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    HSPA1A heat shock 70kDa protein 1A [ Homo sapiens ]

    Gene ID: 3303, updated on 19-May-2012
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    Summary

    Official Symbol
    HSPA1Aprovided by HGNC
    Official Full Name
    heat shock 70kDa protein 1Aprovided by HGNC
    Primary source
    HGNC:5232
    Locus tag
    DAQB-147D11.1
    See related
    Ensembl:ENSG00000204389; HPRD:00774; MIM:140550; Vega:OTTHUMG00000031201
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSP72; HSPA1; HSP70I; HSPA1B; HSP70-1; HSP70-1A; FLJ54303; FLJ54370; FLJ54392; FLJ54408; FLJ75127
    Summary
    This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    6p21.3
    Sequence :
    Chromosome: 6; NC_000006.11 (31783291..31785719)
    See HSPA1A in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) Neighboring gene heat shock 70kDa protein 1-like Neighboring gene heat shock 70kDa protein 1B Neighboring gene chromosome 6 open reading frame 48 Neighboring gene small nucleolar RNA, C/D box 48

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. Martins-de-Souza D, et al. J Proteome Res, 2012 Apr 6. PMID 22360420.
    2. Hsp70 alters tau function and aggregation in an isoform specific manner. Voss K, et al. Biochemistry, 2012 Jan 31. PMID 22236337.
    3. Radioresistance of human glioma spheroids and expression of HSP70, p53 and EGFr. Fedrigo CA, et al. Radiat Oncol, 2011 Nov 11. PMID 22077956.
    4. Identification of key residues for protein conformational transition using elastic network model. Su JG, et al. J Chem Phys, 2011 Nov 7. PMID 22070286.
    5. Hepatitis E virus ORF2 protein activates the pro-apoptotic gene CHOP and anti-apoptotic heat shock proteins. John L, et al. PLoS One, 2011. PMID 21966512.

