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TNIP1 TNFAIP3 interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 10318, updated on 26-Nov-2014
Official Symbol
TNIP1provided by HGNC
Official Full Name
TNFAIP3 interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:16903
See related
Ensembl:ENSG00000145901; HPRD:09216; MIM:607714; Vega:OTTHUMG00000163722
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VAN; NAF1; ABIN-1; nip40-1
Summary
This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
See TNIP1 in Epigenomics, MapViewer
Location:
5q32-q33.1
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 5 NC_000005.10 (151029943..151087660, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (150409504..150467221, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 35 pseudogene Neighboring gene glutathione peroxidase 3 (plasma) Neighboring gene annexin A6 Neighboring gene coiled-coil domain containing 69

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
NHGRI GWA Catalog
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
NHGRI GWA Catalog
Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.
NHGRI GWA Catalog
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
NHGRI GWA Catalog
Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Nef nef Nef-associated factor 1 (Naf1) binds to HIV-1 Nef through amino acids 94-412 of Naf1; overexpression of Naf1 in 293T cells increases CD4 expression, and Nef suppresses this activity of Naf1 to downregulate CD4 PubMed
matrix gag VAN is efficiently incorporated into HIV-1 virions, presumably as a result of binding to HIV-1 Matrix PubMed
gag The C-terminus (amino acids 468-637) of virion-associated matrix-interacting protein (VAN) binds to HIV-1 Matrix and has been proposed to play a role in the nuclear import of the HIV-1 preintegration complex PubMed

Go to the HIV-1, Human Interaction Database

  • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
  • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0113

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mitogen-activated protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ubiquitin-specific protease activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
MyD88-dependent toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
defense response TAS
Traceable Author Statement
more info
PubMed 
glycoprotein biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of viral genome replication TAS
Traceable Author Statement
more info
PubMed 
positive regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
translation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
intracellular TAS
Traceable Author Statement
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
TNFAIP3-interacting protein 1
Names
TNFAIP3-interacting protein 1
Nef-associated factor 1 SNP
HIV-1 Nef-interacting protein
virion-associated nuclear shuttling protein
A20-binding inhibitor of NF-kappa-B activation 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030590.1 

    Range
    5001..62718
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001252385.1NP_001239314.1  TNFAIP3-interacting protein 1 isoform 1

    See proteins identical to NP_001239314.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AB252973, AK074400, AK303573, AW589284, DC374977
    Consensus CDS
    CCDS75359.1
    UniProtKB/TrEMBL
    B7Z8K2
    UniProtKB/Swiss-Prot
    Q15025
    Related
    ENSP00000374029, ENST00000389378
    Conserved Domains (4) summary
    cd09803
    Location:452500
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam15058
    Location:26149
    Speriolin_N; Speriolin N terminus
    cl19113
    Location:298431
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
    cl19252
    Location:214251
    MreC; rod shape-determining protein MreC
  2. NM_001252386.1NP_001239315.1  TNFAIP3-interacting protein 1 isoform 2

    See proteins identical to NP_001239315.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains multiple differences in the coding region, compared to variant 1, one of which is the use of a downstream start codon. Isoform 2 has a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB252975, AK074400, AW589284, BX640647, DC374977
    Consensus CDS
    CCDS58982.1
    UniProtKB/Swiss-Prot
    Q15025
    Related
    ENSP00000429891, OTTHUMP00000224610, ENST00000520931, OTTHUMT00000374909
    Conserved Domains (4) summary
    cd09803
    Location:399447
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam13863
    Location:253373
    DUF4200; Domain of unknown function (DUF4200)
    cl19113
    Location:245378
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
    cl19252
    Location:161198
    MreC; rod shape-determining protein MreC
  3. NM_001252390.1NP_001239319.1  TNFAIP3-interacting protein 1 isoform 3

