CD3G CD3g molecule, gamma (CD3-TCR complex) [Homo sapiens (human)] - Gene

Summary

Go to the top of the page Help

Official Symbol: CD3Gprovided by HGNC
Official Full Name: CD3g molecule, gamma (CD3-TCR complex)provided by HGNC
Primary source: HGNC:1675
See related: HPRD:07037; MIM:186740
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: T3G; CD3-GAMMA
Summary: The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]

Genomic context

Go to the top of the page Help

Location :: 11q23

Sequence :: Chromosome: 11; NC_000011.9 (118215059..118224497)

See CD3G in Epigenomics, MapViewer

Chromosome 11 - NC_000011.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In conclusion, TCR-gamma expression seems to be rare and is confined to cytotoxic primary cutaneous T-cell lymphomas
Title: TCR-γ expression in primary cutaneous T-cell lymphomas.
roles of CD3G polymorphisms in predisposition for HCC
Title: A functional insertion/deletion polymorphism in the proximal promoter of CD3G is associated with susceptibility for hepatocellular carcinoma in Chinese population.
Altered expression of the TCR signaling related genes CD3 and FcepsilonRIgamma in patients with aplastic anemia.
Title: Altered expression of the TCR signaling related genes CD3 and FcεRIγ in patients with aplastic anemia.
Data show that the expressions of CD3, CD4 were significantly associated with overall survival(OS) of non-small cell lung cancer (NSCLC) patients.
Title: [Expression and clinical significance of CD3, CD4 and COX-2 in non-small cell lung cancer].
A transgenic T cell receptor gammadelta-low expressing subset of T cells accumulates in mouse epidermis after IL-23 injections.
Title: Epidermal CCR6+ γδ T cells are major producers of IL-22 and IL-17 in a murine model of psoriasiform dermatitis.
Data show that TCRzeta phosphorylation signal pathways were affected in CD3gamma(-/-) primary and HVS-transformed T cells.
Title: CD3γ-independent pathways in TCR-mediated signaling in mature T and iNKT lymphocytes.
Study characterized the expression pattern of CD3-gamma, -delta, -epsilon and -zeta chain genes from placenta, which contributes to further understanding of the features of T-cell immune status in placenta.
Title: The expression pattern of CD3 chain genes in fetal/maternal interface.
Data show that the expression pattern of the four CD3 chains was epsilon>zeta>delta>gamma in peripheral blood mononuclear cells from MM, while a gamma>epsilon>zeta>delta expression pattern was found in healthy controls.
Title: Change in expression pattern of TCR-CD3 complex in patients with multiple myeloma.
A combination of trastuzumab antibody and phosphoantigen-stimulated gammadelta T-lymphocytes increases the efficacy of trastuzumab alone against HER-2-positive breast carcinoma cell lines in vivo and mammary carcinoma xenografts in mice.
Title: Stimulated γδ T cells increase the in vivo efficacy of trastuzumab in HER-2+ breast cancer.
CD3gamma and CD3delta evolved from a common precursor gene to optimize major histocompatibility antigen (MHC)-triggered alphabeta T cell receptor activation.
Title: Distinctive CD3 heterodimeric ectodomain topologies maximize antigen-triggered activation of alpha beta T cell receptors.

Submit: New GeneRIF Correction See all (30)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

