1    BIND  PubMed ARF-BP1 interacts with and ubiquitinates p53. 
    NP_000537.2 NP_937861.1 ING1    BIND  PubMed p53 interacts with ING1b. This interaction was modelled on a demonstrated interaction between p53 from an unspecified species and human ING1b. 
    NP_000537.2 NP_057246.2 ING4    BIND  PubMed p53 interacts with p29ING4. 
    NP_000537.2 NP_115705.2 ING5    BIND  PubMed p53 interacts with p28ING5. 
    NP_000537.2 NP_043512.1 Jvgp5    BIND  PubMed p53 interacts with JC virus large T-antigen. 
    NP_000537.2 AF527840.1 MDM2    BIND  PubMed p53 interacts with the hdm2 promoter. 
    NP_000537.2 NC_000012.9 MDM2    BIND  PubMed p53 interacts with mdm2 promoter. 
    NP_000537.2 NC_000012.9 MDM2    BIND  PubMed TP53 (p53) interacts with the MDM2-promoter. 
    NP_000537.2 NP_002383.1 MDM2    BIND  PubMed Mdm2 interacts with p53. 
    NP_000537.2 NP_002383.1 MDM2    BIND  PubMed An unspecified isoform of MDM2 interacts with and ubiquitinates p53. This interaction was modeled on a demonstrated interaction between MDM2 from an unspecified species and human p53. 
    NP_000537.2 NP_002383.1 MDM2    BIND  PubMed An unspecified isoform of Mdm2 ubiquitinates p53. This interaction was modeled on a demonstrated interaction between Mdm2 and p53 both from an unspecified species. 
    NP_000537.2 NP_002383.1 MDM2    BIND  PubMed Mdm2 ubiquitinates p53. 
    NP_000537.2 NP_002383.1 MDM2    BIND  PubMed Mdm2 interacts with p53. 
    NP_000537.2 NP_002383.1 MDM2    BIND  PubMed Mdm2 interacts with p53. 
    NP_000537.2 NP_002383.1 MDM2    BIND  PubMed Mdm2 interacts with and ubiquitinates p53 
    NP_000537.2 NP_002383.1 MDM2    BIND  PubMed Mdm2 ubiquitinates p53. This interaction was modeled on a demonstrated interaction between mouse Mdm2 and human p53. 
    NP_000537.2 NP_002383.1 MDM2    BIND  PubMed Hdm2 interacts with p53. 
    NP_000537.2 MDM2    BIND  PubMed p53 interacts with unspecified isoform of Mdm2. 
    NP_000537.2 MDM2    BIND  PubMed hdm2 interacts with p53. This interaction was modeled on a demonstrated interaction between hdm2 and p53 both from an unspecified species. 
    NP_000537.2 MDM2    BIND  PubMed p53 interacts with Mdm2. 
    NP_000537.2 MDM2    BIND  PubMed p53 interacts with mdm2. This interaction was modelled on a demonstrated interaction between human p53 and mdm2 from an unspecified species. 
    NP_000537.2 MDM2    BIND  PubMed Mdm2 interacts with and ubiquitinates p53. 
    NP_000537.2 MDM2    BIND  PubMed An unspecified isoform of HDM2 interacts with p53. This interaction was modelled on a demonstrated interaction between human HDM2 and p53 from an unspecified species. 
    NP_000537.2 MDM2    BIND  PubMed An unspecifed isoform of Mdm2 interacts with p53. 
    NP_000537.2 MDM2    BIND  PubMed MDM2 (HDM2) interacts with TP53 (p53). This interaction was modeled on a demonstrated interaction between MDM2 from an unspecified species, and human TP53. 
    NP_000537.2 MDM2    BIND  PubMed p53 interacts with Mdm2. 
    NP_000537.2 MDM2    BIND  PubMed HDM-2 interacts with p53 
    NP_000537.2 MDM2    BIND  PubMed p53 interacts with and is ubiquitinated by Mdm2. 
    NP_000537.2 MRE11A    BIND  PubMed Mre11 interacts with p53. This interaction was modeled on a demonstrated interaction between Mre11 and p53 both from African green monkey. 
    NP_000537.2 NP_002439.1 MSX1    BIND  PubMed MSX1 interacts with TP53 (p53). This interaction was modeled on a demonstrated interaction between MSX1 from an unspecified species, and human p53. 
    NP_000537.2 NP_004730.2 MTA2    BIND  PubMed PID interacts with p53. 
    NP_000537.2 NP_002447.3 MUC1    BIND  PubMed MUC1 C-ter interacts with p53. 
    NP_000537.2 NP_000167.1 NR3C1    BIND  PubMed p53 interacts with GR. This interaction was modelled on a demonstrated interaction between p53 from an unspecified species and GR from an unspecified species. 
    NP_000537.2 NP_002519.1 NTHL1    BIND  PubMed NTH1 interacts with p53. 
    NP_000537.2 NP_057250.1 PIAS1    BIND  PubMed PIAS1 interacts with p53. This interaction was modeled on a demonstrated interaction between human PIAS1 and p53 from an unspecified species. 
    NP_000537.2 NP_006654.1 PPP1R13L    BIND  PubMed iASPP interacts with p53 
    NP_000537.2 NP_002706.1 PPP2CA    BIND  PubMed p53 interacts with PPP2CA. This interaction is modeled on a demonstrated interaction between p53 from an unspecified source and human PP2AC. 
    NP_000537.2 NP_001527.2 PRMT1    BIND  PubMed PRMT1 interacts with p53. This interaction was modeled on a demonstrated interaction between rat PRMT1 and human p53. 
    NP_000537.2 NP_000954.1 PTGS2    BIND  PubMed COX-2 interacts with p53. 
    NP_000537.2 NP_004210.1 PTTG1    BIND  PubMed p53 interacts with securin. 
    NP_000537.2 NC_000008.9 RECQL4    BIND  PubMed TP53 (p53) interacts with the RECQL4 (RECQ4) promoter. 
    NP_000537.2 NP_071902.2 RFWD2    BIND  PubMed The ubiquitin ligase COP1 interacts with p53 to cause p53 degradation. 
    NP_000537.2 AF029081.1 SFN    BIND  PubMed p53 interacts with the SFN (14-3-3-sigma) promoter. 
    NP_000537.2 NT_037485.3 SFN    BIND  PubMed p53 interacts with 14-3-3-sigma promoter. 
    NP_000537.2 NP_056292.1 SIN3A    BIND  PubMed p53 interacts with mSin3A. This interaction was modeled on a demonstrated interaction between human p53 and mSin3A from an unspecified species. 
    NP_000537.2 NP_054725.1 SMG1    BIND  PubMed hSMG-1 phosphorylates p53. 
    NP_000537.2 NP_612482.2 SP1    BIND  PubMed p53 interacts with Sp1. 
    NP_000537.2 NP_612482.2 SP1    BIND  PubMed TP53 (p53) interacts with Sp1. 
    NP_000537.2 NP_612482.2 SP1    BIND  PubMed TP53 (p53) interacts with SP1. 
    NP_000537.2 NP_612482.2 SP1    BIND  PubMed p53 interacts with Sp1. 
    NP_000537.2 NP_003343.1 SUMO1    BIND  PubMed p53 interacts with SUMO-1. This interaction was modelled on a demonstrated interaction between p53 from human and SUMO-1 from an unspecified species. 
    NP_000537.2 NP_043127.1 SV40gp6    BIND  PubMed p53 interacts with SV40 large T antigen. This interaction was modelled on a demonstrated interaction between p53 from an unsepcified species and SV40 large T antigen. 
    NP_000537.2 NP_043127.1 SV40gp6    BIND  PubMed p53 interacts with SV40 large T antigen. This interaction was modelled on a demonstrated interaction between p53 from an unspecified species and Simian virus 40 large T antigen. 
    NP_000537.2 NP_003211.1 TFAP2A    BIND  PubMed p53 interacts with AP2alpha. 
    NP_000537.2 NP_003213.1 TFAP2C    BIND  PubMed p53 interacts with AP2gamma. This interaction was modelled on a demonstrated interaction between p53 from human and AP2gamma from an unspecified species. 
    NP_000537.2 NC_000008.9 TNFRSF10B    BIND  PubMed p53 interacts with DR5. 
    NP_000537.2 NC_000008.9 TNFRSF10C    BIND  PubMed TP53 (p53) interacts with TNFRSF10C (TRAIL-R3) gene. 
    NP_000537.2 NP_005793.2 TOPORS    BIND  PubMed Topors interacts with p53. This interaction was modelled on a demonstrated interaction between human Topors and mouse p53. 
    NP_000537.2 NP_000537.2 TP53    BIND  PubMed p53 interacts with itself. 
    NP_000537.2 NP_000537.2 TP53    BIND  PubMed p53 exists as a dimer in solution. 
    NP_000537.2 NP_000537.2 TP53    BIND  PubMed p53 interacts with itself to form a dimer, trimer and tetramer of p53. 
    NP_000537.2 NC_000002.9 TP53I3    BIND  PubMed p53 interacts with PIG3 promoter. 
    NP_000537.2 NP_003320.2 TXN    BIND  PubMed p53 interacts with Trx. 
    NP_000537.2 NP_003336.1 UBE2I    BIND  PubMed UBE2I interacts with TP53. This interaction was modelled on a demonstrated interaction between D. melanogaster Lwr (DmUbc9) and p53 from an unspecified species. 
    NP_000537.2 NP_003336.1 UBE2I    BIND  PubMed p53 interacts with Ubc9. This interaction was modelled on a demonstrated interaction between p53 from human and Ubc9 from an unspecified species. 
    NP_000537.2 NP_003461.1 USP7    BIND  PubMed p53 interacts with HAUSP. 
    NP_000537.2 NP_000544.1 WRN    BIND  PubMed WRN interacts with p53. 
    NP_000537.2 NP_001460.1 XRCC6    BIND  PubMed TP53 (p53) interacts with XRCC6 (Ku70). 
    NP_000537.2 NP_003394.1 YY1    BIND  PubMed YY1 interacts with p53. 
    NP_000537.2 NP_054373.1 nef    BIND  PubMed Nef interacts with p53. 
    NP_000537.2 NP_057857.2 nef    BIND  PubMed Nef interacts with p53. 
    NP_000537.2 AAB87527.2     BIND  PubMed NS5A interacts with p53. 
    NP_000537.2 AC091842.3     BIND  PubMed p53 interacts with PTTG1 promoter. 
    NP_000537.2 AF411827.1     BIND  PubMed p53 interacts with puma. 
    NP_000537.2 AP001132.4     BIND  PubMed p53 interacts with CHEK1 promoter. 
    NP_000537.2 NC_000002.9     BIND  PubMed p53 interacts with MSH2 promoter. 
    NP_000537.2 NC_000002.9     BIND  PubMed p53 interacts with MSH6 promoter. 
    NP_000537.2 NT_032977.6     BIND  PubMed p53 interacts with GADD45 p53RE, a p53 responsive element (RE) found in the GADD45 gene. 
    NP_000537.2 U24170.1     BIND  PubMed p53 interacts with the p21 promoter. 
    NP_000537.2 U24170.1     BIND  PubMed p53 interacts with p21. 
    NP_000537.2 X63571.1     BIND  PubMed p53 interacts with p53con. 
    NP_000537.2 Z85996.1     BIND  PubMed p53 interacts with the CDKN1A (p21) promoter. 
    NP_000537.2     BIND  PubMed p53 interacts with Zn2+. 
    NP_000537.2     BIND  PubMed p53 interacts with the CyclinA/Cdk2 complex. This interaction was modeled on a demonstrated interaction between human p53 and CyclinA/Cdk2 complex from an unspecified species. 
    NP_000537.2     BIND  PubMed p53 interacts with CKII. 
    NP_000537.2     BIND  PubMed p53 interacts with PID complex. 
    NP_000537.2     BIND  PubMed DNA binding domain of tumor suppressor protein p53 binds a zinc ion. 
    NP_000537.2     BIND  PubMed RITA interacts with p53. 
    NP_000537.2     BIND  PubMed SIRT1/NAD+ complex interacts with p53. This interaction was modeled on a demonstrated interaction between Thermotoga maritima SIRT1/NAD+ complex and human p53. 
    P04637 P00519 ABL1    HPRD  PubMed  
    P04637 P68133 ACTA1    HPRD  PubMed  
    P04637 Q9GZV1 ANKRD2    HPRD  PubMed  
    P04637 P12429 ANXA3    HPRD  PubMed  
    P04637 P27695 APEX1    HPRD  PubMed  
    P04637 Q99856 ARID3A    HPRD  PubMed  
    P04637 O95376 ARIH2    HPRD  PubMed  
    P04637 P36405 ARL3    HPRD  PubMed  
    P04637 P18847 ATF3    HPRD  PubMed  
    P04637 Q13315 ATM    HPRD  PubMed  
    P04637 Q13535 ATR    HPRD  PubMed  
    P04637 O14965 AURKA    HPRD  PubMed  
    P04637 Q16611 BAK1    HPRD  PubMed  
    P04637 BTG3 associated nuclear protein BANP    HPRD  PubMed  
    P04637 Q99728 BARD1    HPRD  PubMed  
    P04637 P10415 BCL2    HPRD  PubMed  
    P04637 Q07817 BCL2L1    HPRD  PubMed  
    P04637 P11274 BCR    HPRD  PubMed  
    P04637 P54132 BLM    HPRD  PubMed  
    P04637 P38398 BRCA1    HPRD  PubMed  
    P04637 P51587 BRCA2    HPRD  PubMed  