    See proteins identical to NP_001239319.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (3) is longer and contains a distinct C-terminus, compared to isoform 1. Variants 3, 4, 5 and 8 encode the same protein (isoform 3).
    Source sequence(s)
    AB252970, AC008641, AK074400, AK290999, AW589284
    Consensus CDS
    CCDS34280.1
    UniProtKB/TrEMBL
    A8K4N4
    UniProtKB/Swiss-Prot
    Q15025
    Related
    ENSP00000428187, OTTHUMP00000224613, ENST00000522226, OTTHUMT00000374912
    Conserved Domains (5) summary
    cd09803
    Location:452500
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam13863
    Location:306426
    DUF4200; Domain of unknown function (DUF4200)
    pfam15058
    Location:26149
    Speriolin_N; Speriolin N terminus
    cl19113
    Location:298431
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
    cl19252
    Location:214251
    MreC; rod shape-determining protein MreC
  4. NM_001252391.1NP_001239320.1  TNFAIP3-interacting protein 1 isoform 3

    See proteins identical to NP_001239320.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (3) is longer and contains a distinct C-terminus, compared to isoform 1. Variants 3, 4, 5 and 8 encode the same protein (isoform 3).
    Source sequence(s)
    AB252970, AK074400, AW589284, DA643531
    Consensus CDS
    CCDS34280.1
    UniProtKB/Swiss-Prot
    Q15025
    Related
    ENSP00000317891, OTTHUMP00000224611, ENST00000315050, OTTHUMT00000374910
    Conserved Domains (5) summary
    cd09803
    Location:452500
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam13863
    Location:306426
    DUF4200; Domain of unknown function (DUF4200)
    pfam15058
    Location:26149
    Speriolin_N; Speriolin N terminus
    cl19113
    Location:298431
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
    cl19252
    Location:214251
    MreC; rod shape-determining protein MreC
  5. NM_001252392.1NP_001239321.1  TNFAIP3-interacting protein 1 isoform 4

    See proteins identical to NP_001239321.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses two alternate splice sites in the 3' coding region, compared to variant 1. The resulting isoform (4) is longer and contains a distinct C-terminus, compared to isoform 1. Variants 6 and 7 encode the same protein (isoform 4).
    Source sequence(s)
    AB252971, AK074400, AW589284, DA643531
    Consensus CDS
    CCDS58985.1
    UniProtKB/Swiss-Prot
    Q15025
    Related
    ENSP00000428243, OTTHUMP00000224612, ENST00000523338, OTTHUMT00000374911
    Conserved Domains (5) summary
    cd09803
    Location:452500
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam13863
    Location:306426
    DUF4200; Domain of unknown function (DUF4200)
    pfam15058
    Location:26149
    Speriolin_N; Speriolin N terminus
    cl19113
    Location:298431
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
    cl19252
    Location:214251
    MreC; rod shape-determining protein MreC
  6. NM_001252393.1NP_001239322.1  TNFAIP3-interacting protein 1 isoform 4

    See proteins identical to NP_001239322.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses two alternate splice sites in the 3' coding region, compared to variant 1. The resulting isoform (4) is longer and contains a distinct C-terminus, compared to isoform 1. Variants 6 and 7 encode the same protein (isoform 4).
    Source sequence(s)
    AB252973, AK074400, AW589284, DC374977
    Consensus CDS
    CCDS58985.1
    UniProtKB/Swiss-Prot
    Q15025
    Conserved Domains (5) summary
    cd09803
    Location:452500
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam13863
    Location:306426
    DUF4200; Domain of unknown function (DUF4200)
    pfam15058
    Location:26149
    Speriolin_N; Speriolin N terminus
    cl19113
    Location:298431
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
    cl19252
    Location:214251
    MreC; rod shape-determining protein MreC
  7. NM_001258454.1NP_001245383.1  TNFAIP3-interacting protein 1 isoform 3

