CCL5 chemokine (C-C motif) ligand 5 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: CCL5provided by HGNC
Official Full Name: chemokine (C-C motif) ligand 5provided by HGNC
Primary source: HGNC:10632
See related: Ensembl:ENSG00000161570; HPRD:01751; MIM:187011; Vega:OTTHUMG00000132949
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SISd; SCYA5; RANTES; TCP228; D17S136E
Summary: This gene is one of several CC cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 17q11.2-q12

Sequence :: Chromosome: 17; NC_000017.10 (34198495..34207377, complement)

See CCL5 in Epigenomics, MapViewer

Chromosome 17 - NC_000017.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study suggests that RANTES polymorphisms might be associated with the occurrence of acute GVHD rather than of chronic GVHD and also of relapse-free survival in the patients treated with allo-HSCT.
Title: RANTES polymorphisms and the risk of graft-versus-host disease in human leukocyte antigen-matched sibling allogeneic hematopoietic stem cell transplantation.
RANTES and its receptor CCR5 may contribute to gastric cancer metastasis through influencing the balance of Th1/Th2.
Title: Role of RANTES and its receptor in gastric cancer metastasis.
The current cluster analysis identified meaningful adult asthma phenotypes linked to the functional CCL5 and ADRB2 genotypes.
Title: Asthma phenotypes in Japanese adults - their associations with the CCL5 and ADRB2 genotypes.
Study found that the plasma concentration of RANTES was associated with the clinical severity of chronic rhinosinusitis in Taiwanese patients.
Title: Plasma RANTES and eotaxin levels are correlated with the severity of chronic rhinosinusitis.
Data from the current meta-analysis do not support the existence of a relationship between G-403A polymorphism in RANTES and the development of CAD.
Title: RANTES gene G-403A polymorphism and coronary artery disease: a meta analysis of observational studies.
There were significant increases in plasma monocyte chemotactic protein 1 (MCP-1) (CCL1) and regulated upon activation normal T cell expressed and secreted (RANTES) (CCL5) with age.
Title: Normal ageing is associated with an increase in Th2 cells, MCP-1 (CCL1) and RANTES (CCL5), with differences in sCD40L and PDGF-AA between sexes.
Serum CCL3, CCL5 and CCL18 are independently associated with the risk of short-term mortality in acute coronary syndrome patients.
Title: Chemokines CCL3/MIP1α, CCL5/RANTES and CCL18/PARC are independent risk predictors of short-term mortality in patients with acute coronary syndromes.
Tumor-infiltrating monocytic myeloid-derived suppressor cells produce high levels of transgenic CCR5 ligands CCL3, CCL4, and CCL5 and directly attract regulatory T cells (Tregs) in a CCR5-dependent manner.
Title: Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth.
MCP-1, RANTES and fractalkine independently participate in the pathogenesis of plaque vulnerability and subsequent plaque rupture.
Title: Independent roles of monocyte chemoattractant protein-1, regulated on activation, normal T-cell expressed and secreted and fractalkine in the vulnerability of coronary atherosclerotic plaques.
CCL5 is a pivotal mediator of Langerhans cells recruitment into epidermis.
Title: CCL5 and CCL20 mediate immigration of Langerhans cells into the epidermis of full thickness human skin equivalents.