    P04637 Q92994 BRF1    HPRD  PubMed  
    P04637 Q9BX70 BTBD2    HPRD  PubMed  
    P04637 Q06187 BTK    HPRD  PubMed  
    P04637 Q8TDN4 CABLES1    HPRD  PubMed  
    P04637 Q9BTV7 CABLES2    HPRD  PubMed  
    P04637 P07384 CAPN1    HPRD  PubMed  
    P04637 Q9BWC9 CCDC106    HPRD  PubMed  
    P04637 P55774 CCL18    HPRD  PubMed  
    P04637 P20248 CCNA2    HPRD  PubMed  
    P04637 P51959 CCNG1    HPRD  PubMed  
    P04637 P51946 CCNH    HPRD  PubMed  
    P04637 P48643 CCT5    HPRD  PubMed  
    P04637 P29965 CD40LG    HPRD  PubMed  
    P04637 Q9UNH5 CDC14A    HPRD  PubMed  
    P04637 O60729 CDC14B    HPRD  PubMed  
    P04637 P30307 CDC25C    HPRD  PubMed  
    P04637 P60953 CDC42    HPRD  PubMed  
    P04637 P06493 CDK1    HPRD  PubMed  
    P04637 P24941 CDK2    HPRD  PubMed  
    P04637 Q00535 CDK5    HPRD  PubMed  
    P04637 P50750 CDK9    HPRD  PubMed  
    P04637 P42773 CDKN2C    HPRD  PubMed  
    P04637 Q03701 CEBPZ    HPRD  PubMed  
    P04637 Q12873 CHD3    HPRD  PubMed  
    P04637 O14757 CHEK1    HPRD  PubMed  
    P04637 O96017 CHEK2    HPRD  PubMed  
    P04637 O15111 CHUK    HPRD  PubMed  
    P04637 P61201 COPS2    HPRD  PubMed  
    P04637 Q9UNS2 COPS3    HPRD  PubMed  
    P04637 Q9BT78 COPS4    HPRD  PubMed  
    P04637 Q92905 COPS5    HPRD  PubMed  
    P04637 Q7L5N1 COPS6    HPRD  PubMed  
    P04637 Q9UBW8 COPS7A    HPRD  PubMed  
    P04637 Q99627 COPS8    HPRD  PubMed  
    P04637 Q14061 COX17    HPRD  PubMed  
    P04637 P20023 CR2    HPRD  PubMed  
    P04637 Q92793 CREBBP    HPRD  PubMed  
    P04637 P48729 CSNK1A1    HPRD  PubMed  
    P04637 P48730 CSNK1D    HPRD  PubMed  
    P04637 P68400 CSNK2A1    HPRD  PubMed  
    P04637 P67870 CSNK2B    HPRD  PubMed  
    P04637 Q8IWT3 CUL9    HPRD  PubMed  
    P04637 Q9UER7 DAXX    HPRD  PubMed  
    P04637 P17844 DDX5    HPRD  PubMed  
    P04637 Q15392 DHCR24    HPRD  PubMed  
    P04637 O14641 DVL2    HPRD  PubMed  
    P04637 Q01094 E2F1    HPRD  PubMed  
    P04637 E4F transcription factor 1 E4F1    HPRD  PubMed  
    P04637 P13639 EEF2    HPRD  PubMed  
    P04637 O95967 EFEMP2    HPRD  PubMed  
    P04637 P18146 EGR1    HPRD  PubMed  
    P04637 P19525 EIF2AK2    HPRD  PubMed  
    P04637 P20042 EIF2S2    HPRD  PubMed  
    P04637 P55199 ELL    HPRD  PubMed  
    P04637 Q09472 EP300    HPRD  PubMed  
    P04637 P29320 EPHA3    HPRD  PubMed  
    P04637 P19447 ERCC3    HPRD  PubMed  
    P04637 Q03468 ERCC6    HPRD  PubMed  
    P04637 P84090 ERH    HPRD  PubMed  
    P04637 P03372 ESR1    HPRD  PubMed  
    P04637 Q9BQD7 FAM173A    HPRD  PubMed  
    P04637 Q86XK2 FBXO11    HPRD  PubMed  
    P04637 Q9H0Q3 FXYD6    HPRD  PubMed  
    P04637 Q9BVP2 GNL3    HPRD  PubMed  
    P04637 Q13098 GPS1    HPRD  PubMed  
    P04637 Q13227 GPS2    HPRD  PubMed  
    P04637 P49841 GSK3B    HPRD  PubMed  
    P04637 Q03013 GSTM4    HPRD  PubMed  
    P04637 P32780 GTF2H1    HPRD  PubMed  
    P04637 Q15486 GUSBP1    HPRD  PubMed  
    P04637 Q5JVS0 HABP4    HPRD  PubMed  
    P04637 Q13547 HDAC1    HPRD  PubMed  
    P04637 Q92769 HDAC2    HPRD  PubMed  
    P04637 O15379 HDAC3    HPRD  PubMed  
    P04637 Q16665 HIF1A    HPRD  PubMed  
    P04637 Q86Z02 HIPK1    HPRD  PubMed  
    P04637 Q9H2X6 HIPK2    HPRD  PubMed  
    P04637 P09429 HMGB1    HPRD  PubMed  
    P04637 P26583 HMGB2    HPRD  PubMed  
    P04637 P41235 HNF4A    HPRD  PubMed  
    P04637 P07900 HSP90AA1    HPRD  PubMed  
    P04637 P08238 HSP90AB1    HPRD  PubMed  
    P04637 Heat shock 70 KD protein 1A HSPA1A    HPRD  PubMed  
    P04637 P38646 HSPA9    HPRD  PubMed  
    P04637 P04792 HSPB1    HPRD  PubMed  
    P04637 P42858 HTT    HPRD  PubMed  
    P04637 Q7Z6Z7 HUWE1    HPRD  PubMed  
    P04637 Q16666 IFI16    HPRD  PubMed  
    P04637 Q9UK53 ING1    HPRD  PubMed  
    P04637 Q9UNL4 ING4    HPRD  PubMed  
    P04637 Q8WYH8 ING5    HPRD  PubMed  
    P04637 Q92831 KAT2B    HPRD  PubMed  
    P04637 Q92993 KAT5    HPRD  PubMed  
    P04637 O43474 KLF4    HPRD  PubMed  
    P04637 Q99612 KLF6    HPRD  PubMed  
    P04637 P52292 KPNA2    HPRD  PubMed  
    P04637 Q14974 KPNB1    HPRD  PubMed  
    P04637 Q16363 LAMA4    HPRD  PubMed  
    P04637 Q15013 MAD2L1BP    HPRD  PubMed  
    P04637 Q96M61 MAGEB18    HPRD  PubMed  
    P04637 P28482 MAPK1    HPRD  PubMed  
    P04637 P53779 MAPK10    HPRD  PubMed  
    P04637 P27361 MAPK3    HPRD  PubMed  
    P04637 P45983 MAPK8    HPRD  PubMed  
    P04637 P45984 MAPK9    HPRD  PubMed  
    P04637 Q8IW41 MAPKAPK5    HPRD  PubMed  
    P04637 Q14676 MDC1    HPRD  PubMed  
    P04637 Q00987 MDM2    HPRD  PubMed  
    P04637 O15151 MDM4    HPRD  PubMed  
    P04637 Q15648 MED1    HPRD  PubMed  
    P04637 Q9NVC6 MED17    HPRD  PubMed  
    P04637 P14174 MIF    HPRD  PubMed  
    P04637 P51948 MNAT1    HPRD  PubMed  
    P04637 P41218 MNDA    HPRD  PubMed  
    P04637 Q99547 MPHOSPH6    HPRD  PubMed  
    P04637 P28360 MSX1    HPRD  PubMed  
    P04637 Q13330 MTA1    HPRD  PubMed  
    P04637 O94776 MTA2    HPRD  PubMed  
    P04637 P55209 NAP1L1    HPRD  PubMed  
    P04637 P19338 NCL    HPRD  PubMed  
    P04637 Q99608 NDN    HPRD  PubMed  
    P04637 Q15843 NEDD8    HPRD  PubMed  
    P04637 P25963 NFKBIA    HPRD  PubMed  
    P04637 P23511 NFYA    HPRD  PubMed  
    P04637 P25208 NFYB    HPRD  PubMed  
    P04637 P30419 NMT1    HPRD  PubMed  
    P04637 O60551 NMT2    HPRD  PubMed  
    P04637 P06748 NPM1    HPRD  PubMed  
    P04637 P15559 NQO1    HPRD  PubMed  
    P04637 P04150 NR3C1    HPRD  PubMed  
    P04637 P22736 NR4A1    HPRD  PubMed  
    P04637 Q15102 PAFAH1B3    HPRD  PubMed  
    P04637 P09874 PARP1    HPRD  PubMed  
    P04637 Q96KB5 PBK    HPRD  PubMed  
    P04637 Q9UN74 PCDHA4    HPRD  PubMed  
    P04637 P35232 PHB    HPRD  PubMed  
    P04637 O75925 PIAS1    HPRD  PubMed  
    P04637 Q8N2W9 PIAS4    HPRD  PubMed  
    P04637 Q13526 PIN1    HPRD  PubMed  
    P04637 Q9UM63 PLAGL1    HPRD  PubMed  
    P04637 P53350 PLK1    HPRD  PubMed  
    P04637 Q9H4B4 PLK3    HPRD  PubMed  
    P04637 P29590 PML    HPRD  PubMed  
    P04637 P00491 PNP    HPRD  PubMed  
    P04637 P09884 POLA1    HPRD  PubMed  
    P04637 Q15181 PPA1    HPRD  PubMed  
    P04637 P62136 PPP1CA    HPRD  PubMed  
    P04637 P36873 PPP1CC    HPRD  PubMed  
    P04637 Q8WUF5 PPP1R13L    HPRD  PubMed  
    P04637 Protein phosphatase 2A, catalytic subunit, alpha isoform PPP2CA    HPRD  PubMed  
    P04637 Q00005 PPP2R2B    HPRD  PubMed  
    P04637 P49642 PRIM1    HPRD  PubMed  
    P04637 P17252 PRKCA    HPRD  PubMed  
    P04637 P78527 PRKDC    HPRD  PubMed  
    P04637 O75569 PRKRA    HPRD  PubMed  
    P04637 Q99873 PRMT1    HPRD  PubMed  
    P04637 O00231 PSMD11    HPRD  PubMed  
    P04637 P60484 PTEN    HPRD  PubMed  
    P04637 P35354 PTGS2    HPRD  PubMed  
    P04637 Q05397 PTK2    HPRD  PubMed  
    P04637 O95997 PTTG1    HPRD  PubMed  
    P04637 P20338 RAB4A    HPRD  PubMed  
    P04637 Q06609 RAD51    HPRD  PubMed  
    P04637 Q96PM5 RCHY1    HPRD  PubMed  
    P04637 Q8NHY2 RFWD2    HPRD  PubMed  
    P04637 P27694 RPA1    HPRD  PubMed  
    P04637 P31350 RRM2    HPRD  PubMed  
    P04637 Q7LG56 RRM2B    HPRD  PubMed  
    P04637 P29034 S100A2    HPRD  PubMed  
    P04637 P26447 S100A4    HPRD  PubMed  
    P04637 P05109 S100A8    HPRD  PubMed  
    P04637 P04271 S100B    HPRD  PubMed  
    P04637 P21673 SAT1    HPRD  PubMed  
    P04637 O15126 SCAMP1    HPRD  PubMed  
    P04637 P50453 SERPINB9    HPRD  PubMed  
    P04637 Q8WTS6 SETD7    HPRD  PubMed  
    P04637 Scotin SHISA5    HPRD  PubMed  
    P04637 Q96ST3 SIN3A    HPRD  PubMed  
    P04637 Q96EB6 SIRT1    HPRD  PubMed  
    P04637 Q15796 SMAD2    HPRD  PubMed  
    P04637 P84022 SMAD3    HPRD  PubMed  
    P04637 P51532 SMARCA4    HPRD  PubMed  
    P04637 Q12824 SMARCB1    HPRD  PubMed  
    P04637 Q16637 SMN2    HPRD  PubMed  
    P04637 Q9NRG4 SMYD2    HPRD  PubMed  
    P04637 P63162 SNRPN    HPRD  PubMed  
    P04637 P08047 SP1    HPRD  PubMed  
    P04637 Q02447 SP3    HPRD  PubMed  
    P04637 P32745 SSTR3    HPRD  PubMed  
    P04637 Q15831 STK11    HPRD  PubMed  
    P04637 Q13043 STK4    HPRD  PubMed  
    P04637 Stimulated by retinoic acid 13 homolog STRA13    HPRD  PubMed  
    P04637 Q13190 STX5    HPRD  PubMed  
    P04637 P49888 SULT1E1    HPRD  PubMed  
    P04637 P63165 SUMO1    HPRD  PubMed  
    P04637 Q86TM6 SYVN1    HPRD  PubMed  
    P04637 O75528 TADA3    HPRD  PubMed  
    P04637 Q15573 TAF1A    HPRD  PubMed  
    P04637 Q53T94 TAF1B    HPRD  PubMed  
    P04637 Q15572 TAF1C    HPRD  PubMed  
    P04637 Q16594 TAF9    HPRD  PubMed  
    P04637 Q9HBM6 TAF9B    HPRD  PubMed  
    P04637 P20226 TBP    HPRD  PubMed  
    P04637 P42680 TEC    HPRD  PubMed  
    P04637 Q99973 TEP1    HPRD  PubMed  
    P04637 P05549 TFAP2A    HPRD  PubMed  
    P04637 Q92754 TFAP2C    HPRD  PubMed  
    P04637 Q14186 TFDP1    HPRD  PubMed  
    P04637 Q8NA92 THAP8    HPRD  PubMed  
    P04637 P37243 THRB    HPRD  PubMed  
    P04637 P04183 TK1    HPRD  PubMed  
    P04637 P11387 TOP1    HPRD  PubMed  
    P04637 P11388 TOP2A    HPRD  PubMed  
    P04637 Q02880 TOP2B    HPRD  PubMed  
    P04637 Q9NS56 TOPORS    HPRD  PubMed  
    P04637 P04637 TP53    HPRD  PubMed  
    P04637 Q12888 TP53BP1    HPRD  PubMed  
    P04637 Q13625 TP53BP2    HPRD  PubMed  
    P04637 Q96A56 TP53INP1    HPRD  PubMed  
    P04637 Q96S44 TP53RK    HPRD  PubMed  
    P04637 Q9H3D4 TP63    HPRD  PubMed  
    P04637 O15350 TP73    HPRD  PubMed  
    P04637 O43715 TRIAP1    HPRD  PubMed  
    P04637 Q99816 TSG101    HPRD  PubMed  
    P04637 Ubiquitin B UBB    HPRD  PubMed  
    P04637 P49459 UBE2A    HPRD  PubMed  
    P04637 P63279 UBE2I    HPRD  PubMed  
    P04637 P61086 UBE2K    HPRD  PubMed  
    P04637 Q05086 UBE3A    HPRD  PubMed  
    P04637 Q93009 USP7    HPRD  PubMed  
    P04637 Q99986 VRK1    HPRD  PubMed  
    P04637 Q9C0J8 WDR33    HPRD  PubMed  
    P04637 Q14191 WRN    HPRD  PubMed  
    P04637 P19544 WT1    HPRD  PubMed  
    P04637 Q9NZC7 WWOX    HPRD  PubMed  
    P04637 P12956 XRCC6    HPRD  PubMed  
    P04637 P67809 YBX1    HPRD  PubMed  
    P04637 P61981 YWHAG    HPRD  PubMed  
    P04637 P63104 YWHAZ    HPRD  PubMed  
    P04637 Q8TBK6 ZCCHC10    HPRD  PubMed  
    P04637 Q9UKY1 ZHX1    HPRD  PubMed  
    P04637 Q9UQR1 ZNF148    HPRD  PubMed  
    P04637 P17028 ZNF24    HPRD  PubMed  
    P04637 O43257 ZNHIT1    HPRD  PubMed  
    P04637 O43261     HPRD  PubMed  
    BioGRID:113010 BioGRID:106543 ABL1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113010 BioGRID:106640 ADH5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:122932 AGBL2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:106690 AGT    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:113684 AIMP2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113010 BioGRID:117669 ANKRD2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:106803 ANXA3    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:106807 ANXA7    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:106825 APEX1    BioGRID  PubMed Co-purification 
