KDR kinase insert domain receptor (a type III receptor tyrosine kinase) [Homo sapiens (human)] - Gene

Summary

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Official Symbol: KDRprovided by HGNC
Official Full Name: kinase insert domain receptor (a type III receptor tyrosine kinase)provided by HGNC
Primary source: HGNC:6307
See related: Ensembl:ENSG00000128052; HPRD:01867; MIM:191306; Vega:OTTHUMG00000128734
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FLK1; CD309; VEGFR; VEGFR2
Summary: Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]

Genomic context

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Location :: 4q11-q12

Sequence :: Chromosome: 4; NC_000004.11 (55944426..55991762, complement)

See KDR in Epigenomics, MapViewer

Chromosome 4 - NC_000004.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

VEGFR2 internalization may be a generic requirement for pro-angiogenic growth factors to activate endothelial ERK1/2 signaling
Title: Essential role for endocytosis in the growth factor-stimulated activation of ERK1/2 in endothelial cells.
Beta(2)-GPI suppresses VEGF-induced phosphorylation of VEGF receptor 2.
Title: β₂-glycoprotein I inhibits VEGF-induced endothelial cell growth and migration via suppressing phosphorylation of VEGFR2, ERK1/2, and Akt.
TXNIP is essential for VEGFR2 internalization in Rab5 positive endosomes, which is required for endothelial cell growth and angiogenesis.
Title: Thioredoxin-interacting protein mediates sustained VEGFR2 signaling in endothelial cells required for angiogenesis.
Brucine potently suppresses angiogenesis by targeting VEGFR2 activation and may be a viable drug candidate in anti-angiogenesis and anti-cancer therapies.
Title: Brucine, an indole alkaloid from Strychnos nux-vomica attenuates VEGF-induced angiogenesis via inhibiting VEGFR2 signaling pathway in vitro and in vivo.
Perturbation of the HSP70-HSP90 heat-shock protein axis stimulates degradation of endothelial VEGFR2.
Title: A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair.
miR-17-3p is a negative regulator of the angiogenic phenotype of endothelial cells through its ability to modulate the expression of Flk-1, which is implicated in the pleiotropic effects of miR-17-92 in angiogenesis.
Title: MiR-17-3p inhibits angiogenesis by downregulating flk-1 in the cell growth signal pathway.
This is the first report demonstrating that Myo1c is an important mediator of VEGF-induced VEGFR2 delivery to the cell surface and plays a role in angiogenic signaling.
Title: The myosin motor Myo1c is required for VEGFR2 delivery to the cell surface and for angiogenic signaling.
Our findings suggested that VEGFR-2 gene variants might contribute to glioma susceptibility.
Title: Association between genetic variations of vascular endothelial growth factor receptor 2 and glioma in the Chinese Han population.
We defined a molecular mechanism by which FAS1 domain protein blocks the association between alpha 5 beta 3 integrin and VEGFR-2
Title: FAS1 domain protein inhibits VEGF165-induced angiogenesis by targeting the interaction between VEGFR-2 and αvβ3 integrin.
The KDR -604C/1192A/1719T haplotype increased the risk of pediatric moyamoya (p = 0.024).
Title: The role of VEGF and KDR polymorphisms in moyamoya disease and collateral revascularization.

Submit: New GeneRIF Correction See all (442)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Hemangioma, capillary infantile