Submit: New GeneRIF Correction See all (287)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120-mediated upregulation of CCL5 expression requires the NF-kappaB pathway in astrocytes	PubMed
	env	The binding of HIV-1 gp120 to CCR5 and entry of macrophage-tropic HIV-1 isolates into cells is blocked by CCR5 antagonists or the chemokine RANTES, which interacts with CCR5	PubMed
	env	Exposure of macrophages to purified CCR5- or CXCR4-tropic HIV-1 envelope glycoprotein gp120 induces secretion of high levels of macrophage inflammatory protein 1alpha (MIP-1alpha), MIP-1beta, RANTES, and tumor necrosis factor alpha	PubMed
	env	NK cells exposed to CXCR4-tropic HIV-1 gp120 produce lower levels of CC chemokines RANTES, MIP-1alpha, and MIP-1beta compared with that produced from untreated NK cells	PubMed
	env	RANTES, stromal derived factor-1alpha (SDF-1alpha), macrophage-derived chemokine (MDC), and their combination attenuate HIV-1 gp120-induced food and water intake decrease in rats	PubMed
	env	HIV-1 gp120 induced cell death is inhibited by a CCR5-mediated neuroprotective pathway that involves protein kinase Akt/PKB as an essential component and can be triggered by the CCR5 agonists MIP-1beta and RANTES	PubMed
	env	CXCR4-tropic HIV-1 gp120 augments the expression of RANTES, IP-10, MCP-1, and LTN in peripheral blood mononuclear cells (PBMCs), while CCR5-tropic HIV-1 gp120 also induces an increase in both IP-10 and MCP-1 production	PubMed
	env	A synthetic peptide domain of the V3 region of HIV-1 gp120 activates the FPRL1 receptor in monocytes and neutrophils and causes reduced response to several chemokines that use multiple cell receptors, including SDF-1alpha and RANTES	PubMed
	env	Chemokines such as fractalkine, macrophage-derived chemokine (MDC), RANTES, and SDF-1alpha are able to block gp120-induced apoptosis of hippocampal neurons; both fractalkine and MDC activate ERK-1/2, while SDF-1alpha activates CREB	PubMed
Envelope transmembrane glycoprotein gp41	env	RANTES, MIP-1beta, and anti-CD4 antibodies inhibit CCR5-dependent cell-cell fusion mediated by HIV-1 gp120 and gp41 from macrophage-tropic isolates	PubMed
	env	HIV-1 gp41 stimulates microglial cell production of cytokines (TNF-alpha, IL-1beta, and IL-6) and chemokines (RANTES and MIP-1alpha)	PubMed
Nef, p27	nef	HIV-1 Nef-pulsed iDCs downregulate MIP-1beta and RANTES expression in NK cells	PubMed
	nef	HIV-1 Nef upregulates the production of RANTES/CCL5 in microglial cells	PubMed
Tat, p14	tat	HIV-1 Tat upregulates RANTES expression in monocyte-derived dendritic cells (MDDC), thereby driving Th1-type immune responses	PubMed
	tat	RANTES inhibits HIV-1 Tat-induced apoptosis, a protective effect mediated by the induction of MCP-1	PubMed
	tat	HIV-1 Tat cooperates with RANTES in inducing monocyte migration	PubMed
	tat	Astrocyte cultures treated with morphine and Tat show exaggerated increases in chemokine release, including monocyte chemoattractant protein-1 (MCP-1), RANTES, and IL-6	PubMed
	tat	RANTES is upregulated by HIV-1 Tat treatment in human epithelial cells	PubMed
	tat	HIV-1 Tat upregulates RANTES expression in human microglial cells, an effect that could contribute to the neuropathogenesis if HIV-1	PubMed
Vpr, p15	vpr	HIV-1 Vpr regulates expression of RANTES, including upregulation in microglial cells and downregulation in primary lymphocytes and macrophages	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_002976.2	NP_001544.1	IGFBP7	BIND	PubMed	Mac25/AGM interacts with RANTES. This interaction was modeled on a demonstrated interaction between mouse Mac25/AGM and human RANTES.
P13501	O00590	CCBP2	HPRD	PubMed
P13501	P13501	CCL5	HPRD	PubMed
P13501	P32246	CCR1	HPRD	PubMed
P13501	P51677	CCR3	HPRD	PubMed
P13501	P51679	CCR4	HPRD	PubMed
P13501	P51681	CCR5	HPRD	PubMed
P13501	Q9NPB9	CCRL1	HPRD	PubMed
P13501	Q16570	DARC	HPRD	PubMed
P13501	P27487	DPP4	HPRD	PubMed
P13501	P62993	GRB2	HPRD	PubMed
P13501	Q16270	IGFBP7	HPRD	PubMed
P13501	P02776	PF4	HPRD	PubMed
P13501	P01833	PIGR	HPRD	PubMed
P13501	P18827	SDC1	HPRD	PubMed
P13501	P31431	SDC4	HPRD	PubMed
P13501	P13611	VCAN	HPRD	PubMed
BioGRID:112255	BioGRID:107643	CCBP2	BioGRID	PubMed	Reconstituted Complex
BioGRID:112255	BioGRID:112251	CCL2	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:112255	BioGRID:107635	CCR1	BioGRID	PubMed	Reconstituted Complex
BioGRID:112255	BioGRID:107637	CCR3	BioGRID	PubMed	Reconstituted Complex
BioGRID:112255	BioGRID:107638	CCR4	BioGRID	PubMed	Reconstituted Complex
BioGRID:112255	BioGRID:107639	CCR5	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:112255	BioGRID:117171	EDC4	BioGRID	PubMed	Two-hybrid
BioGRID:112255	BioGRID:109790	IL8	BioGRID	PubMed	Reconstituted Complex
BioGRID:112255	BioGRID:205897	Igfbp7	BioGRID	PubMed	Reconstituted Complex
BioGRID:112255	BioGRID:111840	RANGAP1	BioGRID	PubMed	Two-hybrid
BioGRID:112255	BioGRID:111902	RELA	BioGRID	PubMed	Two-hybrid
BioGRID:112255	BioGRID:112284	SDC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112255	BioGRID:112286	SDC4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112255	BioGRID:112409	SLC2A5	BioGRID	PubMed	Two-hybrid
BioGRID:112255	BioGRID:113056	TRIP6	BioGRID	PubMed	Two-hybrid
BioGRID:112255	BioGRID:107844	VCAN	BioGRID	PubMed	Reconstituted Complex

