ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: ARHGDIAprovided by HGNC
Official Full Name: Rho GDP dissociation inhibitor (GDI) alphaprovided by HGNC
Primary source: HGNC:678
See related: Ensembl:ENSG00000141522; HPRD:03565; MIM:601925
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GDIA1; RHOGDI; RHOGDI-1; MGC117248
Summary: Aplysia Ras-related homologs (ARHs), also called Rho genes, belong to the RAS gene superfamily encoding small guanine nucleotide exchange (GTP/GDP) factors. The ARH proteins may be kept in the inactive, GDP-bound state by interaction with GDP dissociation inhibitors, such as ARHGDIA (Leffers et al., 1993 [PubMed 8262133]).[supplied by OMIM, Jan 2009]

Help top of page

Genomic context

Location :: 17q25.3

Sequence :: Chromosome: 17; NC_000017.10 (79825597..79829282, complement)

See ARHGDIA in Epigenomics, MapViewer

Chromosome 17 - NC_000017.10 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Rho GDI may be useful as a diagnostic biomarker and/or a therapeutic to prevent colon and prostate cancer metastasis
Title: Rho GDP-dissociation inhibitor alpha is associated with cancer metastasis in colon and prostate cancer.
Loss of GDIalpha expression promotes the development and progression of prostate cancer.
Title: RhoGDIα suppresses growth and survival of prostate cancer cells.
Both the mRNA and protein expressions of Rho-GDI in the decidual tissues were significantly higher in the normal pregnancy group than in the two severe preeclampsia groups.
Title: [Expression of Rho-GDP dissociation inhibitor in the decidual tissues of preeclampsia patients and its clinical implication].
Data show that knockdown of S100P led to downregulation of thioredoxin 1 and beta-tubulin and upregulation of RhoGDIA, all potential therapeutic targets in cancer.
Title: Targeting S100P inhibits colon cancer growth and metastasis by Lentivirus-mediated RNA interference and proteomic analysis.
RhoGDIalpha-dependent balance between RhoA and RhoC is a key regulator of cancer cell tumorigenesis
Title: RhoGDIα-dependent balance between RhoA and RhoC is a key regulator of cancer cell tumorigenesis.
The RhoGDIalpha protein is located in the acrosome and flagellum of human sperm, and might be involved in sperm movement, capacitation and acrosome reaction.
Title: [Expression of RhoGDI alpha in human testes and sperm and its correlation with the success rate of IVF].
We provide evidence that ARHGDIA, COBLL1, and TM4SF1 are negative regulators of apoptosis in cultured tumor cells.
Title: Genes associated with prognosis after surgery for malignant pleural mesothelioma promote tumor cell survival in vitro.
XIAP was found to negatively regulate RhoGDI SUMOylation, which might affect its activity in controlling cell motility
Title: X-linked inhibitor of apoptosis protein (XIAP) mediates cancer cell motility via Rho GDP dissociation inhibitor (RhoGDI)-dependent regulation of the cytoskeleton.
Loss of Rho GDIalpha enhances metastasis and resistance to tamoxifen via effects on both ERalpha and MTA2 in models of ERalpha-positive breast cancer and in tumors of tamoxifen-treated patients.
Title: Loss of Rho GDIα and resistance to tamoxifen via effects on estrogen receptor α.
The authors show here that the endocytic pathway followed by Clostridium perfringens Iota and Clostridium botulinum C2 toxins is independent of clathrin but requires the activity of dynamin and is regulated by Rho-GDI.
Title: Endocytosis and toxicity of clostridial binary toxins depend on a clathrin-independent pathway regulated by Rho-GDI.

Submit: New GeneRIF Correction See all (30)

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	In Jurkat cells expressing HIV-1 Tat, decreased expression levels are found for basic cytoskeletal proteins such as actin, beta-tubulin, annexin, cofilin, gelsolin, and Rac/Rho-GDI complex	PubMed
Vpr	vpr	HIV-1 Vpr-expressing Jurkat T cell clones showed a significant upregulation of Rho GDI expression	PubMed