    BioGRID:113010 BioGRID:106847 APOH    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:120191 APTX    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:106862 AR    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:113010 BioGRID:115694 ARIH2    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:106896 ARL3    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:117368 ASF1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:129236 ASPM    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:106957 ATF3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113010 BioGRID:106962 ATM    BioGRID  PubMed Biochemical Activity; Phenotypic Enhancement; Protein-peptide; Reconstituted Complex 
    BioGRID:113010 BioGRID:107027 ATR    BioGRID  PubMed Biochemical Activity; Protein-peptide; Reconstituted Complex 
    BioGRID:113010 BioGRID:112666 AURKA    BioGRID  PubMed Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex; Two-hybrid 
    BioGRID:113010 BioGRID:114646 AURKB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:113909 AXIN1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:256680 Atm    BioGRID  PubMed Biochemical Activity 
    BioGRID:113010 BioGRID:599925 Atr    BioGRID  PubMed Biochemical Activity 
    BioGRID:113010 BioGRID:107047 BACH1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:107049 BAG1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:113010 BioGRID:121017 BAIAP2L1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:107054 BAK1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:120308 BANP    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex 
    BioGRID:113010 BioGRID:107056 BARD1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113010 BioGRID:107068 BCL2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:107070 BCL2L1    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:107083 BCR    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:107110 BLM    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid 
    BioGRID:113010 BioGRID:107117 BMP1    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:107140 BRCA1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification; Reconstituted Complex 
    BioGRID:113010 BioGRID:107142 BRCA2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:113010 BioGRID:122599 BRCC3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:113010 BioGRID:116108 BRD8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:114946 BRE    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:113010 BioGRID:109227 BRF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:120778 BTBD2    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:114457 BTRC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:207288 Banp    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:113010 BioGRID:124877 CABLES1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:123628 CABLES2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:115760 CARM1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113010 BioGRID:120867 CCAR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:118952 CCDC106    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:112265 CCL18    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:107331 CCNA2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113010 BioGRID:107340 CCNG1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:107342 CCNH    BioGRID  PubMed Affinity Capture-Western; Far Western 
    BioGRID:113010 BioGRID:116603 CCT5    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:114126 CDC14A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113010 BioGRID:114125 CDC14B    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:107433 CDC42    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:107420 CDK1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113010 BioGRID:107452 CDK2    BioGRID  PubMed Biochemical Activity 
    BioGRID:113010 BioGRID:107455 CDK5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:107457 CDK7    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113010 BioGRID:107458 CDK8    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113010 BioGRID:107459 CDK9    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:113010 BioGRID:107460 CDKN1A    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113010 BioGRID:107463 CDKN2A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:107465 CDKN2C    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:115455 CEBPZ    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:114364 CFLAR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:107532 CHD3    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:121709 CHD8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:107536 CHEK1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-localization 
    BioGRID:113010 BioGRID:116369 CHEK2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113010 BioGRID:116183 COPS5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:115374 COX17    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:107775 CREB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-localization; FRET; Phenotypic Suppression; Reconstituted Complex 
    BioGRID:113010 BioGRID:107836 CSNK1A1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:107869 CTBP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:115159 CUL7    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:116736 CUL9    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification; Reconstituted Complex 
    BioGRID:113010 BioGRID:250314 Chek2    BioGRID  PubMed Biochemical Activity 
    BioGRID:113010 BioGRID:127478 DAB2IP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:107982 DAPK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:107985 DAXX    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:108065 DHFR    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113010 BioGRID:115589 DLEU1    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:115360 DNAJB6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:108123 DNMT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:108135 DPH1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:108189 DVL2    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:108209 E4F1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113010 BioGRID:108258 EEF2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:119026 EFEMP2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113010 BioGRID:108278 EGR1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:122908 EHMT1    BioGRID  PubMed Biochemical Activity 
    BioGRID:113010 BioGRID:116123 EHMT2    BioGRID  PubMed Biochemical Activity 
    BioGRID:113010 BioGRID:111596 EIF2AK2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:113010 BioGRID:117726 EIF2C1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:118041 EIF2C2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:114411 EIF2S2    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:113828 ELL    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113010 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-fractionation; Phenotypic Suppression; Protein-peptide; Reconstituted Complex 
    BioGRID:113010 BioGRID:108356 EPHA3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113010 BioGRID:108380 ERCC2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113010 BioGRID:108383 ERCC3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:108386 ERCC6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:108390 ERH    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:108403 ESR1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113010 BioGRID:117034 ETHE1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:122439 FAM173A    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:123173 FBXO11    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:119962 FBXO42    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:113010 BioGRID:108577 FKBP3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:119799 FXYD6    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:115448 G3BP1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:115237 G3BP2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:108014 GADD45A    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:117690 GNL3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:120037 GNL3L    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:109132 GPS2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:109187 GSK3B    BioGRID  PubMed Affinity Capture-Western; Phenotypic Enhancement; Two-hybrid 
    BioGRID:113010 BioGRID:109203 GSTM4    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:109220 GTF2H1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113010 BioGRID:117104 GTPBP4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:109268 H2AFX    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:116587 HABP4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:113010 BioGRID:109316 HDAC2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113010 BioGRID:115083 HDAC9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:121581 HECW2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:109338 HIF1A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:128490 HIPK1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113010 BioGRID:118815 HIPK2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:113010 BioGRID:115420 HIPK3    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:109402 HMGA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:109389 HMGB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:109414 HNF4A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113010 BioGRID:35364 HSC82    BioGRID  PubMed Co-crystal Structure; Reconstituted Complex 
    BioGRID:113010 BioGRID:35923 HSP82    BioGRID  PubMed Co-crystal Structure; Reconstituted Complex 
    BioGRID:113010 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:109535 HSPA1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:109540 HSPA4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:109541 HSPA5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:109544 HSPA8    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:109545 HSPA9    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113010 BioGRID:109547 HSPB1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113010 BioGRID:109314 HTT    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113010 BioGRID:115385 HUWE1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:113010 BioGRID:265613 Hipk1    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:109654 IFI16    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:109701 IGF1R    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:115886 IGF2BP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:109767 IKBKB    BioGRID  PubMed Biochemical Activity 