Pathways from BioSystems

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Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
Chemokine receptors bind chemokines, organism-specific biosystem (from REACTOME)
Chemokine receptors bind chemokines, organism-specific biosystemChemokine receptors are cytokine receptors found on the surface of certain cells, which interact with a type of cytokine called a chemokine. Following interaction, these receptors trigger a flux of i...
Chemokine signaling pathway, organism-specific biosystem (from KEGG)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, conserved biosystem (from KEGG)
Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytosolic DNA-sensing pathway, organism-specific biosystem (from KEGG)
Cytosolic DNA-sensing pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
Cytosolic DNA-sensing pathway, conserved biosystem (from KEGG)
Cytosolic DNA-sensing pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
EBV LMP1 signaling, organism-specific biosystem (from WikiPathways)
EBV LMP1 signaling, organism-specific biosystembased on science-slides...
Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystem (from KEGG)
Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystemTwo major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA)....
Epithelial cell signaling in Helicobacter pylori infection, conserved biosystem (from KEGG)
Epithelial cell signaling in Helicobacter pylori infection, conserved biosystemTwo major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA)....
G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
GPCR ligand binding, organism-specific biosystem (from REACTOME)
GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
Herpes simplex infection, organism-specific biosystem (from KEGG)
Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Herpes simplex infection, conserved biosystem (from KEGG)
Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Influenza A, organism-specific biosystem (from KEGG)
Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
Influenza A, conserved biosystem (from KEGG)
Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
Prion diseases, organism-specific biosystem (from KEGG)
Prion diseases, organism-specific biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
Prion diseases, conserved biosystem (from KEGG)
Prion diseases, conserved biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
Rheumatoid arthritis, organism-specific biosystem (from KEGG)
Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
Rheumatoid arthritis, conserved biosystem (from KEGG)
Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
Syndecan-1-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
Syndecan-1-mediated signaling events, organism-specific biosystem
Syndecan-1-mediated signaling events
Syndecan-4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
Syndecan-4-mediated signaling events, organism-specific biosystem
Syndecan-4-mediated signaling events
TWEAK Signaling Pathway, organism-specific biosystem (from WikiPathways)
TWEAK Signaling Pathway, organism-specific biosystemTNF related weak inducer of apoptosis (TWEAK) is a small pleiotropic cytokine of the TNF super family and its gene is located at chromosome 17p13.1. TWEAK has been reported to be expressed in tissues...
Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
Toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
Validated targets of C-MYC transcriptional repression, organism-specific biosystem (from Pathway Interaction Database)
Validated targets of C-MYC transcriptional repression, organism-specific biosystem
Validated targets of C-MYC transcriptional repression

