NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: NFATC2provided by HGNC
Official Full Name: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2provided by HGNC
Primary source: HGNC:7776
Locus tag: RP5-1009H6.1
See related: Ensembl:ENSG00000101096; HPRD:02730; MIM:600490; Vega:OTTHUMG00000032747
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NFAT1; NFATP
Summary: This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]

Genomic context

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Location :: 20q13.2

Sequence :: Chromosome: 20; NC_000020.10 (50003494..50179370, complement)

See NFATC2 in Epigenomics, MapViewer

Chromosome 20 - NC_000020.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

LCN2 and TWEAKR-TWEAK as crucial downstream effectors of NFAT1 that regulate breast cancer cell motility and invasive capacity.
Title: Lipocalin 2, the TNF-like receptor TWEAKR and its ligand TWEAK act downstream of NFAT1 to regulate breast cancer cell invasion.
Data elucidate a previously unidentified mechanism by which galectin-3 regulates autotaxin and assign a novel role for NFAT1 during melanoma progression.
Title: Galectin-3 contributes to melanoma growth and metastasis via regulation of NFAT1 and autotaxin.
Endorepellin affects angiogenesis by antagonizing diverse VEGFR2-evoked signaling pathways: transcriptional repression of hypoxia-inducible factor 1alpha and VEGFA and concurrent inhibition of NFAT1 activation.
Title: Endorepellin affects angiogenesis by antagonizing diverse vascular endothelial growth factor receptor 2 (VEGFR2)-evoked signaling pathways: transcriptional repression of hypoxia-inducible factor 1α and VEGFA and concurrent inhibition of nuclear factor of activated T cell 1 (NFAT1) activation.
NFAT1 directly binds to distal sites in the c-Myc promoter with different affinities.
Title: Transcriptional regulation of the c-Myc promoter by NFAT1 involves negative and positive NFAT-responsive elements.
Here we show that the calcineurin/nuclear factor of activated T cells c2 (NFATc2) pathway has an antiapoptotic role in melanoma cells.
Title: NFATc2 is a potential therapeutic target in human melanoma.
Transcription factor NFAT1 activates the mdm2 oncogene independent of p53.
Title: Transcription factor NFAT1 activates the mdm2 oncogene independent of p53.
NFAT1 and NFAT2 facilitated IL-17A expression in human T cells, though distinct mechanisms might be involved in these effects
Title: NFAT1 and NFAT2 differentially regulate IL-17A expression in human T cells.
The present study investigated the effect of heart failure aetiology on Ca(+2) handling proteins and NFAT1, MEF2C and GATA4 (transcription factors) in the same cardiac tissue.
Title: Differences in MEF2 and NFAT transcriptional pathways according to human heart failure aetiology.
Inhibition of NFAT or targeting of NFATc3 with small interfering RNA (siRNA) lowers the AIF-1/IRT-1 ratio and favours an anti-proliferative outcome for atherosclerosis.
Title: NFAT regulates the expression of AIF-1 and IRT-1: yin and yang splice variants of neointima formation and atherosclerosis.
calcium responsiveness of IL-31 promoter required NFAT binding sites that bind NFATc1 and NFATc2 in vitro and in vivo.
Title: Transcriptional activation of the IL31 gene by NFAT and STAT6.

