MUC1 mucin 1, cell surface associated [Homo sapiens] - Gene

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Summary

Official Symbol: MUC1provided by HGNC
Official Full Name: mucin 1, cell surface associatedprovided by HGNC
Primary source: HGNC:7508
Locus tag: RP11-263K19.2
See related: Ensembl:ENSG00000185499; HPRD:01152; MIM:158340; Vega:OTTHUMG00000035681
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EMA; PEM; PUM; KL-6; MAM6; PEMT; CD227; H23AG; MUC-1; MUC-1/X; MUC1/ZD; MUC-1/SEC
Summary: This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

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Genomic context

Location :: 1q21

Sequence :: Chromosome: 1; NC_000001.10 (155158300..155162706, complement)

See MUC1 in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MUC1-C oncoprotein contributes to TCF7L2 activation and thereby promotes cyclin D1 expression in breast cancer cells.
Title: MUC1-C oncoprotein induces TCF7L2 transcription factor activation and promotes cyclin D1 expression in human breast cancer cells.
MUC1 is expressed on the majority of T-regulatory cells (CD4(+)/CD25(+)/FoxP3(+)) in humans (>90%).
Title: MUC1 mucin is expressed on human T-regulatory cells: function in both co-stimulation and co-inhibition.
human airway epithelia express catalytically active NEU1 sialidase that regulates EGFR- and MUC1-dependent signaling and bacterial adhesion.
Title: NEU1 sialidase expressed in human airway epithelia regulates epidermal growth factor receptor (EGFR) and MUC1 protein signaling.
These findings indicate that the MUC1-C subunit regulates glycolysis and that this response is conferred in part by PKM2.
Title: MUC1-C oncoprotein regulates glycolysis and pyruvate kinase M2 activity in cancer cells.
results indicate that MUC1 downregulation alters the phenotype and tumorigenicity of MKN45 gastric carcinoma cells and also the expression of several molecules that can be involved in tumorigenic events
Title: Impact of MUC1 mucin downregulation in the phenotypic characteristics of MKN45 gastric carcinoma cell line.
This report is the first, to the best of our knowledge, demonstrating that the inflammatory response in airway epithelial cells during infection with NTHi is controlled by MUC1 mucin, mainly through the suppression of TLR2 signaling
Title: Antiinflammatory role of MUC1 mucin during infection with nontypeable Haemophilus influenzae.
Gastrointestinal stromal tumours infrequently show focal EMA positivity
Title: Gastrointestinal stromal tumours can express CD10 and epithelial membrane antigen but not oestrogen receptor or HMB45.
epidermal growth factor receptor tyrosine phosphorylates MUC1, leading to an increase in its association with TLR5, thereby competitively and reversibly inhibiting recruitment of MyD88 to TLR5 and downstream signaling events.
Title: Membrane-tethered MUC1 mucin is phosphorylated by epidermal growth factor receptor in airway epithelial cells and associates with TLR5 to inhibit recruitment of MyD88.
Overexpression of MUC1 enhances proangiogenic activity of non-small-cell lung cancer cells through activation of Akt and extracellular signal-regulated kinase pathways.
Title: Overexpression of MUC1 enhances proangiogenic activity of non-small-cell lung cancer cells through activation of Akt and extracellular signal-regulated kinase pathways.
Forty-seven specimens of renal parenchyma tumors were studied immunohistochemically for the expression of EMA.
Title: The diagnostic value of EMA expression in the renal parenchyma tumors.

Submit: New GeneRIF Correction See all (325)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma.

Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels.

