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    CD81 CD81 molecule [ Homo sapiens ]

    Gene ID: 975, updated on 19-May-2012
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    Summary

    Official Symbol
    CD81provided by HGNC
    Official Full Name
    CD81 moleculeprovided by HGNC
    Primary source
    HGNC:1701
    See related
    Ensembl:ENSG00000110651; HPRD:08924; MIM:186845; Vega:OTTHUMG00000009892
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    S5.7; CVID6; TAPA1; TSPAN28
    Summary
    The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    11p15.5
    Sequence :
    Chromosome: 11; NC_000011.9 (2398547..2418649)
    See CD81 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene tetraspanin 32 Neighboring gene ribosomal protein L26 pseudogene 30 Neighboring gene tumor suppressing subtransferable candidate 4 Neighboring gene transient receptor potential cation channel, subfamily M, member 5

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Inhibition of HCV 3a genotype entry through host CD81 and HCV E2 antibodies. Ashfaq UA, et al. J Transl Med, 2011 Nov 10. PMID 22074322.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Hepatitis C virus is primed by CD81 protein for low pH-dependent fusion. Sharma NR, et al. J Biol Chem, 2011 Sep 2. PMID 21737455.
    5. CD81 is essential for the formation of membrane protrusions and regulates Rac1-activation in adhesion-dependent immune cell migration. Quast T, et al. Blood, 2011 Aug 18. PMID 21677313.

    See all (145) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Heptatitis c virus (HCV) specific E2 and host CD81 antibodies reduce HCV pseudoparticle entry.
      Title: Inhibition of HCV 3a genotype entry through host CD81 and HCV E2 antibodies.
    2. Hepatitis C virus is primed by CD81 protein for low pH-dependent fusion
      Title: Hepatitis C virus is primed by CD81 protein for low pH-dependent fusion.
    3. CD81 is required for the formation of actin membrane protrusions via RAC1 activation in adhesion-dependent immune cell migration.
      Title: CD81 is essential for the formation of membrane protrusions and regulates Rac1-activation in adhesion-dependent immune cell migration.
    4. Expression of human factors CD81, claudin-1, scavenger receptor, and occludin in mouse hepatocytes does not confer susceptibility to hepatitis B virus entry into the liver.
      Title: Expression of human factors CD81, claudin-1, scavenger receptor, and occludin in mouse hepatocytes does not confer susceptibility to HCV entry.
    5. E2-CD81 engagement may contribute to Hepatitis C virus-associated B cell lymphoproliferative disorders and insufficient neutralizing antibody production.
      Title: Hepatitis C virus protects human B lymphocytes from Fas-mediated apoptosis via E2-CD81 engagement.
    6. show for the first time that CD9 and CD81 act as molecular partners of trimeric FcvarepsilonRI on human antigen-presenting cell
      Title: Tetraspanins CD9 and CD81 are molecular partners of trimeric FcɛRI on human antigen-presenting cells.
    7. Membrane-Associated RING-CH proteins MARCH VIII and MARCH IV associate with Bap31 and target CD81 and CD44 to lysosomes
      Title: Membrane-Associated RING-CH proteins associate with Bap31 and target CD81 and CD44 to lysosomes.
    8. Structural characterization of CD81-Claudin-1 hepatitis C virus receptor complexes.
      Title: Structural characterization of CD81-Claudin-1 hepatitis C virus receptor complexes.
    9. Hepatitis C virus entry and the tetraspanin CD81.
      Title: Hepatitis C virus entry and the tetraspanin CD81.
    10. analysis of interacting regions of CD81 and two of its partners, EWI-2 and EWI-2wint, and their effect on hepatitis C virus infection
      Title: Interacting regions of CD81 and two of its partners, EWI-2 and EWI-2wint, and their effect on hepatitis C virus infection.
    Submit: New GeneRIF Correction See all (84)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Immunodeficiency, common variable, 6

