RAB11A RAB11A, member RAS oncogene family [Homo sapiens (human)] - Gene

Summary

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Official Symbol: RAB11Aprovided by HGNC
Official Full Name: RAB11A, member RAS oncogene familyprovided by HGNC
Primary source: HGNC:9760
See related: Ensembl:ENSG00000103769; HPRD:05715; MIM:605570; Vega:OTTHUMG00000133162
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: YL8
Summary: The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Genomic context

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Location :: 15q22.31

Sequence :: Chromosome: 15; NC_000015.9 (66161797..66184329)

See RAB11A in Epigenomics, MapViewer

Chromosome 15 - NC_000015.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

The potential roles of the Rab11 pathway in the trafficking, assembly and budding steps of negative-strand viruses.
Title: Role of the Rab11 pathway in negative-strand virus assembly.
Rab11 depletion gives rise to accumulation of recycling carriers containing endocytosed transferrin and transferrin receptor beneath the plasma membrane.
Title: Rab11 regulates exocytosis of recycling vesicles at the plasma membrane.
findings show 2 mother centriole appendage proteins, centriolin and cenexin/ODF2, regulate association of the endosome components Rab11, the Evi5, and the exocyst at the mother centriole
Title: The centrosome regulates the Rab11- dependent recycling endosome pathway at appendages of the mother centriole.
Rab11A/myosin Vb/Rab11-FIP2 complex frames two late recycling steps of langerin from the ERC to the plasma membrane
Title: A Rab11A/myosin Vb/Rab11-FIP2 complex frames two late recycling steps of langerin from the ERC to the plasma membrane.
TBC1D14 binds activated Rab11 but is not a GAP for Rab11, and loss of Rab11 prevents TBC1D14-induced tubulation of recycling endosomes.
Title: TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes.
Our data suggest a selective role of PICK1 in clustering and reducing the recycling rates of PDZ domain binding partners sorted to the Rab11-dependent recycling pathway.
Title: Protein interacting with C kinase 1 (PICK1) reduces reinsertion rates of interaction partners sorted to Rab11-dependent slow recycling pathway.
Recycling was accompanied by dephosphorylation of VEGFR-2 between Rab4 and Rab11 vesicles and quantitatively and qualitatively altered signal output.
Title: Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output.
Our results uncover a critical host factor with an essential contribution to influenza virus genome delivery and reveal a potential role for RAB11A in the transport of ribonucleoprotein cargo.
Title: RAB11A is essential for transport of the influenza virus genome to the plasma membrane.
The authors propose that influenza virus ribonucleoproteins are routed from the nucleus to the pericentriolar recycling endosome (RE), where they access a Rab11-dependent vesicular transport pathway to the cell periphery.
Title: A Rab11- and microtubule-dependent mechanism for cytoplasmic transport of influenza A virus viral RNA.
Rabin8 and Rab11 are associated with the Bardet-Biedl syndrome.
Title: Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome.

