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    SRSF7 serine/arginine-rich splicing factor 7 [ Homo sapiens ]

    Gene ID: 6432, updated on 11-May-2012
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    Summary

    Official Symbol
    SRSF7provided by HGNC
    Official Full Name
    serine/arginine-rich splicing factor 7provided by HGNC
    Primary source
    HGNC:10789
    See related
    Ensembl:ENSG00000115875; HPRD:08991; MIM:600572; Vega:OTTHUMG00000102076
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    9G8; AAG3; SFRS7
    Summary
    The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
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    Genomic context

    Location :
    2p22.1
    Sequence :
    Chromosome: 2; NC_000002.11 (38970741..38978636, complement)
    See SRSF7 in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein L-like Neighboring gene galactose mutarotase (aldose 1-epimerase) Neighboring gene N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) pseudogene Neighboring gene tetratricopeptide repeat domain 39D, pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). Lopitz-Otsoa F, et al. J Proteomics, 2012 Jun 6. PMID 22178446.
    2. Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). Zhao J, et al. J Proteomics, 2011 Dec 21. PMID 21907836.
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    5. SFRS7-mediated splicing of tau exon 10 is directly regulated by STOX1A in glial cells. van Abel D, et al. PLoS One, 2011. PMID 21755018.

    See all (46) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Upregulation of total tau expression (SFRS7-independent) and tau exon 10 splicing (SFRS7-dependent), as shown in this study to be both affected by STOX1A, is known to have implications in neurodegeneration.
      Title: SFRS7-mediated splicing of tau exon 10 is directly regulated by STOX1A in glial cells.
    2. The authors report that siRNA knockdown of SRp20 or 9G8 resulted in about a 10 fold decrease in herpes simplex virus 1 yields and in nuclear accumulation of polyA+ RNA.
      Title: SR proteins SRp20 and 9G8 contribute to efficient export of herpes simplex virus 1 mRNAs.
    3. eIF3f mediates restriction of HIV-1 expression through a set of factors that includes eIF3f, the SR protein 9G8, and the cyclin-dependent kinase 11 (CDK11).
      Title: HIV-1 mRNA 3' end processing is distinctively regulated by eIF3f, CDK11, and splice factor 9G8.
    4. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
      Title: Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
    5. 9G8 was shown to enhance expression of unspliced RNA containing either the Mason-Pfizer monkey virus constitutive transport element
      Title: The shuttling SR protein 9G8 plays a role in translation of unspliced mRNA containing a constitutive transport element.
    6. SR proteins 9G8 and ASF/SF2 exhibit higher affinity for TAP/NXF1 when hypophosphorylated
      Title: A molecular link between SR protein dephosphorylation and mRNA export.
    7. These results indicate that 9G8 plays a key role in regulation of exon 10 splicing and imply a pathogenic role in neurodegenerative diseases.
      Title: SR protein 9G8 modulates splicing of tau exon 10 via its proximal downstream intron, a clustering region for frontotemporal dementia mutations.
    8. SR proteins 9G8, SC35, ASF/SF2, and SRp40 have effects on the utilization of the A1 to A5 splicing sites of HIV-1 RNA
      Title: Differential effects of the SR proteins 9G8, SC35, ASF/SF2, and SRp40 on the utilization of the A1 to A5 splicing sites of HIV-1 RNA.
    9. SR proteins ASF/SF2, SC35 and 9G8 can down-regulate the late steps of HIV-1 replication via negative impact on RNA splicing and virion production.
      Title: Dual effect of the SR proteins ASF/SF2, SC35 and 9G8 on HIV-1 RNA splicing and virion production.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat synergizes with type I activators, such as Sp1 and CTF, to enhance transcript elongation and exon skipping, suggesting Tat function leads to the inhibition of splicing factors SF2/ASF and 9G8 PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q16629 Q96S94 CCNL2    HPRD  PubMed  
    Q16629 Q9UQ88 CDK11A    HPRD  PubMed  
    Q16629 Q9BWU1 CDK19    HPRD  PubMed  
    Q16629 Q16630 CPSF6    HPRD  PubMed  
    Q16629 O75319 DUSP11    HPRD  PubMed  
    Q16629 Q9UBU9 NXF1    HPRD  PubMed  
    Q16629 Q15366 PCBP2    HPRD  PubMed  
    Q16629 Q8WXA9 SREK1    HPRD  PubMed  
    BioGRID:112330 BioGRID:114024 DUSP11    BioGRID  PubMed Two-hybrid 
    BioGRID:112330 BioGRID:109318 HDGF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112330 BioGRID:110811 NEDD4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112330 BioGRID:111865 RBBP6    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:112330 BioGRID:114952 RBM39    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112330 BioGRID:116125 RNPS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112330 BioGRID:126754 SREK1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex; Two-hybrid 
    BioGRID:112330 BioGRID:115544 SRRM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112330 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112330 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the SRSF7 gene: The SRSF7 gene is conserved in chimpanzee, , dog, cow, mouse, chicken, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, and rice.
    • Map Viewer (Mouse)