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_002447.3	U17193.1	BAX	BIND	PubMed	MUC1 C-ter interacts with the Bax promoter.
NP_002447.3	U24170.1	CDKN1A	BIND	PubMed	MUC1 C-ter interacts with the p21 promoter.
NP_002447.3	NP_000537.2	TP53	BIND	PubMed	MUC1 C-ter interacts with p53.
NP_877418.1	NP_001895.1	CTNNB1	BIND	PubMed	MUC1 interacts with beta-catenin.
NP_877418.1	NP_005219.2	EGFR	BIND	PubMed	MUC1 interacts with and is tyrosine-phosphorylated by EGFR.
NP_877418.1	NP_005408.1	SRC	BIND	PubMed	MUC1 interacts with c-Src.
P15941	P00519	ABL1	HPRD	PubMed
P15941	P25054	APC	HPRD	PubMed
P15941	NP_001895.1	CTNNB1	HPRD	PubMed
P15941	P35222	CTNNB1	HPRD	PubMed
P15941	NP_001322.1	CTNND1	HPRD	PubMed
P15941	O60716	CTNND1	HPRD	PubMed
P15941	NP_005219.1	EGFR	HPRD	PubMed
P15941	P00533	EGFR	HPRD	PubMed
P15941	NP_004439.1	ERBB2	HPRD	PubMed
P15941	P04626	ERBB2	HPRD	PubMed
P15941	NP_001973.1	ERBB3	HPRD	PubMed
P15941	P21860	ERBB3	HPRD	PubMed
P15941	NP_005226.1	ERBB4	HPRD	PubMed
P15941	Q15303	ERBB4	HPRD	PubMed
P15941	GalNAc Transferase 1	GALNT1	HPRD	PubMed
P15941	Q10472	GALNT1	HPRD	PubMed
P15941	NP_938080.1	GALNT10	HPRD	PubMed
P15941	Q86SR1	GALNT10	HPRD	PubMed
P15941	Q8IXK2	GALNT12	HPRD	PubMed
P15941	NP_004472.1	GALNT2	HPRD	PubMed
P15941	Q10471	GALNT2	HPRD	PubMed
P15941	NP_473451.2	GALNTL2	HPRD	PubMed
P15941	Q8N3T1	GALNTL2	HPRD	PubMed
P15941	NP_002077.1	GRB2	HPRD	PubMed
P15941	P62993	GRB2	HPRD	PubMed
P15941	NP_002084.2	GSK3B	HPRD	PubMed
P15941	P49841	GSK3B	HPRD	PubMed
P15941	NP_002221.1	JUP	HPRD	PubMed
P15941	P14923	JUP	HPRD	PubMed
P15941	P06239	LCK	HPRD	PubMed
P15941	P07948	LYN	HPRD	PubMed
P15941	NP_060277.1	OSGEP	HPRD	PubMed
P15941	Q9NPF4	OSGEP	HPRD	PubMed
P15941	NP_006245.1	PRKCD	HPRD	PubMed
P15941	Q05655	PRKCD	HPRD	PubMed
P15941	Q9BZZ2	SIGLEC1	HPRD	PubMed
P15941	NP_005624.2	SOS1	HPRD	PubMed
P15941	Q07889	SOS1	HPRD	PubMed
P15941	NP_005408.1	SRC	HPRD	PubMed
P15941	P12931	SRC	HPRD	PubMed
P15941	P43403	ZAP70	HPRD	PubMed
BioGRID:110669	BioGRID:106821	APC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110669	BioGRID:107880	CTNNB1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110669	BioGRID:107881	CTNND1	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Reconstituted Complex
BioGRID:110669	BioGRID:198512	Ctnnb1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110669	BioGRID:108276	EGFR	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:110669	BioGRID:108376	ERBB2	BioGRID	PubMed	Affinity Capture-Western; Co-localization
BioGRID:110669	BioGRID:108377	ERBB3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110669	BioGRID:108378	ERBB4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110669	BioGRID:108403	ESR1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110669	BioGRID:122816	GALNT12	BioGRID	PubMed	Biochemical Activity
BioGRID:110669	BioGRID:114240	GALNT4	BioGRID	PubMed	Biochemical Activity
BioGRID:110669	BioGRID:109142	GRB2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:110669	BioGRID:109187	GSK3B	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110669	BioGRID:109931	JUP	BioGRID	PubMed	Affinity Capture-Western; Co-localization
BioGRID:110669	BioGRID:110245	LYN	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110669	BioGRID:111566	PRKCD	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:110669	BioGRID:112537	SOS1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110669	BioGRID:112592	SRC	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex

Function	Evidence Code	Pubs
RNA polymerase II core promoter proximal region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
p53 binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info
transcription cofactor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	IDA Inferred from Direct Assay more info	PubMed
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IDA Inferred from Direct Assay more info	PubMed
O-glycan processing	TAS Traceable Author Statement more info
anti-apoptosis	IDA Inferred from Direct Assay more info	PubMed
cellular protein metabolic process	TAS Traceable Author Statement more info
negative regulation of transcription by competitive promoter binding	IDA Inferred from Direct Assay more info	PubMed
positive regulation of histone H4 acetylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter in response to stress	IDA Inferred from Direct Assay more info	PubMed
post-translational protein modification	TAS Traceable Author Statement more info
regulation of transcription from RNA polymerase II promoter in response to stress	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
Golgi lumen	TAS Traceable Author Statement more info
apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
cell surface	IBA Inferred from Biological aspect of Ancestor more info
cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
extracellular region	IEA Inferred from Electronic Annotation more info
integral to plasma membrane	TAS Traceable Author Statement more info	PubMed
nuclear chromatin	IDA Inferred from Direct Assay more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: mucin-1

Names: mucin-1; episialin; DF3 antigen; H23 antigen; krebs von den Lungen-6; mucin 1, transmembrane; tumor-associated mucin; carcinoma-associated mucin; polymorphic epithelial mucin; peanut-reactive urinary mucin; tumor associated epithelial mucin; breast carcinoma-associated antigen DF3; tumor-associated epithelial membrane antigen

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029383.1 RefSeqGene

Range

5001..9407

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001018016.2 → NP_001018016.1 mucin-1 isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses alternate in-frame splice sites for two exons, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.

Source sequence(s)

AA425062, BC120975, J05581

Consensus CDS

CCDS30882.1

UniProtKB/Swiss-Prot

P15941

UniProtKB/TrEMBL

Q0VAP5

Related

ENSP00000357377, OTTHUMP00000033787, ENST00000368392, OTTHUMT00000086736

Conserved Domains (1) summary

cl02507
Location:45 – 161
Blast Score: 290

SEA; SEA domain
NM_001018017.2 → NP_001018017.1 mucin-1 isoform 3 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site, compared to variant 1. The resulting isoform (3) is shorter than isoform 1.

Source sequence(s)

AA425062, AL713999, BC120974, J05581

Consensus CDS

CCDS30883.1

UniProtKB/Swiss-Prot

P15941

UniProtKB/TrEMBL

Q0VAP6

Related

ENSP00000357375, OTTHUMP00000033795, ENST00000368390, OTTHUMT00000086748

Conserved Domains (1) summary

cl02507
Location:36 – 152
Blast Score: 290

SEA; SEA domain
NM_001044390.2 → NP_001037855.1 mucin-1 isoform 5 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (5) has multiple differences which result in a frameshift in the central coding region, compared to variant 1. These differences result in a shorter isoform (5), compared to isoform 1.

Source sequence(s)

AA425062, AL713999, AY327582, J05581

Consensus CDS

CCDS41409.1

UniProtKB/Swiss-Prot

P15941

Related

ENSP00000339690, OTTHUMP00000033792, ENST00000343256, OTTHUMT00000086742
NM_001044391.2 → NP_001037856.1 mucin-1 isoform 6 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (6) has multiple differences but maintains the reading frame, compared to variant 1. These differences result in a shorter isoform (6), compared to isoform 1.

Source sequence(s)

AA425062, AL713999, AY327583, J05581

UniProtKB/Swiss-Prot

P15941

UniProtKB/TrEMBL

Q7Z551

Conserved Domains (2) summary

cl00944
Location:110 – 145
Blast Score: 78

KdpC; K+-transporting ATPase, c chain

cl02507
Location:36 – 76
Blast Score: 99

SEA; SEA domain
NM_001044392.2 → NP_001037857.1 mucin-1 isoform 7 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (7) has multiple differences but maintains the reading frame, compared to variant 1. These differences result in a shorter isoform (7), compared to isoform 1.