Submit: New GeneRIF Correction See all (40)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Gag, Pr55	gag	HIV-1 Gag and viral RNA preferentially co-localize with multivesicular bodies and Rab11a endosomes	PubMed
	gag	Rab11a modulates intracellular Gag expression in U1 cells	PubMed
Nef, p27	nef	RAB11(Q67L) mutant induces significant reversal of HLA-I A2 downregulation by HIV-1 Nef through redistributing HLA-I A2 from the perinuclear vesicles to the peripheral punctate vesicles at the plasma membrane	PubMed
	nef	HIV-1 Nef co-localization with Rab11A GTPase is revealed by staining in the peripheral and perinuclear compartments	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_004654.1	NP_056285.1	RAB11FIP5	BIND	PubMed	Rab11 interacts with the carboxy terminus, including the coiled-coil region, of Gaf-1.
P62491	Q7LBR1	CHMP1B	HPRD	PubMed
P62491	Q9Y3E7	CHMP3	HPRD	PubMed
P62491	P50395	GDI2	HPRD	PubMed
P62491	Q9Y4I1	MYO5A	HPRD	PubMed
P62491	Q9ULV0	MYO5B	HPRD	PubMed
P62491	P30153	PPP2R1A	HPRD	PubMed
P62491	P30154	PPP2R1B	HPRD	PubMed
P62491	P49768	PSEN1	HPRD	PubMed
P62491	P49810	PSEN2	HPRD	PubMed
P62491	P62491	RAB11A	HPRD	PubMed
P62491	Q6WKZ4	RAB11FIP1	HPRD	PubMed
P62491	Q7L804	RAB11FIP2	HPRD	PubMed
P62491	O75154	RAB11FIP3	HPRD	PubMed
P62491	Q86YS3	RAB11FIP4	HPRD	PubMed
P62491	Q9BXF6	RAB11FIP5	HPRD	PubMed
P62491	RAB3A interacting protein like 1	RAB3IL1	HPRD	PubMed
P62491	P53611	RABGGTB	HPRD	PubMed
P62491	Q12846	STX4	HPRD	PubMed
P62491	P21731	TBXA2R	HPRD	PubMed
P62491	Q5JSH3	WDR44	HPRD	PubMed
BioGRID:114299	BioGRID:107776	ATF2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114299	BioGRID:107235	CACNA2D1	BioGRID	PubMed	Co-fractionation
BioGRID:114299	BioGRID:107506	CFTR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114299	BioGRID:121394	CHMP1B	BioGRID	PubMed	Two-hybrid
BioGRID:114299	BioGRID:119660	CHMP3	BioGRID	PubMed	Two-hybrid
BioGRID:114299	BioGRID:124070	CYSTM1	BioGRID	PubMed	Co-fractionation
BioGRID:114299	BioGRID:123857	DTNBP1	BioGRID	PubMed	Two-hybrid
BioGRID:114299	BioGRID:108309	ELAVL1	BioGRID	PubMed	Affinity Capture-RNA
BioGRID:114299	BioGRID:108621	FN1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114299	BioGRID:108933	GDI2	BioGRID	PubMed	Reconstituted Complex
BioGRID:114299	BioGRID:109147	GRIA1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114299	BioGRID:109148	GRIA2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114299	BioGRID:109537	HSPA1L	BioGRID	PubMed	Co-fractionation
BioGRID:114299	BioGRID:109541	HSPA5	BioGRID	PubMed	Co-fractionation
BioGRID:114299	BioGRID:114089	IKBKG	BioGRID	PubMed	Reconstituted Complex
BioGRID:114299	BioGRID:109822	ILF3	BioGRID	PubMed	Co-fractionation
BioGRID:114299	BioGRID:114375	KAT2B	BioGRID	PubMed	Two-hybrid
BioGRID:114299	BioGRID:110713	MYH10	BioGRID	PubMed	Co-fractionation
BioGRID:114299	BioGRID:110712	MYH9	BioGRID	PubMed	Co-fractionation
BioGRID:114299	BioGRID:111510	PPP2R1A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114299	BioGRID:111511	PPP2R1B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114299	BioGRID:114661	RAB11B	BioGRID	PubMed	Co-fractionation
BioGRID:114299	BioGRID:123189	RAB11FIP1	BioGRID	PubMed	Affinity Capture-MS; Far Western; Reconstituted Complex; Two-hybrid
BioGRID:114299	BioGRID:116514	RAB11FIP2	BioGRID	PubMed	Far Western; Two-hybrid
BioGRID:114299	BioGRID:115076	RAB11FIP3	BioGRID	PubMed	Far Western; Reconstituted Complex; Two-hybrid
BioGRID:114299	BioGRID:124079	RAB11FIP4	BioGRID	PubMed	Far Western; Reconstituted Complex; Two-hybrid
BioGRID:114299	BioGRID:117518	RAB11FIP5	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:114299	BioGRID:111799	RAB1A	BioGRID	PubMed	Co-fractionation
BioGRID:114299	BioGRID:123619	RAB1B	BioGRID	PubMed	Co-fractionation
BioGRID:114299	BioGRID:111804	RAB3IL1	BioGRID	PubMed	Two-hybrid
BioGRID:114299	BioGRID:111806	RAB5A	BioGRID	PubMed	Co-fractionation
BioGRID:114299	BioGRID:113624	RAB7A	BioGRID	PubMed	Co-fractionation
BioGRID:114299	BioGRID:117406	RCHY1	BioGRID	PubMed	Two-hybrid
BioGRID:114299	BioGRID:112296	SEC13	BioGRID	PubMed	Two-hybrid
BioGRID:114299	BioGRID:119615	TDP2	BioGRID	PubMed	Two-hybrid
BioGRID:114299	BioGRID:113156	TYRP1	BioGRID	PubMed	Co-fractionation
BioGRID:114299	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
BioGRID:114299	BioGRID:118920	UQCR10	BioGRID	PubMed	Co-fractionation
BioGRID:114299	BioGRID:113364	YWHAG	BioGRID	PubMed	Two-hybrid

