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CD163 CD163 molecule [ Homo sapiens (human) ]

Gene ID: 9332, updated on 22-May-2016
Official Symbol
CD163provided by HGNC
Official Full Name
CD163 moleculeprovided by HGNC
Primary source
HGNC:HGNC:1631
See related
Ensembl:ENSG00000177575 HPRD:05708; MIM:605545; Vega:OTTHUMG00000168353
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
M130; MM130; SCARI1
Summary
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Orthologs
Location:
12p13.3
Exon count:
17
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (7470816..7503818, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (7623412..7656414, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927882 Neighboring gene CD163 molecule like 1 Neighboring gene M-phase phosphoprotein 8 pseudogene Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 31 Neighboring gene nucleolar protein interacting with the FHA domain of MKI67 pseudogene 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of hematological and biochemical traits in a Japanese population.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of CD163 molecule by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef downregulates CD163 expression in M2-type macrophages PubMed

Go to the HIV-1, Human Interaction Database

  • Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystem (from REACTOME)
    Binding and Uptake of Ligands by Scavenger Receptors, organism-specific biosystemScavenger receptors bind free extracellular ligands as the initial step in clearance of the ligands from the body (reviewed in Ascenzi et al. 2005, Areschoug and Gordon 2009, Nielsen et al. 2010). So...
  • Scavenging of heme from plasma, organism-specific biosystem (from REACTOME)
    Scavenging of heme from plasma, organism-specific biosystemFree heme is damaging to tissues as it intercalates into biologic membranes, perturbing lipid bilayers and promoting the conversion of low-density lipoprotein to cytotoxic oxidized products. Moreover...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
scavenger receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acute-phase response IEA
Inferred from Electronic Annotation
more info
 
receptor-mediated endocytosis TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
scavenger receptor cysteine-rich type 1 protein M130
Names
hemoglobin scavenger receptor
macrophage-associated antigen

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029826.1 RefSeqGene

    Range
    5001..38003
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004244.5NP_004235.4  scavenger receptor cysteine-rich type 1 protein M130 isoform a precursor

    See identical proteins and their annotated locations for NP_004235.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as long tail variant 1, represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AI129762, BC051281, DA619387, DB291765
    Consensus CDS
    CCDS8578.1
    UniProtKB/Swiss-Prot
    Q86VB7
    Related
    ENSP00000352071, OTTHUMP00000238617, ENST00000359156, OTTHUMT00000399396
    Conserved Domains (2) summary
    smart00202
    Location:719819
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:835925
    SRCR; Scavenger receptor cysteine-rich domain
  2. NM_203416.3NP_981961.2  scavenger receptor cysteine-rich type 1 protein M130 isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as short tail variant, uses an alternate splice site in the 3' coding region compared to variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform b which is shorter, and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AI129762, BC051281, DA619387, DB291765, DQ058615
    Consensus CDS
    CCDS53742.1
    UniProtKB/Swiss-Prot
    Q86VB7
    Related
    ENSP00000403885, OTTHUMP00000238620, ENST00000432237, OTTHUMT00000399399
    Conserved Domains (2) summary
    smart00202
    Location:719819
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:835925
    SRCR; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    7470816..7503818 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253529.3XP_005253586.1  

    Conserved Domains (2) summary
    smart00202
    Location:719819
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:835925
    SRCR; Scavenger receptor cysteine-rich domain
  2. XM_005253528.3XP_005253585.1  

    UniProtKB/TrEMBL
    C9JHR8
    Related
    ENSP00000379863, OTTHUMP00000238619, ENST00000396620, OTTHUMT00000399398
    Conserved Domains (2) summary
    smart00202
    Location:752852
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:868958
    SRCR; Scavenger receptor cysteine-rich domain

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    7622379..7655379 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)