Submit: New GeneRIF Correction See all (80)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 and anti-CD4 antibodies induce a specific, significant decrease in the binding activity of NF-AT, NF-kappa B and AP-1, which leads to an inhibition of IL-2 production and cell proliferation	PubMed
	env	Using either anti-CD4 monoclonal antibodies or HIV-1 gp120 binding to CD4 reveals a common epitope-specific activation of both the HIV-1 LTR and of the transcription factors NF-kappa B and NF-AT	PubMed
Nef, p27	nef	The induction of NFAT1 and NFAT2 is impaired by HIV-1 Nef in sub-optimally activated/resting T cells	PubMed
	nef	HIV-1 Nef super induces the transcription factors NFAT1 and NFAT2 during activation of HIV-infected quiescent T cells	PubMed
Tat, p14	tat	The transcription factors NF-KappaB and NF-AT contribute to the Tat-induced activation of the HERV-K (HML-2) gag RNA transcripts in Jurkat T cells and in primary lymphocytes	PubMed
	tat	Transcription factors NFAT and AP-1 (c-Jun/c-Fos) are required for HIV-1 Tat-induced upregulation of COX-2	PubMed
	tat	HIV-1 Tat expression in Jurkat T cells enhances cooperative NFAT/AP-1- but not AP-1-dependent transcription independent of its ability to transactivate the HIV-1 LTR	PubMed
	tat	NFAT1 inhibits Tat-mediated transactivation of the HIV-1 LTR promoter through a direct binding interaction between the two proteins	PubMed
	tat	HIV-1 Tat enhances NFAT1-driven transcription in Jurkat T cells through a direct protein-protein interaction between the two proteins	PubMed
	tat	Induction of TNF-alpha by HIV-1 Tat is inhibited by cyclosporin A, an inhibitor of calcineurin that acts by preventing the dephosphorylation of NF-AT	PubMed
	tat	HIV-1 Tat upregulation of the IL-2 promoter maps to the NFAT motif of the IL-2 enhancer, suggesting Tat-mediated enhancement of NFAT1 transactivation may explain the upregulation of IL-2 that occurs during HIV-1 infection	PubMed
	tat	HIV-1 Tat binds to NFAT1, an interaction mediated by the N-terminus of Tat (amino acids 1-26) and the transactivation domain of NFAT1 (amino acids 1-96)	PubMed
Vpr, p15	vpr	HIV-1 Vpr upregulates NFAT-directed gene expression	PubMed
pol	gag-pol	NFATc facilitates HIV-1 RT reverse transcription activity and enhances HIV-1 infectivity in human T cells	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
Q13469	Q92793	CREBBP	HPRD	PubMed
Q13469	P18146	EGR1	HPRD	PubMed
Q13469	Q05215	EGR4	HPRD	PubMed
Q13469	Q09472	EP300	HPRD	PubMed
Q13469	Q9BZS1	FOXP3	HPRD	PubMed
Q13469	Q15306	IRF4	HPRD	PubMed
Q13469	Q9Y3C7	MED31	HPRD	PubMed
Q13469	Q14814	MEF2D	HPRD	PubMed
Q13469	Q13469	NFATC2	HPRD	PubMed
Q13469	Q8NCF5	NFATC2IP	HPRD	PubMed
Q13469	Q13526	PIN1	HPRD	PubMed
Q13469	P16298	PPP3CB	HPRD	PubMed
Q13469	P63098	PPP3R1	HPRD	PubMed
Q13469	Q05513	PRKCZ	HPRD	PubMed
Q13469	Q16594	TAF9	HPRD	PubMed
Q13469	P08670	VIM	HPRD	PubMed
Q13469	P27348	YWHAQ	HPRD	PubMed
Q13469	P63104	YWHAZ	HPRD	PubMed
BioGRID:110846	BioGRID:107777	CREBBP	BioGRID	PubMed	Reconstituted Complex
BioGRID:110846	BioGRID:107821	CSE1L	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110846	BioGRID:108347	EP300	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110846	BioGRID:119170	FOXP3	BioGRID	PubMed	Co-localization
BioGRID:110846	BioGRID:109420	HNRNPA1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110846	BioGRID:114353	IQGAP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110846	BioGRID:131797	IRF2BP2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:110846	BioGRID:109870	IRF4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110846	BioGRID:109928	JUN	BioGRID	PubMed	Reconstituted Complex
BioGRID:110846	BioGRID:110035	KPNB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110846	BioGRID:125700	LRRK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110846	BioGRID:111585	MAPK8	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110846	BioGRID:111587	MAPK9	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110846	BioGRID:119211	MED31	BioGRID	PubMed	Two-hybrid
BioGRID:110846	BioGRID:110373	MEF2D	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110846	BioGRID:110846	NFATC2	BioGRID	PubMed	Co-crystal Structure; Reconstituted Complex
BioGRID:110846	BioGRID:111317	PIN1	BioGRID	PubMed	Reconstituted Complex
BioGRID:110846	BioGRID:111510	PPP2R1A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110846	BioGRID:111576	PRKCZ	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:110846	BioGRID:112706	SUV39H1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110846	BioGRID:112743	TAF9	BioGRID	PubMed	Reconstituted Complex
BioGRID:110846	BioGRID:112881	TFAP4	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:110846	BioGRID:110040	TNPO1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110846	BioGRID:113603	TUBA1A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110846	BioGRID:113272	VIM	BioGRID	PubMed	Two-hybrid

