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    IL10 interleukin 10 [ Homo sapiens (human) ]

    Gene ID: 3586, updated on 19-May-2013
    Official Symbol
    IL10provided by HGNC
    Official Full Name
    interleukin 10provided by HGNC
    Primary source
    HGNC:5962
    Locus tag
    RP11-262N9.1
    See related
    Ensembl:ENSG00000136634; HPRD:00495; MIM:124092; Vega:OTTHUMG00000036386
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CSIF; TGIF; GVHDS; IL-10; IL10A
    Summary
    The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]
    Location :
    1q31-q32
    Sequence :
    Chromosome: 1; NC_000001.10 (206940948..206945839, complement)
    See IL10 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 Neighboring gene mitogen-activated protein kinase-activated protein kinase 2 Neighboring gene ribosomal protein S14 pseudogene 1 Neighboring gene interleukin 19 Neighboring gene interleukin 20

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Pitfalls in determining the cytokine profile of human T cells. Olsen I, et al. J Immunol Methods, 2013 Apr 30. PMID 23416458.
    2. Interleukin-10 controls the protective effects of circulating microparticles from patients with septic shock on tissue-engineered vascular media. Mostefai HA, et al. Clin Sci (Lond), 2013 Jul 1. PMID 23379624.
    3. Cutting edge: An inactive chromatin configuration at the IL-10 locus in human neutrophils. Tamassia N, et al. J Immunol, 2013 Mar 1. PMID 23355741.
    4. Pathogen-triggered activation of plasmacytoid dendritic cells induces IL-10-producing B cells in response to Staphylococcus aureus. Parcina M, et al. J Immunol, 2013 Feb 15. PMID 23325892.
    5. Conditioned medium from adipose tissue-derived mesenchymal stem cells induces CD4+FOXP3+ cells and increases IL-10 secretion. Ivanova-Todorova E, et al. J Biomed Biotechnol, 2012. PMID 23251077.

    See all (1955) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. this meta-analysis suggested that IL-10 promoter polymorphisms were associated with asthma risk
      Title: Interleukin-10 promoter polymorphisms and asthma risk: a meta-analysis.
    2. Interleukin-6 and interleukin-10 may have a different role in the pathogenesis of abdominal aortic aneurysm.
      Title: Inverse production of IL-6 and IL-10 by abdominal aortic aneurysm explant tissues in culture.
    3. Data indicate that the dose response curve for phorbol 12-myristate 13-acetate (PMA)/Ionomycin differed for IL-10 compared to IL-17 and IFN-gamma production by T4 cells.
      Title: Pitfalls in determining the cytokine profile of human T cells.
    4. increased by microparticles from patients with sepsis
      Title: Interleukin-10 controls the protective effects of circulating microparticles from patients with septic shock on tissue-engineered vascular media.
    5. The STAT1 pathway might be involved in the regulation of IL-10 expression in HepG2.2.15 cells.
      Title: Interleukin-10 is expressed in HepG2.2.15 cells and regulated by STAT1 pathway.
    6. In contrast to colonization with S. aureus alone, co-colonization with lactobacilli associated with suppression of IL-4- (p = 0.004), IL-10- (p = 0.004) and IFN-gamma (p = 0.034) secreting cells.
      Title: Early-life gut bacteria associate with IL-4-, IL-10- and IFN-γ production at two years of age.
    7. we suggest that IL-10 induced by E6 promotes cell growth and migration capability and consequent poor survival and relapse in HPV-positive oral squamous cell carcinomas
      Title: Differential impact of IL-10 expression on survival and relapse between HPV16-positive and -negative oral squamous cell carcinomas.
    8. Recombinant A. actinomycetemcomitans GroEL protein affects CD4+ T cells to differentiate into IFNgamma IL10-secreting T-bet+ T helper1 cells.
      Title: Aggregatibacter actinomycetemcomitans GroEL protein promotes conversion of human CD4+ T cells into IFNγ IL10 producing Tbet+ Th1 cells.
    9. haplotype in IL-10 promoter was involved in the development of cancer.
      Title: The IL-10 promoter haplotype and cancer risk: evidence from a meta-analysis.
    10. IL-10-592-CC, IL-28-rs8099917-TT and IL-28-rs12979860-CC genotypes were significantly higher in responders than in non-responders
      Title: Polymorphisms in interleukin-10 and interleukin-28B genes in Egyptian patients with chronic hepatitis C virus genotype 4 and their effect on the response to pegylated interferon/ribavirin-therapy.
    Submit: New GeneRIF Correction See all (1191)