    Pathways from BioSystems

    • Cleavage of Growing Transcript in the Termination Region, organism-specific biosystem (from REACTOME)
      Cleavage of Growing Transcript in the Termination Region, organism-specific biosystemThis section includes the cleavage of both polyadenylated and non-polyadenylated transcripts. In the former case polyadenylation has to precede transcript cleavage, while in the latter case there is ...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
      Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
    • RNA Polymerase II Transcription, organism-specific biosystem (from REACTOME)
      RNA Polymerase II Transcription, organism-specific biosystem
      RNA Polymerase II Transcription
    • RNA Polymerase II Transcription Termination, organism-specific biosystem (from REACTOME)
      RNA Polymerase II Transcription Termination, organism-specific biosystemThe detailed annotation of this section will be completed in the next release.
    • Spliceosome, organism-specific biosystem (from KEGG)
      Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, conserved biosystem (from KEGG)
      Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Transport of Mature Transcript to Cytoplasm, organism-specific biosystem (from REACTOME)
      Transport of Mature Transcript to Cytoplasm, organism-specific biosystemTransport of mRNA through the Nuclear Pore Complex (NPC) is a dynamic process involving distinct machinery and receptor subsets. The separation of the two compartments and the regulation of this tran...
    • Transport of Mature mRNA derived from an Intron-Containing Transcript, organism-specific biosystem (from REACTOME)
      Transport of Mature mRNA derived from an Intron-Containing Transcript, organism-specific biosystemTransport of mRNA from the nucleus to the cytoplasm, where it is translated into protein, is highly selective and closely coupled to correct RNA processing. This coupling is achieved by the nuclear p...
    • mRNA 3'-end processing, organism-specific biosystem (from REACTOME)
      mRNA 3'-end processing, organism-specific biosystemThe 3' ends of eukaryotic mRNAs are generated by posttranscriptional processing of an extended primary transcript. For almost all RNAs, 3'-end processing consists of two steps: (i) the mRNA is first ...
    • mRNA Splicing, organism-specific biosystem (from REACTOME)
      mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
    • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
      mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...
    • mRNA Splicing - Minor Pathway, organism-specific biosystem (from REACTOME)
      mRNA Splicing - Minor Pathway, organism-specific biosystemThe splicing of a subset of pre-mRNA introns occurs by a second pathway, designated the AT-AC or U12-dependent splicing pathway. AT-AC introns have highly conserved, non-canonical splice sites that ...
    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    RNA splicing TAS
    Traceable Author Statement
    more info
    		  
    gene expression TAS
    Traceable Author Statement
    more info
    		  
    mRNA 3'-end processing TAS
    Traceable Author Statement
    more info
    		  
    mRNA export from nucleus TAS
    Traceable Author Statement
    more info
    		  
    mRNA processing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of nuclear mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nuclear mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
    		  
    termination of RNA polymerase II transcription TAS
    Traceable Author Statement
    more info
    		  
    transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    serine/arginine-rich splicing factor 7
    Names
    serine/arginine-rich splicing factor 7
    splicing factor 9G8
    SR splicing factor 7
    aging-associated protein 3
    splicing factor, arginine/serine-rich 7, 35kDa
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031684.2 → NP_001026854.1  serine/arginine-rich splicing factor 7 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC074366, AY166860
      Consensus CDS
      CCDS33183.1
      UniProtKB/Swiss-Prot
      Q16629
      Related
      ENSP00000325905, OTTHUMP00000128261, ENST00000313117, OTTHUMT00000219889
      Conserved Domains (2) summary
      cd00590
      Location:12 – 81
      Blast Score: 183
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
      cl15298
      Location:106 – 119
      Blast Score: 73
      zf-CCHC; Zinc knuckle

    2. NM_001195446.1 → NP_001182375.1  serine/arginine-rich splicing factor 7 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC074366, AK297161, AY166860, DC358626
      Consensus CDS
      CCDS56115.1
      UniProtKB/TrEMBL
      B4DLU6
      UniProtKB/TrEMBL
      G5E9M3
      UniProtKB/Swiss-Prot
      Q16629
      Related
      ENSP00000402264, ENST00000446327
      Conserved Domains (2) summary
      cd00590
      Location:12 – 81
      Blast Score: 185
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
      cl15298
      Location:106 – 119
      Blast Score: 73
      zf-CCHC; Zinc knuckle

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      38970741..38978636, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      38709469..38717368, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_006276.36: Suppressed sequence

      Description
      NM_006276.36: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC074366.6 AAX93102.1
    genomic CH471053.2 EAX00363.1
      EAX00364.1
      EAX00365.1
      EAX00366.1
    genomic L41887.1 AAA88098.1
    mRNA AB445102.1 BAI99737.1
    mRNA AF055270.1 AAF00003.1
    mRNA AK091425.1 BAC03661.1
    mRNA AK225141.1 None
    mRNA AK293667.1 BAG57113.1
    mRNA AK297161.1 BAG59658.1
    mRNA AY166860.1 AAN87842.1
    mRNA AY513287.1 AAT08040.1
    mRNA BC000997.2 AAH00997.1
    mRNA BC017369.2 AAH17369.1
    mRNA BC017908.1 AAH17908.1
    mRNA BC022328.1 AAH22328.1
    mRNA BT006745.1 AAP35391.1
    mRNA DC358626.1 None
    mRNA L22253.1 AAA35495.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q16629.1 GenPept UniProtKB/Swiss-Prot:Q16629
    Q8NB80 GenPept UniProtKB/TrEMBL:Q8NB80
    Q9UL60 GenPept UniProtKB/TrEMBL:Q9UL60
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

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