Source sequence(s)

AA425062, AL713999, AY327584, J05581

Consensus CDS

CCDS41408.1

UniProtKB/Swiss-Prot

P15941

UniProtKB/TrEMBL

Q7Z550

Related

ENSP00000357381, OTTHUMP00000033790, ENST00000368396, OTTHUMT00000086740

Conserved Domains (2) summary

cl00944
Location:119 – 154
Blast Score: 78

KdpC; K+-transporting ATPase, c chain

cl02507
Location:45 – 85
Blast Score: 99

SEA; SEA domain
NM_001044393.2 → NP_001037858.1 mucin-1 isoform 8 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (8) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (8) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AA425062, AL713999, AY327598, J05581

UniProtKB/Swiss-Prot

P15941

UniProtKB/TrEMBL

Q7Z538
NM_001204285.1 → NP_001191214.1 mucin-1 isoform 9 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (9) has multiple differences but maintains the reading frame, compared to variant 1. The encoded isoform (9) is longer than isoform 1.

Source sequence(s)

AA425062, AL713999, J05581

Consensus CDS

CCDS55640.1

UniProtKB/TrEMBL

B1AVQ5

UniProtKB/Swiss-Prot

P15941

Related

ENSP00000357380, OTTHUMP00000033786, ENST00000368395, OTTHUMT00000086735

Conserved Domains (2) summary

PLN02217
Location:81 – 179
Blast Score: 110

PLN02217; probable pectinesterase/pectinesterase inhibitor

cl02507
Location:254 – 372
Blast Score: 350

SEA; SEA domain
NM_001204286.1 → NP_001191215.1 mucin-1 isoform 10 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (10) has multiple differences but maintains the reading frame, compared to variant 1. The encoded isoform (10) is longer than isoform 1.

Source sequence(s)

AA425062, AH001451, AL713999, J05581

UniProtKB/Swiss-Prot

P15941

Conserved Domains (2) summary

PLN02217
Location:90 – 188
Blast Score: 110

PLN02217; probable pectinesterase/pectinesterase inhibitor

cl02507
Location:263 – 381
Blast Score: 350

SEA; SEA domain
NM_001204287.1 → NP_001191216.1 mucin-1 isoform 11 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (11) uses an alternate splice site, compared to variant 1. The encoded isoform (11) is longer than isoform 1.

Source sequence(s)

AA425062, EF583647, J05581

UniProtKB/TrEMBL

A5YRU5

UniProtKB/Swiss-Prot

P15941

Conserved Domains (1) summary

cl02507
Location:64 – 179
Blast Score: 332

SEA; SEA domain
NM_001204288.1 → NP_001191217.1 mucin-1 isoform 12 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (12) has multiple differences, one of which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (12) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AA425062, EF583649, J05581

UniProtKB/TrEMBL

A5YRU7

UniProtKB/Swiss-Prot

P15941

Conserved Domains (1) summary

cl02507
Location:45 – 150
Blast Score: 268

SEA; SEA domain
NM_001204289.1 → NP_001191218.1 mucin-1 isoform 13 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (13) has multiple differences but maintains the reading frame, compared to variant 1. The encoded isoform (13) is shorter than isoform 1.

Source sequence(s)

AA425062, AL713999, EF583652, J05581

UniProtKB/TrEMBL

A5YRV0

UniProtKB/Swiss-Prot

P15941

Related

ENSP00000343482, ENST00000338684

Conserved Domains (1) summary

cl02507
Location:63 – 135
Blast Score: 188

SEA; SEA domain
NM_001204290.1 → NP_001191219.1 mucin-1 isoform 14 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (14) has multiple differences but maintains the reading frame, compared to variant 1. The encoded isoform (14) is shorter than isoform 1.