    Review eQTL and phenotype association data in this region using PheGenI

    NHGRI GWAS Catalog

    show more
    Protein Gene Interaction Pubs
    Env, gp160, envelope glycoprotein env HIV-infected cells are responsible for higher IL-10 secretion after activation, which serves as one of the reasons for suppressed CD8 responses to HIV-1 Pol and Env PubMed
    env Chimeric HIV-1 gp140 - CD40L trimers can target and activate dendritic cells to release IL-6, IL-10 and IL-12 PubMed
    Envelope surface glycoprotein gp120 env HIV-1 gp120 induces IL-10 expression in monocyte-derived dendritic cells via a mannose C-type lectin receptor and ERK signaling pathway PubMed
    env Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta PubMed
    env HIV-1 gp120 cooperates with BAFF and cytokines IL-4 and IL-10 to activate mannose C-type lectin receptors-expressing B cells PubMed
    env HIV-1 gp120-induced reduction of IL-12 parallels IL-10 induction and inhibits translocation of CD40 to the surface of monocytes PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 induces IL-10 expression in human monocytes and gp41-induced IL-10 expression leads to reduced IL-2 and interferon-gamma production PubMed
    env IL-10 inhibits gp41-induced IL-6 production and reduces the expression of IL-6 mRNA PubMed
    env Secretion of IL-10 is upregulated by HIV-1 gp41 in monocytes through activation of cAMP/adenylate cyclase and p70 (S6)-kinase; up-regulation of IL-10 is paralleled by an enhanced expression of the chemokine receptor CCR5 PubMed
    Gag, Pr55 gag HIV-1 Gag virus-like particles expressed by recombinant baculoviruses activate human PBMC to release IL-10 in a dose and time dependent manner PubMed
    gag Immunosuppressive peptides corresponding to amino acids 218-238 of the Capsid protein of HIV-1 Gag upregulate prostaglandin E2 production and induce IL-10 secretion PubMed
    Nef, p27 nef HIV-1 Nef inhibits IFN-gamma-induced apoptosis and upregulates TNF-alpha, IL-6 and MIP-3a production by Caco-2 cells while downregulating IL-10 production PubMed
    nef HIV-1 Nef significantly upregulates IL-10 protein and mRNA expression in monocytes but not in T or B lymphocytes; by contrast, SEA induced IL-10 protein and mRNA expression in T lymphocytes but not in monocytes or B lymphocytes PubMed
    nef Extracellular HIV-1 Nef induces interleukin (IL)-10 mRNA expression in human PBMCs as well as in H9 T and U937 promonocytic human cell lines; release of IL-10 into supernatants from PBMCs stimulated with Nef is dose-dependent PubMed
    nef HIV-1 Nef suppresses immunoglobulin class-switch DNA recombination by inducing IkappaBalpha and SOCS proteins, which block CD154, IL-4 and IL-10 cytokine signaling via NF-kappaB and STAT transcription factors PubMed
    nef Herbimycin A significantly blocks HIV-1 Nef-induced production of IL-10 at both the protein and the mRNA level, demonstrating the involvement of a herbimycin A-sensitive Protein tyrosine kinase in the signal transduction pathway for exogenous HIV-1 Nef PubMed
    Tat, p14 tat HIV-1 Tat induces production of IL-10 through the activation of PKC beta(II) and delta isozymes in human monocytes and macrophages PubMed
    tat Tat-induced IL-10 expression is regulated by p38 MAPK- and CaMK II-activated CREB-1 as well as Sp-1 transcription factors PubMed
    tat Calmodulin and calmodulin-dependent protein kinase-II (CaMK-II)-activated p38 MAPK play a role in extracellular Tat-induced IL-10 expression in primary human monocytes PubMed
    tat Ets1- and Sp1-binding sites as specific inducible responsive elements are required for HIV-1 Tat-induced IL-10 promoter activation; Ets-1 is essential for the Tat-induced activation of IL-10 PubMed
    tat Tat stimulates NF-kappaB-inducing kinase IKKalpha translocation from the cytoplasm to the nucleus in monocytes, which leads to IKKalpha and CBP/p300 recruitment to the IL-10 promoter and histone H3 phosphorylation (Ser 10) and acetylation (Lys 14) PubMed
    tat Tat activates at least three signaling pathways concurrently, including NF-kappaB, PKC, ERK1/2 and p38 MAP kinases and IKKalpha pathways, to promote production of IL-10 PubMed
    tat Monocytes treated with HIV-1 clade C Tat show significant upregulation of anti-inflammatory cytokines, IL-4 and IL-10, as compared to clade B Tat-treated cultures PubMed
    tat The cysteine to serine mutation at position 31 in HIV-1 clade C Tat results in a marked decrease in IL-10 production in monocytes compared with clade B Tat. p38alpha/p38beta and phosphoinositide 3-kinase are crucial to Tat-induced IL-10 production PubMed
    tat IL10 and STAT3 are required for HIV-1 Tat-mediated inhibition of autophagy in bystander macrophages/monocytic cells PubMed
    tat HIV-1 Tat upregulates expression of IL-10 in peripheral blood monocytes, macrophages, and T-cell lines through a protein kinase C dependent mechanism involving NF-kappa B, ERK1, and ERK2 PubMed
    tat IL-10 inhibits HIV-1 gene expression in an HIV-1 Tat-dependent manner by downregulating cyclin T1 expression through the induction of proteasome-mediated proteolysis in human macrophages PubMed