Pathways from BioSystems

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Aquaporin-mediated transport, organism-specific biosystem (from REACTOME)
Aquaporin-mediated transport, organism-specific biosystemAquaporins (AQP's) are six-pass transmembrane proteins that form channels in membranes. Each monomer contains a central channel formed in part by two asparagine-proline-alanine motifs (NPA boxes) tha...
Arf6 downstream pathway, organism-specific biosystem (from Pathway Interaction Database)
Arf6 downstream pathway, organism-specific biosystem
Arf6 downstream pathway
Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem (from KEGG)
Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
Endocrine and other factor-regulated calcium reabsorption, conserved biosystem (from KEGG)
Endocrine and other factor-regulated calcium reabsorption, conserved biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
Endocytosis, organism-specific biosystem (from KEGG)
Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Endocytosis, conserved biosystem (from KEGG)
Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Membrane Trafficking, organism-specific biosystem (from REACTOME)
Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
Notch signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
Notch signaling pathway, organism-specific biosystem
Notch signaling pathway
Pancreatic secretion, organism-specific biosystem (from KEGG)
Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
Pancreatic secretion, conserved biosystem (from KEGG)
Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
Regulation of Water Balance by Renal Aquaporins, organism-specific biosystem (from REACTOME)
Regulation of Water Balance by Renal Aquaporins, organism-specific biosystemIn the kidney water and solutes are passed out of the bloodstream and into the proximal tubule via the slit-like structure formed by nephrin in the glomerulus. Water is reabsorbed from the filtrate d...
Thromboxane A2 receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
Thromboxane A2 receptor signaling, organism-specific biosystem
Thromboxane A2 receptor signaling
Translocation of GLUT4 to the Plasma Membrane, organism-specific biosystem (from REACTOME)
Translocation of GLUT4 to the Plasma Membrane, organism-specific biosystemIn adipocytes and myocytes insulin signaling causes intracellular vesicles carrying the GLUT4 glucose transporter to translocate to the plasma membrane, allowing the cells to take up glucose from the...
Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
Transmembrane transport of small molecules, organism-specific biosystem
Transmembrane transport of small molecules
Vasopressin-regulated water reabsorption, organism-specific biosystem (from KEGG)
Vasopressin-regulated water reabsorption, organism-specific biosystemIn the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adju...
Vasopressin-regulated water reabsorption, conserved biosystem (from KEGG)
Vasopressin-regulated water reabsorption, conserved biosystemIn the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adju...