    See proteins identical to NP_001245383.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 3, 4, 5 and 8 encode the same protein (isoform 3).
    Source sequence(s)
    AC008641, AY012155
    Consensus CDS
    CCDS34280.1
    UniProtKB/Swiss-Prot
    Q15025
    Conserved Domains (5) summary
    cd09803
    Location:452500
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam13863
    Location:306426
    DUF4200; Domain of unknown function (DUF4200)
    pfam15058
    Location:26149
    Speriolin_N; Speriolin N terminus
    cl19113
    Location:298431
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
    cl19252
    Location:214251
    MreC; rod shape-determining protein MreC
  8. NM_001258455.1NP_001245384.1  TNFAIP3-interacting protein 1 isoform 5

    See proteins identical to NP_001245384.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks an exon and uses an alternate splice site in the 3' coding region which results in a frameshift compared to variant 1. The resulting protein (isoform 5) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB177543, AC008641
    Consensus CDS
    CCDS58984.1
    UniProtKB/Swiss-Prot
    Q15025
    Conserved Domains (4) summary
    cd09803
    Location:452500
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam15058
    Location:26149
    Speriolin_N; Speriolin N terminus
    cl19113
    Location:298431
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
    cl19252
    Location:214251
    MreC; rod shape-determining protein MreC
  9. NM_001258456.1NP_001245385.1  TNFAIP3-interacting protein 1 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks two exons in the 3' coding region which results in a frameshift compared to variant 1. The resulting protein (isoform 6) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB177544, AC008641
    Consensus CDS
    CCDS58983.1
    UniProtKB/Swiss-Prot
    Q15025
    Related
    ENSP00000484665, ENST00000610874
    Conserved Domains (4) summary
    cd09803
    Location:452500
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam15058
    Location:26149
    Speriolin_N; Speriolin N terminus
    cl19113
    Location:298431
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
    cl19252
    Location:214251
    MreC; rod shape-determining protein MreC
  10. NM_006058.4NP_006049.3  TNFAIP3-interacting protein 1 isoform 3

    See proteins identical to NP_006049.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (3) is longer and contains a distinct Cz-terminus, compared to isoform 1. Variants 3, 4, 5 and 8 encode the same protein (isoform 3).
    Source sequence(s)
    AB252972, AK074400, AW589284, DC374977
    Consensus CDS
    CCDS34280.1
    UniProtKB/Swiss-Prot
    Q15025
    Conserved Domains (5) summary
    cd09803
    Location:452500
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam13863
    Location:306426
    DUF4200; Domain of unknown function (DUF4200)
    pfam15058
    Location:26149
    Speriolin_N; Speriolin N terminus
    cl19113
    Location:298431
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
    cl19252
    Location:214251
    MreC; rod shape-determining protein MreC

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000005.10 

    Range
    151029943..151087660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714752.1XP_006714815.1  

    UniProtKB/Swiss-Prot
    Q15025
    Conserved Domains (4) summary
    cd09803
    Location:452500
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam15058
    Location:26149
    Speriolin_N; Speriolin N terminus
    cl19113
    Location:298431
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
    cl19252
    Location:214251
    MreC; rod shape-determining protein MreC
  2. XM_006714751.1XP_006714814.1  

    See proteins identical to XP_006714814.1

    UniProtKB/Swiss-Prot
    Q15025
    Related
    ENSP00000483944, ENST00000610535
    Conserved Domains (4) summary
    cd09803
    Location:452500
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam15058
    Location:26149
    Speriolin_N; Speriolin N terminus
    cl19113
    Location:298431
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
    cl19252
    Location:214251
    MreC; rod shape-determining protein MreC
  3. XM_005268355.1XP_005268412.1  

    See proteins identical to XP_005268412.1

    Conserved Domains (4) summary
    cd09803
    Location:452500
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam15058
    Location:26149
    Speriolin_N; Speriolin N terminus
    cl19113
    Location:298431
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
    cl19252
    Location:214251
    MreC; rod shape-determining protein MreC

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 

    Range
    149842296..149900016
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000137.1 

    Range
    145555312..145613010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)