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    RBMX RNA binding motif protein, X-linked [ Homo sapiens (human) ]

    Gene ID: 27316, updated on 14-May-2013
    Official Symbol
    RBMXprovided by HGNC
    Official Full Name
    RNA binding motif protein, X-linkedprovided by HGNC
    Primary source
    HGNC:9910
    Locus tag
    RP11-1114A5.1
    See related
    Ensembl:ENSG00000147274; HPRD:02186; MIM:300199; Vega:OTTHUMG00000022517
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNMX; HNRPG; RBMXP1; RBMXRT; hnRNP-G
    Summary
    This gene belongs to the RBMY gene family which includes candidate Y chromosome spermatogenesis genes. This gene, an active X chromosome homolog of the Y chromosome RBMY gene, is widely expressed whereas the RBMY gene evolved a male-specific function in spermatogenesis. Pseudogenes of this gene, found on chromosomes 1, 4, 9, 11, and 6, were likely derived by retrotransposition from the original gene. Alternatively spliced transcript variants encoding different isoforms have been identified. A snoRNA gene (SNORD61) is found in one of its introns. [provided by RefSeq, Sep 2009]
    Location :
    Xq26.3
    Sequence :
    Chromosome: X; NC_000023.10 (135951353..135962939, complement)
    See RBMX in Epigenomics, MapViewer

    Chromosome X - NC_000023.10Genomic Context describing neighboring genes Neighboring gene RAN, member RAS oncogene family pseudogene 4 Neighboring gene RAB28, member RAS oncogene family pseudogene Neighboring gene small nucleolar RNA, C/D box 61 Neighboring gene ribosomal protein L22 pseudogene Neighboring gene transmembrane 9 superfamily member 2 pseudogene Neighboring gene serine/arginine repetitive matrix 1 pseudogene 3