MIM: 602089

Genetic Testing Registry

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 downregulates KDR expression in human mesenchymal stem cells	PubMed
Nef, p27	nef	HIV-1 Nef upregulates VEGFR2 and its co-receptor neuropilin-1 and downregulates the expression of semaphorin 3a in podocytes	PubMed
Tat, p14	tat	HIV-1 Tat inhibits the differentiation of mesenchymal stem cells (MSCs) to endothelial cells by downregulating the expression of VEGF-induced endothelial markers such as Flt-1, KDR and vWF	PubMed
	tat	Adhesion of endothelial cells to HIV-1 Tat triggers a signal transduction pathway, which leads to phosphorylation of VEGFR2 and pp60src and activation of ERK1/2	PubMed
	tat	Endothelial cell adherent to HIV-1 Tat induces upregulation of VEGFR2, integrin (3) subunit, pp60src and recruits VEGFR2, integrin (3) subunit, paxillin, focal adhesion kinase, and pp60src to ventral plasma membranes	PubMed
	tat	The phosphorylation of vascular endothelial growth factor receptor type 2 (Flk-1/KDR) induces the ability of Tat to stimulate focal adhesion assembly and the migration of human brain micro vascular endothelial cells (HBMECs)	PubMed
	tat	Sulfated polymannuroguluronate, a novel anti-AIDS drug candidate, greatly arrests Tat-driven KDR phosphorylation and blocks the interaction between Tat and integrin beta1, thus inhibiting the phosphorylation of the kinases FAK, paxillin and MAPKs	PubMed
	tat	Kinase insert domain receptor (a type III receptor tyrosine kinase) 1 is upregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells	PubMed
	tat	VEGFR2 is upregulated by HIV-1 Tat treatment in human epithelial cells	PubMed
	tat	HIV-1 Tat, through its basic region (amino acids 49-57), binds and activates VEGFR-2, an effect associated with Tat-mediated pathogenesis and induction of angiogenesis in AIDS-associated Kaposi's sarcoma	PubMed
	tat	The interaction of HIV-1 Tat with KDR/VEGFR2 is implicated in the activation of ERK1 and ERK2 signaling pathways	PubMed
	tat	The activation of AKT and the protection of Kaposi's sarcoma cells from apoptosis mediated by HIV-1 Tat involves the interaction of Tat with VEGFR2	PubMed
nucleocapsid	gag	KDR is upregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_002244.1	BAA25798.1	SHC2	BIND	PubMed	Sck interacts with KDR.
NP_002244.1	NP_003367.3	VEGFA	BIND	PubMed	VEGF interacts with KDR.
NP_002244.1	NP_003367.3	VEGFA	BIND	PubMed	VEGF-A interacts with VEGFR-2. This interaction was modeled on a demonstrated interaction between human VEGF-A and VEGFR-2 from an unspecified species.
NP_002244.1	NP_003367.3	VEGFA	BIND	PubMed	VEGF165 interacts with KDR. This interaction was modeled on a demonstrated interaction between human VEGF165 and KDR from an unspecified species.
NP_002244.1	NP_005420.1	VEGFC	BIND	PubMed	VEGF-C interacts with VEGFR-2. This interaction was modeled on a demonstrated interaction between human VEGF-C and VEGFR-2 from an unspecified species.
NP_002244.1	AAB29220.2		BIND	PubMed	VEGF-E NZ2 interacts with VEGFR-2. This interaction was modeled on a demonstrated interaction between Orf virus VEGF-E NZ2 and VEGFR-2 from an unspecified species.
NP_002244.1	AAB29223.1		BIND	PubMed	VEGF-E NZ7 interacts with VEGFR-2. This interaction was modeled on a demonstrated interaction between Orf virus VEGF-E NZ7 and VEGFR-2 from an unspecified species.
NP_002244.1	P67863		BIND	PubMed	Vammin interacts with KDR. This interaction was modeled on a demonstrated interaction between Western sand viper vammin and KDR from an unspecified species.
