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NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 [ Homo sapiens (human) ]

Gene ID: 4773, updated on 7-Jul-2014
Official Symbol
NFATC2provided by HGNC
Official Full Name
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2provided by HGNC
Primary source
HGNC:7776
Locus tag
RP5-1009H6.1
See related
Ensembl:ENSG00000101096; HPRD:02730; MIM:600490; Vega:OTTHUMG00000032747
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NFAT1; NFATP
Summary
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]
See NFATC2 in Epigenomics, MapViewer
Location:
20q13.2
Exon count :
12
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 20 NC_000020.11 (51386957..51562831, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (50003494..50179370, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, subfamily G, member 1 Neighboring gene ribosomal protein SA pseudogene 1 Neighboring gene microRNA 3194 Neighboring gene ATPase, class II, type 9A Neighboring gene ribosomal protein L29 pseudogene Neighboring gene spalt-like transcription factor 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
NHGRI GWA Catalog
Genome-wide association study (GWAS) for molar-incisor hypomineralization (MIH).
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 and anti-CD4 antibodies induce a specific, significant decrease in the binding activity of NF-AT, NF-kappa B and AP-1, which leads to an inhibition of IL-2 production and cell proliferation PubMed
env Using either anti-CD4 monoclonal antibodies or HIV-1 gp120 binding to CD4 reveals a common epitope-specific activation of both the HIV-1 LTR and of the transcription factors NF-kappa B and NF-AT PubMed
Nef, p27 nef HIV-1 Nef super induces the transcription factors NFAT1 and NFAT2 during activation of HIV-infected quiescent T cells PubMed
nef The induction of NFAT1 and NFAT2 is impaired by HIV-1 Nef in sub-optimally activated/resting T cells PubMed
Tat, p14 tat The transcription factors NF-KappaB and NF-AT contribute to the Tat-induced activation of the HERV-K (HML-2) gag RNA transcripts in Jurkat T cells and in primary lymphocytes PubMed
tat Transcription factors NFAT and AP-1 (c-Jun/c-Fos) are required for HIV-1 Tat-induced upregulation of COX-2 PubMed
tat HIV-1 Tat expression in Jurkat T cells enhances cooperative NFAT/AP-1- but not AP-1-dependent transcription independent of its ability to transactivate the HIV-1 LTR PubMed
tat NFAT1 inhibits Tat-mediated transactivation of the HIV-1 LTR promoter through a direct binding interaction between the two proteins PubMed
tat HIV-1 Tat enhances NFAT1-driven transcription in Jurkat T cells through a direct protein-protein interaction between the two proteins PubMed
tat Induction of TNF-alpha by HIV-1 Tat is inhibited by cyclosporin A, an inhibitor of calcineurin that acts by preventing the dephosphorylation of NF-AT PubMed
tat HIV-1 Tat upregulation of the IL-2 promoter maps to the NFAT motif of the IL-2 enhancer, suggesting Tat-mediated enhancement of NFAT1 transactivation may explain the upregulation of IL-2 that occurs during HIV-1 infection PubMed
tat HIV-1 Tat binds to NFAT1, an interaction mediated by the N-terminus of Tat (amino acids 1-26) and the transactivation domain of NFAT1 (amino acids 1-96) PubMed
Vpr, p15 vpr HIV-1 Vpr upregulates NFAT-directed gene expression PubMed
pol gag-pol NFATc facilitates HIV-1 RT reverse transcription activity and enhances HIV-1 infectivity in human T cells PubMed

Go to the HIV-1, Human Protein Interaction Database

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  • Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem (from Pathway Interaction Database)
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    Heart Development, organism-specific biosystemThis pathway has been largely adapted from an article by Deepak Srivastava, Cell. 2006 Sep 22;126(6):1037-48. In this pathway are known transcription factors, miRNAs and regulatory proteins that impa...
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    Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
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  • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
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  • Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
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  • Wnt signaling pathway, organism-specific biosystem (from KEGG)
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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
transcription regulatory region DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
cell migration IDA
Inferred from Direct Assay
more info
 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytokine production IEA
Inferred from Electronic Annotation
more info
 
innate immune response TAS
Traceable Author Statement
more info
 
positive regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
response to drug IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
NOT nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
transcription factor complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
nuclear factor of activated T-cells, cytoplasmic 2
Names
nuclear factor of activated T-cells, cytoplasmic 2
NF-ATc2
NFAT pre-existing subunit
T cell transcription factor NFAT1
T-cell transcription factor NFAT1
NFAT transcription complex, preexisting component
preexisting nuclear factor of activated T-cells 2
nuclear factor of activated T-cells, preexisting component

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136021.2NP_001129493.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform D

    See proteins identical to NP_001129493.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate first exon and contains an alternate exon in the 3' end compared to variant 2, that causes a frameshift. The resulting isoform (D) has shorter and distinct N- and C-termini compared to isoform C.
    Source sequence(s)
    AK226146, AL035682, BE674599, EU887574
    Consensus CDS
    CCDS46614.1
    UniProtKB/Swiss-Prot
    Q13469
    Conserved Domains (2) summary
    cd07881
    Location:378552
    Blast Score: 964
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cd01178
    Location:557657
    Blast Score: 470
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  2. NM_001258292.1NP_001245221.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform E

