CD63 CD63 molecule [Homo sapiens] - Gene

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Summary

Official Symbol: CD63provided by HGNC
Official Full Name: CD63 moleculeprovided by HGNC
Primary source: HGNC:1692
See related: Ensembl:ENSG00000135404; HPRD:01121; MIM:155740; Vega:OTTHUMG00000170454
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MLA1; ME491; LAMP-3; OMA81H; TSPAN30
Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]

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Genomic context

Location :: 12q12-q13

Sequence :: Chromosome: 12; NC_000012.11 (56119230..56122910, complement)

See CD63 in Epigenomics, MapViewer

Chromosome 12 - NC_000012.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Loss of CD63 has a similar phenotype to loss of P-selectin itself, thus CD63 is an essential cofactor to P-selectin.
Title: CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin.
shRNA knockdown in B lymphoblastoid cell line results to increased CD4(+) T-cell recognition
Title: The role of tetraspanin CD63 in antigen presentation via MHC class II.
decreased levels of CD63 were associated with distant and lymph node metastasis status and does play a direct role in human gastric carcinogenesis.
Title: Down-regulation of TM4SF is associated with the metastatic potential of gastric carcinoma TM4SF members in gastric carcinoma.
C-terminal modifications that retain LMP1 in Golgi compartments preclude assembly within CD63-enriched domains and/or exosomal discharge leading to NF-kappaB overstimulation.
Title: LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-κB activation.
These findings suggest that CD63 plays an early post-entry role prior to or at the reverse transcription step.
Title: A post-entry role for CD63 in early HIV-1 replication.
ameloblastin is expressed in osteoblasts and functions as a promoting factor for osteogenic differentiation via a novel pathway through the interaction between CD63 and integrin beta1
Title: Ameloblastin regulates osteogenic differentiation by inhibiting Src kinase via cross talk between integrin beta1 and CD63.
Surface expression of the novel CD63 variant is a distinguishing feature of mast cells, which are are stable, multiple-use cells capable of surviving and delivering several consecutive hits
Title: A granular variant of CD63 is a regulator of repeated human mast cell degranulation.
this work provides the first evidence of a TIMP-4/CD63 association in astrocytoma tumor cells
Title: TIMP-4 and CD63: new prognostic biomarkers in human astrocytomas.
CD63 expression results from only the anaphylactic degranulation form of histamine release.
Title: Expression of CD203c and CD63 in human basophils: relationship to differential regulation of piecemeal and anaphylactic degranulation processes.
Serum sCD163 is a homogenous protein covering more than 94% of the CD163 ectodomain including the haptoglobin-hemoglobin -binding region.
Title: Soluble macrophage-derived CD163: a homogenous ectodomain protein with a dissociable haptoglobin-hemoglobin binding.

Submit: New GeneRIF Correction See all (45)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
capsid	gag	In human macrophages, HIV-1 Capsid (p24) co-localizes with MHC II (HLA-DR), CD63, and Lamp1 in MHC II compartments	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
P08962	O00189	AP4M1	HPRD	PubMed
P08962	P27701	CD82	HPRD	PubMed
P08962	P21926	CD9	HPRD	PubMed
P08962	P28068	HLA-DMB	HPRD	PubMed
P08962	P01903	HLA-DRA	HPRD	PubMed
P08962	P23229	ITGA6	HPRD	PubMed
P08962	Phosphatidylinositol 4 kinase type II	PI4K2A	HPRD	PubMed
P08962	Q9P2B2	PTGFRN	HPRD	PubMed
P08962	P01033	TIMP1	HPRD	PubMed
BioGRID:107405	BioGRID:107413	CD81	BioGRID	PubMed	Co-fractionation
BioGRID:107405	BioGRID:109935	CD82	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107405	BioGRID:107366	CD9	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107405	BioGRID:109354	HLA-DMB	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107405	BioGRID:109357	HLA-DOB	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107405	BioGRID:109367	HLA-DRA	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107405	BioGRID:109894	ITGB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107405	BioGRID:110015	KIT	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107405	BioGRID:111710	PTGFRN	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107405	BioGRID:116470	RNF13	BioGRID	PubMed	Co-localization
BioGRID:107405	BioGRID:112600	SRF	BioGRID	PubMed	Two-hybrid
BioGRID:107405	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:107405	BioGRID:1205537	gag	BioGRID	PubMed	Co-fractionation
BioGRID:107405	BioGRID:1205539	vif	BioGRID	PubMed	Co-fractionation

Process	Evidence Code	Pubs
blood coagulation	TAS Traceable Author Statement more info
platelet activation	TAS Traceable Author Statement more info
platelet degranulation	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
endosome	IEA Inferred from Electronic Annotation more info
endosome membrane	IDA Inferred from Direct Assay more info	PubMed
integral to membrane	IEA Inferred from Electronic Annotation more info
integral to plasma membrane	TAS Traceable Author Statement more info	PubMed
late endosome membrane	IEA Inferred from Electronic Annotation more info
lysosomal membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	TAS Traceable Author Statement more info
platelet dense granule membrane	TAS Traceable Author Statement more info

General protein information

Preferred Names: CD63 antigen

Names: CD63 antigen; tspan-30; granulophysin; tetraspanin-30; melanoma-associated antigen MLA1; CD63 antigen (melanoma 1 antigen); melanoma-associated antigen ME491; ocular melanoma-associated antigen; lysosomal-associated membrane protein 3; lysosome-associated membrane glycoprotein 3

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008347.1 RefSeqGene

Range

4454..8684

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001257389.1 → NP_001244318.1 CD63 antigen isoform A

Status: REVIEWED

Description

Transcript Variant: This variant (3) has an alternate 5' UTR exon, compared to variant 1. Variants 1 and 3-6 encode the same isoform A.

