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    CXCR3 chemokine (C-X-C motif) receptor 3 [ Homo sapiens ]

    Gene ID: 2833, updated on 13-May-2012

    Summary

    Official Symbol
    CXCR3provided by HGNC
    Official Full Name
    chemokine (C-X-C motif) receptor 3provided by HGNC
    Primary source
    HGNC:4540
    See related
    Ensembl:ENSG00000186810; HPRD:02936; MIM:300574; Vega:OTTHUMG00000033326
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R
    Summary
    This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]

    Genomic context

    Location :
    Xq13
    Sequence :
    Chromosome: X; NC_000023.10 (70835766..70838367, complement)
    See CXCR3 in Epigenomics, MapViewer

    Chromosome X - NC_000023.10Genomic Context describing neighboring genes Neighboring gene O-linked N-acetylglucosamine (GlcNAc) transferase Neighboring gene acidic repeat containing Neighboring gene uncharacterized protein CXorf49-like Neighboring gene uncharacterized LOC441501

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Nef nef Significant increases in neuronal cell death resulting from HIV-1 Nef-induced upregulation of IP-10 is reduced by an antibody directed against human CXCR3, suggesting an interaction of CXCR3 with Nef PubMed
    Tat tat HIV-1 Tat can inhibit CXCR3-mediated functions by interfering with the chemotactic activity of IP-10/CXCL10, an effect mediated by Tat amino acids 25-31 PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P49682 P02778 CXCL10    HPRD  PubMed  
    P49682 O14625 CXCL11    HPRD  PubMed  
    P49682 O43927 CXCL13    HPRD  PubMed  
    P49682 Q07325 CXCL9    HPRD  PubMed  
    P49682 P49682 CXCR3    HPRD  PubMed  
    P49682 P02776 PF4    HPRD  PubMed  
    BioGRID:109094 BioGRID:109839 CXCL10    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109094 BioGRID:112275 CXCL11    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109094 BioGRID:115814 CXCL13    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109094 BioGRID:110429 CXCL9    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109094 BioGRID:111219 PF4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109094 BioGRID:107844 VCAN    BioGRID  PubMed Reconstituted Complex 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    • CXCR3-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CXCR3-mediated signaling events, organism-specific biosystem
      CXCR3-mediated signaling events
    • Chemokine receptors bind chemokines, organism-specific biosystem (from REACTOME)
      Chemokine receptors bind chemokines, organism-specific biosystemChemokine receptors are cytokine receptors found on the surface of certain cells, which interact with a type of cytokine called a chemokine. Following interaction, these receptors trigger a flux of i...
    • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, conserved biosystem (from KEGG)
      Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
      GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
    • GPCRs, Other, organism-specific biosystem (from WikiPathways)
      GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
    • Peptide GPCRs, organism-specific biosystem (from WikiPathways)
      Peptide GPCRs, organism-specific biosystem
      Peptide GPCRs
    • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    C-X-C chemokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    G-protein coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    chemokine binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    chemokine receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular component movement TAS
    Traceable Author Statement
    more info
    PubMed 
    chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    elevation of cytosolic calcium ion concentration TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    C-X-C chemokine receptor type 3
    Names
    C-X-C chemokine receptor type 3
    CXC-R3
    CXCR-3
    Mig receptor
    IP10 receptor
    IP-10 receptor
    G protein-coupled receptor 9
    chemokine (C-X-C) receptor 3
    interferon-inducible protein 10 receptor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029076.1 RefSeqGene

      Range
      5001..7602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001142797.1NP_001136269.1  C-X-C chemokine receptor type 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in an isoform (2, also known as CXCR3-B) with a longer and distinct N-terminus compared to isoform 1. This isoform acts as functional receptor for chemokine CXCL4/PF4 (PMID:12782716).
      Source sequence(s)
      AF469635, X95876
      Consensus CDS
      CCDS48135.1
      UniProtKB/Swiss-Prot
      P49682
      Related
      ENSP00000362795, OTTHUMP00000032170, ENST00000373691, OTTHUMT00000081854
      Conserved Domains (1) summary
      pfam00001
      Location:163365
      Blast Score: 376
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. NM_001504.1NP_001495.1  C-X-C chemokine receptor type 3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1 (also known as CXCR3-A). This isoform functions as a receptor for chemokines CXCL9/Mig, CXCL10/IP-10, and CXCL11/I-TAC (PMID:12782716).
      Source sequence(s)
      X95876
      Consensus CDS
      CCDS14416.1
      UniProtKB/Swiss-Prot
      P49682
      Related
      ENSP00000362797, OTTHUMP00000070257, ENST00000373693, OTTHUMT00000144141
      Conserved Domains (1) summary
      pfam00001
      Location:116318
      Blast Score: 360
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000023.10 Reference GRCh37.p5 Primary Assembly

      Range
      70835766..70838367, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000155.1 Alternate HuRef

      Range
      64650668..64653542, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AB032735.1 BAA92297.1
    genomic AB032736.1 BAA92298.1
    genomic AL590763.2 (157490..160091) None
    genomic CH471132.2 EAX05283.1
    genomic CQ834242.1 CAH05336.1
    genomic HI574346.1 CBX47662.1
    genomic U32674.1 AAC50505.1
    genomic Z79783.1 CAB02143.1
    mRNA AF469635.1 AAP55851.1
    mRNA AK313679.1 BAG36429.1
    mRNA AY242128.1 AAO92295.1
    mRNA BC034403.1 AAH34403.1
    mRNA X95876.1 CAA65126.1
    other-genetic DQ892460.2 ABM83386.1
    other-genetic DQ895673.2 ABM86599.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49682.2 GenPept UniProtKB/Swiss-Prot:P49682

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