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    SFPQ splicing factor proline/glutamine-rich [ Homo sapiens ]

    Gene ID: 6421, updated on 11-May-2012
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    Summary

    Official Symbol
    SFPQprovided by HGNC
    Official Full Name
    splicing factor proline/glutamine-richprovided by HGNC
    Primary source
    HGNC:10774
    See related
    Ensembl:ENSG00000116560; HPRD:07284; MIM:605199; Vega:OTTHUMG00000004157
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PSF; POMP100; DKFZp547C228; DKFZp667K0521; DKFZp686K1282
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    Genomic context

    Location :
    1p34.3
    Sequence :
    Chromosome: 1; NC_000001.10 (35641975..35648082, complement)
    Chromosome: 1; NC_000001.10 (35649201..35658743, complement)
    See SFPQ in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L12 pseudogene Neighboring gene zinc finger, MYM-type 1 Neighboring gene zinc finger, MYM-type 4 Neighboring gene ribosomal protein L5 pseudogene 4 Neighboring gene RNA, Ro-associated Y5 pseudogene 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). Lopitz-Otsoa F, et al. J Proteomics, 2012 Jun 6. PMID 22178446.
    2. A cohesin-RAD21 interactome. Panigrahi AK, et al. Biochem J, 2012 Mar 15. PMID 22145905.
    3. The splicing factor proline-glutamine rich (SFPQ/PSF) is involved in influenza virus transcription. Landeras-Bueno S, et al. PLoS Pathog, 2011 Nov. PMID 22114566.
    4. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.

    See all (93) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. results indicate that SFPQ/PSF is a host factor essential for influenza virus transcription that increases the efficiency of viral mRNA polyadenylation
      Title: The splicing factor proline-glutamine rich (SFPQ/PSF) is involved in influenza virus transcription.
    2. Data reveal a new player in tau exon 10 alternative splicing regulation and uncover a previously unknown mechanism of PSF in regulating tau pre-mRNA splicing.
      Title: PSF suppresses tau exon 10 inclusion by interacting with a stem-loop structure downstream of exon 10.
    3. RVxF motifs play an important role in controlling the multifunctional properties of p54nrb and PSF in the regulation of gene transcription
      Title: Consensus PP1 binding motifs regulate transcriptional corepression and alternative RNA splicing activities of the steroid receptor coregulators, p54nrb and PSF.
    4. SFPQ/NONO heterodimer is involved in the early stage of the DSB response.
      Title: Involvement of Matrin 3 and SFPQ/NONO in the DNA damage response.
    5. PSF influences repair via direct, local, interaction with the DNA substrate
      Title: Sequences in PSF/SFPQ mediate radioresistance and recruitment of PSF/SFPQ-containing complexes to DNA damage sites in human cells.
    6. these results identify PSF as a repressor of STAT6-mediated transcription that functions through recruitment of HDAC to the STAT6 transcription complex, and delineates a novel regulatory mechanism of IL-4 signaling
      Title: PTB-associated splicing factor (PSF) functions as a repressor of STAT6-mediated Ig epsilon gene transcription by recruitment of HDAC1.
    7. In response to hyperosmotic stress, p38 also regulates formation of complexes between hDlg and PSF.
      Title: p38gamma regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock.
    8. GSK3/TRAP150, complex regulates CD45 alternative splicing and demonstrate a paradigm for signal transduction from the cell surface to the RNA processing machinery through the multifunctional protein PSF.
      Title: Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing.
    9. PSF (polypyrimidine tract-binding protein-associated splicing factor) and p54(nrb), two highly related proteins involved in transcription and RNA processing, are identified as new binding partners of hnRNP M.
      Title: hnRNP M interacts with PSF and p54(nrb) and co-localizes within defined nuclear structures.
    10. Disruption of the growth hormone receptor polypyrimidine tract causes aberrant mRNA splicing resulting in growth hormone insensitivity.
      Title: Identification and characterisation of a novel GHR defect disrupting the polypyrimidine tract and resulting in GH insensitivity.
    Submit: New GeneRIF Correction See all (30)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Genome-wide association study identifies a common variant associated with risk of endometrial cancer.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_005057.1 NP_031389.3 NONO    BIND  PubMed PSF interacts with p54nrb 
    NP_005057.1 NP_003277.1 TOP1    BIND  PubMed Top1 interacts with PSF 
    P23246 Q9NQT4 EXOSC5    HPRD  PubMed  
    P23246 Q14192 FHL2    HPRD  PubMed  
    P23246 P35637 FUS    HPRD  PubMed  
    P23246 Q9UK76 HN1    HPRD  PubMed  
    P23246 Q15233 NONO    HPRD  PubMed  
    P23246 PSPC1 PSPC1    HPRD  PubMed  
    P23246 P26599 PTBP1    HPRD  PubMed  
    P23246 P23246 SFPQ    HPRD  PubMed  
    P23246 Q96ST3 SIN3A    HPRD  PubMed  
    P23246 Q99717 SMAD5    HPRD  PubMed  
    P23246 P09012 SNRPA    HPRD  PubMed  
    P23246 Q8WXA9 SREK1    HPRD  PubMed  
    P23246 P11387 TOP1    HPRD  PubMed  
    P23246 P62988 UBB    HPRD  PubMed  
    P23246 Q9UBW7 ZMYM2    HPRD  PubMed  
    BioGRID:112319 BioGRID:223223 AI837181    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112319 BioGRID:106819 APBB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112319 BioGRID:106862 AR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112319 BioGRID:107424 CDC5L    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:112319 BioGRID:971788 EBNA-LP    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:112319 BioGRID:121243 EXOSC5    BioGRID  PubMed Two-hybrid 
    BioGRID:112319 BioGRID:108565 FHL2    BioGRID  PubMed Two-hybrid 
    BioGRID:112319 BioGRID:114094 GAS7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112319 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112319 BioGRID:109316 HDAC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112319 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112319 BioGRID:119338 HN1    BioGRID  PubMed Two-hybrid 
    BioGRID:112319 BioGRID:111580 MAPK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112319 BioGRID:204968 Mapk13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112319 BioGRID:201430 Mki67    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112319 BioGRID:110904 NONO    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:112319 BioGRID:109165 NR3C1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112319 BioGRID:110983 NR4A2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112319 BioGRID:207330 Nono    BioGRID  PubMed Co-purification 
    BioGRID:112319 BioGRID:111317 PIN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112319 BioGRID:111326 PITX3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:112319 BioGRID:117417 POT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112319 BioGRID:111493 PPP1CA    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:112319 BioGRID:111570 PRKCI    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112319 BioGRID:120792 PRPF40A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112319 BioGRID:111697 PTBP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112319 BioGRID:111817 RAC1    BioGRID  PubMed Two-hybrid 
    BioGRID:112319 BioGRID:111822 RAD21    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112319 BioGRID:203038 Rxra    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112319 BioGRID:112319 SFPQ    BioGRID  PubMed Two-hybrid 
    BioGRID:112319 BioGRID:117439 SIN3A    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:112319 BioGRID:112479 SMARCA2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112319 BioGRID:112486 SMARCD1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112319 BioGRID:112490 SMN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112319 BioGRID:112510 SNRPA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112319 BioGRID:116597 SNW1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112319 BioGRID:112550 SP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112319 BioGRID:112553 SP3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112319 BioGRID:126754 SREK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112319 BioGRID:115544 SRRM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112319 BioGRID:117071 SRRM2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112319 BioGRID:112655 STAT6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112319 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:112319 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112319 BioGRID:203256 Sin3a    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112319 BioGRID:112734 TADA2A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112319 BioGRID:116120 TCERG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112319 BioGRID:113003 TOP1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:112319 BioGRID:115505 TOPORS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112319 BioGRID:204183 Thra    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112319 BioGRID:116466 U2AF2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112319 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex; Two-hybrid 
    BioGRID:112319 BioGRID:116363 WBP4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112319 BioGRID:119707 WWOX    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112319 BioGRID:113534 ZMYM2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    alternative nuclear mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    paraspeckles IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    splicing factor, proline- and glutamine-rich
    Names
    splicing factor, proline- and glutamine-rich
    hPOMp100
    100 kDa DNA-pairing protein
    PTB-associated splicing factor
    PTB-associated-splicing factor
    DNA-binding p52/p100 complex, 100 kDa subunit
    polypyrimidine tract binding protein associated
    polypyrimidine tract-binding protein-associated splicing factor
    polypyrimidine tract-binding protein-associated-splicing factor
    splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)
    splicing factor proline/glutamine rich (polypyrimidine tract-binding protein-associated)
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005066.2 → NP_005057.1  splicing factor, proline- and glutamine-rich