    See all (320) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
      Title: Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
    2. neoadjuvant chemoradiation and postoperative radiotherapy has an effect on expression of heat shock protein 70 (HSP70) in head and neck vessels
      Title: Effect of neoadjuvant chemoradiation and postoperative radiotherapy on expression of heat shock protein 70 (HSP70) in head and neck vessels.
    3. Data suggest that Hsp70-1 over-expression may promote human limbo-corneal epithelial cells progenitor cell survival on amniotic membrane, possibly through the cytoprotective and anti-apoptotic effect of Hsp70-1.
      Title: Up-regulation of heat shock protein 70-1 (Hsp70-1) in human limbo-corneal epithelial cells cultivated on amniotic membrane: A proteomic study.
    4. Data indicate that Hsp70/HSPA1A inhibits aggregation of tau in isoform-specific fashion while having little impact on tau isoforms to mediate microtubule assembly; targeting Hsp70 may provide a therapeutic approach for treatment of tauopathies.
      Title: Hsp70 alters tau function and aggregation in an isoform specific manner.
    5. Key residues for the human heat shock protein 70 conformational transition was studied using elastic network model.
      Title: Identification of key residues for protein conformational transition using elastic network model.
    6. The inverse correlation between cellular Hsp72 levels and susceptibility to apoptosis support the notion that Hsp72 acts as a significant neuroprotective factor, enabling post-mitotic neurons to withstand lethal stress that induces apoptosis.
      Title: Modulation of cellular Hsp72 levels in undifferentiated and neuron-like SH-SY5Y cells determines resistance to staurosporine-induced apoptosis.
    7. Analysis suggests that HEV ORF2 interacts with Hsp72. In addition, Hsp72 shows nuclear accumulation in ORF2 expressing cells.
      Title: Hepatitis E virus ORF2 protein activates the pro-apoptotic gene CHOP and anti-apoptotic heat shock proteins.
    8. analysis of radioresistance of human glioma spheroids and expression of HSP70, p53 and EGFr
      Title: Radioresistance of human glioma spheroids and expression of HSP70, p53 and EGFr.
    9. Data show that that TAp73beta counteracts the anti-apoptotic effect of TAp73alpha by preventing Hsp72 induction.
      Title: Hsp72 mediates TAp73α anti-apoptotic effects in small cell lung carcinoma cells.
    10. The +190G/C polymorphism of HSPA1A may contribute to influence eHsp70 levels in controls and anti-Hsp70 antibody levels in ACS, and the +190G/C genotypes, eHsp70 and anti-Hsp70 antibody levels may have a joint effect on the risk of ACS.
      Title: Variants of HSPA1A in combination with plasma Hsp70 and anti-Hsp70 antibody levels associated with higher risk of acute coronary syndrome.
    Submit: New GeneRIF Correction See all (141)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Over expression of hsp70 with a herpes viral amplicon vector protects cultured hippocampal rat neurons from gp120 neurotoxicity PubMed
    env The exposure of permissive CD4+ cells to HIV-1 gp120 increases the synthesis and nuclear translocation of 70kDa heat shock protein PubMed
    Pr55(Gag) gag Hsp70 co-sediments with HIV-1 capsid protein in sucrose density gradients, providing evidence that it is specifically incorporated into HIV-1 virions through an interaction with HIV-1 Gag proteins PubMed
    gag Hsp70 is incorporated into HIV-1 virions through an interaction with HIV-1 Gag PubMed
    Tat tat Hsp70 and Hsp90 and Cdc37 regulate the stabilization and folding of CDK9 as well as the assembly of an active CDK9/cyclin T1 complex responsible for P-TEFb-mediated HIV-1 Tat transactivation PubMed
    Vpr vpr HIV-1 Vpr binds to Hsp70 in coimmunoprecipitation assays PubMed
    vpr Hsp70, a heat-shock protein contributing to cellular stress responses, inhibits nuclear translocation of HIV-1 Vpr; Hsp70 stimulates HIV-1 nuclear import and replication in macrophages in the absence of Vpr. PubMed
    vpr Overexpression of Heat shock protein 70 (Hsp70) in yeast and mammalian cells inhibits HIV-1 Vpr-induced cell cycle G2 arrest, and suppression of Hsp70 expression by RNAi increases Vpr-dependent apoptosis PubMed
    vpr HIV-1 Vpr competes with Hsp70 for binding to karyopherin alpha PubMed
    matrix gag Hsp70 facilitates nuclear import of HIV-1 preintegration complexes by stimulating the binding of HIV-1 Matrix to karyopherin alpha PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Heat shock 70 KD protein 1A O95831 AIFM1    HPRD  PubMed  
    Heat shock 70 KD protein 1A O14727 APAF1    HPRD  PubMed  
    Heat shock 70 KD protein 1A P27695 APEX1    HPRD  PubMed  
    Heat shock 70 KD protein 1A P04114 APOB    HPRD  PubMed  
    Heat shock 70 KD protein 1A P54253 ATXN1    HPRD  PubMed  
    Heat shock 70 KD protein 1A Q99933 BAG1    HPRD  PubMed  
    Heat shock 70 KD protein 1A O95816 BAG2    HPRD  PubMed  
    Heat shock 70 KD protein 1A O95817 BAG3    HPRD  PubMed  
    Heat shock 70 KD protein 1A O95429 BAG4    HPRD  PubMed  
    Heat shock 70 KD protein 1A P10415 BCL2    HPRD  PubMed  
    Heat shock 70 KD protein 1A Q8TDC3 BRSK1    HPRD  PubMed  
    Heat shock 70 KD protein 1A Q15878 CACNA1E    HPRD  PubMed  
    Heat shock 70 KD protein 1A P50750 CDK9    HPRD  PubMed  
    Heat shock 70 KD protein 1A O60884 DNAJA2    HPRD  PubMed  
    Heat shock 70 KD protein 1A Q96EY1 DNAJA3    HPRD  PubMed  
    Heat shock 70 KD protein 1A P25685 DNAJB1    HPRD  PubMed  
    Heat shock 70 KD protein 1A Q9UBS4 DNAJB11    HPRD  PubMed  
    Heat shock 70 KD protein 1A Q13217 DNAJC3    HPRD  PubMed  
    Heat shock 70 KD protein 1A Q8WXU2 DYX1C1    HPRD  PubMed  
    Heat shock 70 KD protein 1A P19525 EIF2AK2    HPRD  PubMed  
    Heat shock 70 KD protein 1A Q00597 FANCC    HPRD  PubMed  
    Heat shock 70 KD protein 1A Q05586 GRIN1    HPRD  PubMed  
    Heat shock 70 KD protein 1A O15399 GRIN2D    HPRD  PubMed  
    Heat shock 70 KD protein 1A P51610 HCFC1    HPRD  PubMed  
    Heat shock 70 KD protein 1A O75506 HSBP1    HPRD  PubMed  
    Heat shock 70 KD protein 1A Q00613 HSF1    HPRD  PubMed  
    Heat shock 70 KD protein 1A Heat shock 70 KD protein 1A HSPA1A    HPRD  PubMed  
    Heat shock 70 KD protein 1A P11142 HSPA8    HPRD  PubMed  
