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CD1A CD1a molecule [ Homo sapiens (human) ]

Gene ID: 909, updated on 12-May-2015
Official Symbol
CD1Aprovided by HGNC
Official Full Name
CD1a moleculeprovided by HGNC
Primary source
HGNC:HGNC:1634
See related
Ensembl:ENSG00000158477; HPRD:01776; MIM:188370; Vega:OTTHUMG00000017512
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
R4; T6; CD1; FCB6; HTA1
Summary
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Orthologs
See CD1A in MapViewer
Location:
1q23.1
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (158248329..158258269)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (158218119..158228059)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene elongation factor, RNA polymerase II, 2 pseudogene 1 Neighboring gene CD1d molecule Neighboring gene ribosomal protein S10 pseudogene 8 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 5 Neighboring gene CD1c molecule

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef impairs the generation of a CD3epsilon(+)CD5(+) CD1a(+) T cell differentiation precursor stage that initiates a D-J rearrangement of the TCRbeta locus PubMed
nef CD1a molecules are downregulated by and co-localized with Nef in CD1a-transfected cells; this co-localization is dependent upon the CD1a cytoplasmic tail from amino acid position 325 to 327 PubMed
Tat tat CD4 and CD1a surface expression are greatly decreased in Tat expression Jurkat cells PubMed
tat Only the wild-type Tat induces CD1A-expressing MDDC maturation and increases the production of cytokines TNF-alpha, IL-12, MIP-1alpha, and MIP-1beta PubMed
tat CD1A-expressing monocyte-derived dendritic cells (MDDC) efficiently uptake wild-type and Cys-22 Tat but not oxidized Tat PubMed

Go to the HIV-1, Human Interaction Database

  • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
    Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hematopoietic cell lineage, conserved biosystem (from KEGG)
    Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
beta-2-microglobulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
endogenous lipid antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
 
exogenous lipid antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
 
lipopeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
antigen processing and presentation, exogenous lipid antigen via MHC class Ib IBA
Inferred from Biological aspect of Ancestor
more info
 
immune response NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
endosome membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
T-cell surface glycoprotein CD1a
Names
T-cell surface glycoprotein CD1a
CD1A antigen, a polypeptide
T-cell surface antigen T6/Leu-6
cluster of differentiation 1 A
cortical thymocyte antigen CD1A
differentiation antigen CD1-alpha-3
epidermal dendritic cell marker CD1a
hTa1 thymocyte antigen

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001763.2NP_001754.2  T-cell surface glycoprotein CD1a precursor

    See identical proteins and their annotated locations for NP_001754.2

    Status: REVIEWED

    Source sequence(s)
    AL121986, CA432941, DB108750, M28825
    Consensus CDS
    CCDS1174.1
    UniProtKB/Swiss-Prot
    P06126
    Related
    ENSP00000289429, OTTHUMP00000018907, ENST00000289429, OTTHUMT00000046349
    Conserved Domains (2) summary
    cd07698
    Location:202295
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cl08246
    Location:47198
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    158248329..158258269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510117.1XP_011508419.1  

    Conserved Domains (2) summary
    cd07698
    Location:191284
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cl08246
    Location:36187
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
  2. XM_011510118.1XP_011508420.1  

    Conserved Domains (2) summary
    cl08246
    Location:47198
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    cl11960
    Location:202239
    Ig; Immunoglobulin domain

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    159620301..159624433
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)