Source sequence(s)

AA425062, EF583654, J05581

UniProtKB/TrEMBL

A5YRV2

UniProtKB/Swiss-Prot

P15941

Conserved Domains (1) summary

cl02507
Location:42 – 114
Blast Score: 187

SEA; SEA domain
NM_001204291.1 → NP_001191220.1 mucin-1 isoform 15 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (15) has multiple differences but maintains the reading frame, compared to variant 1. The encoded isoform (15) is shorter than isoform 1.

Source sequence(s)

AA425062, AL713999, EF670708, J05581

UniProtKB/TrEMBL

A6ZID6

UniProtKB/Swiss-Prot

P15941

Conserved Domains (1) summary

cl02507
Location:62 – 138
Blast Score: 197

SEA; SEA domain
NM_001204292.1 → NP_001191221.1 mucin-1 isoform 16 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (16) has multiple differences compared to variant 1, one of which results in a translational frameshift in the central coding region. The encoded isoform (16) is shorter than isoform 1.

Source sequence(s)

AA425062, AL713999, EF670709, J05581

UniProtKB/TrEMBL

A6ZID7

UniProtKB/Swiss-Prot

P15941

Conserved Domains (1) summary

cl02507
Location:80 – 136
Blast Score: 153

SEA; SEA domain
NM_001204293.1 → NP_001191222.1 mucin-1 isoform 17 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (17) lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (17) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AA425062, AL713999, EF670711, J05581

Consensus CDS

CCDS55642.1

UniProtKB/TrEMBL

A6ZID9

UniProtKB/Swiss-Prot

P15941

Related

ENSP00000357378, ENST00000368393

Conserved Domains (1) summary

cl02507
Location:55 – 158
Blast Score: 301

SEA; SEA domain
NM_001204294.1 → NP_001191223.1 mucin-1 isoform 18 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (18) has multiple differences compared to variant 1, one of which results in a translational frameshift in the central coding region. The encoded isoform (18) is shorter than isoform 1.

Source sequence(s)

AA425062, AL713999, EF670712, J05581

Consensus CDS

CCDS55641.1

UniProtKB/TrEMBL

A6ZIE0

UniProtKB/Swiss-Prot

P15941

Related

ENSP00000357383, OTTHUMP00000033794, ENST00000368398, OTTHUMT00000086747

Conserved Domains (1) summary

cl02507
Location:71 – 127
Blast Score: 153

SEA; SEA domain
NM_001204295.1 → NP_001191224.1 mucin-1 isoform 19 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (19) has multiple differences but maintains the reading frame, compared to variant 1. These differences result in a shorter isoform (19), compared to isoform 1.

Source sequence(s)

AA425062, AL713999, EF670716, J05581

UniProtKB/TrEMBL

A6ZIE4

UniProtKB/Swiss-Prot

P15941

Related

ENSP00000342814, OTTHUMP00000033793, ENST00000342482, OTTHUMT00000086743

Conserved Domains (1) summary

cl02507
Location:45 – 85
Blast Score: 101

SEA; SEA domain
NM_001204296.1 → NP_001191225.1 mucin-1 isoform 20 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (20) has multiple differences compared to variant 1, one of which results in a translational frameshift in the central coding region. The encoded isoform (20) is shorter than isoform 1.

Source sequence(s)

AA425062, FJ226053, J05581

UniProtKB/TrEMBL

B6ECB3

UniProtKB/Swiss-Prot

P15941
NM_001204297.1 → NP_001191226.1 mucin-1 isoform 21 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (21) has multiple differences but maintains the reading frame, compared to variant 1. These differences result in a shorter isoform (21), compared to isoform 1.

Source sequence(s)

AA425062, EF670718, J05581

UniProtKB/TrEMBL

A6ZIE6

UniProtKB/Swiss-Prot

P15941

Related

ENSP00000357374, OTTHUMP00000033789, ENST00000368389, OTTHUMT00000086739

Conserved Domains (1) summary

cl02507
Location:64 – 103
Blast Score: 143

SEA; SEA domain
NM_002456.5 → NP_002447.4 mucin-1 isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents isoform 1.

