CD69 CD69 molecule [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: CD69provided by HGNC
Official Full Name: CD69 moleculeprovided by HGNC
Primary source: HGNC:1694
See related: Ensembl:ENSG00000110848; HPRD:00119; MIM:107273; Vega:OTTHUMG00000168481
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AIM; EA1; MLR-3; CLEC2C; GP32/28; BL-AC/P26
Summary: This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011]

Help top of page

Genomic context

Location :: 12p13

Sequence :: Chromosome: 12; NC_000012.11 (9905082..9913497, complement)

See CD69 in Epigenomics, MapViewer

Chromosome 12 - NC_000012.11 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Increased CD4(+) CD69(+) CD25(-) T cells exert a critical role in hepatocellular carcinoma progression and might represent a clinically aggressive tumor phenotype.
Title: Increased CD4(+) CD69(+) CD25(-) T cells in patients with hepatocellular carcinoma are associated with tumor progression.
Results suggest that H. pylori induces CD69 expression through the activation of NF-kappaB, and that cagPAI might be relevant in the induction of CD69 expression in T cells. CD69 in T cells may play a role in H. pylori-induced gastritis.
Title: Induction of CD69 expression by cagPAI-positive Helicobacter pylori infection.
Caffeine does not appear to depress Natural killer cell CD69 expression.
Title: Effect of a single and repeated dose of caffeine on antigen-stimulated human natural killer cell CD69 expression after high-intensity intermittent exercise.
Studies provide a mechanistic link between CD69 and the regulation of T(H)17 responses.
Title: CD69: an unexpected regulator of TH17 cell-driven inflammatory responses.
The expression of CD69 in T lymphocytes from nasal polyps was abnormally high.
Title: [Examination expression of CD3 and CD69 in nasal polyps].
Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
Title: In silico replication of the genome-wide association results of the Type 1 Diabetes Genetics Consortium.
binding of N-acetyl-d-hexosamines to soluble CD69 is highly cooperative at molecular level
Title: Cooperation between subunits is essential for high-affinity binding of N-acetyl-D-hexosamines to dimeric soluble and dimeric cellular forms of human CD69.
structure refined to 1.37 A resolution provides further details of the overall structure and the asymmetric interface between the monomers in the native dimer
Title: The high-resolution structure of the extracellular domain of human CD69 using a novel polymer.
analysis of CD69 molecules on human CD4+ T cell membrane
Title: AFM- and NSOM-based force spectroscopy and distribution analysis of CD69 molecules on human CD4+ T cell membrane.
Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.

Submit: New GeneRIF Correction See all (28)

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.

Help top of page

HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 significantly inhibits CD69 expression in phytohemagglutinin-stimulated T cells in vitro and may also affect T-cell activation in vivo	PubMed
Nef	nef	HIV-1 Nef downregulates CD69 in Jurkat cells in a concentration-dependent manner	PubMed
	nef	HIV-1 Nef blocks a receptor-proximal event in CD3 signaling by downregulating CD69 expression on the cell surface; mutations at amino acid residues P72, P75, R105 and R106 in Nef disrupts the ability of Nef to block CD3 signaling	PubMed
Tat	tat	HIV-1 Tat binds to a cell surface receptor and activates a cell surface-mediated signal pathway in K562 cells, leading to the activation of NF-kappa B and the induction of CD69	PubMed
Vpr	vpr	Human endothelial cell (EC)-stimulated virus-producing cells (p24(high) T cells) are activated to sometimes express CD69 (but not CD25, HLA-DR, VLA-1, or effector cytokines) in the presence of HIV-1 Vpr	PubMed

Go to the HIV-1, Human Protein Interaction Database

Help top of page

Products	Interactant	Other Gene	Complex	Source	Pubs	Description
Q07108	Q07108	CD69		HPRD	PubMed

Function	Evidence Code	Pubs
binding	IEA Inferred from Electronic Annotation more info
sugar binding	IEA Inferred from Electronic Annotation more info
transmembrane signaling receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
cellular response to drug	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
external side of plasma membrane	IEA Inferred from Electronic Annotation more info
integral to plasma membrane	TAS Traceable Author Statement more info	PubMed
membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: early activation antigen CD69

Names: early activation antigen CD69; leukocyte surface antigen Leu-23; early T-cell activation antigen p60; early lymphocyte activation antigen; activation inducer molecule (AIM/CD69); C-type lectin domain family 2, member C; CD69 antigen (p60, early T-cell activation antigen)

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001781.2 → NP_001772.1 early activation antigen CD69

Status: REVIEWED

Source sequence(s)

AC007068, Z22576

Consensus CDS

CCDS8604.1

UniProtKB/Swiss-Prot

Q07108

UniProtKB/TrEMBL

Q53ZX0

Related

ENSP00000228434, OTTHUMP00000238849, ENST00000228434, OTTHUMT00000399876

Conserved Domains (1) summary

cd03593
Location:85 – 196
Blast Score: 349

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000012.11 Reference GRCh37.p5 Primary Assembly

Range

9905082..9913497, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000144.1 Alternate HuRef

Range

9648014..9656429, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NR_026671.1: Suppressed sequence

Description

NR_026671.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
NR_026672.1: Suppressed sequence

Description

NR_026672.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC007068.17 (102615..111030)	None
genomic	CH471094.1	EAW96122.1
		EAW96123.1
genomic	HI574208.1	CBX47593.1
genomic	Z30426.1	CAA83017.1
genomic	Z38109.1	CAA86225.1
mRNA	AK291869.1	BAF84558.1
mRNA	AK303174.1	BAG64271.1
mRNA	AK303383.1	BAG64439.1
mRNA	AY238518.1	AAO63584.1
mRNA	BC007037.1	AAH07037.1
mRNA	L07555.1	AAB46359.1
mRNA	Z22576.1	CAA80298.1
other-genetic	DQ893175.2	ABM84101.1
other-genetic	DQ896474.2	ABM87473.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q07108.1	GenPept	UniProtKB/Swiss-Prot:Q07108
Q53ZX0	GenPept	UniProtKB/TrEMBL:Q53ZX0
Q6LAB3	GenPept	UniProtKB/TrEMBL:Q6LAB3