General gene information

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Markers

SHGC-82517 (e-PCR)
- UniSTS:104463

WI-15108 (e-PCR)
- UniSTS:83480

D8S2279 (e-PCR)
- UniSTS:473907

D15S728E (e-PCR)
- UniSTS:151622

STS-N21208 (e-PCR)
- UniSTS:22088

1982 (e-PCR)
- UniSTS:17748

RAB11A_474 (e-PCR)
- UniSTS:277632

A008D11 (e-PCR)
- UniSTS:63361

D15S913 (e-PCR)
- UniSTS:53930

D15S857 (e-PCR)
- UniSTS:153537

RH80236 (e-PCR)
- UniSTS:83908

D15S710E (e-PCR)
- UniSTS:21195

WI-17132 (e-PCR)
- UniSTS:10960

RAB11A (e-PCR)
- UniSTS:264165

Homology

Homologs of the RAB11A gene: The RAB11A gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and rice.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
GTP binding	IEA Inferred from Electronic Annotation more info
GTPase activity	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
syntaxin binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
melanosome transport	ISS Inferred from Sequence or Structural Similarity more info
neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
plasma membrane to endosome transport	NAS Non-traceable Author Statement more info	PubMed
protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
protein transport	IEA Inferred from Electronic Annotation more info
regulation of long-term neuronal synaptic plasticity	IEA Inferred from Electronic Annotation more info
regulation of protein transport	IEA Inferred from Electronic Annotation more info
small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info
transmembrane transport	TAS Traceable Author Statement more info
vesicle-mediated transport	IDA Inferred from Direct Assay more info	PubMed
water transport	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
cytoplasmic vesicle membrane	TAS Traceable Author Statement more info
mitochondrion	IEA Inferred from Electronic Annotation more info
phagocytic vesicle	IDA Inferred from Direct Assay more info
phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info
protein complex	IDA Inferred from Direct Assay more info	PubMed
recycling endosome	ISS Inferred from Sequence or Structural Similarity more info
recycling endosome membrane	IEA Inferred from Electronic Annotation more info
trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed
transport vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ras-related protein Rab-11A

Names: ras-related protein Rab-11A; rab-11; RAB 11A, member oncogene family

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001206836.1 → NP_001193765.1 ras-related protein Rab-11A isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AC084854, AK300008, BC013348, BC047114, DC300743

Consensus CDS

CCDS58373.1

UniProtKB/TrEMBL

B4DT13

UniProtKB/Swiss-Prot

P62491

Conserved Domains (2) summary

pfam13401
Location:14 – 131
Blast Score: 94

AAA_22; AAA domain

cd01868
Location:9 – 146
Blast Score: 823

Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25
NM_004663.4 → NP_004654.1 ras-related protein Rab-11A isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC084854, BC013348, BC047114, DC300743

Consensus CDS

CCDS10212.1

UniProtKB/Swiss-Prot

P62491

Related

ENSP00000261890, OTTHUMP00000164214, ENST00000261890, OTTHUMT00000256864

Conserved Domains (2) summary

PLN03110
Location:5 – 215
Blast Score: 844

PLN03110; Rab GTPase; Provisional

cd01868
Location:9 – 173
Blast Score: 977

Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000015.9 Reference GRCh37.p10 Primary Assembly

Range

66161797..66184329

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000147.1 Alternate HuRef

Range

42986532..43009063

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018926.1 Alternate CHM1_1.0

Range

46218971..46241503

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01038835.1 (82759..105290)	None
genomic	AC084854.11 (106476..128983)	None
genomic	AMYH01006720.1 (67223..89755)	None
genomic	CH471082.1	EAW77752.1
		EAW77753.1
mRNA	AF000231.1	AAC32887.1
mRNA	AF498946.1	AAM21094.1
mRNA	AK054930.1	None
mRNA	AK297549.1	BAG59943.1
mRNA	AK298961.1	BAG61057.1
mRNA	AK300008.1	BAG61825.1
mRNA	AK311770.1	BAG34713.1
mRNA	BC013348.2	AAH13348.1
mRNA	BC047114.1	None
mRNA	BI550703.1	None
mRNA	BT020151.1	AAV38953.1
mRNA	BT020154.1	AAV38956.1
mRNA	CR407669.1	CAG28597.1
mRNA	CR536493.1	CAG38732.1
mRNA	DC300743.1	None
mRNA	X53143.1	CAA37300.1
mRNA	X56740.1	CAA40064.1
other-genetic	DQ893054.2	ABM83980.1
other-genetic	DQ896303.2	ABM87302.1