P35968	P24666	ACP1	HPRD	PubMed
P35968	P08758	ANXA5	HPRD	PubMed
P35968	Q13535	ATR	HPRD	PubMed
P35968	P51813	BMX	HPRD	PubMed
P35968	Q03135	CAV1	HPRD	PubMed
P35968	P22681	CBL	HPRD	PubMed
P35968	P33151	CDH5	HPRD	PubMed
P35968	P39060	COL18A1	HPRD	PubMed
P35968	P46108	CRK	HPRD	PubMed
P35968	P32927	CSF2RB	HPRD	PubMed
P35968	P35222	CTNNB1	HPRD	PubMed
P35968	P50570	DNM2	HPRD	PubMed
P35968	O43915	FIGF	HPRD	PubMed
P35968	P17948	FLT1	HPRD	PubMed
P35968	P35916	FLT4	HPRD	PubMed
P35968	Q8WU20	FRS2	HPRD	PubMed
P35968	P06241	FYN	HPRD	PubMed
P35968	P29992	GNA11	HPRD	PubMed
P35968	P50148	GNAQ	HPRD	PubMed
P35968	Q13322	GRB10	HPRD	PubMed
P35968	P62993	GRB2	HPRD	PubMed
P35968	P07900	HSP90AA1	HPRD	PubMed
P35968	P46940	IQGAP1	HPRD	PubMed
P35968	P05106	ITGB3	HPRD	PubMed
P35968	P35968	KDR	HPRD	PubMed
P35968	P16333	NCK1	HPRD	PubMed
P35968	O14786	NRP1	HPRD	PubMed
P35968	P41231	P2RY2	HPRD	PubMed
P35968	P19174	PLCG1	HPRD	PubMed
P35968	P16885	PLCG2	HPRD	PubMed
P35968	Q06124	PTPN11	HPRD	PubMed
P35968	P29350	PTPN6	HPRD	PubMed
P35968	P20936	RASA1	HPRD	PubMed
P35968	Q9NP31	SH2D2A	HPRD	PubMed
P35968	Q15464	SHB	HPRD	PubMed
P35968	P29353	SHC1	HPRD	PubMed
P35968	SHC (Src homology 2 domain containing) transforming protein 2	SHC2	HPRD	PubMed
P35968	P12931	SRC	HPRD	PubMed
P35968	P42224	STAT1	HPRD	PubMed
P35968	Q96PV0	SYNGAP1	HPRD	PubMed
P35968	P35625	TIMP3	HPRD	PubMed
P35968	P15692	VEGFA	HPRD	PubMed
P35968	P49767	VEGFC	HPRD	PubMed
P35968	P07947	YES1	HPRD	PubMed
BioGRID:109992	BioGRID:106568	ACP1	BioGRID	PubMed	Two-hybrid
BioGRID:109992	BioGRID:113684	AIMP2	BioGRID	PubMed	Two-hybrid
BioGRID:109992	BioGRID:106805	ANXA5	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:109992	BioGRID:114457	BTRC	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:109992	BioGRID:107315	CBL	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:109992	BioGRID:107438	CDH5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109992	BioGRID:123311	COL18A1	BioGRID	PubMed	Reconstituted Complex
BioGRID:109992	BioGRID:107837	CSNK1D	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:109992	BioGRID:114032	CUL1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109992	BioGRID:118965	EPN1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109992	BioGRID:116887	FBXW11	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:109992	BioGRID:108567	FIGF	BioGRID	PubMed	Reconstituted Complex
BioGRID:109992	BioGRID:108609	FLT1	BioGRID	PubMed	Biochemical Activity
BioGRID:109992	BioGRID:109144	GRB10	BioGRID	PubMed	Two-hybrid
BioGRID:109992	BioGRID:109142	GRB2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109992	BioGRID:114353	IQGAP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109992	BioGRID:111351	PLCG1	BioGRID	PubMed	Reconstituted Complex
BioGRID:109992	BioGRID:111375	PLXNA1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109992	BioGRID:111856	RASA1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109992	BioGRID:112358	SHB	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109992	BioGRID:112361	SHC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109992	BioGRID:117302	SHC2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:109992	BioGRID:112592	SRC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:109992	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:109992	BioGRID:113265	VEGFA	BioGRID	PubMed	Biochemical Activity