HIV-1 protein interactions

Go to the top of the page Help

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 inhibits CD3-induced Lck activation and cellular tyrosine phosphorylation, particularly of phosphoinositide-specific phospholipase C-gamma-1	PubMed
	env	Binding of HIV-1 gp120 to the CD4 receptor molecule results in co-stimulation of CD3-induced T cell activation	PubMed
	env	HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells	PubMed
	env	HIV-1 gp120 induces CD4 association with lymphocyte surface molecules CD3, CD11a, CD27, CD45RA, CD45RB, CD45RO, CD49d, CD38, CD26, CD59, CD95 and class I MHC molecules	PubMed
	env	Treatment of CD4+ T cells with HIV-1 gp120 significantly increases CD4 association with CD3, CD45RA, CD45RB, CD59, CD38, CD26 and HLA class I, and decreases that with CD45RC	PubMed
Envelope transmembrane glycoprotein gp41	env	Gp41 TMD co-localizes with the CD3-TCR complex and inhibits T-cell activation induced by antibodies to CD3	PubMed
	env	HIV-1 gp41 peptide (amino acids 581-597) inhibits lymphoproliferation stimulated via the T-cell-activation molecules CD3, CD2, and CD28, as well as via direct stimulation mediated by phorbol ester combined with ionomycin	PubMed
	env	A synthetic peptide containing residues 581-597 from HIV-1 gp41 inhibits protein kinase C (pkC)-mediated phosphorylation of the CD3 gamma-chain in intact cells and directly inhibits partially purified pkC	PubMed
Gag, Pr55	gag	CD3/28-treated resting CD4+ T cells produce more HIV-1 Gag protein than untreated cells	PubMed
	gag	Interferon-gamma can counteract the inhibitory effect of peptides based on the Capsid protein of HIV-1 Gag on antibody response to SRC	PubMed
	gag	Peptides corresponding to amino acids 218-238 of the Capsid protein of HIV-1 Gag inhibited anti-CD3-induced lymphoproliferation but did not directly affect anti-CD2 activation	PubMed
	gag	Synthetic peptides corresponding to amino acids 218-238 of the Capsid protein of HIV-1 Gag have been shown to inhibit in a dose dependent manner the induction of a specific antibody response to the sheep red cell (SRC) antigen through the T3-Ti complex	PubMed
Nef, p27	nef	HIV-1 Nef interacts with CD3 in living cells	PubMed
	nef	HIV-1 nef alleles from the great majority of primate lentiviruses, including HIV-2, downregulate TCR-CD3 from infected T cells and thereby block their responsiveness to activation	PubMed
	nef	Expression of HIV-1 Tat and/or HIV-1 Nef in the absence of HIV-1 Rev leads to downregulation of CD3-gamma gene transcripts and TCR/CD3 surface density	PubMed
Tat, p14	tat	HIV-1 Tat interacts with CD3 and CD28 to co-stimulate IL-2 and IL-8 expression	PubMed
Vpu, p16	vpu	HIV-1 Vpu interacts with CD3 in living cells	PubMed
capsid	gag	Synthetic peptides corresponding to amino acids 218-238 of HIV-1 Capsid have been shown to inhibit in a dose dependent manner the induction of a specific antibody response to the sheep red cell (SRC) antigen through the T3-Ti complex	PubMed
	gag	Interferon-gamma can counteract the inhibitory effect of HIV-1 Capsid based peptides on antibody response to SRC	PubMed
	gag	Peptides corresponding to amino acids 218-238 of HIV-1 Capsid inhibited anti-CD3-induced lymphoproliferation but did not directly affect anti-CD2 activation	PubMed
nucleocapsid	gag	HIV-1 NC upregulates CD3G antigen, gamma in HEK 293T cells	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Source	Pubs	Description
P09693	P04234	CD3D	HPRD	PubMed
P09693	P07766	CD3E	HPRD	PubMed
P09693	T cell antigen receptor, alpha		HPRD	PubMed
P09693	T cell antigen receptor, beta		HPRD	PubMed
P09693	T cell antigen receptor, delta		HPRD	PubMed
BioGRID:107355	BioGRID:107354	CD3E	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107355	BioGRID:108810	FYN	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107355	BioGRID:109165	NR3C1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107355	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