      Status: VALIDATED

      Source sequence(s)
      BC051192, X70944
      Consensus CDS
      CCDS388.1
      UniProtKB/Swiss-Prot
      P23246
      UniProtKB/TrEMBL
      Q86VG2
      Related
      ENSP00000349748, OTTHUMP00000004329, ENST00000357214, OTTHUMT00000011984
      Conserved Domains (2) summary
      cd00590
      Location:298 – 366
      Blast Score: 187
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
      pfam08075
      Location:444 – 495
      Blast Score: 252
      NOPS; NOPS (NUC059) domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10

      Range
      35641975..35648082, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_110484.1 RNA Sequence

    2. XR_110485.1 RNA Sequence

    3. XR_110486.1 RNA Sequence

    Alternate HuRef

    Genomic

    1. AC_000133.1

      Range
      33760232..33766799, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_112064.1 RNA Sequence

    2. XR_112062.1 RNA Sequence

    3. XR_112063.1 RNA Sequence

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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL590434.16 CAI12467.1
    genomic CH471059.2 EAX07421.1
      EAX07422.1
      EAX07423.1
      EAX07424.1
      EAX07425.1
      EAX07426.1
    mRNA AK307985.1 None
    mRNA AL831889.1 None
    mRNA AL833670.1 None
    mRNA BC000546.1 None
    mRNA BC004534.2 AAH04534.2
    mRNA BC027708.2 AAH27708.1
    mRNA BC027717.2 None
    mRNA BC051192.1 AAH51192.1
    mRNA BX537811.1 None
    mRNA X16850.1 CAA34747.1
    mRNA X70944.1 CAA50283.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23246.2 GenPept UniProtKB/Swiss-Prot:P23246
    Q6PIX2 GenPept UniProtKB/TrEMBL:Q6PIX2
    Q86VG2 GenPept UniProtKB/TrEMBL:Q86VG2
    Q9BSV4 GenPept UniProtKB/TrEMBL:Q9BSV4
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

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