Pathways from BioSystems

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Angiogenesis, organism-specific biosystem (from WikiPathways)
Angiogenesis, organism-specific biosystemThis pathway is a concise and simplified version of the basic proteins involved in angiogenesis. The proces is regulated by hyopoxia, which results in the transcription of eg. VEGF1, FGF2, PDGFbeta, ...
Cardiac Progenitor Differentiation, organism-specific biosystem (from WikiPathways)
Cardiac Progenitor Differentiation, organism-specific biosystemFactors involved in the induction of cardiac differentiation in vitro and in vivo. This model was based on the below two review articles.
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Endocytosis, organism-specific biosystem (from KEGG)
Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Endocytosis, conserved biosystem (from KEGG)
Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Focal Adhesion, organism-specific biosystem (from WikiPathways)
Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal adhesion, organism-specific biosystem (from KEGG)
Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal adhesion, conserved biosystem (from KEGG)
Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
HIF-2-alpha transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
HIF-2-alpha transcription factor network, organism-specific biosystem
HIF-2-alpha transcription factor network
Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...
Integrins in angiogenesis, organism-specific biosystem (from Pathway Interaction Database)
Integrins in angiogenesis, organism-specific biosystem
Integrins in angiogenesis
Neurophilin interactions with VEGF and VEGFR, organism-specific biosystem (from REACTOME)
Neurophilin interactions with VEGF and VEGFR, organism-specific biosystemThe plasma membrane-associated Neuropilin receptors NRP-1 and -2 bind some of the VEGF proteins and associate with VEGF receptor proteins. NRP-1 binds VEGF-A165, -B, and PLGF-2; NRP-2 also binds VEGF...
Notch-mediated HES/HEY network, organism-specific biosystem (from Pathway Interaction Database)
Notch-mediated HES/HEY network, organism-specific biosystem
Notch-mediated HES/HEY network
PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
Proteoglycans in cancer, organism-specific biosystem (from KEGG)
Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Proteoglycans in cancer, conserved biosystem (from KEGG)
Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
S1P1 pathway, organism-specific biosystem (from Pathway Interaction Database)
S1P1 pathway, organism-specific biosystem
S1P1 pathway
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signaling by VEGF, organism-specific biosystem (from REACTOME)
Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
Signaling events mediated by TCPTP, organism-specific biosystem (from Pathway Interaction Database)
Signaling events mediated by TCPTP, organism-specific biosystem
Signaling events mediated by TCPTP
Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
Signaling events mediated by VEGFR1 and VEGFR2
VEGF binds to VEGFR leading to receptor dimerization, organism-specific biosystem (from REACTOME)
VEGF binds to VEGFR leading to receptor dimerization, organism-specific biosystemThe binding of VEGF ligands to VEGFR receptors in the cell membrane induces dimerization and activation of the latter, initiating intracellular signaling cascades that result in proliferation, surviv...
VEGF ligand-receptor interactions, organism-specific biosystem (from REACTOME)
VEGF ligand-receptor interactions, organism-specific biosystemThe VEGF family is encoded by seven genes (VEGF-A, B, C, D, E: PLGF (Placenta Growth Factor)-1, 2). Six isoforms of VEGF-A protein, containing 121, 145, 165, 183, 189, and 206 amino acid residues, an...
VEGF signaling pathway, organism-specific biosystem (from KEGG)
VEGF signaling pathway, organism-specific biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
VEGF signaling pathway, conserved biosystem (from KEGG)
VEGF signaling pathway, conserved biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...

General gene information

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Markers

RH70435 (e-PCR)
- UniSTS:1288

G20520 (e-PCR)
- UniSTS:62237

A005U41 (e-PCR)
- UniSTS:62238

SHGC-59221 (e-PCR)
- UniSTS:47905

SHGC-59525 (e-PCR)
- UniSTS:47937

SHGC-50925 (e-PCR)
- UniSTS:31855

KDR (e-PCR)
- UniSTS:479862

GDB:626090 (e-PCR)
- UniSTS:158389

GDB:626093 (e-PCR)
- UniSTS:158390

KDR (e-PCR)
- UniSTS:503486

Genotypes

See KDR SNP Geneview Report
See KDR SNP Genotype Report
See KDR SNP Variation Viewer Report