Go to the top of the page Help

Adaptive Immune System, organism-specific biosystem (from REACTOME)
Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
CXCR4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
CXCR4-mediated signaling events, organism-specific biosystem
CXCR4-mediated signaling events
Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
Costimulation by the CD28 family, organism-specific biosystemOptimal activation of T-lymphocytes requires at least two signals. A primary one is delivered by the T-cell receptor (TCR) complex after antigen recognition and additional costimulatory signals are d...
Downstream TCR signaling, organism-specific biosystem (from REACTOME)
Downstream TCR signaling, organism-specific biosystemChanges in gene expression are required for the T cell to gain full proliferative competence and to produce effector cytokines. Three transcription factors in particular have been found to play a key...
Downstream signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
Downstream signaling in naive CD8+ T cells, organism-specific biosystem
Downstream signaling in naive CD8+ T cells
FCGR activation, organism-specific biosystem (from REACTOME)
FCGR activation, organism-specific biosystemCross-linking of FCGRs with IgG coated immune complexes results in tyrosine phosphorylation of the immuno tyrosine activation motif (ITAMs) of the rececptor by membrane-bound tyrosine kinases of the ...
Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystem (from REACTOME)
Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystemPhagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phag...
Generation of second messenger molecules, organism-specific biosystem (from REACTOME)
Generation of second messenger molecules, organism-specific biosystemIn addition to serving as a scaffold via auto-phosphorylation, ZAP-70 also phosphorylates a restricted set of substrates following TCR stimulation - including LAT and SLP-76. These substrates have be...
HTLV-I infection, organism-specific biosystem (from KEGG)
HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
HTLV-I infection, conserved biosystem (from KEGG)
HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
Hematopoietic cell lineage, conserved biosystem (from KEGG)
Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
IL12 signaling mediated by STAT4, organism-specific biosystem (from Pathway Interaction Database)
IL12 signaling mediated by STAT4, organism-specific biosystem
IL12 signaling mediated by STAT4
IL12-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
IL12-mediated signaling events, organism-specific biosystem
IL12-mediated signaling events
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
Measles, organism-specific biosystem (from KEGG)
Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
Measles, conserved biosystem (from KEGG)
Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
PD-1 signaling, organism-specific biosystem (from REACTOME)
PD-1 signaling, organism-specific biosystemThe Programmed cell death protein 1 (PD-1) is one of the negative regulators of TCR signaling. PD-1 may exert its effects on cell differentiation and survival directly by inhibiting early activation ...
Phosphorylation of CD3 and TCR zeta chains, organism-specific biosystem (from REACTOME)
Phosphorylation of CD3 and TCR zeta chains, organism-specific biosystemPrior to T cell receptor (TCR) stimulation, CD4/CD8 associated Lck remains seperated from the TCR and is maintained in an inactive state by the action of Csk. Csk phosphorylates the negative regulato...
Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystem (from REACTOME)
Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystemThe actin cytoskeleton is fundamental for phagocytosis and members of the Rho family GTPases RAC and CDC42 are involved in actin cytoskeletal regulation leading to pseudopod extension. Active RAC and...
Role of phospholipids in phagocytosis, organism-specific biosystem (from REACTOME)
Role of phospholipids in phagocytosis, organism-specific biosystemPhospholipases play an integral role in phagocytosis by generating essential second messengers. An early step in phagocytic signaling is the association of PIP2 and IP3 with the phagocytic cup. These...
T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
T cell receptor signaling pathway, conserved biosystem (from KEGG)
T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
TCR Signaling Pathway, organism-specific biosystem (from WikiPathways)
TCR Signaling Pathway, organism-specific biosystemThe T-cell antigen receptor (TCR) complex is composed of a ligand-binding subunit, the ? and ? chains, and a signaling subunit, namely the CD3?, ? and ? chains and the TCR? chain. This complex partic...
TCR signaling, organism-specific biosystem (from REACTOME)
TCR signaling, organism-specific biosystemThe TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen p...
TCR signaling in naive CD4+ T cells, organism-specific biosystem (from Pathway Interaction Database)
TCR signaling in naive CD4+ T cells, organism-specific biosystem
TCR signaling in naive CD4+ T cells
TCR signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
TCR signaling in naive CD8+ T cells, organism-specific biosystem
TCR signaling in naive CD8+ T cells
Translocation of ZAP-70 to Immunological synapse, organism-specific biosystem (from REACTOME)
Translocation of ZAP-70 to Immunological synapse, organism-specific biosystemThe dual phosphorylated ITAMs recruit Syk kinase ZAP-70 via their tandem SH2 domains (step 4). ZAP-70 subsequently undergoes phosphorylation on multiple tyrosine residues for further activation. ZAP-...