    Vpr, p15 vpr HIV-1 Vpr modulates expression of interleukin 10 (IL-10), increasing or suppressing IL-10 expression through varying effects on NF-kappa B activity in different cell lines PubMed
    vpr HIV-1 Vpr upregulates the production of interleukin 10 (IL-10) in dendritic cells PubMed
    capsid gag Immunosuppressive peptides corresponding to HIV-1 Capsid amino acids 218-238 upregulate prostaglandin E2 production and induce IL-10 secretion PubMed
    pol gag-pol HIV-infected cells are responsible for higher IL-10 secretion after activation, which serves as one of the reasons for suppressed CD8 responses to HIV-1 Pol and Env PubMed
    gag-pol IL-10 inhibits HIV-1 replication in primary tissue culture-derived macrophages in a dose-dependent manner, decreases HIV-1 reverse transcription upon macrophage infection, and subsequently mediates viral latency in vitro PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    P22301 P01023 A2M    HPRD  PubMed  
    P22301 P22301 IL10    HPRD  PubMed  
    P22301 Q13651 IL10RA    HPRD  PubMed  
    P22301 Q08334 IL10RB    HPRD  PubMed  
    BioGRID:109800 BioGRID:106524 A2M    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109800 BioGRID:109800 IL10    BioGRID  PubMed Co-crystal Structure 
    BioGRID:109800 BioGRID:109801 IL10RA    BioGRID  PubMed Co-crystal Structure; Co-purification; Reconstituted Complex 
    • African trypanosomiasis, organism-specific biosystem (from KEGG)
      African trypanosomiasis, organism-specific biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
    • African trypanosomiasis, conserved biosystem (from KEGG)
      African trypanosomiasis, conserved biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
    • Allograft rejection, organism-specific biosystem (from KEGG)
      Allograft rejection, organism-specific biosystemAllograft rejection is the consequence of the recipient's alloimmune response to nonself antigens expressed by donor tissues. After transplantation of organ allografts, there are two pathways of anti...
    • Allograft rejection, conserved biosystem (from KEGG)
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    • Amoebiasis, organism-specific biosystem (from KEGG)
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    • Amoebiasis, conserved biosystem (from KEGG)
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    • Asthma, organism-specific biosystem (from KEGG)
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    • Asthma, conserved biosystem (from KEGG)
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    • Autoimmune thyroid disease, organism-specific biosystem (from KEGG)
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    • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
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    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
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    • Cytokines and Inflammatory Response, organism-specific biosystem (from WikiPathways)
      Cytokines and Inflammatory Response, organism-specific biosystemInflammation is a protective response to infection by the immune system that requires communication between different classes of immune cells to coordinate their actions. Acute inflammation is an imp...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • IL4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL4-mediated signaling events, organism-specific biosystem
      IL4-mediated signaling events
    • Intestinal immune network for IgA production, organism-specific biosystem (from KEGG)
      Intestinal immune network for IgA production, organism-specific biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
    • Intestinal immune network for IgA production, conserved biosystem (from KEGG)
      Intestinal immune network for IgA production, conserved biosystemThe intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies tha...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Leishmaniasis, organism-specific biosystem (from KEGG)
      Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Leishmaniasis, conserved biosystem (from KEGG)
      Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Malaria, organism-specific biosystem (from KEGG)
      Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
    • Malaria, conserved biosystem (from KEGG)
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    • Pertussis, organism-specific biosystem (from KEGG)
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    • Pertussis, conserved biosystem (from KEGG)
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      Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem
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    • Systemic lupus erythematosus, organism-specific biosystem (from KEGG)
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    • Toxoplasmosis, conserved biosystem (from KEGG)
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    • Tuberculosis, organism-specific biosystem (from KEGG)
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    Markers