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

PMC156606P1 (e-PCR)
- UniSTS:271408

D8S2278 (e-PCR)
- UniSTS:473906

D8S2279 (e-PCR)
- UniSTS:473907

GDB:607766 (e-PCR)
- UniSTS:158282

L18426 (e-PCR)
- UniSTS:34648

RH39335 (e-PCR)
- UniSTS:89440

G10660 (e-PCR)
- UniSTS:56422

D1S1425 (e-PCR)
- UniSTS:149621

PMC16375P1 (e-PCR)
- UniSTS:271478

Ccl5 (e-PCR), detects polymorphism
- UniSTS:530818

PMC126614P1 (e-PCR)
- UniSTS:270542

PMC126614P2 (e-PCR)
- UniSTS:270543

PMC126614P3 (e-PCR)
- UniSTS:270544

PMC126614P4 (e-PCR)
- UniSTS:270545

PMC126614P5 (e-PCR)
- UniSTS:270546

PMC126614P6 (e-PCR)
- UniSTS:270547

PMC126614P7 (e-PCR)
- UniSTS:270548

PMC116027P1 (e-PCR)
- UniSTS:270306

PMC116027P2 (e-PCR)
- UniSTS:270307

RH103439 (e-PCR)
- UniSTS:97764

Homology

Homologs of the CCL5 gene: The CCL5 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
CCR1 chemokine receptor binding	IDA Inferred from Direct Assay more info	PubMed
CCR1 chemokine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
CCR1 chemokine receptor binding	TAS Traceable Author Statement more info	PubMed
CCR4 chemokine receptor binding	TAS Traceable Author Statement more info	PubMed
CCR5 chemokine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
chemoattractant activity	IDA Inferred from Direct Assay more info	PubMed
chemokine activity	IDA Inferred from Direct Assay more info	PubMed
chemokine activity	NAS Non-traceable Author Statement more info	PubMed
chemokine receptor antagonist activity	IDA Inferred from Direct Assay more info	PubMed
chemokine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
phosphatidylinositol phospholipase C activity	IDA Inferred from Direct Assay more info	PubMed
phospholipase activator activity	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein self-association	IDA Inferred from Direct Assay more info	PubMed
receptor signaling protein tyrosine kinase activator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
MAPK cascade	IMP Inferred from Mutant Phenotype more info
activation of phospholipase D activity	IDA Inferred from Direct Assay more info	PubMed
calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
cell-cell signaling	IDA Inferred from Direct Assay more info	PubMed
cellular calcium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
cellular protein complex assembly	IDA Inferred from Direct Assay more info	PubMed
cellular response to fibroblast growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
cellular response to interferon-gamma	IEP Inferred from Expression Pattern more info	PubMed
cellular response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info
cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
chemokine-mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
chemotaxis	NAS Non-traceable Author Statement more info	PubMed
dendritic cell chemotaxis	TAS Traceable Author Statement more info	PubMed
eosinophil chemotaxis	IDA Inferred from Direct Assay more info	PubMed
exocytosis	IDA Inferred from Direct Assay more info	PubMed
inflammatory response	IDA Inferred from Direct Assay more info
leukocyte cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
lipopolysaccharide-mediated signaling pathway	IDA Inferred from Direct Assay more info
macrophage chemotaxis	TAS Traceable Author Statement more info	PubMed
monocyte chemotaxis	IC Inferred by Curator more info	PubMed
negative regulation by host of viral transcription	IDA Inferred from Direct Assay more info	PubMed
negative regulation of G-protein coupled receptor protein signaling pathway	IDA Inferred from Direct Assay more info	PubMed
negative regulation of T cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of chemokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
negative regulation of macrophage apoptotic process	IEA Inferred from Electronic Annotation more info
negative regulation of viral genome replication	IDA Inferred from Direct Assay more info	PubMed
neutrophil activation	IDA Inferred from Direct Assay more info	PubMed
positive chemotaxis	IDA Inferred from Direct Assay more info	PubMed
positive regulation of JAK-STAT cascade	TAS Traceable Author Statement more info	PubMed
positive regulation of T cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of T cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
positive regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of activation of JAK2 kinase activity	TAS Traceable Author Statement more info	PubMed
positive regulation of calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell-cell adhesion mediated by integrin	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cellular biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of homotypic cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
positive regulation of innate immune response	TAS Traceable Author Statement more info
positive regulation of macrophage chemotaxis	IDA Inferred from Direct Assay more info	PubMed
positive regulation of monocyte chemotaxis	IDA Inferred from Direct Assay more info	PubMed
positive regulation of natural killer cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
positive regulation of phosphatidylinositol 3-kinase cascade	IDA Inferred from Direct Assay more info	PubMed
positive regulation of phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of smooth muscle cell migration	IDA Inferred from Direct Assay more info
positive regulation of smooth muscle cell proliferation	IDA Inferred from Direct Assay more info
positive regulation of translational initiation	NAS Non-traceable Author Statement more info	PubMed
positive regulation of tyrosine phosphorylation of STAT protein	IDA Inferred from Direct Assay more info	PubMed
positive regulation of viral genome replication	TAS Traceable Author Statement more info	PubMed
protein kinase B signaling cascade	IMP Inferred from Mutant Phenotype more info
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein tetramerization	IDA Inferred from Direct Assay more info	PubMed
regulation of T cell activation	IDA Inferred from Direct Assay more info	PubMed
regulation of chronic inflammatory response	TAS Traceable Author Statement more info	PubMed
response to toxic substance	IDA Inferred from Direct Assay more info	PubMed
response to virus	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
extracellular region	TAS Traceable Author Statement more info
extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-C motif chemokine 5