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Overexpression of CD81 and CD9 renders cells less susceptible to HIV-1 gp120/gp41-mediated syncytia formation; antibodies raised against CD9 and CD81 enhance syncytia formation PubMed
    Pr55(Gag) gag HIV-1 Gag proteins co-localize with CD63 and CD81 in intracellular exosomes PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_004347.1 NP_671491.1 HCVgp1    BIND  PubMed E2 interacts with CD81. 
    NP_004347.1 NP_671491.1 HCVgp1    BIND  PubMed CD81 interacts with E2. 
    NP_004347.1 NP_751921.1 HCVgp1    BIND  PubMed E2 interacts with CD81. 
    NP_004347.1 NP_751921.1 HCVgp1    BIND  PubMed CD81 interacts with E2. 
    NP_004347.1 P27958     BIND  PubMed E2 interacts with CD81. This interaction was modeled on a demonstrated interaction between E2 from an unspecified HCV strain and Human CD81. 
    NP_004347.1     BIND  PubMed The Hepatitis C virus E1E2 glycoprotein heterodimer interacts with human CD81. 
    P60033 P15391 CD19    HPRD  PubMed  
    P60033 P60033 CD81    HPRD  PubMed  
    P60033 P21926 CD9    HPRD  PubMed  
    P60033 Q8TDM6 DLG5    HPRD  PubMed  
    P60033 P13164 IFITM1    HPRD  PubMed  
    P60033 Q969P0 IGSF8    HPRD  PubMed  
    P60033 Q9C086 INO80B    HPRD  PubMed  
    P60033 P13612 ITGA4    HPRD  PubMed  
    P60033 P10721 KIT    HPRD  PubMed  
    P60033 Q99972 MYOC    HPRD  PubMed  
    P60033 Q9P2B2 PTGFRN    HPRD  PubMed  
    P60033 P29353 SHC1    HPRD  PubMed  
    P60033 O14817 TSPAN4    HPRD  PubMed  
    P60033 Q05516 ZBTB16    HPRD  PubMed  
    BioGRID:107413 BioGRID:107368 CD19    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107413 BioGRID:107358 CD4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107413 BioGRID:110346 CD46    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107413 BioGRID:107405 CD63    BioGRID  PubMed Co-fractionation 
    BioGRID:107413 BioGRID:107413 CD81    BioGRID  PubMed Co-crystal Structure 
    BioGRID:107413 BioGRID:107366 CD9    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:107413 BioGRID:107771 CR2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107413 BioGRID:114662 DLG5    BioGRID  PubMed Two-hybrid 
    BioGRID:107413 BioGRID:114091 IFITM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107413 BioGRID:125011 IGSF8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107413 BioGRID:123646 INO80B    BioGRID  PubMed Two-hybrid 
    BioGRID:107413 BioGRID:109883 ITGA4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107413 BioGRID:109894 ITGB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107413 BioGRID:110015 KIT    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107413 BioGRID:111710 PTGFRN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107413 BioGRID:111865 RBBP6    BioGRID  PubMed Two-hybrid 
    BioGRID:107413 BioGRID:211790 Rnf128    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107413 BioGRID:112961 TSPAN4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107413 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107413 BioGRID:113498 ZBTB16    BioGRID  PubMed Two-hybrid 
    BioGRID:107413 BioGRID:1205537 gag    BioGRID  PubMed Co-fractionation 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • B cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      B cell receptor signaling pathway, organism-specific biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • B cell receptor signaling pathway, conserved biosystem (from KEGG)
      B cell receptor signaling pathway, conserved biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • Hepatitis C, organism-specific biosystem (from KEGG)
      Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Hepatitis C, conserved biosystem (from KEGG)
      Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
    • Malaria, organism-specific biosystem (from KEGG)
      Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Malaria, conserved biosystem (from KEGG)
      Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    Process Evidence Code Pubs
    activation of MAPK activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    entry of virus into host cell TAS
    Traceable Author Statement
    more info
    		 PubMed 
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphatidylinositol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    phosphatidylinositol metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of 1-phosphatidylinositol 4-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of immune response TAS
    Traceable Author Statement
    more info
    		  
    response to wounding IEA
    Inferred from Electronic Annotation
    more info
    		  
    virion attachment, binding of host cell surface receptor TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    immunological synapse IDA
    Inferred from Direct Assay
    more info
    		  
    integral to plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    CD81 antigen
    Names
    CD81 antigen
    tspan-28
    tetraspanin-28
    26 kDa cell surface protein TAPA-1
    CD81 antigen (target of antiproliferative antibody 1)
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023386.1 RefSeqGene

      Range
      5001..25103
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_142

    mRNA and Protein(s)

    1. NM_004356.3 → NP_004347.1  CD81 antigen

      Status: REVIEWED

      Source sequence(s)
      BC002978, BG397506, BQ709484, CB055265, M33680
      Consensus CDS
      CCDS7734.1
      UniProtKB/Swiss-Prot
      P60033
      Related
      ENSP00000263645, OTTHUMP00000011528, ENST00000263645, OTTHUMT00000027357
      Conserved Domains (2) summary
      cd03151
      Location:113 – 202
      Blast Score: 167
      CD81_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:9 – 230
      Blast Score: 299
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      2398547..2418649
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      2188870..2209001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC124057.12 (142672..155081) None
    genomic AC129929.5 (2088..9780) None
    genomic CH471158.1 EAX02507.1
      EAX02508.1
    genomic EF064749.1 ABK41932.1
    mRNA AB209380.1 BAD92617.1
    mRNA BC002978.1 AAH02978.1
    mRNA BC093047.1 AAH93047.1
    mRNA BG397506.1 None
    mRNA BQ709484.1 None
    mRNA BT019507.1 AAV38314.1
    mRNA BT019508.1 AAV38315.1
    mRNA CB055265.1 None
    mRNA M33680.1 AAA36663.1
    other-genetic DQ891836.2 ABM82762.1
    other-genetic DQ891849.2 ABM82775.1
    other-genetic DQ895022.2 ABM85948.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60033.1 GenPept UniProtKB/Swiss-Prot:P60033
    Q59FS9 GenPept UniProtKB/TrEMBL:Q59FS9
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

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