    BioGRID:113010 BioGRID:109833 ING1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:109834 ING2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:119331 ING4    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex 
    BioGRID:113010 BioGRID:124016 ING5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:123747 ITCH    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:129744 KANSL1    BioGRID  PubMed Biochemical Activity 
    BioGRID:113010 BioGRID:108918 KAT2A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:114375 KAT2B    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113010 BioGRID:115779 KAT5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:113703 KAT6A    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:116315 KAT7    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:123914 KAT8    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:113010 BioGRID:116667 KDM1A    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:113010 BioGRID:115148 KIAA0087    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:110038 KPNA4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:110035 KPNB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:117486 L3MBTL1    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex 
    BioGRID:113010 BioGRID:110104 LAMA4    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:534783 LOC613037    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:115432 LRPPRC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:114955 MAD2L1BP    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:113688 MAFK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:110275 MAGEA2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:130398 MAGEB18    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:111580 MAPK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:111588 MAPK10    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:111581 MAPK3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:111585 MAPK8    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:113010 BioGRID:111587 MAPK9    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113010 BioGRID:115014 MDC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:110355 MDH1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:110359 MDM4    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex 
    BioGRID:113010 BioGRID:111465 MED1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:114830 MED17    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113010 BioGRID:114807 MED21    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113010 BioGRID:110384 MEN1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113010 BioGRID:110443 MLL    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113010 BioGRID:120990 MLL5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:110474 MNAT1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:115495 MPHOSPH6    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:110573 MSH2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:109211 MSH6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:120467 MSL2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:114562 MTA1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex 
    BioGRID:113010 BioGRID:114652 MTA2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:113010 BioGRID:122289 MTHFSD    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:115670 MYL9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:204966 Mapk1    BioGRID  PubMed Biochemical Activity 
    BioGRID:113010 BioGRID:201373 Mdm4    BioGRID  PubMed Biochemical Activity 
    BioGRID:113010 BioGRID:110771 NCL    BioGRID  PubMed Affinity Capture-Western; Far Western 
    BioGRID:113010 BioGRID:114973 NCOR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:110772 NDN    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113010 BioGRID:110815 NEDD8    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:110859 NFKBIA    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113010 BioGRID:110866 NFYA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:110867 NFYB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:117586 NOC2L    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:110917 NOTCH4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:110929 NPM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:113796 NPRL3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:110898 NQO2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:109165 NR3C1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:109407 NR4A1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:119670 NUB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:114202 NUMB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:120751 OTUB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:120738 OTUD5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113010 BioGRID:117111 PADI4    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:113010 BioGRID:111087 PAFAH1B3    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:106652 PARP1    BioGRID  PubMed Affinity Capture-Western; Far Western 
    BioGRID:113010 BioGRID:121084 PCDHA4    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:114682 PDLIM7    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:111264 PHB    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:113010 BioGRID:111271 PHF1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113010 BioGRID:114124 PIAS1    BioGRID  PubMed Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:113010 BioGRID:114523 PIAS2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113010 BioGRID:111317 PIN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113010 BioGRID:114690 PIWIL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:111341 PLAGL1    BioGRID  PubMed Phenotypic Enhancement; Reconstituted Complex 
    BioGRID:113010 BioGRID:107663 PLK3    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113010 BioGRID:111384 PML    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:113010 BioGRID:110921 PNP    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:111418 POLA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:111460 PPA1    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:116059 PPP1R13L    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:111523 PPP4C    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113010 BioGRID:123894 PRAM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:113575 PRDM2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:111577 PRKDC    BioGRID  PubMed Biochemical Activity; Protein-peptide 
    BioGRID:113010 BioGRID:114143 PRKRA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:111598 PRKRIR    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113010 BioGRID:109512 PRMT1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113010 BioGRID:115491 PRMT3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:111675 PSMC3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:111678 PSMC5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:111688 PSMD10    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:111689 PSMD11    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:111683 PSMD4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:115492 PSME3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:111700 PTEN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:111715 PTGS2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:111719 PTK2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:114663 PTTG1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:202265 Pml    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:111805 RAB4A    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:111823 RAD23A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:111825 RAD51    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification; Reconstituted Complex 
    BioGRID:113010 BioGRID:111843 RAP1B    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:115160 RB1CC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:111864 RBBP5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113010 BioGRID:107529 RCC1    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:117406 RCHY1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:113010 BioGRID:111913 RFC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:125593 RFFL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:122136 RFWD2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:120460 RFWD3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:121119 RNF20    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:123169 RNF34    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:127416 RNF38    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:112037 RPA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:112055 RPL11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:114752 RPL23    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:112073 RPL26    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:112045 RPL5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:112102 RPS3    BioGRID  PubMed FRET 
    BioGRID:113010 BioGRID:112115 RPS7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:112155 RRM2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:119071 RRM2B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:116997 RYBP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:112171 RYK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113010 BioGRID:112183 S100A4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113010 BioGRID:112187 S100A8    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:112193 S100B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:112210 SAT1    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:117594 SENP3    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:113010 BioGRID:117571 SERBP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:111290 SERPINB9    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:107318 SERPINH1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:118845 SETD2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:123332 SETD7    BioGRID  PubMed Biochemical Activity; Co-crystal Structure 
    BioGRID:113010 BioGRID:132490 SETD8    BioGRID  PubMed Biochemical Activity 
    BioGRID:113010 BioGRID:109072 SFN    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:117439 SIN3A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:116901 SIN3B    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113010 BioGRID:116983 SIRT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:115823 SIVA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:32469 SIZ1    BioGRID  PubMed Biochemical Activity 