Names: C-C motif chemokine 5; eoCP; SIS-delta; beta-chemokine RANTES; small-inducible cytokine A5; T-cell specific protein p288; t cell-specific protein P228; T-cell-specific protein RANTES; eosinophil chemotactic cytokine; small inducible cytokine A5 (RANTES); small inducible cytokine subfamily A (Cys-Cys), member 5; regulated upon activation, normally T-expressed, and presumably secreted

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_015990.1 RefSeqGene

Range

5001..13883

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002985.2 → NP_002976.2 C-C motif chemokine 5 precursor

Status: REVIEWED

Source sequence(s)

AB023654, BC008600, BG272739, M21121

Consensus CDS

CCDS11300.1

UniProtKB/TrEMBL

D0EI67

UniProtKB/Swiss-Prot

P13501

Related

ENSP00000293272, OTTHUMP00000163880, ENST00000293272, OTTHUMT00000256486

Conserved Domains (1) summary

cd00272
Location:33 – 89
Blast Score: 191

Chemokine_CC; Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000017.10 Reference GRCh37.p10 Primary Assembly

Range

34198495..34207377, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000149.1 Alternate HuRef

Range

30383508..30392390, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018928.1 Alternate CHM1_1.0

Range

34261889..34270771, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AB023652.1	BAA76937.1
genomic	AB023653.1	BAA76938.1
genomic	AB023654.1	BAA76939.1
genomic	ABBA01011239.1 (10696..19578)	None
genomic	AC015849.5 (38876..47758)	None
genomic	AF088219.1	AAC63331.1
genomic	AMYH01008356.1 (11562..20444)	None
genomic	CH471147.2	EAW80120.1
genomic	DQ017060.1	AAY22177.1
genomic	GN344039.1	CAY55955.1
genomic	GQ504011.1	ACW84342.1
mRNA	AF043341.1	AAC03541.1
mRNA	AF266753.1	AAF73070.1
mRNA	AK312212.1	BAG35145.1
mRNA	BC008600.1	AAH08600.1
mRNA	BG272739.1	None
mRNA	DQ230537.1	ABB69929.1
mRNA	M21121.1	AAA36725.1
other-genetic	DQ891490.2	ABM82416.1
other-genetic	DQ894681.2	ABM85607.1