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ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha [ Homo sapiens (human) ]

Gene ID: 396, updated on 16-Apr-2014
Official Symbol
ARHGDIAprovided by HGNC
Official Full Name
Rho GDP dissociation inhibitor (GDI) alphaprovided by HGNC
Primary source
HGNC:678
See related
Ensembl:ENSG00000141522; HPRD:03565; MIM:601925; Vega:OTTHUMG00000178352
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GDIA1; NPHS8; RHOGDI; RHOGDI-1; HEL-S-47e
Summary
Aplysia Ras-related homologs (ARHs), also called Rho genes, belong to the RAS gene superfamily encoding small guanine nucleotide exchange (GTP/GDP) factors. The ARH proteins may be kept in the inactive, GDP-bound state by interaction with GDP dissociation inhibitors, such as ARHGDIA (Leffers et al., 1993 [PubMed 8262133]).[supplied by OMIM, Jan 2009]
Location :
17q25.3
Sequence :
Chromosome: 17; NC_000017.11 (81867721..81871406, complement)
See ARHGDIA in Epigenomics, MapViewer

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 27 Neighboring gene prolyl 4-hydroxylase, beta polypeptide Neighboring gene Aly/REF export factor Neighboring gene anaphase promoting complex subunit 11 Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene neuropeptide B

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat, p14 tat In Jurkat cells expressing HIV-1 Tat, decreased expression levels are found for basic cytoskeletal proteins such as actin, beta-tubulin, annexin, cofilin, gelsolin, and Rac/Rho-GDI complex PubMed
Vpr, p15 vpr HIV-1 Vpr-expressing Jurkat T cell clones showed a significant upregulation of Rho GDI expression PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
Rho GDP-dissociation inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
cellular component movement TAS
Traceable Author Statement
more info
PubMed 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of axonogenesis TAS
Traceable Author Statement
more info
 
negative regulation of cell adhesion TAS
Traceable Author Statement
more info
PubMed 
neurotrophin TRK receptor signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of axonogenesis TAS
Traceable Author Statement
more info
 
regulation of axonogenesis TAS
Traceable Author Statement
more info
 
regulation of catalytic activity TAS
Traceable Author Statement
more info
PubMed 
regulation of protein localization IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
immunological synapse IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
rho GDP-dissociation inhibitor 1
Names
rho GDP-dissociation inhibitor 1
rho GDI 1
rho-GDI alpha
epididymis secretory sperm binding protein Li 47e

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001185077.1NP_001172006.1  rho GDP-dissociation inhibitor 1 isoform a

    See proteins identical to NP_001172006.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    BC005851, BM552638
    Consensus CDS
    CCDS11788.1
    UniProtKB/Swiss-Prot
    P52565
    UniProtKB/TrEMBL
    V9HWE8
    Conserved Domains (1) summary
    pfam02115
    Location:1201
    Blast Score: 929
    Rho_GDI; RHO protein GDP dissociation inhibitor
  2. NM_001185078.1NP_001172007.1  rho GDP-dissociation inhibitor 1 isoform b

    See proteins identical to NP_001172007.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AK300816, BC005851, DC406556
    Consensus CDS
    CCDS58609.1
    UniProtKB/Swiss-Prot
    P52565
    Related
    ENSP00000383556, OTTHUMP00000259328, ENST00000400721, OTTHUMT00000441680
    Conserved Domains (1) summary
    pfam02115
    Location:1157
    Blast Score: 634
    Rho_GDI; RHO protein GDP dissociation inhibitor
  3. NM_004309.4NP_004300.1  rho GDP-dissociation inhibitor 1 isoform a

    See proteins identical to NP_004300.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    BC005851, DC406556
    Consensus CDS
    CCDS11788.1
    UniProtKB/Swiss-Prot
    P52565
    UniProtKB/TrEMBL
    V9HWE8
    Related
    ENSP00000269321, OTTHUMP00000259327, ENST00000269321, OTTHUMT00000441679
    Conserved Domains (1) summary
    pfam02115
    Location:1201
    Blast Score: 929
    Rho_GDI; RHO protein GDP dissociation inhibitor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38 Primary Assembly

    Range
    81867721..81871406, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000149.1 Alternate HuRef

    Range
    75227385..75230633, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    79911833..79915499, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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