    BioGRID:113010 BioGRID:112388 SKI    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:110262 SMAD2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:110263 SMAD3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:112481 SMARCA4    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex 
    BioGRID:113010 BioGRID:112482 SMARCB1    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex 
    BioGRID:113010 BioGRID:112483 SMARCC1    BioGRID  PubMed Co-fractionation 
    BioGRID:113010 BioGRID:112487 SMARCD2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:112490 SMN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113010 BioGRID:121411 SMURF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:121274 SMYD2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113010 BioGRID:112522 SNRPN    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:112542 SOX4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:112550 SP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:112553 SP3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:123158 SPSB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:112655 STAT6    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:112670 STK11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:115563 STUB1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113010 BioGRID:112680 STX5    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:112660 SULT1E1    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113010 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:112496 SUMO3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:114042 SUPT3H    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:115242 SUPT7L    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:124085 SYVN1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:203256 Sin3a    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:125555 TADA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:112734 TADA2A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:115737 TADA3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:112735 TAF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:112744 TAF10    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:114484 TAF1A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113010 BioGRID:114483 TAF1B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113010 BioGRID:114482 TAF1C    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113010 BioGRID:117998 TAF5L    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:112741 TAF6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:112743 TAF9    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:135668 TAG    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:112771 TBP    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:112855 TDG    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:112870 TEP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113010 BioGRID:112878 TFAP2A    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid 
    BioGRID:113010 BioGRID:112880 TFAP2C    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113010 BioGRID:112885 TFDP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:128269 THAP8    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:112924 THRB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:112938 TK1    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:113003 TOP1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113010 BioGRID:113006 TOP2A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:113008 TOP2B    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:115505 TOPORS    BioGRID  PubMed Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:113010 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-purification; Reconstituted Complex 
    BioGRID:113010 BioGRID:113011 TP53BP1    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Co-localization; Reconstituted Complex; Two-hybrid 
    BioGRID:113010 BioGRID:113012 TP53BP2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:113010 BioGRID:125152 TP53INP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:125211 TP53RK    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113010 BioGRID:113030 TPT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:121957 TRAPPC11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:119573 TRIAP1    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:113010 BioGRID:114333 TRIM24    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:111919 TRIM27    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:113010 BioGRID:115457 TRIM28    BioGRID  PubMed Biochemical Activity 
    BioGRID:113010 BioGRID:121918 TRMT11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:113900 TRRAP    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:113010 BioGRID:113102 TSG101    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:113123 TTK    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:113010 BioGRID:116721 TTLL5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:113146 TXN    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113010 BioGRID:202471 Tmsb4x    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:113167 UBE2A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:113177 UBE2I    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Two-hybrid 
    BioGRID:113010 BioGRID:113182 UBE2N    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:113010 BioGRID:113185 UBE3A    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:113010 BioGRID:115566 UBE4B    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-fractionation; Reconstituted Complex 
    BioGRID:113010 BioGRID:119501 UBR5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:113192 UCHL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:113200 UFD1L    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:125434 UHRF2    BioGRID  PubMed Affinity Capture-Western; Far Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:119697 UIMC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:114173 USO1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:114554 USP10    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:113010 BioGRID:113866 USP11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113010 BioGRID:121696 USP29    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:115939 USP39    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113010 BioGRID:123904 USP42    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:113010 BioGRID:113622 USP7    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Protein-peptide; Reconstituted Complex 
    BioGRID:113010 BioGRID:116026 UTP14A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:113264 VDR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:113269 VHL    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:113282 VRK1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113010 BioGRID:113283 VRK2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113010 BioGRID:120620 WDR33    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:121649 WDR48    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113010 BioGRID:116272 WDR5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113010 BioGRID:113323 WRN    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:113327 WT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:119707 WWOX    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113010 BioGRID:113349 XRCC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:108822 XRCC6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:247100 Xrcc6    BioGRID  PubMed Biochemical Activity 
    BioGRID:113010 BioGRID:110959 YBX1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:113366 YWHAZ    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:113360 YY1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:121667 ZBTB2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:119488 ZBTB7A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:120174 ZCCHC10    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:121427 ZMIZ1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113010 BioGRID:123701 ZMIZ2    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:115989 ZMYND11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:113501 ZNF148    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:113403 ZNF24    BioGRID  PubMed Two-hybrid 
    BioGRID:113010 BioGRID:127098 ZNF420    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113010 BioGRID:122868 ZNF668    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113010 BioGRID:115730 ZNHIT1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113010 BioGRID:1205539 vif    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Activation of BH3-only proteins, organism-specific biosystem (from REACTOME)
      Activation of BH3-only proteins, organism-specific biosystemThe BH3-only members act as sentinels that selectively trigger apoptosis in response to developmental cues or stress-signals like DNA damages. Widely expressed mammalian BH3-only proteins are thought...
    • Activation of NOXA and translocation to mitochondria, organism-specific biosystem (from REACTOME)
      Activation of NOXA and translocation to mitochondria, organism-specific biosystemNOXA is transactivated in a p53-dependent manner and by E2F1. Activated NOXA is translocated to mitochondria.
    • Activation of PUMA and translocation to mitochondria, organism-specific biosystem (from REACTOME)
      Activation of PUMA and translocation to mitochondria, organism-specific biosystemPuma is transactivated in a p53-dependent manner and by E2F1. Activated Puma is translocated to mitochondria.
    • Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Amyotrophic lateral sclerosis (ALS), conserved biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), conserved biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Aurora A signaling, organism-specific biosystem (from Pathway Interaction Database)
      Aurora A signaling, organism-specific biosystem
      Aurora A signaling
    • Autodegradation of the E3 ubiquitin ligase COP1, organism-specific biosystem (from REACTOME)
      Autodegradation of the E3 ubiquitin ligase COP1, organism-specific biosystemCOP1 is one of several E3 ubiquitin ligases responsible for the tight regulation of p53 abundance. Following DNA damage, COP1 dissociates from p53 and is inactivated by autodegradation via a path...
    • BARD1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      BARD1 signaling events, organism-specific biosystem
      BARD1 signaling events
    • Basal cell carcinoma, organism-specific biosystem (from KEGG)
      Basal cell carcinoma, organism-specific biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
    • Basal cell carcinoma, conserved biosystem (from KEGG)