    Genotypes

    Homology

    Clone Names

    • MGC126450, MGC126451

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    growth factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    interleukin-10 receptor binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    B cell differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    B cell proliferation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    branching involved in labyrinthine layer morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell-cell signaling IC
    Inferred by Curator
    more info
    		 PubMed 
    cellular response to estradiol stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to lipopolysaccharide NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    cytoplasmic sequestering of NF-kappaB NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    hemopoiesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    inflammatory response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    leukocyte chemotaxis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of B cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of MHC class II biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    negative regulation of T cell proliferation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    negative regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    negative regulation of chronic inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of cytokine secretion involved in immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of growth of symbiont in host IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of interferon-alpha biosynthetic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    negative regulation of interferon-gamma production IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of interleukin-12 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of membrane protein ectodomain proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of myeloid dendritic cell activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of tumor necrosis factor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of tumor necrosis factor production IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of B cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of MHC class II biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of cytokine secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    receptor biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of isotype switching NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    regulation of sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to carbon monoxide IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to drug IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to glucocorticoid stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to inactivity IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to molecule of bacterial origin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    type 2 immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Preferred Names
    interleukin-10
    Names
    interleukin-10
    T-cell growth inhibitory factor
    cytokine synthesis inhibitory factor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012088.1 RefSeqGene

      Range
      5001..9892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000572.2 → NP_000563.1  interleukin-10 precursor

      Status: REVIEWED

      Source sequence(s)
      BC022315, M57627
      Consensus CDS
      CCDS1467.1
      UniProtKB/Swiss-Prot
      P22301
      UniProtKB/TrEMBL
      Q6FGW4
      Related
      ENSP00000412237, OTTHUMP00000034567, ENST00000423557, OTTHUMT00000088564
      Conserved Domains (1) summary
      smart00188
      Location:37 – 173
      Blast Score: 563
      IL10; Interleukin-10 family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p10 Primary Assembly

      Range
      206940948..206945839, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      177639274..177644165, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018912.1 Alternate CHM1_1.0

      Range
      213745828..213750719, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01010192.1 (105211..110102) None
    genomic AF295024.1 AAK19173.1
    genomic AF418271.1 AAL06594.1
    genomic AL513315.15 (2079..6970) None
    genomic AMYH01001678.1 (81952..86843) None
    genomic CH471100.2 EAW93524.1
    genomic DQ217938.1 ABB01008.1
    genomic GQ405199.1 ACV30066.1
    genomic U16720.1 AAA80104.1
    genomic X78437.2 CAA55201.2
    mRNA AF043333.1 AAC03534.1
    mRNA AY029171.1 AAK38162.1
    mRNA BC022315.1 None
    mRNA BC104252.1 AAI04253.1
    mRNA BC104253.1 AAI04254.1
    mRNA CR541993.1 CAG46790.1
    mRNA CR542028.1 CAG46825.1
    mRNA M57627.1 AAA63207.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22301.1 GenPept UniProtKB/Swiss-Prot:P22301

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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      Supplemental Content

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      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • Books
        Links between Entrez Gene and 'Books' are established if a GeneID is explicitly referenced in a book.
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • ClinVar
        Related medical variations
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • GAP
        GAP Links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • MedGen
        Related information in MedGen
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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