SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: SLC9A2provided by HGNC
Official Full Name: solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2provided by HGNC
Primary source: HGNC:11072
See related: Ensembl:ENSG00000115616; HPRD:02756; MIM:600530; Vega:OTTHUMG00000130778
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NHE2

Help top of page

Genomic context

Location :: 2q11.2

Sequence :: Chromosome: 2; NC_000002.11 (103236166..103327809)

See SLC9A2 in Epigenomics, MapViewer

Chromosome 2 - NC_000002.11 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Phosphorylation of nPKC-delta results in activation of ERK1/2 kinase and subsequent induction of Egr-1. Subsequently, Egr-1 directly targets NHE2 promoter and promotes NHE2 transcriptional upregulation by interaction with NHE2-PMA response element.
Title: PKCδ-dependent activation of ERK1/2 leads to upregulation of the human NHE2 transcriptional activity in intestinal epithelial cell line C2BBe1.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
The functional and molecular expression of NHEs in cultured human endolymphatic sac (ES) epithelial cells was determined and the effect of IFN-gamma on NHE function, was examined.
Title: Interferon-gamma suppresses Na+ -H+ exchanger in cultured human endolymphatic sac epithelial cells.
Report morphological adaptation with preserved proliferation/NHE2 content in the colon of patients with short bowel syndrome.
Title: Morphological adaptation with preserved proliferation/transporter content in the colon of patients with short bowel syndrome.
Functional coupling of the downregulated in adenoma Cl-/base exchanger DRA and the apical Na+/H+ exchangers NHE2 and NHE3 in intestinal epithelial cells.
Title: Functional coupling of the downregulated in adenoma Cl-/base exchanger DRA and the apical Na+/H+ exchangers NHE2 and NHE3.
T84 human colon cells contain three isoforms of the Na+/H+ exchanger, NHE1, NHE2, and NHE4, but not the Cl-dependent NHE
Title: NHE1, NHE2, and NHE4 contribute to regulation of cell pH in T84 colon cancer cells.
No mutation was found in the coding regions and intron-exon boundaries of the genes for CA II, CA IV, CA XIV, kNCB1, NHE3, NHE8, NHRF1, NHRF2 and SLC26A6 amplified from genomic DNA of family members with pRTA.
Title: Familial pure proximal renal tubular acidosis--a clinical and genetic study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Extensive genetic analysis of 10 candidate genes for hypertension in Japanese.
expression of the human NHE2 promoter is controlled by Sp1 and Sp3 by interactions with the proximal promoter and the transcription initiation site of NHE2
Title: Sp1 and Sp3 control constitutive expression of the human NHE2 promoter by interactions with the proximal promoter and the transcription initiation site.
In humans, NHE2 transcripts appear to be gestationally regulated, which may contribute to changes in NHE activity.
Title: Gestational profile of Na+/H+ exchanger and Cl-/HCO3- anion exchanger mRNA expression in placenta using real-time QPCR.

Submit: New GeneRIF Correction

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
Q9UBY0	P00519	ABL1	HPRD	PubMed
Q9UBY0	Q99653	CHP	HPRD	PubMed
Q9UBY0	P27986	PIK3R1	HPRD	PubMed
Q9UBY0	P20936	RASA1	HPRD	PubMed
Q9UBY0	Q9UBY0	SLC9A2	HPRD	PubMed
Q9UBY0	P02549	SPTA1	HPRD	PubMed
Q9UBY0	Q13813	SPTAN1	HPRD	PubMed
Q9UBY0	P12931	SRC	HPRD	PubMed
BioGRID:112439	BioGRID:106543	ABL1	BioGRID	PubMed	Reconstituted Complex
BioGRID:112439	BioGRID:116421	CHP	BioGRID	PubMed	Reconstituted Complex
BioGRID:112439	BioGRID:121996	CHP2	BioGRID	PubMed	Reconstituted Complex
BioGRID:112439	BioGRID:111856	RASA1	BioGRID	PubMed	Reconstituted Complex
BioGRID:112439	BioGRID:112586	SPTA1	BioGRID	PubMed	Reconstituted Complex
BioGRID:112439	BioGRID:112592	SRC	BioGRID	PubMed	Reconstituted Complex
BioGRID:112439	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
antiporter activity	IEA Inferred from Electronic Annotation more info
sodium:hydrogen antiporter activity	IEA Inferred from Electronic Annotation more info
solute:hydrogen antiporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
cation transport	IEA Inferred from Electronic Annotation more info
ion transport	TAS Traceable Author Statement more info
protein localization	IEA Inferred from Electronic Annotation more info
proton transport	IEA Inferred from Electronic Annotation more info
regulation of pH	IEA Inferred from Electronic Annotation more info
sodium ion export	IEA Inferred from Electronic Annotation more info
sodium ion transport	IEA Inferred from Electronic Annotation more info
transmembrane transport	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
integral to membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	TAS Traceable Author Statement more info

General protein information

Preferred Names: sodium/hydrogen exchanger 2

Names: sodium/hydrogen exchanger 2; NHE-2; Na(+)/H(+) exchanger 2; solute carrier family 9 member 2; solute carrier family 9 (sodium/hydrogen exchanger), member 2; solute carrier family 9 (sodium/hydrogen exchanger), isoform 2

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003048.3 → NP_003039.2 sodium/hydrogen exchanger 2 precursor

Status: VALIDATED

Source sequence(s)

AA843986, AF073299, AK129936, BC035787

Consensus CDS

CCDS2062.1

UniProtKB/Swiss-Prot

Q9UBY0

Related

ENSP00000233969, OTTHUMP00000161338, ENST00000233969, OTTHUMT00000253292

Conserved Domains (1) summary

TIGR00840
Location:74 – 630
Blast Score: 1803

b_cpa1; sodium/hydrogen exchanger 3

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000002.11 Reference GRCh37.p5 Primary Assembly

Range

103236166..103327809

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000134.1 Alternate HuRef

Range

97000460..97092035

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC007239.3	AAF19248.1
genomic	CH471127.2	EAX01788.1
		EAX01789.1
mRNA	AA843986.1	None
mRNA	AF073299.1	AAD41635.1
mRNA	AK129936.1	None
mRNA	BC035787.1	None
mRNA	BC136377.1	AAI36378.1
mRNA	BC136378.1	AAI36379.1
mRNA	S83549.1	AAB50820.1