      Basal cell carcinoma, conserved biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
    • Bladder cancer, organism-specific biosystem (from KEGG)
      Bladder cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • Bladder cancer, conserved biosystem (from KEGG)
      Bladder cancer, conserved biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
      Cell Cycle Checkpoints, organism-specific biosystemA hallmark of the human cell cycle in normal somatic cells is its precision. This remarkable fidelity is achieved by a number of signal transduction pathways, known as checkpoints, which monitor cell...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
      Chronic myeloid leukemia, organism-specific biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Chronic myeloid leukemia, conserved biosystem (from KEGG)
      Chronic myeloid leukemia, conserved biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Colorectal cancer, organism-specific biosystem (from KEGG)
      Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Colorectal cancer, conserved biosystem (from KEGG)
      Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
    • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
      Direct p53 effectors, organism-specific biosystem
      Direct p53 effectors
    • Endometrial cancer, organism-specific biosystem (from KEGG)
      Endometrial cancer, organism-specific biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
    • Endometrial cancer, conserved biosystem (from KEGG)
      Endometrial cancer, conserved biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • ErbB signaling pathway, organism-specific biosystem (from WikiPathways)
      ErbB signaling pathway, organism-specific biosystemThe ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with ...
    • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
      Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
    • Fluoropyrimidine Activity, organism-specific biosystem (from WikiPathways)
      Fluoropyrimidine Activity, organism-specific biosystemThe main mechanism of 5-FU activation is conversion to fluorodeoxyuridine monophosphate (FdUMP) which inhibits the enzyme thymidylate synthase (TYMS), an important part of the folate-homocysteine cyc...
    • G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
      G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
    • G1/S DNA Damage Checkpoints, organism-specific biosystem (from REACTOME)
      G1/S DNA Damage Checkpoints, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding ...
    • Glioma, organism-specific biosystem (from KEGG)
      Glioma, organism-specific biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • Glioma, conserved biosystem (from KEGG)
      Glioma, conserved biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • Glucocorticoid receptor regulatory network, organism-specific biosystem (from Pathway Interaction Database)
      Glucocorticoid receptor regulatory network, organism-specific biosystem
      Glucocorticoid receptor regulatory network
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Hepatitis C, organism-specific biosystem (from KEGG)
      Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Hepatitis C, conserved biosystem (from KEGG)
      Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Huntington's disease, organism-specific biosystem (from KEGG)
      Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Huntington's disease, conserved biosystem (from KEGG)
      Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, organism-specific biosystem (from Pathway Interaction Database)
      Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, organism-specific biosystem
      Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
    • Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
      Intrinsic Pathway for Apoptosis, organism-specific biosystemThe intrinsic (Bcl-2 inhibitable or mitochondrial) pathway of apoptosis functions in response to various types of intracellular stress including growth factor withdrawal, DNA damage, unfolding stress...
    • LKB1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      LKB1 signaling events, organism-specific biosystem
      LKB1 signaling events
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Melanoma, organism-specific biosystem (from KEGG)
      Melanoma, organism-specific biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • Melanoma, conserved biosystem (from KEGG)
      Melanoma, conserved biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Non-small cell lung cancer, organism-specific biosystem (from KEGG)
      Non-small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
    • Non-small cell lung cancer, conserved biosystem (from KEGG)
      Non-small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
    • PLK3 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      PLK3 signaling events, organism-specific biosystem
      PLK3 signaling events
    • Pancreatic cancer, organism-specific biosystem (from KEGG)
      Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pancreatic cancer, conserved biosystem (from KEGG)
      Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Pre-NOTCH Expression and Processing, organism-specific biosystem (from REACTOME)
      Pre-NOTCH Expression and Processing, organism-specific biosystemIn humans and other mammals the NOTCH gene family has four members, NOTCH1, NOTCH2, NOTCH3 and NOTCH4, encoded on four different chromosomes. Their transcription is developmentally regulated and tiss...
    • Pre-NOTCH Transcription and Translation, organism-specific biosystem (from REACTOME)
      Pre-NOTCH Transcription and Translation, organism-specific biosystemIn humans, the NOTCH protein family has four members: NOTCH1, NOTCH2, NOTCH3 and NOTCH4. NOTCH1 protein was identified first, as the product of a chromosome 9 gene translocated in T-cell acute lympho...
    • Prostate cancer, organism-specific biosystem (from KEGG)
      Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Prostate cancer, conserved biosystem (from KEGG)
      Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
      Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by NOTCH, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH, organism-specific biosystemThe Notch Signaling Pathway (NSP) is a highly conserved pathway for cell-cell communication. NSP is involved in the regulation of cellular differentiation, proliferation, and specification. For exam...
    • Signaling events mediated by HDAC Class III, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by HDAC Class III, organism-specific biosystem
      Signaling events mediated by HDAC Class III
    • Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem (from Pathway Interaction Database)
      Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem
      Signaling mediated by p38-alpha and p38-beta
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Stabilization of p53, organism-specific biosystem (from REACTOME)
      Stabilization of p53, organism-specific biosystemLater studies pin-pointed that a single serine (Ser-15) was phosphorylated by ATM and phosphorylation of Ser-15 was rapidly-induced in IR-treated cells and this response was ATM-dependent (Canman et ...
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • TP53 network, organism-specific biosystem (from WikiPathways)
      TP53 network, organism-specific biosystemP53 is not a lonely genome guardian, it operates with the assistance of p73 and p63 within a complex network including distinct but complementary pathways. This protein family presents a high le...
    • Thyroid cancer, organism-specific biosystem (from KEGG)
      Thyroid cancer, organism-specific biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
    • Thyroid cancer, conserved biosystem (from KEGG)
      Thyroid cancer, conserved biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
    • Transcriptional activation of cell cycle inhibitor p21, organism-specific biosystem (from REACTOME)
      Transcriptional activation of cell cycle inhibitor p21, organism-specific biosystemBoth p53-independent and p53-dependent mechanisms of induction of p21 mRNA have been demonstrated. p21 is transcriptionally activated by p53 after DNA damage (el-Deiry et al., 1993).
    • Transcriptional activation of p53 responsive genes, organism-specific biosystem (from REACTOME)
      Transcriptional activation of p53 responsive genes, organism-specific biosystemp53 causes G1 arrest by inducing the expression of a cell cycle inhibitor, p21 (El-Deiry et al, 1993; Harper et al, 1993; Xiong et al, 1993). P21 binds and inactivates Cyclin-Cdk complexes that medi...
    • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
      Transcriptional misregulation in cancer, organism-specific biosystem
      Transcriptional misregulation in cancer
    • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
      Transcriptional misregulation in cancer, conserved biosystem
      Transcriptional misregulation in cancer
    • Validated targets of C-MYC transcriptional activation, organism-specific biosystem (from Pathway Interaction Database)
      Validated targets of C-MYC transcriptional activation, organism-specific biosystem
      Validated targets of C-MYC transcriptional activation
    • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluri...
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • miRNAs involved in DDR, organism-specific biosystem (from WikiPathways)
      miRNAs involved in DDR, organism-specific biosystemMicroRNA clusters involved in de DNA damage response. Genes they regulated and genes that regulate them. All genes presented in this pathway can also be found in the pathway "DNA damage response(Homo...
    • p53 pathway, organism-specific biosystem (from Pathway Interaction Database)
      p53 pathway, organism-specific biosystem
      p53 pathway
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53-Dependent G1 DNA Damage Response, organism-specific biosystem (from REACTOME)
      p53-Dependent G1 DNA Damage Response, organism-specific biosystemMost of the damage-induced modifications of p53 are dependent on the ATM kinase. The first link between ATM and p53 was predicted based on the earlier studies that showed that AT cells exhibit a redu...
    • p53-Dependent G1/S DNA damage checkpoint, organism-specific biosystem (from REACTOME)
      p53-Dependent G1/S DNA damage checkpoint, organism-specific biosystemThe arrest at G1/S checkpoint is mediated by the action of a widely known tumor suppressor protein, p53. Loss of p53 functions, as a result of mutations in cancer prevent the G1/S checkpoint (Kuerbi...
    • p75(NTR)-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
      p75(NTR)-mediated signaling, organism-specific biosystem
      p75(NTR)-mediated signaling

