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ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha [ Homo sapiens (human) ]

Gene ID: 396, updated on 27-Apr-2015
Official Symbol
ARHGDIAprovided by HGNC
Official Full Name
Rho GDP dissociation inhibitor (GDI) alphaprovided by HGNC
Primary source
HGNC:HGNC:678
See related
Ensembl:ENSG00000141522; HPRD:03565; MIM:601925; Vega:OTTHUMG00000178352
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GDIA1; NPHS8; RHOGDI; RHOGDI-1; HEL-S-47e
Summary
This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Orthologs
See ARHGDIA in MapViewer
Location:
17q25.3
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (81867719..81871406, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79825595..79829282, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 27 Neighboring gene prolyl 4-hydroxylase, beta polypeptide Neighboring gene Aly/REF export factor Neighboring gene anaphase promoting complex subunit 11 Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene neuropeptide B

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat In Jurkat cells expressing HIV-1 Tat, decreased expression levels are found for basic cytoskeletal proteins such as actin, beta-tubulin, annexin, cofilin, gelsolin, and Rac/Rho-GDI complex PubMed
Vpr vpr HIV-1 Vpr-expressing Jurkat T cell clones showed a significant upregulation of Rho GDI expression PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC117248

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
Rho GDP-dissociation inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
movement of cell or subcellular component TAS
Traceable Author Statement
more info
PubMed 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of axonogenesis TAS
Traceable Author Statement
more info
 
negative regulation of cell adhesion TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
neurotrophin TRK receptor signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of axonogenesis TAS
Traceable Author Statement
more info
 
regulation of axonogenesis TAS
Traceable Author Statement
more info
 
regulation of protein localization IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
semaphorin-plexin signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
immunological synapse IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
rho GDP-dissociation inhibitor 1
Names
rho GDP-dissociation inhibitor 1
GDP-dissociation inhibitor, aplysia RAS-related 1
epididymis secretory sperm binding protein Li 47e

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034210.1 RefSeqGene

    Range
    5001..8688
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001185077.2NP_001172006.1  rho GDP-dissociation inhibitor 1 isoform a

    See identical proteins and their annotated locations for NP_001172006.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform (a). Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AI391750, AI751683, BC005851, BM552638, CF132324
    Consensus CDS
    CCDS11788.1
    UniProtKB/Swiss-Prot
    P52565
    UniProtKB/TrEMBL
    V9HWE8
    Conserved Domains (1) summary
    pfam02115
    Location:1201
    Rho_GDI; RHO protein GDP dissociation inhibitor
  2. NM_001185078.2NP_001172007.1  rho GDP-dissociation inhibitor 1 isoform b

    See identical proteins and their annotated locations for NP_001172007.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AI391750, AI751683, AK300816, BC005851, DC406556
    Consensus CDS
    CCDS58609.1
    UniProtKB/Swiss-Prot
    P52565
    Related
    ENSP00000383556, OTTHUMP00000259328, ENST00000400721, OTTHUMT00000441680
    Conserved Domains (1) summary
    pfam02115
    Location:1157
    Rho_GDI; RHO protein GDP dissociation inhibitor
  3. NM_001301240.1NP_001288169.1  rho GDP-dissociation inhibitor 1 isoform c

    See identical proteins and their annotated locations for NP_001288169.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (c) is longer than isoform a. Variants 4 and 5 encode the same isoform (c).
    Source sequence(s)
    AI391750, AI751683, BC005851, BF343803, BI768191, BQ674863, DC406556
    UniProtKB/TrEMBL
    J3QQX2
    UniProtKB/Swiss-Prot
    P52565
    Conserved Domains (1) summary
    pfam02115
    Location:1171
    Rho_GDI; RHO protein GDP dissociation inhibitor
  4. NM_001301241.1NP_001288170.1  rho GDP-dissociation inhibitor 1 isoform c

    See identical proteins and their annotated locations for NP_001288170.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (c) is longer than isoform a. Variants 4 and 5 encode the same isoform (c).
    Source sequence(s)
    AI391750, AI751683, BC005851, BI755343, CF132324
    UniProtKB/TrEMBL
    J3QQX2
    UniProtKB/Swiss-Prot
    P52565
    Conserved Domains (1) summary
    pfam02115
    Location:1171
    Rho_GDI; RHO protein GDP dissociation inhibitor
  5. NM_001301242.1NP_001288171.1  rho GDP-dissociation inhibitor 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and lacks an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (d) is longer than isoform a.
    Source sequence(s)
    AI391750, AI751683, BC005851, BP325393, DC406556
    UniProtKB/Swiss-Prot
    P52565
    Conserved Domains (1) summary
    pfam02115
    Location:1145
    Rho_GDI; RHO protein GDP dissociation inhibitor
  6. NM_001301243.1NP_001288172.1  rho GDP-dissociation inhibitor 1 isoform e

    See identical proteins and their annotated locations for NP_001288172.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and contains an alternate segment in the central coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (e) is longer than isoform a.
    Source sequence(s)
    AI391750, AI751683, BC005851, CF132249, DC406556
    UniProtKB/Swiss-Prot
    P52565
    Conserved Domains (1) summary
    pfam02115
    Location:1246
    Rho_GDI; RHO protein GDP dissociation inhibitor
  7. NM_004309.5NP_004300.1  rho GDP-dissociation inhibitor 1 isoform a

    See identical proteins and their annotated locations for NP_004300.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AI391750, AI751683, BC005851, DC406556
    Consensus CDS
    CCDS11788.1
    UniProtKB/Swiss-Prot
    P52565
    UniProtKB/TrEMBL
    V9HWE8
    Related
    ENSP00000269321, OTTHUMP00000259327, ENST00000269321, OTTHUMT00000441679
    Conserved Domains (1) summary
    pfam02115
    Location:1201
    Rho_GDI; RHO protein GDP dissociation inhibitor

RNA

  1. NR_125441.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' terminal exon and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI391750, AI751683, BC005851, DA433004, DC406556

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    81867719..81871406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523574.1XP_011521876.1  

    See identical proteins and their annotated locations for XP_011521876.1

    Conserved Domains (1) summary
    pfam02115
    Location:1246
    Rho_GDI; RHO protein GDP dissociation inhibitor

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    79911831..79915499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)