IRF1 interferon regulatory factor 1 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: IRF1provided by HGNC
Official Full Name: interferon regulatory factor 1provided by HGNC
Primary source: HGNC:6116
See related: Ensembl:ENSG00000125347; HPRD:00961; MIM:147575; Vega:OTTHUMG00000059497
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MAR; IRF-1
Summary: IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppressoion. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 5q31.1

Sequence :: Chromosome: 5; NC_000005.9 (131817301..131826465, complement)

See IRF1 in Epigenomics, MapViewer

Chromosome 5 - NC_000005.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Expression of interferon regulatory factor (IRF)1 and signal transducer and activator of transcription (STAT)1 mediates host defense against Mycobacterium tuberculosis through the cellular response to interferon (IFN)-gamma.
Title: Evidence for postinitiation regulation of mRNA biogenesis in tuberculosis.
Data show that not only NF-kB p65, but also the interferon regulatory factor 1 (IRF1) and certain antigen rocessing achinery (APM) components are low in a subset of Neuroblastoma (NB) cell lines with aggressive features.
Title: IRF1 and NF-kB restore MHC class I-restricted tumor antigen processing and presentation to cytotoxic T cells in aggressive neuroblastoma.
Smad7 was able to activate the caspase 8 promoter through recruitment of the interferon regulatory factor 1 (IRF1) transcription factor to the interferon-stimulated response element (ISRE) site.
Title: Smad7 protein induces interferon regulatory factor 1-dependent transcriptional activation of caspase 8 to restore tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis.
The increased expressions of OB-R, IRF-1 and GR-beta in airway smooth muscle cells (ASMCs) of obese rats with asthma may play a role in the onset of obese asthma and glucocorticoid resistance.
Title: [Expressions of OB-R, IRF-1 and GR-β in airway smooth muscle cells of obese rats with asthma].
The E3 docking site was not available when IRF1 was in its DNA-bound conformation and cognate DNA-binding sequences strongly suppressed ubiquitination, showing a relationship between ligase binding and site-specific modification in the DNA-binding domain
Title: DNA-binding regulates site-specific ubiquitination of IRF-1.
IRF-1 is a key regulator of IL-18BPa expression and IL-18 bioactivity in rheumatoid arthritis synovial fibroblasts.
Title: Blocking of interferon regulatory factor 1 reduces tumor necrosis factor α-induced interleukin-18 bioactivity in rheumatoid arthritis synovial fibroblasts by induction of interleukin-18 binding protein a: role of the nuclear interferon regulatory factor 1-NF-κB-c-jun complex.
The association of IRF1 and IRF8 variants with tuberculosis susceptibility was investigated.
Title: Tagging single nucleotide polymorphisms in the IRF1 and IRF8 genes and tuberculosis susceptibility.
Subjects with an anti-inflammatory response to a meal produced triglycerides that was enriched in nonesterified fatty acids, decreased IRF-1 expression, increased miR-126 activity, and diminished monocyte arrest.
Title: IRF-1 and miRNA126 modulate VCAM-1 expression in response to a high-fat meal.
The modulation of IRFs seen in filarial (and presumably other tissue-sensitive helminths) underlies suppression of malaria-specific cytokines/chemokines that play a crucial role in immunity to malaria.
Title: Interferon regulatory factor modulation underlies the bystander suppression of malaria antigen-driven IL-12 and IFN-γ in filaria-malaria co-infection.
Immunohistochemically, the lining synovium of Rheumatoid Aarthritis clearly expressed IRF1
Title: Gene expression analysis of rheumatoid arthritis synovial lining regions by cDNA microarray combined with laser microdissection: up-regulation of inflammation-associated STAT1, IRF1, CXCL9, CXCL10, and CCL5.

Submit: New GeneRIF Correction See all (139)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts.

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.

Meta-analysis of genome-wide association studies in &gt;80 000 subjects identifies multiple loci for C-reactive protein levels.

New gene functions in megakaryopoiesis and platelet formation.

Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Nef, p27	nef	HIV-1 Nef-induced signal transducer and activator of transcription 1 (STAT1) activation results in increased expression of interferon regulatory factor-1 (IRF-1) in recombinant Nef-treated human monocyte-derived macrophages (MDMs)	PubMed
Tat, p14	tat	HIV-1 Tat represses transcription of the LMP2 gene by competing with STAT1 (signal transducer and activator of transcription 1) for binding to IRF-1 (interferon-regulatory factor-1) at the LMP2 promoter	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NC_000005.8		CSNK2A1	BIND	PubMed	An unspecified isoform of CK2-alpha interacts with IRF-1 promoter.
NC_000005.8	NP_001311.3	CSNK2B	BIND	PubMed	CK2-beta interacts with IRF-1 promoter.
NC_000005.8		CTDP1	BIND	PubMed	An unspecified isoform of CTD interacts with IRF-1 promoter.
NC_000005.8	NP_001929.1	DR1	BIND	PubMed	Dr1 interacts with IRF-1 promoter.
NC_000005.8	NP_006433.2	DRAP1	BIND	PubMed	DRAP1 interacts with IRF-1 promoter.
NC_000005.8	NP_000113.1	ERCC3	BIND	PubMed	TFIIH interacts with IRF-1 promoter.
NC_000005.8	NP_002087.1	GTF2F1	BIND	PubMed	TFIIF interacts with IRF-1 promoter.
NC_000005.8		MED23	BIND	PubMed	An unspecified isoform of MED23 interacts with IRF-1 promoter.
NC_000005.8	NP_004796.1	POLR2D	BIND	PubMed	Rbp4 interacts with IRF-1 promoter.
NC_000005.8	NP_004796.1	POLR2D	BIND	PubMed	Rbp4 interacts with IRF-1.
NC_000005.8	NP_006704.2	SUB1	BIND	PubMed	PC4 interacts with IRF-1 promoter.
NC_000005.8	NP_003185.1	TBP	BIND	PubMed	TBP interacts with IRF-1 promoter.
NP_002189.1	NP_041325.1	E6	BIND	PubMed	Human papillomavirus type 16 (HPV16) protein E6 interacts with human host protein IRF-1.
P10914	Q09472	EP300	HPRD	PubMed
P10914	P17096	HMGA1	HPRD	PubMed
P10914	Q02556	IRF8	HPRD	PubMed
P10914	Q92831	KAT2B	HPRD	PubMed
P10914	P19838	NFKB1	HPRD	PubMed
P10914	Q04206	RELA	HPRD	PubMed
P10914	P42224	STAT1	HPRD	PubMed
BioGRID:109867	BioGRID:107461	CDKN1B	BioGRID	PubMed	Two-hybrid
BioGRID:109867	BioGRID:107777	CREBBP	BioGRID	PubMed	Reconstituted Complex
BioGRID:109867	BioGRID:108347	EP300	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109867	BioGRID:109304	HCFC1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109867	BioGRID:109402	HMGA1	BioGRID	PubMed	Reconstituted Complex
BioGRID:109867	BioGRID:109621	IRF8	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:109867	BioGRID:115652	IRF9	BioGRID	PubMed	Two-hybrid
BioGRID:109867	BioGRID:108918	KAT2A	BioGRID	PubMed	Reconstituted Complex
BioGRID:109867	BioGRID:114375	KAT2B	BioGRID	PubMed	Reconstituted Complex
BioGRID:109867	BioGRID:115156	KEAP1	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
BioGRID:109867	BioGRID:110358	MDM2	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:109867	BioGRID:110929	NPM1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:109867	BioGRID:111797	QARS	BioGRID	PubMed	Two-hybrid
BioGRID:109867	BioGRID:116397	SEC63	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109867	BioGRID:112316	SET	BioGRID	PubMed	Reconstituted Complex
BioGRID:109867	BioGRID:112481	SMARCA4	BioGRID	PubMed	Co-localization
BioGRID:109867	BioGRID:112551	SP2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109867	BioGRID:112566	SPI1	BioGRID	PubMed	Reconstituted Complex
BioGRID:109867	BioGRID:112649	STAT1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:109867	BioGRID:115563	STUB1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:109867	BioGRID:113039	TRAF3	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
BioGRID:109867	BioGRID:115457	TRIM28	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:109867	BioGRID:117968	TRMT2A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:109867	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation; Reconstituted Complex
BioGRID:109867	BioGRID:110959	YBX1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:109867	BioGRID:1205541	tat	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid

Pathways from BioSystems

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Apoptosis, organism-specific biosystem (from WikiPathways)
Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
Glucocorticoid receptor regulatory network, organism-specific biosystem (from Pathway Interaction Database)
Glucocorticoid receptor regulatory network, organism-specific biosystem
Glucocorticoid receptor regulatory network
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
Hepatitis C, organism-specific biosystem (from KEGG)
Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
Hepatitis C, conserved biosystem (from KEGG)
Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
IFN-gamma pathway, organism-specific biosystem (from Pathway Interaction Database)
IFN-gamma pathway, organism-specific biosystem
IFN-gamma pathway
IL-7 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-7 Signaling Pathway, organism-specific biosystemInterleukin-7 belongs to a family of cytokines, which includes IL-2, IL-4, IL-9, IL-15 and IL-21. It signals through a receptor complex consisting of IL-7 receptor alpha chain (IL7RA) and a common ga...
IL12 signaling mediated by STAT4, organism-specific biosystem (from Pathway Interaction Database)
IL12 signaling mediated by STAT4, organism-specific biosystem
IL12 signaling mediated by STAT4
IL6-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
IL6-mediated signaling events, organism-specific biosystem
IL6-mediated signaling events
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
Interferon Signaling, organism-specific biosystem (from REACTOME)
Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
Interferon alpha/beta signaling, organism-specific biosystem (from REACTOME)
Interferon alpha/beta signaling, organism-specific biosystemType I interferons (IFNs) are composed of various genes including IFN alpha (IFNA), beta (IFNB), omega, epsilon, and kappa. In humans the IFNA genes are composed of more than 13 subfamily genes, wher...
Interferon gamma signaling, organism-specific biosystem (from REACTOME)
Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
Pertussis, organism-specific biosystem (from KEGG)
Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
Pertussis, conserved biosystem (from KEGG)
Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
Prolactin Signaling Pathway, organism-specific biosystem (from WikiPathways)
Prolactin Signaling Pathway, organism-specific biosystemProlactin (PRL), a pleiotropic polypeptide hormone, mostly secreted by the lactotrophic cells of anterior pituitary gland and to a lesser extent expressed in numerous extra pituitary tissues such as ...
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemRIG-I-like helicases (RLHs) the retinoic acid inducible gene-I (RIG-I) and melanoma differentiation associated gene 5 (MDA5) are RNA helicases that recognize viral RNA present within the cytoplasm. F...
Regulation of Telomerase, organism-specific biosystem (from Pathway Interaction Database)
Regulation of Telomerase, organism-specific biosystem
Regulation of Telomerase
Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
TRAF6 mediated IRF7 activation, organism-specific biosystem (from REACTOME)
TRAF6 mediated IRF7 activation, organism-specific biosystemTRAF6 is crucial for both RIG-I- and MDA5-mediated antiviral responses. The absence of TRAF6 resulted in enhanced viral replication and a significant reduction in the production of type I IFNs and IL...
Type II interferon signaling (IFNG), organism-specific biosystem (from WikiPathways)
Type II interferon signaling (IFNG), organism-specific biosystemAdapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several ...