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    DNA strand annealing activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    MDM2 binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    RNA polymerase II transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    chaperone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    copper ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    damaged DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    histone acetyltransferase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    histone deacetylase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    p53 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    protease binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein N-terminus binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		  
    protein phosphatase 2A binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    zinc ion binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    B cell lineage commitment IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA damage response, signal transduction by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    DNA damage response, signal transduction by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    		  
    DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
    Traceable Author Statement
    more info
    		  
    DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    DNA strand renaturation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ER overload response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Ras protein signal transduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    T cell differentiation in thymus IEA
    Inferred from Electronic Annotation
    more info
    		  
    T cell lineage commitment IEA
    Inferred from Electronic Annotation
    more info
    		  
    T cell proliferation involved in immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    base-excision repair TAS
    Traceable Author Statement
    more info
    		 PubMed 
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    cell aging IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell cycle arrest IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell cycle arrest IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell cycle checkpoint TAS
    Traceable Author Statement
    more info
    		  
    cell differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cell proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cellular protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cellular response to UV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    cellular response to drug IEP
    Inferred from Expression Pattern
    more info
    		  
    cellular response to glucose starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		  
    cellular response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    		  
    central nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    chromosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    determination of adult lifespan ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    double-strand break repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    embryo development ending in birth or egg hatching IEA
    Inferred from Electronic Annotation
    more info
    		  
    gastrulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    induction of apoptosis by intracellular signals TAS
    Traceable Author Statement
    more info
    		 PubMed 
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitotic cell cycle G1/S transition DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    multicellular organismal development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of helicase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of neuroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of transcription from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    negative regulation of transcription, DNA-dependent ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    negative regulation of transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    oxidative stress-induced premature senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of cell aging IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of cell cycle arrest IMP
    Inferred from Mutant Phenotype
    more info
    		  
    positive regulation of histone deacetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    positive regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of neuron apoptosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    positive regulation of peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    positive regulation of protein oligomerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		  
    positive regulation of release of cytochrome c from mitochondria IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of thymocyte apoptosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    positive regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription, DNA-dependent IMP
    Inferred from Mutant Phenotype
    more info
    		  
    protein complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein import into nucleus, translocation IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein tetramerization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    rRNA transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of mitochondrial membrane permeability TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    replicative senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to X-ray IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    response to antibiotic IEP
    Inferred from Expression Pattern
    more info
    		  
    response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    response to salt stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transduction by p53 class mediator resulting in induction of apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    somitogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    PML body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    chromatin assembly complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    insoluble fraction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with nuclear body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nuclear matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    replication fork IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with transcription factor TFIID complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    cellular tumor antigen p53
    Names
    cellular tumor antigen p53
    antigen NY-CO-13
    mutant p53 protein
    phosphoprotein p53
    p53 tumor suppressor
    truncated p53 protein
    tumor suppressor TP53
    transformation-related protein 53
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_017013.2 RefSeqGene

      Range
      5001..24149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000546.5 → NP_000537.3  cellular tumor antigen p53 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Both variants 1 and 2 encode isoform a.
      Source sequence(s)
      AK223026, DA453049, DQ186650, X02469
      Consensus CDS
      CCDS11118.1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Related
      ENSP00000269305, OTTHUMP00000221333, ENST00000269305, OTTHUMT00000367397
      Conserved Domains (3) summary
      pfam07710
      Location:319 – 359
      Blast Score: 185
      P53_tetramer; P53 tetramerisation motif
      pfam08563
      Location:5 – 29
      Blast Score: 104
      P53_TAD; P53 transactivation motif
      cd08367
      Location:109 – 288
      Blast Score: 720
      P53; P53 DNA-binding domain

    2. NM_001126112.2 → NP_001119584.1  cellular tumor antigen p53 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AB082923, AK223026, DA453049, DQ186650, X02469
      Consensus CDS
      CCDS11118.1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Related
      ENSP00000391478, OTTHUMP00000221334, ENST00000445888, OTTHUMT00000367398
      Conserved Domains (3) summary
      pfam07710
      Location:319 – 359
      Blast Score: 185
      P53_tetramer; P53 tetramerisation motif
      pfam08563
      Location:5 – 29
      Blast Score: 104
      P53_TAD; P53 transactivation motif
      cd08367
      Location:109 – 288
      Blast Score: 720
      P53; P53 DNA-binding domain

    3. NM_001126113.2 → NP_001119585.1  cellular tumor antigen p53 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an additional exon in the 3' region, resulting in an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c, also known as p53gamma) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK223026, DA453049, DQ186649, DQ186650
      Consensus CDS
      CCDS45605.1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Related
      ENSP00000398846, OTTHUMP00000221336, ENST00000455263, OTTHUMT00000367400
      Conserved Domains (2) summary
      pfam08563
      Location:5 – 29
      Blast Score: 101
      P53_TAD; P53 transactivation motif
      cd08367
      Location:109 – 288
      Blast Score: 715
      P53; P53 DNA-binding domain

    4. NM_001126114.2 → NP_001119586.1  cellular tumor antigen p53 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an additional exon in the 3' region, resulting in an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b, also known as p53beta) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK223026, DA453049, DQ186648, DQ186649, DQ186650
      Consensus CDS
      CCDS45606.1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Related
      ENSP00000391127, OTTHUMP00000221337, ENST00000420246, OTTHUMT00000367401
      Conserved Domains (2) summary
      pfam08563
      Location:5 – 29
      Blast Score: 101
      P53_TAD; P53 transactivation motif
      cd08367
      Location:109 – 288
      Blast Score: 713
      P53; P53 DNA-binding domain

    5. NM_001126115.1 → NP_001119587.1  cellular tumor antigen p53 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate internal promoter, lacks a few 5' exons but has an alternate 5' exon, differs in the 5' UTR, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (d, also known as delta133p53) is shorter at the N-terminus, compared to isoform a. This variant is supported by data in PMID:16131611.
      Source sequence(s)
      AC087388, AK223026, DQ186650
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Related
      ENSP00000425104, OTTHUMP00000221340, ENST00000509690, OTTHUMT00000367411
      Conserved Domains (2) summary
      pfam07710
      Location:187 – 227
      Blast Score: 182
      P53_tetramer; P53 tetramerisation motif
      cd08367
      Location:1 – 156
      Blast Score: 611
      P53; P53 DNA-binding domain

    6. NM_001126116.1 → NP_001119588.1  cellular tumor antigen p53 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate internal promoter, lacks a few 5' exons but has an alternate 5' exon, differs in the 5' UTR, uses a downstream in-frame start codon, and includes an alternate exon in the 3' region resulting in an alternate 3' coding region, compared to variant 1. The encoded isoform (e, also known as delta133p53beta) is shorter at the N-terminus and has a shorter and distinct C-terminus, compared to isoform a. This variant is supported by data in PMID:16131611.
      Source sequence(s)
      AC087388, AK223026, DQ186651
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Conserved Domains (1) summary
      cd08367
      Location:1 – 156
      Blast Score: 598
      P53; P53 DNA-binding domain