Go to the HIV-1, Human Protein Interaction Database

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
NP_004300.1	NP_002567.3	PAK1	BIND	PubMed	Pak1 interacts with and phosphorylates RhoGDI. This interaction was modeled on a demonstrated interaction between Pak1 from an unspecified species and human RhoGDI.
P52565	O96019	ACTL6A	HPRD	PubMed
P52565	P52565	ARHGDIA	HPRD	PubMed
P52565	P60953	CDC42	HPRD	PubMed
P52565	P46527	CDKN1B	HPRD	PubMed
P52565	P39748	FEN1	HPRD	PubMed
P52565	P14923	JUP	HPRD	PubMed
P52565	Q96PU5	NEDD4L	HPRD	PubMed
P52565	P63000	RAC1	HPRD	PubMed
P52565	P15153	RAC2	HPRD	PubMed
P52565	P35241	RDX	HPRD	PubMed
P52565	P61586	RHOA	HPRD	PubMed
P52565	Q99963	SH3GL3	HPRD	PubMed
P52565	Q11206	ST3GAL4	HPRD	PubMed
P52565	Q6EEV6	SUMO4	HPRD	PubMed
P52565	P15498	VAV1	HPRD	PubMed
BioGRID:106889	BioGRID:106601	ACTL6A	BioGRID	PubMed	Two-hybrid
BioGRID:106889	BioGRID:106889	ARHGDIA	BioGRID	PubMed	Reconstituted Complex
BioGRID:106889	BioGRID:107054	BAK1	BioGRID	PubMed	Two-hybrid
BioGRID:106889	BioGRID:107106	BID	BioGRID	PubMed	Co-purification
BioGRID:106889	BioGRID:107293	CASP10	BioGRID	PubMed	Co-purification
BioGRID:106889	BioGRID:107291	CASP8	BioGRID	PubMed	Co-purification
BioGRID:106889	BioGRID:117030	CBX5	BioGRID	PubMed	Two-hybrid
BioGRID:106889	BioGRID:107433	CDC42	BioGRID	PubMed	Affinity Capture-MS; Co-purification; Two-hybrid
BioGRID:106889	BioGRID:107461	CDKN1B	BioGRID	PubMed	Two-hybrid
BioGRID:106889	BioGRID:108025	DHX9	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106889	BioGRID:108286	EIF2B1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106889	BioGRID:108403	ESR1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106889	BioGRID:108431	EWSR1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106889	BioGRID:113271	EZR	BioGRID	PubMed	Co-purification
BioGRID:106889	BioGRID:114302	FADD	BioGRID	PubMed	Co-purification
BioGRID:106889	BioGRID:106851	FAS	BioGRID	PubMed	Co-purification
BioGRID:106889	BioGRID:106852	FASLG	BioGRID	PubMed	Co-purification
BioGRID:106889	BioGRID:108528	FEN1	BioGRID	PubMed	Two-hybrid
BioGRID:106889	BioGRID:117047	HAAO	BioGRID	PubMed	Two-hybrid
BioGRID:106889	BioGRID:115060	HERPUD1	BioGRID	PubMed	Two-hybrid
BioGRID:106889	BioGRID:128670	HNRNPA3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106889	BioGRID:109423	HNRNPAB	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106889	BioGRID:115886	IGF2BP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106889	BioGRID:109931	JUP	BioGRID	PubMed	Two-hybrid
BioGRID:106889	BioGRID:111583	MAPK6	BioGRID	PubMed	Two-hybrid
BioGRID:106889	BioGRID:111585	MAPK8	BioGRID	PubMed	Co-purification
BioGRID:106889	BioGRID:110584	MSN	BioGRID	PubMed	Co-purification
BioGRID:106889	BioGRID:116915	NEDD4L	BioGRID	PubMed	Two-hybrid
BioGRID:106889	BioGRID:111817	RAC1	BioGRID	PubMed	Affinity Capture-MS; Co-crystal Structure; Co-purification; Reconstituted Complex; Two-hybrid
BioGRID:106889	BioGRID:111818	RAC2	BioGRID	PubMed	Co-purification; Two-hybrid
BioGRID:106889	BioGRID:111819	RAC3	BioGRID	PubMed	Two-hybrid
BioGRID:106889	BioGRID:111894	RDX	BioGRID	PubMed	Reconstituted Complex
BioGRID:106889	BioGRID:106880	RHOA	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-purification; Two-hybrid
BioGRID:106889	BioGRID:106882	RHOC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106889	BioGRID:106884	RHOG	BioGRID	PubMed	Two-hybrid
BioGRID:106889	BioGRID:106892	RHOH	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:106889	BioGRID:112292	SDHC	BioGRID	PubMed	Two-hybrid
BioGRID:106889	BioGRID:112354	SH3GL3	BioGRID	PubMed	Two-hybrid
BioGRID:106889	BioGRID:113188	SUMO1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106889	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106889	BioGRID:132223	SUMO4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106889	BioGRID:114323	TNFRSF10B	BioGRID	PubMed	Co-purification
BioGRID:106889	BioGRID:112986	TNFRSF1A	BioGRID	PubMed	Co-purification
BioGRID:106889	BioGRID:115501	TRIM13	BioGRID	PubMed	Two-hybrid
BioGRID:106889	BioGRID:116472	TWF2	BioGRID	PubMed	Two-hybrid
BioGRID:106889	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:106889	BioGRID:114672	UBE2L6	BioGRID	PubMed	Two-hybrid
BioGRID:106889	BioGRID:120266	UBE2R2	BioGRID	PubMed	Two-hybrid
BioGRID:106889	BioGRID:119616	UFM1	BioGRID	PubMed	Two-hybrid
BioGRID:106889	BioGRID:106828	XIAP	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
GTPase activator activity	IEA Inferred from Electronic Annotation more info
Rho GDP-dissociation inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
Rho protein signal transduction	IEA Inferred from Electronic Annotation more info
anti-apoptosis	TAS Traceable Author Statement more info	PubMed
cellular component movement	TAS Traceable Author Statement more info	PubMed
negative regulation of axonogenesis	TAS Traceable Author Statement more info
negative regulation of cell adhesion	TAS Traceable Author Statement more info	PubMed
nerve growth factor receptor signaling pathway	TAS Traceable Author Statement more info
positive regulation of axonogenesis	TAS Traceable Author Statement more info
regulation of axonogenesis	TAS Traceable Author Statement more info
regulation of catalytic activity	IEA Inferred from Electronic Annotation more info
regulation of protein localization	IEA Inferred from Electronic Annotation more info
regulation of small GTPase mediated signal transduction	TAS Traceable Author Statement more info
small GTPase mediated signal transduction	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoskeleton	TAS Traceable Author Statement more info	PubMed
cytosol	TAS Traceable Author Statement more info
immunological synapse	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: rho GDP-dissociation inhibitor 1