    Heat shock 70 KD protein 1A HSPBP1 HSPBP1    HPRD  PubMed  
    Heat shock 70 KD protein 1A Q9Y6K9 IKBKG    HPRD  PubMed  
    Heat shock 70 KD protein 1A P05783 KRT18    HPRD  PubMed  
    Heat shock 70 KD protein 1A P08729 KRT7    HPRD  PubMed  
    Heat shock 70 KD protein 1A Q99683 MAP3K5    HPRD  PubMed  
    Heat shock 70 KD protein 1A P00540 MOS    HPRD  PubMed  
    Heat shock 70 KD protein 1A P21757 MSR1    HPRD  PubMed  
    Heat shock 70 KD protein 1A P15559 NQO1    HPRD  PubMed  
    Heat shock 70 KD protein 1A P04150 NR3C1    HPRD  PubMed  
    Heat shock 70 KD protein 1A P50542 PEX5    HPRD  PubMed  
    Heat shock 70 KD protein 1A Protein phosphatase 1, regulatory subunit 15A PPP1R15A    HPRD  PubMed  
    Heat shock 70 KD protein 1A P17252 PRKCA    HPRD  PubMed  
    Heat shock 70 KD protein 1A Q15185 PTGES3    HPRD  PubMed  
    Heat shock 70 KD protein 1A P06454 PTMA    HPRD  PubMed  
    Heat shock 70 KD protein 1A P62834 RAP1A    HPRD  PubMed  
    Heat shock 70 KD protein 1A P61586 RHOA    HPRD  PubMed  
    Heat shock 70 KD protein 1A P13866 SLC5A1    HPRD  PubMed  
    Heat shock 70 KD protein 1A Q9NRH2 SNRK    HPRD  PubMed  
    Heat shock 70 KD protein 1A P48436 SOX9    HPRD  PubMed  
    Heat shock 70 KD protein 1A P50502 ST13    HPRD  PubMed  
    Heat shock 70 KD protein 1A P31948 STIP1    HPRD  PubMed  
    Heat shock 70 KD protein 1A Q9UNE7 STUB1    HPRD  PubMed  
    Heat shock 70 KD protein 1A O14776 TCERG1    HPRD  PubMed  
    Heat shock 70 KD protein 1A O94826 TOMM70A    HPRD  PubMed  
    Heat shock 70 KD protein 1A P04637 TP53    HPRD  PubMed  
    Heat shock 70 KD protein 1A O43715 TRIAP1    HPRD  PubMed  
    Heat shock 70 KD protein 1A O15164 TRIM24    HPRD  PubMed  
    Heat shock 70 KD protein 1A Q9BXA6 TSSK6    HPRD  PubMed  
    Heat shock 70 KD protein 1A Q99614 TTC1    HPRD  PubMed  
    Heat shock 70 KD protein 1A Q8N1V2 WDR16    HPRD  PubMed  
    Heat shock 70 KD protein 1A P31946 YWHAB    HPRD  PubMed  
    Heat shock 70 KD protein 1A P61981 YWHAG    HPRD  PubMed  
    Heat shock 70 KD protein 1A P27348 YWHAQ    HPRD  PubMed  
    Heat shock 70 KD protein 1A P63104 YWHAZ    HPRD  PubMed  
    M11717.1 NP_004497.1 HSF2    BIND  PubMed HSF2 interacts with hsp70i promoter. 
    BioGRID:109535 BioGRID:114579 AIFM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109535 BioGRID:106862 AR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109535 BioGRID:107049 BAG1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109535 BioGRID:114907 BAG3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109535 BioGRID:113647 BAG6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109535 BioGRID:113911 BAP1    BioGRID  PubMed Co-purification 
    BioGRID:109535 BioGRID:107068 BCL2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109535 BioGRID:107459 CDK9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109535 BioGRID:114029 CUL4A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109535 BioGRID:114023 DYRK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109535 BioGRID:108276 EGFR    BioGRID  PubMed PCA 
    BioGRID:109535 BioGRID:128178 EIF2C4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109535 BioGRID:108473 FANCC    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:109535 BioGRID:124619 FCHSD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109535 BioGRID:116686 FNBP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109535 BioGRID:109119 GPR37    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109535 BioGRID:109268 H2AFX    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109535 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109535 BioGRID:109530 HSF1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109535 BioGRID:109552 HSP90AA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109535 BioGRID:114089 IKBKG    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109535 BioGRID:119325 INSIG2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109535 BioGRID:116667 KDM1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109535 BioGRID:110381 MAP3K5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109535 BioGRID:110319 MAX    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109535 BioGRID:110455 MME    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109535 BioGRID:110587 MSR1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109535 BioGRID:125363 MYSM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109535 BioGRID:109165 NR3C1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109535 BioGRID:119018 PACSIN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109535 BioGRID:116413 PACSIN2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109535 BioGRID:118896 PACSIN3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109535 BioGRID:111105 PARK2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109535 BioGRID:114513 PSTPIP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109535 BioGRID:115045 RAPGEF2    BioGRID  PubMed Two-hybrid 
    BioGRID:109535 BioGRID:115301 RBX1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109535 BioGRID:106880 RHOA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109535 BioGRID:112414 SLC5A1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109535 BioGRID:112506 SNCA    BioGRID  PubMed FRET; Reconstituted Complex 
    BioGRID:109535 BioGRID:112504 SNCB    BioGRID  PubMed FRET 
    BioGRID:109535 BioGRID:112545 SOX9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109535 BioGRID:117071 SRRM2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109535 BioGRID:112644 ST13    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109535 BioGRID:112670 STK11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109535 BioGRID:115563 STUB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109535 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109535 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109535 BioGRID:132223 SUMO4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109535 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109535 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109535 BioGRID:131884 USP50    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109535 BioGRID:113364 YWHAG    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Pathways from BioSystems

    • Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Antigen processing and presentation, organism-specific biosystem (from KEGG)
      Antigen processing and presentation, organism-specific biosystem
      Antigen processing and presentation
    • Antigen processing and presentation, conserved biosystem (from KEGG)
      Antigen processing and presentation, conserved biosystem
      Antigen processing and presentation
    • Apoptosis Modulation by HSP70, organism-specific biosystem (from WikiPathways)
      Apoptosis Modulation by HSP70, organism-specific biosystem
      Apoptosis Modulation by HSP70
    • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
      Direct p53 effectors, organism-specific biosystem
      Direct p53 effectors
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • FOXM1 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      FOXM1 transcription factor network, organism-specific biosystem
      FOXM1 transcription factor network
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Legionellosis, organism-specific biosystem (from KEGG)
      Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Legionellosis, conserved biosystem (from KEGG)
      Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Prion diseases, organism-specific biosystem (from KEGG)
      Prion diseases, organism-specific biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
    • Prion diseases, conserved biosystem (from KEGG)
      Prion diseases, conserved biosystemPrion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of ...
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Spliceosome, organism-specific biosystem (from KEGG)
      Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, conserved biosystem (from KEGG)
      Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, 35S U5-snRNP, organism-specific biosystem (from KEGG)
      Spliceosome, 35S U5-snRNP, organism-specific biosystemStructural complex; Genetic information processing; Spliceosome
    • Spliceosome, Prp19/CDC5L complex, organism-specific biosystem (from KEGG)
      Spliceosome, Prp19/CDC5L complex, organism-specific biosystemStructural complex; Genetic information processing; Spliceosome
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
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    General protein information