    7. NM_001126117.1 → NP_001119589.1  cellular tumor antigen p53 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses an alternate internal promoter, lacks a few 5' exons but has an alternate 5' exon, differs in the 5' UTR, uses a downstream in-frame start codon, and includes an alternate exon in the 3' region resulting in an alternate 3' coding region, compared to variant 1. The encoded isoform (f, also known as delta133p53gamma) is shorter at the N-terminus and has a shorter and distinct C-terminus, compared to isoform a. This variant is supported by data in PMID:16131611.
      Source sequence(s)
      AC087388, AK223026, DQ186652
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Conserved Domains (1) summary
      cd08367
      Location:1 – 156
      Blast Score: 602
      P53; P53 DNA-binding domain

    8. NM_001126118.1 → NP_001119590.1  cellular tumor antigen p53 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8, also known as p53I2) retains an intron in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (g, also known as delta40p53 or deltaNp53) is shorter at the N-terminus, compared to isoform a. This variant is supported by data in PMID:21112961.
      Source sequence(s)
      AK223026, DA453049, DC347346, DQ186650, DQ191317, X60016
      UniProtKB/TrEMBL
      H2EHT1
      UniProtKB/Swiss-Prot
      P04637
      UniProtKB/TrEMBL
      Q53GA5
      Conserved Domains (2) summary
      pfam07710
      Location:280 – 320
      Blast Score: 186
      P53_tetramer; P53 tetramerisation motif
      cd08367
      Location:70 – 249
      Blast Score: 716
      P53; P53 DNA-binding domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      7571720..7590863, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      7465169..7484278, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AB118156.1 BAD11806.1
    genomic AC007421.13 (3..3750) None
    genomic AC087388.9 (79616..79782) None
    genomic AF135121.1 AAD28535.1
    genomic AF136271.1 AAD28628.1
    genomic AF209128.1 AAF36354.1
    genomic AF209129.1 AAF36355.1
    genomic AF209130.1 AAF36356.1
    genomic AF209131.1 AAF36357.1
    genomic AF209132.1 AAF36358.1
    genomic AF209133.1 AAF36359.1
    genomic AF209134.1 AAF36360.1
    genomic AF209135.1 AAF36361.1
    genomic AF209136.1 AAF36362.1
    genomic AF209148.1 AAF36374.1
    genomic AF209149.1 AAF36375.1
    genomic AF209150.1 AAF36376.1
    genomic AF209151.1 AAF36377.1
    genomic AF209152.1 AAF36378.1
    genomic AF209153.1 AAF36379.1
    genomic AF209154.1 AAF36380.1
    genomic AF209155.1 AAF36381.1
    genomic AF209156.1 AAF36382.1
    genomic AF210309.1 AAF63442.1
    genomic AF210310.1 AAF63443.1
    genomic AF240684.1 AAK76358.1
    genomic AF240685.1 AAK76359.1
    genomic AY270155.1 AAP30003.1
    genomic AY359814.1 AAR13239.1
    genomic AY390341.1 AAQ90158.1
    genomic AY838896.1 AAV80424.1
    genomic CH471108.2 EAW90140.1
      EAW90141.1
      EAW90142.1
      EAW90143.1
      EAW90144.1
      EAW90145.1
    genomic DQ075362.1 AAZ05887.1
    genomic DQ485151.1 ABF61799.1
    genomic DQ486036.1 ABF51616.1
    genomic DQ486038.1 ABF51617.1
    genomic DQ486039.1 ABF51618.1
    genomic DQ486040.1 ABF51619.1
    genomic DQ812984.1 ABG67755.1
    genomic M13121.1 AAA59987.1
    genomic M22881.1 None
    genomic M22898.1 AAA59988.1
    genomic U63714.1 AAB39322.1
    genomic U94788.1 AAC12971.1
    genomic X54156.1 CAA38095.1
    mRNA AB082923.1 BAC16799.1
    mRNA AF052180.1 None
    mRNA AF307851.1 AAG28785.1
    mRNA AK223026.1 BAD96746.1
    mRNA AK225838.1 None
    mRNA AK297462.1 BAG59884.1
    mRNA AK297927.1 BAG60244.1
    mRNA AK303277.1 BAG64357.1
    mRNA AK312568.1 BAG35463.1
    mRNA AM076970.1 CAJ28922.1
    mRNA AM076971.1 CAJ28924.1
    mRNA AM076972.1 CAJ28923.1
    mRNA AU131823.1 None
    mRNA AY429684.1 AAR10356.1
    mRNA AY627884.1 AAT40418.1
    mRNA BC003596.1 AAH03596.1
    mRNA BT019622.1 AAV38428.1
    mRNA DA308036.1 None
    mRNA DA453049.1 None
    mRNA DA932053.1 None
    mRNA DC347346.1 None
    mRNA DQ186648.1 ABA29753.1
    mRNA DQ186649.1 ABA29754.1
    mRNA DQ186650.1 ABA29755.1
    mRNA DQ186651.1 ABA29756.1
    mRNA DQ186652.1 ABA29757.1
    mRNA DQ191317.1 ABB80262.1
    mRNA DQ263704.1 ABB72446.1
    mRNA DQ286964.1 ABB80266.1
    mRNA DQ401704.1 ABD62752.1
    mRNA DQ485152.1 ABF61800.1
    mRNA DQ648883.1 None
    mRNA DQ648884.1 ABG49480.1
    mRNA DQ648885.1 ABG49481.1
    mRNA DQ648886.1 None
    mRNA DQ648887.1 ABG49482.1
    mRNA EF101867.1 ABL09846.1
    mRNA EF101868.1 ABL09847.1
    mRNA EF101869.1 ABL09848.1
    mRNA FJ207420.1 ACI25593.1
    mRNA JN601513.1 AEY81366.1
    mRNA JN601514.1 AEY81367.1
    mRNA JN601515.1 AEY81368.1
    mRNA JN601516.1 AEY81369.1
    mRNA JN900492.1 AEX20383.1
    mRNA JQ026207.1 None
    mRNA JQ026208.1 None
    mRNA JQ026209.1 None
    mRNA JQ026210.1 None
    mRNA M14694.1 AAA61211.1
    mRNA M14695.1 AAA61212.1
    mRNA X01405.1 CAA25652.1
    mRNA X02469.1 CAA26306.1
    mRNA X60010.1 CAA42625.1
    mRNA X60011.1 CAA42626.1
    mRNA X60012.1 CAA42627.1
    mRNA X60013.1 CAA42628.1
    mRNA X60014.1 CAA42629.1
    mRNA X60015.1 CAA42630.1
    mRNA X60016.1 CAA42631.1
    mRNA X60017.1 CAA42632.1
    mRNA X60018.1 CAA42633.1
    mRNA X60019.1 CAA42634.1
    mRNA X60020.1 CAA42635.1
    other-genetic DQ892492.2 ABM83418.1
    other-genetic DQ895704.2 ABM86630.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04637.4 GenPept UniProtKB/Swiss-Prot:P04637
    Q0PKT5 GenPept UniProtKB/TrEMBL:Q0PKT5
    Q0ZAJ9 GenPept UniProtKB/TrEMBL:Q0ZAJ9
    Q0ZAK0 GenPept UniProtKB/TrEMBL:Q0ZAK0
    Q0ZAK1 GenPept UniProtKB/TrEMBL:Q0ZAK1
    Q19RW5 GenPept UniProtKB/TrEMBL:Q19RW5
    Q19RW6 GenPept UniProtKB/TrEMBL:Q19RW6
    Q1HGV0 GenPept UniProtKB/TrEMBL:Q1HGV0
    Q1HGV1 GenPept UniProtKB/TrEMBL:Q1HGV1
    Q1HGV2 GenPept UniProtKB/TrEMBL:Q1HGV2
    Q1HGV3 GenPept UniProtKB/TrEMBL:Q1HGV3
    Q1MSW8 GenPept UniProtKB/TrEMBL:Q1MSW8
    Q1MSW9 GenPept UniProtKB/TrEMBL:Q1MSW9
    Q1MSX0 GenPept UniProtKB/TrEMBL:Q1MSX0
    Q27HK5 GenPept UniProtKB/TrEMBL:Q27HK5
    Q2XSC7 GenPept UniProtKB/TrEMBL:Q2XSC7
    Q4FEW1 GenPept UniProtKB/TrEMBL:Q4FEW1
    Q53GA5 GenPept UniProtKB/TrEMBL:Q53GA5
    Q5U0E4 GenPept UniProtKB/TrEMBL:Q5U0E4
    Q6IT77 GenPept UniProtKB/TrEMBL:Q6IT77
    Q761V2 GenPept UniProtKB/TrEMBL:Q761V2
    Help top of page

    Additional Links

    Additional Links

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