General gene information

Go to the top of the page Help

Markers

D8S2279 (e-PCR)
- UniSTS:473907

NoName (e-PCR)
- UniSTS:482375

GDB:197879 (e-PCR)
- UniSTS:155984

D1S1425 (e-PCR)
- UniSTS:149621

D11S4362 (e-PCR)
- UniSTS:64885

NoName (e-PCR)
- UniSTS:489646

RH80031 (e-PCR)
- UniSTS:91103

Genotypes

See CD3G SNP Geneview Report
See CD3G SNP Genotype Report
See CD3G SNP Variation Viewer Report

Homology

Homologs of the CD3G gene: The CD3G gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Clone Names

FLJ17620, FLJ17664, FLJ79544, FLJ94613, MGC138597

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
T cell receptor binding	NAS Non-traceable Author Statement more info	PubMed
protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
receptor signaling complex scaffold activity	NAS Non-traceable Author Statement more info	PubMed
transmembrane signaling receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
Fc-gamma receptor signaling pathway involved in phagocytosis	TAS Traceable Author Statement more info
T cell activation	NAS Non-traceable Author Statement more info	PubMed
T cell costimulation	TAS Traceable Author Statement more info
T cell receptor signaling pathway	TAS Traceable Author Statement more info
cell surface receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
establishment or maintenance of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
innate immune response	TAS Traceable Author Statement more info
protein complex assembly	NAS Non-traceable Author Statement more info	PubMed
protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of immune response	TAS Traceable Author Statement more info
regulation of lymphocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
T cell receptor complex	NAS Non-traceable Author Statement more info	PubMed
alpha-beta T cell receptor complex	IEA Inferred from Electronic Annotation more info
integral to plasma membrane	NAS Non-traceable Author Statement more info	PubMed
plasma membrane	TAS Traceable Author Statement more info

General protein information

Go to the top of the page Help

Preferred Names: T-cell surface glycoprotein CD3 gamma chain

Names: T-cell surface glycoprotein CD3 gamma chain; T-cell receptor T3 gamma chain; CD3g molecule, epsilon (CD3-TCR complex); CD3g antigen, gamma polypeptide (TiT3 complex); T-cell antigen receptor complex, gamma subunit of T3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007566.1 RefSeqGene

Range

5001..14439

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_39

mRNA and Protein(s)

NM_000073.2 → NP_000064.1 T-cell surface glycoprotein CD3 gamma chain precursor

Status: REVIEWED

Source sequence(s)

AK310622, DB116263, DC378393, X04145

Consensus CDS

CCDS8395.1

UniProtKB/TrEMBL

B0YIY5

UniProtKB/Swiss-Prot

P09693

Conserved Domains (2) summary

pfam02189
Location:157 – 174
Blast Score: 83

ITAM; Immunoreceptor tyrosine-based activation motif

cd07691
Location:35 – 105
Blast Score: 236

Ig_CD3_gamma_delta; Immunoglobulin (Ig)-like domain of CD3 gamma and delta chains

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000011.9 Reference GRCh37.p10 Primary Assembly

Range

118215059..118224497

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000143.1 Alternate HuRef

Range

114148956..114158393

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018922.1 Alternate CHM1_1.0

Range

118078766..118088199

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AB583162.1	BAJ16153.1
genomic	ABBA01039712.1 (23710..33147)	None
genomic	AMYH01004068.1 (12542..21975)	None
genomic	AP001582.4 (57396..66346)	None
genomic	CH471065.1	EAW67368.1
genomic	EF444965.1	ACA05963.1
genomic	X06026.1	CAA29428.1
mRNA	AK223314.1	BAD97034.1
mRNA	AK310578.1	None
mRNA	AK310622.1	None
mRNA	AK313966.1	BAG36681.1
mRNA	AK315895.1	BAF98786.1
mRNA	BC069685.1	None
mRNA	BC113830.1	AAI13831.1
mRNA	DB116263.1	None
mRNA	DC378393.1	None
mRNA	X04145.1	CAA27764.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P09693.1	GenPept	UniProtKB/Swiss-Prot:P09693

Additional links

Go to the top of the page Help

Additional Links

Epigenomics
MIM 186740
CD3Gbase: Mutation registry for autosomal recessive CD3-gamma immunodeficiency CD3Gbase/
CD3G homepage - Mendelian genes CD3G
Resource of Asian Primary Immunodeficiency Diseases (RAPID) AGID_32
UCSC UCSC
UniGene Hs.2259