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description
    P38159 Coiled-coil domain containing 33 CCDC33    HPRD  PubMed  
    P38159 Q14011 CIRBP    HPRD  PubMed  
    P38159 Q9BTL3 FAM103A1    HPRD  PubMed  
    P38159 P51116 FXR2    HPRD  PubMed  
    P38159 P61978 HNRNPK    HPRD  PubMed  
    P38159 Sam68 like mammalian protein 1 KHDRBS2    HPRD  PubMed  
    P38159 O75525 KHDRBS3    HPRD  PubMed  
    P38159 Q8TBB1 LNX1    HPRD  PubMed  
    P38159 Q92530 PSMF1    HPRD  PubMed  
    P38159 Q9Y580 RBM7    HPRD  PubMed  
    P38159 O60504 SORBS3    HPRD  PubMed  
    P38159 Q8WXA9 SREK1    HPRD  PubMed  
    P38159 P62995 TRA2B    HPRD  PubMed  
    BioGRID:118134 BioGRID:223223 AI837181    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:120937 CAND1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:123126 CCDC33    BioGRID  PubMed Two-hybrid 
    BioGRID:118134 BioGRID:107424 CDC5L    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:118134 BioGRID:107573 CIRBP    BioGRID  PubMed Two-hybrid 
    BioGRID:118134 BioGRID:113387 CNBP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:107841 CSNK2A1    BioGRID  PubMed Biochemical Activity 
    BioGRID:118134 BioGRID:107880 CTNNB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:114030 CUL3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:198534 Cbx1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:108021 DDX5    BioGRID  PubMed Co-fractionation 
    BioGRID:118134 BioGRID:108029 DHX15    BioGRID  PubMed Co-fractionation 
    BioGRID:118134 BioGRID:108237 EEF1A1    BioGRID  PubMed Co-fractionation 
    BioGRID:118134 BioGRID:115119 EIF4A3    BioGRID  PubMed Affinity Capture-MS; Co-fractionation 
    BioGRID:118134 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:199505 Erh    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:123704 FAM103A1    BioGRID  PubMed Two-hybrid 
    BioGRID:118134 BioGRID:108621 FN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:108797 FUS    BioGRID  PubMed Two-hybrid 
    BioGRID:118134 BioGRID:114890 FXR2    BioGRID  PubMed Two-hybrid 
    BioGRID:118134 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:109318 HDGF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:116149 HNRNPA0    BioGRID  PubMed Co-fractionation 
    BioGRID:118134 BioGRID:109420 HNRNPA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:109424 HNRNPC    BioGRID  PubMed Co-fractionation 
    BioGRID:118134 BioGRID:109425 HNRNPD    BioGRID  PubMed Co-fractionation 
    BioGRID:118134 BioGRID:109426 HNRNPF    BioGRID  PubMed Co-fractionation 
    BioGRID:118134 BioGRID:109428 HNRNPH1    BioGRID  PubMed Co-fractionation 
    BioGRID:118134 BioGRID:109431 HNRNPK    BioGRID  PubMed Co-fractionation; Two-hybrid 
    BioGRID:118134 BioGRID:110751 HNRNPM    BioGRID  PubMed Co-fractionation 
    BioGRID:118134 BioGRID:115530 HNRNPR    BioGRID  PubMed Co-fractionation 
    BioGRID:118134 BioGRID:116281 HNRNPUL1    BioGRID  PubMed Co-fractionation 
    BioGRID:118134 BioGRID:109660 IFIT3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:109789 IL7R    BioGRID  PubMed Protein-RNA 
    BioGRID:118134 BioGRID:109883 ITGA4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:119098 ITSN2    BioGRID  PubMed Two-hybrid 
    BioGRID:118134 BioGRID:109920 JAK2    BioGRID  PubMed Two-hybrid 
    BioGRID:118134 BioGRID:115900 KHDRBS1    BioGRID  PubMed Two-hybrid 
    BioGRID:118134 BioGRID:128436 KHDRBS2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Two-hybrid 
    BioGRID:118134 BioGRID:115899 KHDRBS3    BioGRID  PubMed Two-hybrid 
    BioGRID:118134 BioGRID:115114 KIAA0101    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:248934 Khdrbs3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:118134 BioGRID:124219 LNX1    BioGRID  PubMed Two-hybrid 
    BioGRID:118134 BioGRID:110290 MAGOH    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:121122 MEPCE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:110852 NFE2L2    BioGRID  PubMed Two-hybrid 
    BioGRID:118134 BioGRID:122238 NUCKS1    BioGRID  PubMed Co-fractionation 
    BioGRID:118134 BioGRID:115745 NXF1    BioGRID  PubMed Co-fractionation 
    BioGRID:118134 BioGRID:114872 PSMF1    BioGRID  PubMed Two-hybrid 
    BioGRID:118134 BioGRID:116575 RALY    BioGRID  PubMed Co-fractionation 
    BioGRID:118134 BioGRID:115160 RB1CC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:115700 RBM14    BioGRID  PubMed Co-fractionation 
    BioGRID:118134 BioGRID:115478 RBM7    BioGRID  PubMed Two-hybrid 
    BioGRID:118134 BioGRID:115265 RBM8A    BioGRID  PubMed Co-fractionation 
    BioGRID:118134 BioGRID:112079 RPL31    BioGRID  PubMed Co-fractionation 
    BioGRID:118134 BioGRID:112148 RPS28    BioGRID  PubMed Co-fractionation 
    BioGRID:118134 BioGRID:110115 RPSA    BioGRID  PubMed Co-fractionation 
    BioGRID:118134 BioGRID:112155 RRM2    BioGRID  PubMed Co-fractionation 
    BioGRID:118134 BioGRID:112201 SAFB    BioGRID  PubMed Co-fractionation 
    BioGRID:118134 BioGRID:115580 SF3A1    BioGRID  PubMed Co-fractionation 
    BioGRID:118134 BioGRID:113826 SF3A2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:117017 SF3B1    BioGRID  PubMed Co-fractionation 
    BioGRID:118134 BioGRID:119651 SF3B14    BioGRID  PubMed Co-fractionation 
    BioGRID:118134 BioGRID:116188 SF3B2    BioGRID  PubMed Co-fractionation 
    BioGRID:118134 BioGRID:117016 SF3B3    BioGRID  PubMed Co-fractionation 
    BioGRID:118134 BioGRID:115554 SF3B4    BioGRID  PubMed Co-fractionation 
    BioGRID:118134 BioGRID:119602 SIRT7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:114488 SOCS3    BioGRID  PubMed Two-hybrid 
    BioGRID:118134 BioGRID:115475 SORBS3    BioGRID  PubMed Two-hybrid 
    BioGRID:118134 BioGRID:126754 SREK1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:118134 BioGRID:115544 SRRM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:117071 SRRM2    BioGRID  PubMed Affinity Capture-MS; Co-fractionation 
    BioGRID:118134 BioGRID:112653 STAT5A    BioGRID  PubMed Two-hybrid 
    BioGRID:118134 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:207949 Shoc2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:112332 TRA2B    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:118134 BioGRID:214351 Trim69    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:115791 UBD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:124430 USP45    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:113255 VCAM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:113306 WHSC1    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:118134 BioGRID:204613 Ybx1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:118134 BioGRID:125858 ZC3H18    BioGRID  PubMed Co-fractionation 
    BioGRID:118134 BioGRID:121544 ZNF490    BioGRID  PubMed Two-hybrid 
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
      Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
    • Spliceosome, organism-specific biosystem (from KEGG)
      Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, conserved biosystem (from KEGG)
      Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • mRNA Splicing, organism-specific biosystem (from REACTOME)
      mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
    • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
      mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...
    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IDA
    Inferred from Direct Assay
    more info
     
    RNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    core promoter binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA splicing TAS
    Traceable Author Statement
    more info
     
    cellular response to interleukin-1 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    gene expression TAS
    Traceable Author Statement
    more info
     
    mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    PubMed 
    mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
     
    membrane protein ectodomain proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homooligomerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of alternative mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
     
    Component Evidence Code Pubs
    catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular vesicular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear euchromatin IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    supraspliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    RNA-binding motif protein, X chromosome
    Names
    RNA-binding motif protein, X chromosome
    hnRNP G
    glycoprotein p43
    RNA binding motif protein, X chromosome
    heterogeneous nuclear ribonucleoprotein G

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012918.1 RefSeqGene

      Range
      5001..16587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001164803.1NP_001158275.1  RNA-binding motif protein, X chromosome isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks several alternate exon and contains a different 3' end, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus when it is compared to variant 1.
      Source sequence(s)
      AK304868, BM147410, BX647131, DC337568
      Consensus CDS
      CCDS55510.1
      UniProtKB/Swiss-Prot
      P38159
      Related
      ENSP00000411989, OTTHUMP00000024133, ENST00000431446, OTTHUMT00000058509
      Conserved Domains (2) summary
      COG0724
      Location:175
      Blast Score: 181
      COG0724; RNA-binding proteins (RRM domain) [General function prediction only]
      cd00590
      Location:974
      Blast Score: 199
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
    2. NM_002139.3NP_002130.2  RNA-binding motif protein, X chromosome isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the more frequently occurring transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      BC007435, BM147410, BM993214, DC337568
      Consensus CDS
      CCDS14661.1
      UniProtKB/Swiss-Prot
      P38159
      Related
      ENSP00000359645, OTTHUMP00000024132, ENST00000320676, OTTHUMT00000058507
      Conserved Domains (3) summary
      pfam08081
      Location:173217
      Blast Score: 144
      RBM1CTR; RBM1CTR (NUC064) family
      COG0724
      Location:985
      Blast Score: 173
      COG0724; RNA-binding proteins (RRM domain) [General function prediction only]
      cd12382
      Location:786
      Blast Score: 372
      RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins

    RNA

    1. NR_028476.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK091520, BM147410, BM993214, DA925805
    2. NR_028477.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' coding region, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK096015, AK304573, BM147410, BM993214, DC337568

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000023.10 Reference GRCh37.p10 Primary Assembly

      Range
      135951353..135962939, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000155.1 Alternate HuRef

      Range
      125221196..125232578, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018934.1 Alternate CHM1_1.0

      Range
      135909927..135921513, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

      Supplemental Content

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