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    CD14 CD14 molecule [ Homo sapiens ]

    Gene ID: 929, updated on 20-May-2012
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    Summary

    Official Symbol
    CD14provided by HGNC
    Official Full Name
    CD14 moleculeprovided by HGNC
    Primary source
    HGNC:1628
    See related
    Ensembl:ENSG00000170458; HPRD:01151; MIM:158120; Vega:OTTHUMG00000129507
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]
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    Genomic context

    Location :
    5q31.1
    Sequence :
    Chromosome: 5; NC_000005.9 (140011313..140013286, complement)
    See CD14 in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100505798 Neighboring gene HAUS augmin-like complex, subunit 1 pseudogene 1 Neighboring gene ribosomal protein L36 pseudogene 11 Neighboring gene transmembrane and coiled-coil domains 6 Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa Neighboring gene microRNA 3655 Neighboring gene IK cytokine, down-regulator of HLA II

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Gene-gene interactions between candidate gene polymorphisms are associated with total IgE levels in Korean children with asthma. Choi WA, et al. J Asthma, 2012 Apr. PMID 22376040.
    2. Follistatin-related protein/follistatin-like 1 evokes an innate immune response via CD14 and toll-like receptor 4. Murakami K, et al. FEBS Lett, 2012 Feb 17. PMID 22265692.
    3. Toll-like receptor (TLR) 3 immune modulation by unformulated small interfering RNA or DNA and the role of CD14 (in TLR-mediated effects). Weber C, et al. Immunology, 2012 May. PMID 22260507.
    4. CD14 cooperates with complement receptor 3 to mediate MyD88-independent phagocytosis of Borrelia burgdorferi. Hawley KL, et al. Proc Natl Acad Sci U S A, 2012 Jan 24. PMID 22232682.
    5. Association between toll-like receptors/CD14 gene polymorphisms and inflammatory bowel disease in Korean population. Kim EJ, et al. J Korean Med Sci, 2012 Jan. PMID 22219617.

    See all (495) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. human CD14 acts only as co-receptor to human TLR9, but not TLR3, TLR7 or TLR8
      Title: Toll-like receptor (TLR) 3 immune modulation by unformulated small interfering RNA or DNA and the role of CD14 (in TLR-mediated effects).
    2. In Korean asthmatic children, increased serum IgE level was a multi-locus interaction between IL-4Ralpha, IL-13, IL-13Ralpha1, CD14, and CTLA4 polymorphisms. The combination of CTLA4/IL-13 and IL-13/IL-13Ralpha1 polymorphisms showed strong synergistic ...
      Title: Gene-gene interactions between candidate gene polymorphisms are associated with total IgE levels in Korean children with asthma.
    3. The promoter polymorphism at -159 C/T of the CD14 gene is positively associated with IBD, both ulcerative colitis and Crohn's disease.
      Title: Association between toll-like receptors/CD14 gene polymorphisms and inflammatory bowel disease in Korean population.
    4. Data show that circulating levels of sCD14 are increased in rheumatoid arthritis, are highest in patients with increased levels of disease activity, and appear to be influenced by age and race but not by genetic variation in CD14.
      Title: Soluble CD14 and CD14 polymorphisms in rheumatoid arthritis.
    5. In patients with stable coronary artery disease the CRP 1444TT and CD14 260TT variants are associated with larger coronary plaque volume independently of concomitant cardiovascular risk factors.
      Title: CRP and CD14 polymorphisms correlate with coronary plaque volume in patients with coronary artery disease--IVUS substudy of the ENCORE trials.
    6. FSTL1 induced interleukin 6 or interleukin 8 production from target cells in a CD14- and TLR4-dependent manner.
      Title: Follistatin-related protein/follistatin-like 1 evokes an innate immune response via CD14 and toll-like receptor 4.
    7. Data suggest that umbilical cord blood-derived endothelial progenitor cells are confined to CD14-/CD34+ subpopulation and angiogenin1 released from CD14+ subpopulation may be an important factor promoting the EPC colony formation.
      Title: CD14-/CD34+ is the founding population of umbilical cord blood-derived endothelial progenitor cells and angiogenin1 is an important factor promoting the colony formation.
    8. CD14 is required as a co-receptor, with complement recpetor 3, to mediate the phagocytosis of Borrelia burgdorferi.
      Title: CD14 cooperates with complement receptor 3 to mediate MyD88-independent phagocytosis of Borrelia burgdorferi.
    9. study found SNP -159C/T not associated with asthma in Slovenian children; however, non-atopic asthmatics with CT or TT genotypes have lower FEV1/FVC ratio, a measure of bronchial obstruction; they also have increased bronchial hyperreactivity
      Title: CD14 gene polymorphism is not associated with asthma but rather with bronchial obstruction and hyperreactivity in Slovenian children with non-atopic asthma.
    10. The availability of commercial methods for the automated measurement of the soluble CD14 subtype presepsin and lipopolysaccharide binding protein represent a challenge for the evaluation in clinical practice of reliable markers of neonatal sepsis.
      Title: Soluble CD14 subtype presepsin (sCD14-ST) and lipopolysaccharide binding protein (LBP) in neonatal sepsis: new clinical and analytical perspectives for two old biomarkers.
    Submit: New GeneRIF Correction See all (295)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef enhances membrane-bound (m) CD14 expression on monocytes but does not induce the release of soluble CD14 into the culture supernatants of PBMC; the upregulation of mCD14 expression does not involve endogenously produced IL-10 PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P08571 P08174 CD55    HPRD  PubMed  
    P08571 P05107 ITGB2    HPRD  PubMed  
    P08571 P18428 LBP    HPRD  PubMed  
    P08571 Q08380 LGALS3BP    HPRD  PubMed  
    P08571 P02788 LTF    HPRD  PubMed  
    P08571 O60603 TLR2    HPRD  PubMed  
    P08571 O15455 TLR3    HPRD  PubMed  
    P08571 O00206 TLR4    HPRD  PubMed  
    BioGRID:107367 BioGRID:110121 LBP    BioGRID  PubMed Co-purification; Reconstituted Complex 
    BioGRID:107367 BioGRID:110235 LTF    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107367 BioGRID:112952 TLR2    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Amoebiasis, organism-specific biosystem (from KEGG)
      Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Amoebiasis, conserved biosystem (from KEGG)
      Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • LPS transferred from LBP carrier to CD14, organism-specific biosystem (from REACTOME)
      LPS transferred from LBP carrier to CD14, organism-specific biosystemLBP delivers lipid A from bacteria (or bacterial membrane fragments) to CD14 on the surfaces of animal cells, where it is recognised by Toll-like receptor 4 (TLR4). Thus, LBP is an opsonin and CD14 i...
    • Legionellosis, organism-specific biosystem (from KEGG)
      Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Legionellosis, conserved biosystem (from KEGG)
      Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Pathogenic Escherichia coli infection, organism-specific biosystem (from KEGG)
      Pathogenic Escherichia coli infection, organism-specific biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
    • Pathogenic Escherichia coli infection, conserved biosystem (from KEGG)
      Pathogenic Escherichia coli infection, conserved biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
    • Pertussis, organism-specific biosystem (from KEGG)
      Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Pertussis, conserved biosystem (from KEGG)
      Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
      Regulation of Actin Cytoskeleton, organism-specific biosystem
      Regulation of Actin Cytoskeleton
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Salmonella infection, organism-specific biosystem (from KEGG)
      Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Salmonella infection, conserved biosystem (from KEGG)
      Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
    • Toll Receptor Cascades, organism-specific biosystem (from REACTOME)
      Toll Receptor Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
    • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
      Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
      Transcriptional misregulation in cancer, organism-specific biosystem
      Transcriptional misregulation in cancer
    • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
      Transcriptional misregulation in cancer, conserved biosystem
      Transcriptional misregulation in cancer
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    lipopolysaccharide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    lipoteichoic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    opsonin receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    peptidoglycan receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    Toll signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cellular response to lipoteichoic acid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    innate immune response TAS
    Traceable Author Statement
    more info
    		  
    phagocytosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    positive regulation of cytokine secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to heat IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    anchored to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    extracellular region TAS
    Traceable Author Statement
    more info
    		  
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    monocyte differentiation antigen CD14
    Names
    monocyte differentiation antigen CD14
    myeloid cell-specific leucine-rich glycoprotein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023178.1 RefSeqGene

      Range
      5001..6974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000591.3 → NP_000582.1  monocyte differentiation antigen CD14 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Variants 1-4 encode the same protein.
      Source sequence(s)
      BC010507, CF593452, W74441
      Consensus CDS
      CCDS4232.1
      UniProtKB/Swiss-Prot
      P08571
      Related
      ENSP00000304236, OTTHUMP00000159892, ENST00000302014, OTTHUMT00000251681

    2. NM_001040021.2 → NP_001035110.1  monocyte differentiation antigen CD14 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      BC010507, DA426297, W74441
      Consensus CDS
      CCDS4232.1
      UniProtKB/Swiss-Prot
      P08571
      Related
      ENSP00000426543, OTTHUMP00000223711, ENST00000498971, OTTHUMT00000372960

    3. NM_001174104.1 → NP_001167575.1  monocyte differentiation antigen CD14 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      BC010507, BP300412, DA426297, W74441
      Consensus CDS
      CCDS4232.1
      UniProtKB/Swiss-Prot
      P08571
      Related
      ENSP00000385519, ENST00000401743

    4. NM_001174105.1 → NP_001167576.1  monocyte differentiation antigen CD14 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      BC010507, DA269805, DA426297, W74441
      Consensus CDS
      CCDS4232.1
      UniProtKB/Swiss-Prot
      P08571
      Related
      ENSP00000430884, OTTHUMP00000224328, ENST00000519715, OTTHUMT00000374271

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p5 Primary Assembly

      Range
      140011313..140013286, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      135156588..135158561, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC116353.2 (87445..88895) None
    genomic CH471062.2 EAW62037.1
    genomic X06882.1 CAA29999.1
    mRNA AB446505.1 BAG55282.1
    mRNA AF097942.1 AAC83816.1
    mRNA AK313277.1 BAG36085.1
    mRNA AY044269.1 AAL02401.1
    mRNA BC010507.2 AAH10507.1
    mRNA BP300412.1 None
    mRNA BT007331.1 AAP35995.1
    mRNA CF593452.1 None
    mRNA DA269805.1 None
    mRNA DA426297.1 None
    mRNA DA681405.1 None
    mRNA M86511.1 AAA51930.1
    mRNA W74441.1 None
    mRNA X13334.1 CAA31711.1
    other-genetic AM392692.1 CAL37570.1
    other-genetic AM392824.1 CAL37702.1
    other-genetic AM393386.1 CAL38264.1
    other-genetic AM393697.1 CAL38573.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08571.2 GenPept UniProtKB/Swiss-Prot:P08571
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

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