Pathways from BioSystems

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Axon guidance, organism-specific biosystem (from KEGG)
Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
Axon guidance, conserved biosystem (from KEGG)
Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
B cell receptor signaling pathway, organism-specific biosystem (from KEGG)
B cell receptor signaling pathway, organism-specific biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
B cell receptor signaling pathway, conserved biosystem (from KEGG)
B cell receptor signaling pathway, conserved biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem (from Pathway Interaction Database)
Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem
Calcium signaling in the CD4+ TCR pathway
Downstream signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
Downstream signaling in naive CD8+ T cells, organism-specific biosystem
Downstream signaling in naive CD8+ T cells
Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem (from Pathway Interaction Database)
Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem
Fc-epsilon receptor I signaling in mast cells
HTLV-I infection, organism-specific biosystem (from KEGG)
HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
HTLV-I infection, conserved biosystem (from KEGG)
HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
Heart Development, organism-specific biosystem (from WikiPathways)
Heart Development, organism-specific biosystemThis pathway has been largely adapted from an article by Deepak Srivastava, Cell. 2006 Sep 22;126(6):1037-48. In this pathway are known transcription factors, miRNAs and regulatory proteins that impa...
Hepatitis B, organism-specific biosystem (from KEGG)
Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
MAPK signaling pathway, organism-specific biosystem (from KEGG)
MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK signaling pathway, conserved biosystem (from KEGG)
MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
Noncanonical Wnt signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
Noncanonical Wnt signaling pathway, organism-specific biosystem
Noncanonical Wnt signaling pathway
Osteoclast differentiation, organism-specific biosystem (from KEGG)
Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
Osteoclast differentiation, conserved biosystem (from KEGG)
Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem
Role of Calcineurin-dependent NFAT signaling in lymphocytes
T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
T cell receptor signaling pathway, conserved biosystem (from KEGG)
T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
TCR Signaling Pathway, organism-specific biosystem (from WikiPathways)
TCR Signaling Pathway, organism-specific biosystemThe T-cell antigen receptor (TCR) complex is composed of a ligand-binding subunit, the ? and ? chains, and a signaling subunit, namely the CD3?, ? and ? chains and the TCR? chain. This complex partic...
VEGF signaling pathway, organism-specific biosystem (from KEGG)
VEGF signaling pathway, organism-specific biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
VEGF signaling pathway, conserved biosystem (from KEGG)
VEGF signaling pathway, conserved biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem (from Pathway Interaction Database)
Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Wnt signaling pathway, organism-specific biosystem (from KEGG)
Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
Wnt signaling pathway, conserved biosystem (from KEGG)
Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