Source sequence(s)

AA425062, AL713999, J05581, U60261

Consensus CDS

CCDS1098.1

UniProtKB/TrEMBL

B1AVR0

UniProtKB/Swiss-Prot

P15941

Related

ENSP00000338983, OTTHUMP00000033791, ENST00000337604, OTTHUMT00000086741

Conserved Domains (1) summary

cl02507
Location:55 – 170
Blast Score: 332

SEA; SEA domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

155158300..155162706, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

126521570..126525810, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001018021.1: Suppressed sequence

Description

NM_001018021.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
NM_182741.1: Suppressed sequence

Description

NM_182741.1: This RefSeq was permanently suppressed because currently there is insufficient support from non-cancerous tissues for the transcript and protein.

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL713999.28	CAI95071.1
		CAI95072.1
		CAI95073.1
		CAI95074.1
		CAI95075.1
		CAI95076.1
		CAI95077.1
		CAI95078.1
		CAI95079.1
		CAI95080.1
genomic	AY463543.1	AAR18816.1
genomic	CH471121.2	EAW53116.1
		EAW53117.1
		EAW53119.1
genomic	JA362576.1	CCA94570.1
genomic	L38597.1	AAA57348.1
genomic	M35093.1	AAB59612.1
genomic	M61170.2	AAB53150.1
mRNA	AA425062.1	None
mRNA	AF125525.1	AAD27842.1
mRNA	AF348143.1	AAK30142.1
mRNA	AK301575.1	BAG63068.1
mRNA	AY327582.1	AAP97013.1
mRNA	AY327583.1	AAP97014.1
mRNA	AY327584.1	AAP97015.1
mRNA	AY327585.1	AAP97016.1
mRNA	AY327586.1	AAP97017.1
mRNA	AY327587.1	AAP97018.1
mRNA	AY327588.1	AAP97019.1
mRNA	AY327589.1	AAP97020.1
mRNA	AY327590.1	AAP97021.1
mRNA	AY327591.1	AAP97022.1
mRNA	AY327592.1	AAP97023.1
mRNA	AY327595.1	AAP97024.1
mRNA	AY327596.1	AAP97025.1
mRNA	AY327597.1	AAP97026.1
mRNA	AY327598.1	AAP97027.1
mRNA	AY327599.1	AAP97028.1
mRNA	AY327600.1	AAP97029.1
mRNA	AY466157.1	AAR28764.1
mRNA	BC120974.2	AAI20975.1
mRNA	BC120975.2	AAI20976.1
mRNA	BM969296.1	None
mRNA	BM971650.1	None
mRNA	EF583642.1	ABQ59617.1
mRNA	EF583643.1	ABQ59618.1
mRNA	EF583644.1	ABQ59619.1
mRNA	EF583645.1	ABQ59620.1
mRNA	EF583646.1	ABQ59621.1
mRNA	EF583647.1	ABQ59622.1
mRNA	EF583648.1	ABQ59623.1
mRNA	EF583649.1	ABQ59624.1
mRNA	EF583650.1	ABQ59625.1
mRNA	EF583651.1	ABQ59626.1
mRNA	EF583652.1	ABQ59627.1
mRNA	EF583653.1	ABQ59628.1
mRNA	EF583654.1	ABQ59629.1
mRNA	EF583655.1	ABQ59630.1
mRNA	EF583656.1	ABQ59631.1
mRNA	EF670706.1	ABS01293.1
mRNA	EF670707.1	ABS01294.1
mRNA	EF670708.1	ABS01295.1