    Preferred Names
    heat shock 70 kDa protein 1A/1B
    Names
    heat shock 70 kDa protein 1A/1B
    HSP70-1/HSP70-2
    HSP70.1/HSP70.2
    heat shock 70kD protein 1A
    heat shock-induced protein
    heat shock 70 kDa protein 1/2
    dnaK-type molecular chaperone HSP70-1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005345.5 → NP_005336.3  heat shock 70 kDa protein 1A/1B

      Status: REVIEWED

      Source sequence(s)
      AK096017, AK225692, BC002453, DA256622, DA486842
      Consensus CDS
      CCDS34414.1
      UniProtKB/TrEMBL
      A8K5I0
      UniProtKB/TrEMBL
      B3KTT5
      UniProtKB/Swiss-Prot
      P08107
      Related
      ENSP00000364802, OTTHUMP00000029287, ENST00000375651, OTTHUMT00000076401
      Conserved Domains (1) summary
      PTZ00009
      Location:1 – 611
      Blast Score: 2792
      PTZ00009; heat shock 70 kDa protein; Provisional

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      31783291..31785719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_1

    Genomic

    1. NT_167244.1 Reference GRCh37.p5 ALT_REF_LOCI_1

      Range
      3098052..3100480
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.2 Reference GRCh37.p5 ALT_REF_LOCI_2

      Range
      3292871..3295299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.1 Reference GRCh37.p5 ALT_REF_LOCI_3

      Range
      3068878..3071306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.1 Reference GRCh37.p5 ALT_REF_LOCI_6

      Range
      3076938..3079366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      31569698..31572209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AB018045.1 BAA77235.1
    genomic AF134726.1 AAD21816.1
    genomic AL662834.8 (79397..81825) None
    genomic AL671762.10 (23360..25788) None
    genomic AL929592.8 CAI18464.1
      CAI18465.1
      CAI18466.1
    genomic BA000025.2 BAB63300.1
    genomic CH471081.1 EAX03528.1
    genomic CR388202.9 (8598..11026) None
    genomic CR759915.6 (60569..62997) None
    genomic DQ388429.1 ABD48956.1
    genomic DQ451402.1 ABD96830.1
    genomic M11717.1 AAA52697.1
    genomic M24743.1 AAA59844.1
    genomic M59828.1 AAA63226.1
    genomic X04676.1 CAA28381.1
    genomic X04677.1 CAA28382.1
    mRNA AB209818.1 BAD93055.1
    mRNA AK096017.1 BAG53197.1
    mRNA AK225692.1 None
    mRNA AK225699.1 None
    mRNA AK291295.1 BAF83984.1
    mRNA AK294182.1 BAG57500.1
    mRNA AK298056.1 BAG60350.1
    mRNA AK301243.1 BAG62811.1
    mRNA AK301574.1 BAG63067.1
    mRNA AK303980.1 BAG64898.1
    mRNA AK304618.1 BAG65400.1
    mRNA AK304652.1 BAG65428.1
    mRNA BC002453.2 AAH02453.1
    mRNA BC009322.2 AAH09322.1
    mRNA BC018740.1 AAH18740.1
    mRNA DA256622.1 None
    mRNA DA486842.1 None
    other-genetic EU176434.1 ABW03885.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08107.5 GenPept UniProtKB/Swiss-Prot:P08107
    Q59EJ3 GenPept UniProtKB/TrEMBL:Q59EJ3
    Q9UQC1 GenPept UniProtKB/TrEMBL:Q9UQC1
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    Additional Links

    Additional Links

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