Source sequence(s)

BU960599, CB128206, CD250685, CN296813

Conserved Domains (2) summary

cd03166
Location:105 – 202
Blast Score: 440

CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...

pfam00335
Location:9 – 231
Blast Score: 324

Tetraspannin; Tetraspanin family
NM_001257390.1 → NP_001244319.1 CD63 antigen isoform A

Status: REVIEWED

Description

Transcript Variant: This variant (4) has an alternate 5' UTR exon, compared to variant 1. Variants 1 and 3-6 encode the same isoform A.

Source sequence(s)

BG478842, BU960599

Conserved Domains (2) summary

cd03166
Location:105 – 202
Blast Score: 440

CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...

pfam00335
Location:9 – 231
Blast Score: 324

Tetraspannin; Tetraspanin family
NM_001257391.1 → NP_001244320.1 CD63 antigen isoform A

Status: REVIEWED

Description

Transcript Variant: This variant (5) has an alternate 5' UTR segment, compared to variant 1. Variants 1 and 3-6 encode the same isoform A.

Source sequence(s)

AL582859, BE407235, BU960599

Conserved Domains (2) summary

cd03166
Location:105 – 202
Blast Score: 440

CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...

pfam00335
Location:9 – 231
Blast Score: 324

Tetraspannin; Tetraspanin family
NM_001257392.1 → NP_001244321.1 CD63 antigen isoform C

Status: REVIEWED

Description

Transcript Variant: This variant (7) has an alternate splice site in the 5' coding region, compared to variant 1. The resulting isoform (C) lacks an internal segment, compared to isoform A.

Source sequence(s)

AF508304, BU960599, CN484590

Conserved Domains (1) summary

cd03166
Location:82 – 179
Blast Score: 435

CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...
NM_001257400.1 → NP_001244329.1 CD63 antigen isoform D precursor

Status: REVIEWED

Description

Transcript Variant: This variant (8) contains a distinct 5' UTR exon and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (D) has a shorter N-terminus, compared to isoform A. Variants 8 and 9 encode the same isoform D.

Source sequence(s)

BC013017, BG766593, BU960599

Conserved Domains (1) summary

cd03166
Location:23 – 120
Blast Score: 427

CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...
NM_001257401.1 → NP_001244330.1 CD63 antigen isoform D precursor

Status: REVIEWED

Description

Transcript Variant: This variant (9) contains a distinct 5' UTR exon and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (D) has a shorter N-terminus, compared to isoform A. Variants 8 and 9 encode the same isoform D.

Source sequence(s)

BQ434569, BU190521, BU960599

Conserved Domains (1) summary

cd03166
Location:23 – 120
Blast Score: 427

CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...
NM_001257405.1 → NP_001244334.1 CD63 antigen isoform A

Status: REVIEWED

Description

Transcript Variant: This variant (6) has an alternate 5' UTR exon, compared to variant 1. Variants 1 and 3-6 encode the same isoform A.

Source sequence(s)

BU960599, DB495090, EB386351

Conserved Domains (2) summary

cd03166
Location:105 – 202
Blast Score: 440

CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...

pfam00335
Location:9 – 231
Blast Score: 324

Tetraspannin; Tetraspanin family
NM_001780.5 → NP_001771.1 CD63 antigen isoform A

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (A). Variants 1 and 3-6 encode the same isoform A.

Source sequence(s)

BU960599, DB495090, EB386351

Consensus CDS

CCDS8890.1

UniProtKB/Swiss-Prot

P08962

Related

ENSP00000257857, OTTHUMP00000243856, ENST00000257857, OTTHUMT00000409235

Conserved Domains (2) summary

cd03166
Location:105 – 202
Blast Score: 440

CD63_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...

pfam00335
Location:9 – 231
Blast Score: 324

Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000012.11 Reference GRCh37.p5 Primary Assembly

Range

56119230..56122910, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000144.1 Alternate HuRef

Range

53158045..53161726, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001040034.1: Suppressed sequence

Description

NM_001040034.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC009779.18 (8071..11730)	None
genomic	CH471054.1	EAW96827.1
		EAW96828.1
		EAW96829.1
genomic	D00874.1	None
genomic	X62654.1	CAA44519.1
mRNA	AF508304.1	AAM34259.1
mRNA	AK311893.1	BAG34834.1
mRNA	AL582859.3	None
mRNA	AV650763.1	None
mRNA	BC002349.2	AAH02349.1
mRNA	BC013017.2	AAH13017.1
mRNA	BE407235.1	None
mRNA	BG478842.1	None
mRNA	BG766593.1	None
mRNA	BQ434569.1	None
mRNA	BT007073.1	AAP35736.1
mRNA	BT020137.1	AAV38939.1
mRNA	BT020138.1	AAV38940.1
mRNA	BU190521.1	None
mRNA	BU960599.1	None
mRNA	CB128206.1	None
mRNA	CD250685.1	None
mRNA	CN296813.1	None
mRNA	CN296834.1	None
mRNA	CN484590.1	None
mRNA	CR542096.1	CAG46893.1
mRNA	DB495090.1	None
mRNA	EB386351.1	None
mRNA	M58485.1	None
mRNA	M59907.1	AAA63235.1
mRNA	S93788.1	AAB21617.1
mRNA	X07982.1	CAA30792.1
other-genetic	DQ891248.2	ABM82174.1
other-genetic	DQ894433.2	ABM85359.1