General gene information

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Markers

D20S857 (e-PCR), detects polymorphism
- UniSTS:54045

RH36387 (e-PCR)
- UniSTS:2606

AL032542 (e-PCR)
- UniSTS:93288

SHGC-144024 (e-PCR)
- UniSTS:172138

SHGC-85834 (e-PCR)
- UniSTS:103835

STS-M78243 (e-PCR)
- UniSTS:36816

RH38986 (e-PCR)
- UniSTS:91092

D20S128E (e-PCR)
- UniSTS:78049

GDB:555597 (e-PCR)
- UniSTS:157689

Homology

Homologs of the NFATC2 gene: The NFATC2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
DNA binding	TAS Traceable Author Statement more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
transcription regulatory region DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
B cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
cell migration	IDA Inferred from Direct Assay more info
cytokine production	IEA Inferred from Electronic Annotation more info
positive regulation of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
positive regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
regulation of transcription, DNA-dependent	TAS Traceable Author Statement more info	PubMed
response to DNA damage stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
response to drug	IMP Inferred from Mutant Phenotype more info	PubMed
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
actin cytoskeleton	IDA Inferred from Direct Assay more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	TAS Traceable Author Statement more info	PubMed
cytosol	TAS Traceable Author Statement more info
NOT nucleolus	IDA Inferred from Direct Assay more info
nucleus	IDA Inferred from Direct Assay more info
nucleus	TAS Traceable Author Statement more info	PubMed
plasma membrane	IDA Inferred from Direct Assay more info
ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
transcription factor complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nuclear factor of activated T-cells, cytoplasmic 2

Names: nuclear factor of activated T-cells, cytoplasmic 2; NF-ATc2; NFAT pre-existing subunit; T cell transcription factor NFAT1; T-cell transcription factor NFAT1; NFAT transcription complex, preexisting component; preexisting nuclear factor of activated T-cells 2; nuclear factor of activated T-cells, preexisting component

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001136021.2 → NP_001129493.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform D

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate first exon and contains an alternate exon in the 3' end compared to variant 2, that causes a frameshift. The resulting isoform (D) has shorter and distinct N- and C-termini compared to isoform C.

Source sequence(s)

AK226146, AL035682, BE674599, EU887574

Consensus CDS

CCDS46614.1

UniProtKB/Swiss-Prot

Q13469

Conserved Domains (2) summary

cd01178
Location:557 – 657
Blast Score: 417

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

cd07881
Location:378 – 552
Blast Score: 932

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
NM_001258292.1 → NP_001245221.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform E

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate first exon compared to variant 2. The resulting isoform (E) has a shorter and distinct N-terminus compared to isoform C.

Source sequence(s)

AK226146, AL035682, BE674599

UniProtKB/TrEMBL

B5B2P2

Conserved Domains (2) summary

cd01178
Location:557 – 657
Blast Score: 416

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

cd07881
Location:378 – 552
Blast Score: 931

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
NM_001258294.1 → NP_001245223.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform F

Status: REVIEWED

Description

Transcript Variant: This variant (5) has an alternate first exon, an alternate exon in the 3' end, and uses an alternate splice junction at the 5' end of a coding exon compared to variant 2. The resulting isoform (F) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform C. Variants 5 and 7 both encode the same isoform (F).

Source sequence(s)

AL035682, BE674599, EU887575

UniProtKB/TrEMBL

B5B2P0

Conserved Domains (2) summary

cd01178
Location:358 – 458
Blast Score: 415

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

cd07881
Location:179 – 353
Blast Score: 932

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
NM_001258295.1 → NP_001245224.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform G

Status: REVIEWED

Description

Transcript Variant: This variant (6) has an alternate first exon and uses an alternate splice junction at the 5' end of a coding exon compared to variant 2. The resulting isoform (G) is shorter at the N-terminus compared to isoform C. Variants 6 and 8 both encode the same isoform (G).

Source sequence(s)

AL035682, BE674599, EU887579

UniProtKB/TrEMBL

B5B2P4

Conserved Domains (2) summary

cd01178
Location:358 – 458
Blast Score: 413

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

cd07881
Location:179 – 353
Blast Score: 930

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
NM_001258296.1 → NP_001245225.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform F

Status: REVIEWED

Description

Transcript Variant: This variant (7) uses an alternate splice junction at the 5' end of a coding exon and contains an alternate exon in the 3' end compared to variant 2, that causes a frameshift. The resulting isoform (F) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform C. Variants 5 and 7 both encode the same isoform (F).

Source sequence(s)

AL035682, BE674599, EU887576

UniProtKB/TrEMBL

B5B2P0

Conserved Domains (2) summary

cd01178
Location:358 – 458
Blast Score: 415

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

cd07881
Location:179 – 353
Blast Score: 932

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
NM_001258297.1 → NP_001245226.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform G

Status: REVIEWED

Description

Transcript Variant: This variant (8) uses an alternate splice junction at the 5' end of a coding exon compared to variant 2. The resulting isoform (G) is shorter at the N-terminus compared to isoform C. Variants 6 and 8 both encode the same isoform (G).