mRNA	EF670709.1	ABS01296.1
mRNA	EF670710.1	ABS01297.1
mRNA	EF670711.1	ABS01298.1
mRNA	EF670712.1	ABS01299.1
mRNA	EF670713.1	ABS01300.1
mRNA	EF670714.1	ABS01301.1
mRNA	EF670715.1	ABS01302.1
mRNA	EF670716.1	ABS01303.1
mRNA	EF670717.1	ABS01304.1
mRNA	EF670718.1	ABS01305.1
mRNA	EF670719.1	ABS01306.1
mRNA	EF670720.1	ABS01307.1
mRNA	EF670721.1	ABS01308.1
mRNA	EF670722.1	ABS01309.1
mRNA	EF670723.1	ABS01310.1
mRNA	FJ226028.1	ACI25160.1
mRNA	FJ226029.1	ACI25161.1
mRNA	FJ226030.1	ACI25162.1
mRNA	FJ226031.1	ACI25163.1
mRNA	FJ226032.1	ACI25164.1
mRNA	FJ226033.1	ACI25165.1
mRNA	FJ226034.1	ACI25166.1
mRNA	FJ226035.1	ACI25167.1
mRNA	FJ226036.1	ACI25168.1
mRNA	FJ226037.1	ACI25169.1
mRNA	FJ226038.1	ACI25170.1
mRNA	FJ226039.1	ACI25171.1
mRNA	FJ226040.1	ACI25172.1
mRNA	FJ226041.1	ACI25173.1
mRNA	FJ226042.1	ACI25174.1
mRNA	FJ226043.1	ACI25175.1
mRNA	FJ226044.1	ACI25176.1
mRNA	FJ226045.1	ACI25177.1
mRNA	FJ226046.1	ACI25178.1
mRNA	FJ226047.1	ACI25179.1
mRNA	FJ226049.1	ACI25180.1
mRNA	FJ226050.1	ACI25181.1
mRNA	FJ226051.1	ACI25182.1
mRNA	FJ226052.1	ACI25183.1
mRNA	FJ226053.1	ACI25184.1
mRNA	FJ226054.1	ACI25185.1
mRNA	FJ226055.1	ACI25186.1
mRNA	J05581.1	AAA59876.1
mRNA	J05582.1	AAA60019.1
mRNA	M26316.1	AAA36336.1
mRNA	M31823.1	AAA35757.1
mRNA	M32738.1	AAA35804.1
mRNA	M32739.1	AAA35806.1
mRNA	M34088.1	AAA35805.1
mRNA	M34089.1	AAA35807.1
mRNA	S81736.1	AAD14369.1
mRNA	S81781.1	AAD14376.1
mRNA	U60259.1	AAD10856.1
mRNA	U60260.1	AAD10857.1
mRNA	U60261.1	AAD10858.1
mRNA	X52228.1	CAA36477.1
mRNA	X52229.1	CAA36478.1
mRNA	X80761.1	CAA56734.1
mRNA	Z17324.1	CAA78972.1
mRNA	Z17325.1	CAA78973.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P15941.3	GenPept	UniProtKB/Swiss-Prot:P15941
Q14877	GenPept	UniProtKB/TrEMBL:Q14877
Q6S4Y3	GenPept	UniProtKB/TrEMBL:Q6S4Y3
Q7Z536	GenPept	UniProtKB/TrEMBL:Q7Z536
Q7Z537	GenPept	UniProtKB/TrEMBL:Q7Z537
Q7Z538	GenPept	UniProtKB/TrEMBL:Q7Z538
Q7Z539	GenPept	UniProtKB/TrEMBL:Q7Z539
Q7Z540	GenPept	UniProtKB/TrEMBL:Q7Z540
Q7Z541	GenPept	UniProtKB/TrEMBL:Q7Z541
Q7Z542	GenPept	UniProtKB/TrEMBL:Q7Z542
Q7Z543	GenPept	UniProtKB/TrEMBL:Q7Z543
Q7Z544	GenPept	UniProtKB/TrEMBL:Q7Z544
Q7Z545	GenPept	UniProtKB/TrEMBL:Q7Z545
Q7Z546	GenPept	UniProtKB/TrEMBL:Q7Z546
Q7Z547	GenPept	UniProtKB/TrEMBL:Q7Z547
Q7Z548	GenPept	UniProtKB/TrEMBL:Q7Z548
Q7Z549	GenPept	UniProtKB/TrEMBL:Q7Z549
Q7Z550	GenPept	UniProtKB/TrEMBL:Q7Z550
Q7Z551	GenPept	UniProtKB/TrEMBL:Q7Z551
Q9UMI8	GenPept	UniProtKB/TrEMBL:Q9UMI8