Names: rho GDP-dissociation inhibitor 1; rho GDI 1; rho-GDI alpha

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001185077.1 → NP_001172006.1 rho GDP-dissociation inhibitor 1 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.

Source sequence(s)

BC005851, BM552638

Consensus CDS

CCDS11788.1

UniProtKB/Swiss-Prot

P52565

Related

ENSP00000441348, ENST00000541078

Conserved Domains (1) summary

pfam02115
Location:1 – 201
Blast Score: 894

Rho_GDI; RHO protein GDP dissociation inhibitor
NM_001185078.1 → NP_001172007.1 rho GDP-dissociation inhibitor 1 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AK300816, BC005851, DC406556

UniProtKB/TrEMBL

B4DUV9

UniProtKB/Swiss-Prot

P52565

Conserved Domains (1) summary

pfam02115
Location:1 – 157
Blast Score: 608

Rho_GDI; RHO protein GDP dissociation inhibitor
NM_004309.4 → NP_004300.1 rho GDP-dissociation inhibitor 1 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.

Source sequence(s)

BC005851, DC406556

Consensus CDS

CCDS11788.1

UniProtKB/Swiss-Prot

P52565

Related

ENSP00000269321, ENST00000269321

Conserved Domains (1) summary

pfam02115
Location:1 – 201
Blast Score: 894

Rho_GDI; RHO protein GDP dissociation inhibitor

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000017.10 Reference GRCh37.p5 Primary Assembly

Range

79825597..79829282, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000149.1 Alternate HuRef

Range

75227385..75230633, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC137723.6 (39702..43343)	None
genomic	AC145207.2 (115617..119258)	None
genomic	CH471099.1	EAW89697.1
		EAW89698.1
genomic	X63863.1	CAA45344.1
mRNA	AF498926.1	AAM21074.1
mRNA	AK293147.1	BAG56694.1
mRNA	AK300816.1	BAG62471.1
mRNA	AK312347.1	BAG35268.1
mRNA	BC005851.2	AAH05851.1
mRNA	BC005875.2	AAH05875.1
mRNA	BC007630.1	None
mRNA	BC008701.3	AAH08701.1
mRNA	BC009759.2	AAH09759.1
mRNA	BC013846.1	None
mRNA	BC016031.1	AAH16031.1
mRNA	BC016185.1	AAH16185.1
mRNA	BC024258.1	AAH24258.1
mRNA	BC027730.2	AAH27730.1
mRNA	BC028333.1	None
mRNA	BC075827.1	AAH75827.1
mRNA	BC106044.1	AAI06045.1
mRNA	BM552638.1	None
mRNA	BT006884.1	AAP35530.1
mRNA	CR456777.1	CAG33058.1
mRNA	D13989.1	BAA03096.1
mRNA	DC406556.1	None
mRNA	M97579.1	AAA36566.1
mRNA	X69550.1	CAA49281.1
other-genetic	DQ891117.2	ABM82043.1
other-genetic	DQ894296.2	ABM85222.1