General gene information

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Markers

REN70464 (e-PCR)
- UniSTS:395264

REN70465 (e-PCR)
- UniSTS:395265

REN70466 (e-PCR)
- UniSTS:395266

REN70467 (e-PCR)
- UniSTS:395267

GDB:211052 (e-PCR)
- UniSTS:156163

REN70468 (e-PCR)
- UniSTS:395268

REN70469 (e-PCR)
- UniSTS:395269

ECD02816 (e-PCR)
- UniSTS:283909

REN70470 (e-PCR)
- UniSTS:395270

REN70471 (e-PCR)
- UniSTS:395271

REN70472 (e-PCR)
- UniSTS:395272

REN70473 (e-PCR)
- UniSTS:395273

REN70474 (e-PCR)
- UniSTS:395274

D11S2921 (e-PCR)
- UniSTS:152074

REN70475 (e-PCR)
- UniSTS:395275

REN70476 (e-PCR)
- UniSTS:395276

ECD03343 (e-PCR)
- UniSTS:284428

REN70477 (e-PCR)
- UniSTS:395277

REN70478 (e-PCR)
- UniSTS:395278

REN70479 (e-PCR)
- UniSTS:395279

REN70480 (e-PCR)
- UniSTS:395280

REN70481 (e-PCR)
- UniSTS:395281

REN70482 (e-PCR)
- UniSTS:395282

REN70483 (e-PCR)
- UniSTS:395283

GDB:434012 (e-PCR)
- UniSTS:157204

D5S1548 (e-PCR)
- UniSTS:29205

ECD06964 (e-PCR)
- UniSTS:288022

PMC84085P1 (e-PCR)
- UniSTS:273439

ECD02591 (e-PCR)
- UniSTS:283685

PMC120056P1 (e-PCR)
- UniSTS:270377

ECD14446 (e-PCR)
- UniSTS:295467

PMC156606P3 (e-PCR)
- UniSTS:271410

PMC156606P4 (e-PCR)
- UniSTS:271411

D8S2279 (e-PCR)
- UniSTS:473907

sY3084 (e-PCR)
- UniSTS:515126

ECD08800 (e-PCR)
- UniSTS:289848

STS-X14454 (e-PCR)
- UniSTS:64060

ECD03403 (e-PCR)
- UniSTS:284487

PMC109445P2 (e-PCR)
- UniSTS:270170

L17709 (e-PCR)
- UniSTS:42599

D10S16 (e-PCR)
- UniSTS:155756

D15S1477 (e-PCR)
- UniSTS:474482

D1S1423 (e-PCR)
- UniSTS:149619

D1S1425 (e-PCR)
- UniSTS:149621

ECD02679 (e-PCR)
- UniSTS:283773

ECD18635 (e-PCR)
- UniSTS:299645

ECD13250 (e-PCR)
- UniSTS:294280

IRF1_162 (e-PCR)
- UniSTS:277387

D11S3114 (e-PCR)
- UniSTS:152207

ECD19204 (e-PCR)
- UniSTS:300211

GDB:581873 (e-PCR)
- UniSTS:157877

ECD11243 (e-PCR)
- UniSTS:292279

WI-7178 (e-PCR)
- UniSTS:74720

stSG601315 (e-PCR)
- UniSTS:444128

stSG601316 (e-PCR)
- UniSTS:444129

stSG601317 (e-PCR)
- UniSTS:444130

stSG601318 (e-PCR)
- UniSTS:444131

stSG601319 (e-PCR)
- UniSTS:444132

REN70438 (e-PCR)
- UniSTS:395238

REN70439 (e-PCR)
- UniSTS:395239

REN70440 (e-PCR)
- UniSTS:395240

REN70441 (e-PCR)
- UniSTS:395241

GDB:294203 (e-PCR)
- UniSTS:156393

ECD20803 (e-PCR)
- UniSTS:301801

REN70442 (e-PCR)
- UniSTS:395242

REN70443 (e-PCR)
- UniSTS:395243

REN70444 (e-PCR)
- UniSTS:395244

REN70445 (e-PCR)
- UniSTS:395245

REN70446 (e-PCR)
- UniSTS:395246

REN70447 (e-PCR)
- UniSTS:395247

REN70448 (e-PCR)
- UniSTS:395248

REN70449 (e-PCR)
- UniSTS:395249

REN70450 (e-PCR)
- UniSTS:395250

REN70451 (e-PCR)
- UniSTS:395251

REN70452 (e-PCR)
- UniSTS:395252

REN70453 (e-PCR)
- UniSTS:395253

REN70454 (e-PCR)
- UniSTS:395254

REN70455 (e-PCR)
- UniSTS:395255

REN70456 (e-PCR)
- UniSTS:395256

REN70457 (e-PCR)
- UniSTS:395257

REN70458 (e-PCR)
- UniSTS:395258

REN70459 (e-PCR)
- UniSTS:395259

REN70460 (e-PCR)
- UniSTS:395260

REN70461 (e-PCR)
- UniSTS:395261

REN70462 (e-PCR)
- UniSTS:395262

REN70463 (e-PCR)
- UniSTS:395263

Genotypes

See IRF1 SNP Geneview Report
See IRF1 SNP Genotype Report
See IRF1 SNP Variation Viewer Report

