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CD27 CD27 molecule [ Homo sapiens (human) ]

Gene ID: 939, updated on 3-Jan-2016
Official Symbol
CD27provided by HGNC
Official Full Name
CD27 moleculeprovided by HGNC
Primary source
HGNC:HGNC:11922
See related
Ensembl:ENSG00000139193; HPRD:01723; MIM:186711; Vega:OTTHUMG00000168316
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
T14; S152; Tp55; TNFRSF7; S152. LPFS2
Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]
Orthologs
See CD27 in Epigenomics, MapViewer
Location:
12p13
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (6444885..6451718)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6554051..6560884)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31 pseudogene 10 Neighboring gene CD27 antisense RNA 1 Neighboring gene signal recognition particle 14kDa (homologous Alu RNA binding protein) pseudogene 1 Neighboring gene TAP binding protein-like Neighboring gene vesicle associated membrane protein 1 Neighboring gene plakophilin 2 pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of CD27molecule (TNFRSF7: tumor necrosis factor receptor superfamily, member 7) in human B cells PubMed
env HIV-1 gp120 induces CD4 association with lymphocyte surface molecules CD3, CD11a, CD27, CD45RA, CD45RB, CD45RO, CD49d, CD38, CD26, CD59, CD95 and class I MHC molecules PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp140 upregulates the expression of the B cell activation marker CD38 and the memory B cell marker CD27 PubMed
Nef nef Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD27 (TNFRSF7) PubMed
Tat tat HIV-1 Tat upregulates the expression of CD27 in stimulated CD8? T lymphocytes PubMed
Vpu vpu Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD27 (TNFRSF7) PubMed

Go to the HIV-1, Human Interaction Database

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • TNFR2 non-canonical NF-kB pathway, organism-specific biosystem (from REACTOME)
    TNFR2 non-canonical NF-kB pathway, organism-specific biosystemTumor necrosis factor-alpha (TNFA) exerts a wide range of biological effects through TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2). Under normal physiological conditions TNFR2 exhibits more restr...
  • TNFs bind their physiological receptors, organism-specific biosystem (from REACTOME)
    TNFs bind their physiological receptors, organism-specific biosystemMembers of the tumour necrosis factor superfamily (TNFSF) and TNF receptor superfamily (TNFRSF) have crucial roles in both innate and adaptive immunity. These members are implicated in various acquir...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC20393

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane signaling receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
tumor necrosis factor-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
brain development IBA
Inferred from Biological aspect of Ancestor
more info
 
cell surface receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic apoptotic signaling pathway via death domain receptors IBA
Inferred from Biological aspect of Ancestor
more info
 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
immunoglobulin mediated immune response NAS
Non-traceable Author Statement
more info
PubMed 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of T cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of B cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
release of cytoplasmic sequestered NF-kappaB NAS
Non-traceable Author Statement
more info
PubMed 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
 
tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
CD27 antigen
Names
CD27L receptor
T cell activation antigen S152
T-cell activation antigen CD27
tumor necrosis factor receptor superfamily, member 7

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031995.1 RefSeqGene

    Range
    5001..11834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_357

mRNA and Protein(s)

  1. NM_001242.4NP_001233.1  CD27 antigen precursor

    See identical proteins and their annotated locations for NP_001233.1

    Status: REVIEWED

    Source sequence(s)
    AC005840, BC012160, BI225100
    Consensus CDS
    CCDS8545.1
    UniProtKB/Swiss-Prot
    P26842
    Related
    ENSP00000266557, OTTHUMP00000238557, ENST00000266557, OTTHUMT00000399258
    Conserved Domains (1) summary
    cd13408
    Location:4124
    TNFRSF7; Tumor necrosis factor receptor superfamily member 7 (TNFRSF7), also known as CD27

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    6444885..6451718
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521042.1XP_011519344.1  

    Conserved Domains (2) summary
    cd00185
    Location:3458
    TNFRSF; CRD2 [structural motif]
    cl22855
    Location:3478
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    6552929..6559762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)