Source sequence(s)

AL035682, BE674599, EU887580

UniProtKB/TrEMBL

B5B2P4

Conserved Domains (2) summary

cd01178
Location:358 – 458
Blast Score: 413

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

cd07881
Location:179 – 353
Blast Score: 930

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
NM_012340.4 → NP_036472.2 nuclear factor of activated T-cells, cytoplasmic 2 isoform B

Status: REVIEWED

Description

Transcript Variant: This variant (1) contains an alternate exon in the 3' end compared to variant 2, that causes a frameshift. The resulting isoform (B) has a shorter and distinct C-terminus compared to isoform C.

Source sequence(s)

AL035682, BE674599, EU887573, EU887576

Consensus CDS

CCDS33488.1

UniProtKB/TrEMBL

B5B2P0

UniProtKB/Swiss-Prot

Q13469

Related

ENSP00000360619, OTTHUMP00000031291, ENST00000371564, OTTHUMT00000079729

Conserved Domains (2) summary

cd01178
Location:577 – 677
Blast Score: 417

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

cd07881
Location:398 – 572
Blast Score: 934

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
NM_173091.3 → NP_775114.1 nuclear factor of activated T-cells, cytoplasmic 2 isoform C

Status: REVIEWED

Description

Transcript Variant: This variant (2) encodes the longest isoform (C).

Source sequence(s)

AL035682, BE674599, EU887576, EU887578

Consensus CDS

CCDS13437.1

UniProtKB/TrEMBL

B5B2P0

UniProtKB/TrEMBL

B5B2P3

UniProtKB/Swiss-Prot

Q13469

Related

ENSP00000379330, OTTHUMP00000031292, ENST00000396009, OTTHUMT00000079730

Conserved Domains (2) summary

cd01178
Location:577 – 677
Blast Score: 416

IPT_NFAT; IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

cd07881
Location:398 – 572
Blast Score: 933

RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000020.10 Reference GRCh37.p10 Primary Assembly

Range

50003494..50179370, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000152.1 Alternate HuRef

Range

46752104..46926810, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018931.1 Alternate CHM1_1.0

Range

49974919..50150783, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01052794.1 (28970..69804)	None
genomic	ABBA01052795.1	None
genomic	ABBA01052796.1	None
genomic	ABBA01052797.1	None
genomic	ABBA01052798.1	None
genomic	ABBA01052799.1	None
genomic	ABBA01052800.1	None
genomic	ABBA01052801.1	None
genomic	ABBA01052802.1	None
genomic	ABBA01052803.1	None
genomic	AF484568.1	None
genomic	AL035682.16 (6692..89163)	None
genomic	AL035684.25 (111654..148744)	None
genomic	AL132866.29 (102..56415)	None
genomic	AMYH01011980.1 (248585..274607)	None
genomic	AMYH01011981.1	None
genomic	AMYH01011982.1	None
genomic	AMYH01011983.1	None
genomic	CH471077.2	EAW75602.1
		EAW75603.1
mRNA	AK025758.1	None
mRNA	AK226146.1	None
mRNA	AK304147.1	BAH14117.1
mRNA	BC136418.1	AAI36419.1
mRNA	BC144074.1	AAI44075.1
mRNA	BE674599.1	None
mRNA	BF914609.1	None
mRNA	BM463165.1	None
mRNA	BU429325.1	None
mRNA	CD300621.1	None
mRNA	CF136470.1	None
mRNA	CR993438.1	None
mRNA	EU887573.1	ACG55593.1
mRNA	EU887574.1	ACG55594.1
mRNA	EU887575.1	ACG55595.1
mRNA	EU887576.1	ACG55596.1
mRNA	EU887577.1	ACG55597.1
mRNA	EU887578.1	ACG55598.1
mRNA	EU887579.1	ACG55599.1
mRNA	EU887580.1	ACG55600.1
mRNA	U43341.1	AAC50886.1
mRNA	U43342.1	AAC50887.1
mRNA	Z36756.1	None