Homology

Homologs of the IRF1 gene: The IRF1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
DNA binding	TAS Traceable Author Statement more info	PubMed
RNA polymerase II core promoter proximal region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
sequence-specific DNA binding transcription factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
CD8-positive, alpha-beta T cell differentiation	IEA Inferred from Electronic Annotation more info
blood coagulation	TAS Traceable Author Statement more info
cell cycle arrest	IDA Inferred from Direct Assay more info
cellular response to interferon-beta	IDA Inferred from Direct Assay more info	PubMed
cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
cytokine-mediated signaling pathway	TAS Traceable Author Statement more info
defense response to virus	IDA Inferred from Direct Assay more info
induction of apoptosis	IDA Inferred from Direct Assay more info	PubMed
interferon-gamma-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
interferon-gamma-mediated signaling pathway	TAS Traceable Author Statement more info
negative regulation of cell proliferation	TAS Traceable Author Statement more info	PubMed
negative regulation of regulatory T cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of transcription, DNA-dependent	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of interferon-beta production	IMP Inferred from Mutant Phenotype more info
positive regulation of interleukin-12 biosynthetic process	IEA Inferred from Electronic Annotation more info
positive regulation of transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
positive regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info
positive regulation of transcription, DNA-dependent	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of type I interferon production	ISS Inferred from Sequence or Structural Similarity more info
regulation of CD8-positive, alpha-beta T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
regulation of MyD88-dependent toll-like receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
regulation of adaptive immune response	TAS Traceable Author Statement more info	PubMed
regulation of cell cycle	TAS Traceable Author Statement more info	PubMed
regulation of innate immune response	TAS Traceable Author Statement more info	PubMed
transcription from RNA polymerase II promoter	TAS Traceable Author Statement more info	PubMed
type I interferon-mediated signaling pathway	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
cytosol	TAS Traceable Author Statement more info
nuclear chromatin	IDA Inferred from Direct Assay more info	PubMed
nucleoplasm	TAS Traceable Author Statement more info
nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: interferon regulatory factor 1

Names: interferon regulatory factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011450.1 RefSeqGene

Range

5001..14165

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002198.2 → NP_002189.1 interferon regulatory factor 1

Status: REVIEWED

Source sequence(s)

AA402319, AC116366, AK314025, BC009483

Consensus CDS

CCDS4155.1

UniProtKB/Swiss-Prot

P10914

UniProtKB/TrEMBL

Q6FHN8

Related

ENSP00000245414, OTTHUMP00000065831, ENST00000245414, OTTHUMT00000132340

Conserved Domains (1) summary

cd00103
Location:5 – 113
Blast Score: 383

IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000005.9 Reference GRCh37.p10 Primary Assembly

Range

131817301..131826465, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000137.1 Alternate HuRef

Range

127009541..127018697, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018916.1 Alternate CHM1_1.0

Range

132093116..132102280, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01068805.1 (147957..157113)	None
genomic	AC003959.1	AAB93488.1
genomic	AC116366.2 (93575..102291)	None
genomic	AMYH01015615.1 (175137..184301)	None
genomic	CH471062.2	EAW62332.1
genomic	DQ789232.1	ABH05670.1
genomic	L05072.1	AAA36043.1
mRNA	AA402319.1	None
mRNA	AB103081.1	BAD89424.1
mRNA	AB209624.1	BAD92861.1
mRNA	AK298770.1	BAG60912.1
mRNA	AK314025.1	BAG36735.1
mRNA	BC009483.2	AAH09483.1
mRNA	BT019755.1	AAV38560.1
mRNA	BT019756.1	AAV38561.1
mRNA	CR541713.1	CAG46514.1
mRNA	X14454.1	CAA32624.1
other-genetic	DQ893269.2	ABM84195.1
other-genetic	DQ896599.2	ABM87598.1