    See proteins identical to NP_001245221.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate first exon compared to variant 2. The resulting isoform (E) has a shorter and distinct N-terminus compared to isoform C.
    Source sequence(s)
    AK226146, AL035682, BE674599
    Consensus CDS
    CCDS68157.1
    UniProtKB/Swiss-Prot
    Q13469
    Conserved Domains (2) summary
    cd07881
    Location:378552
    Blast Score: 963
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cd01178
    Location:557657
    Blast Score: 469
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  3. NM_001258294.1NP_001245223.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform F

    See proteins identical to NP_001245223.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an alternate first exon, an alternate exon in the 3' end, and uses an alternate splice junction at the 5' end of a coding exon compared to variant 2. The resulting isoform (F) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform C. Variants 5 and 7 both encode the same isoform (F).
    Source sequence(s)
    AL035682, BE674599, EU887575
    Consensus CDS
    CCDS68156.1
    UniProtKB/TrEMBL
    B5B2P0
    Conserved Domains (2) summary
    cd07881
    Location:179353
    Blast Score: 963
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cd01178
    Location:358458
    Blast Score: 467
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  4. NM_001258295.1NP_001245224.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform G

    See proteins identical to NP_001245224.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has an alternate first exon and uses an alternate splice junction at the 5' end of a coding exon compared to variant 2. The resulting isoform (G) is shorter at the N-terminus compared to isoform C. Variants 6 and 8 both encode the same isoform (G).
    Source sequence(s)
    AL035682, BE674599, EU887579
    UniProtKB/TrEMBL
    B5B2P4
    Conserved Domains (2) summary
    cd07881
    Location:179353
    Blast Score: 960
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cd01178
    Location:358458
    Blast Score: 466
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  5. NM_001258296.1NP_001245225.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform F

    See proteins identical to NP_001245225.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate splice junction at the 5' end of a coding exon and contains an alternate exon in the 3' end compared to variant 2, that causes a frameshift. The resulting isoform (F) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform C. Variants 5 and 7 both encode the same isoform (F).
    Source sequence(s)
    AL035682, BE674599, EU887576
    Consensus CDS
    CCDS68156.1
    UniProtKB/TrEMBL
    B5B2P0
    Conserved Domains (2) summary
    cd07881
    Location:179353
    Blast Score: 963
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cd01178
    Location:358458
    Blast Score: 467
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  6. NM_001258297.1NP_001245226.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform G

    See proteins identical to NP_001245226.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) uses an alternate splice junction at the 5' end of a coding exon compared to variant 2. The resulting isoform (G) is shorter at the N-terminus compared to isoform C. Variants 6 and 8 both encode the same isoform (G).
    Source sequence(s)
    AL035682, BE674599, EU887580
    UniProtKB/TrEMBL
    B5B2P4
    Conserved Domains (2) summary
    cd07881
    Location:179353
    Blast Score: 960
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cd01178
    Location:358458
    Blast Score: 466
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  7. NM_012340.4NP_036472.2  nuclear factor of activated T-cells, cytoplasmic 2 isoform B

    See proteins identical to NP_036472.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) contains an alternate exon in the 3' end compared to variant 2, that causes a frameshift. The resulting isoform (B) has a shorter and distinct C-terminus compared to isoform C.
    Source sequence(s)
    AL035682, BE674599, EU887573, EU887576
    Consensus CDS
    CCDS33488.1
    UniProtKB/TrEMBL
    B5B2P0
    UniProtKB/Swiss-Prot
    Q13469
    Related
    ENSP00000360619, OTTHUMP00000031291, ENST00000371564, OTTHUMT00000079729
    Conserved Domains (2) summary
    cd07881
    Location:398572
    Blast Score: 965
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cd01178
    Location:577677
    Blast Score: 469
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.
  8. NM_173091.3NP_775114.1  nuclear factor of activated T-cells, cytoplasmic 2 isoform C

    See proteins identical to NP_775114.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (C).
    Source sequence(s)
    AL035682, BE674599, EU887576, EU887578
    Consensus CDS
    CCDS13437.1
    UniProtKB/TrEMBL
    B5B2P0
    UniProtKB/Swiss-Prot
    Q13469
    Related
    ENSP00000379330, OTTHUMP00000031292, ENST00000396009, OTTHUMT00000079730
    Conserved Domains (2) summary
    cd07881
    Location:398572
    Blast Score: 964
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cd01178
    Location:577677
    Blast Score: 468
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000020.11 

    Range
    51386957..51562831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260413.1XP_005260470.1  

    Conserved Domains (2) summary
    cd07881
    Location:397571
    Blast Score: 964
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cd01178
    Location:576676
    Blast Score: 468
    IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

Alternate HuRef

Genomic

  1. AC_000152.1 

    Range
    46752104..46926810
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 

    Range
    49909009..50084547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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