Homology

Homologs of the KDR gene: The KDR gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, and zebrafish.
Map Viewer (Mouse)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
Hsp90 protein binding	TAS Traceable Author Statement more info	PubMed
growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
integrin binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
receptor signaling protein tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed
transmembrane receptor protein tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed
vascular endothelial growth factor binding	IPI Inferred from Physical Interaction more info
vascular endothelial growth factor-activated receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
angiogenesis	TAS Traceable Author Statement more info	PubMed
branching morphogenesis of an epithelial tube	IEA Inferred from Electronic Annotation more info
calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
calcium-mediated signaling using intracellular calcium source	IMP Inferred from Mutant Phenotype more info	PubMed
cell fate commitment	IEA Inferred from Electronic Annotation more info
cell maturation	IEA Inferred from Electronic Annotation more info
cell migration involved in sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
cellular response to vascular endothelial growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
cellular response to vascular endothelial growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
embryonic hemopoiesis	ISS Inferred from Sequence or Structural Similarity more info
endothelial cell differentiation	IEA Inferred from Electronic Annotation more info
endothelium development	ISS Inferred from Sequence or Structural Similarity more info
lung alveolus development	IEA Inferred from Electronic Annotation more info
lymph vessel development	IEA Inferred from Electronic Annotation more info
negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of endothelial cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
ovarian follicle development	IEA Inferred from Electronic Annotation more info
peptidyl-tyrosine autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of focal adhesion assembly	IDA Inferred from Direct Assay more info	PubMed
positive regulation of mesenchymal cell proliferation	IEA Inferred from Electronic Annotation more info
positive regulation of nitric-oxide synthase biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of nitric-oxide synthase biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of phosphatidylinositol 3-kinase cascade	IDA Inferred from Direct Assay more info	PubMed
positive regulation of positive chemotaxis	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
regulation of cell shape	IDA Inferred from Direct Assay more info	PubMed
signal transduction by phosphorylation	TAS Traceable Author Statement more info	PubMed
surfactant homeostasis	IEA Inferred from Electronic Annotation more info
transmembrane receptor protein tyrosine kinase signaling pathway	TAS Traceable Author Statement more info	PubMed
vascular endothelial growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
vascular endothelial growth factor receptor signaling pathway	TAS Traceable Author Statement more info
vascular endothelial growth factor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
vasculogenesis	ISS Inferred from Sequence or Structural Similarity more info
virus-host interaction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
Golgi apparatus	IDA Inferred from Direct Assay more info
cytoplasmic membrane-bounded vesicle	IEA Inferred from Electronic Annotation more info
early endosome	ISS Inferred from Sequence or Structural Similarity more info
endosome	IDA Inferred from Direct Assay more info
external side of plasma membrane	IEA Inferred from Electronic Annotation more info
extracellular region	IEA Inferred from Electronic Annotation more info
integral to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
membrane raft	IDA Inferred from Direct Assay more info
nucleus	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info
plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: vascular endothelial growth factor receptor 2

Names: vascular endothelial growth factor receptor 2; soluble VEGFR2; fetal liver kinase 1; fetal liver kinase-1; protein-tyrosine kinase receptor Flk-1; tyrosine kinase growth factor receptor

NP_002244.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012004.1 RefSeqGene

Range

5001..52337

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002253.2 → NP_002244.1 vascular endothelial growth factor receptor 2 precursor

Status: REVIEWED

Source sequence(s)

AC111194, AF035121, BP280621

Consensus CDS

CCDS3497.1

UniProtKB/Swiss-Prot

P35968

Related

ENSP00000263923, OTTHUMP00000158928, ENST00000263923, OTTHUMT00000250645

Conserved Domains (8) summary

cd05103
Location:826 – 1167
Blast Score: 1760

PTKc_VEGFR2; Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 2

cd00096
Location:684 – 739
Blast Score: 148

Ig; Immunoglobulin domain

cd05862
Location:239 – 326
Blast Score: 378

Ig1_VEGFR; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R)

cd05864
Location:348 – 417
Blast Score: 348

Ig2_VEGFR-2; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 2 (VEGFR-2)

pfam07679
Location:667 – 754
Blast Score: 211

I-set; Immunoglobulin I-set domain

smart00410
Location:565 – 661
Blast Score: 100

IG_like; Immunoglobulin like

pfam07686
Location:230 – 324
Blast Score: 104

V-set; Immunoglobulin V-set domain

pfam07714
Location:1000 – 1160
Blast Score: 734

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000004.11 Reference GRCh37.p10 Primary Assembly

Range

55944426..55991762, complement

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Alternate HuRef

Genomic

AC_000136.1 Alternate HuRef

Range

51893013..51940346, complement

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Alternate CHM1_1.0

Genomic

NC_018915.1 Alternate CHM1_1.0

Range

55846626..55893967, complement

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Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01003408.1 (14939..62272)	None
genomic	AC021220.7	None
genomic	AC111194.4 (130983..132645)	None
genomic	AMYH01014189.1 (480..47821)	None
genomic	CH471057.1	EAX05462.1
		EAX05463.1
		EAX05464.1
genomic	X89776.1	CAA61916.1
mRNA	AB209901.1	BAD93138.1
mRNA	AF035121.1	AAB88005.1
mRNA	AF063658.1	AAC16450.1
mRNA	AK293668.1	BAG57114.1
mRNA	BC131822.1	AAI31823.1
mRNA	BP280621.1	None
mRNA	EU826563.1	ACF47599.1
mRNA	FJ899739.1	ACR78514.1
mRNA	L04947.1	AAA59459.1
mRNA	X61656.1	CAA43837.1