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    FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) [ Homo sapiens ]

    Gene ID: 2214, updated on 19-May-2012
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    Summary

    Official Symbol
    FCGR3Aprovided by HGNC
    Official Full Name
    Fc fragment of IgG, low affinity IIIa, receptor (CD16a)provided by HGNC
    Primary source
    HGNC:3619
    Locus tag
    RP11-5K23.1
    See related
    Ensembl:ENSG00000203747; HPRD:00903; MIM:146740; Vega:OTTHUMG00000034466
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD16; FCG3; CD16A; FCGR3; IGFR3; FCR-10; FCRIII; FCGRIII; FCRIIIA
    Summary
    This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    1q23
    Sequence :
    Chromosome: 1; NC_000001.10 (161511549..161520413, complement)
    See FCGR3A in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene heat shock 70kDa protein 6 (HSP70B') Neighboring gene ribosomal protein S23 pseudogene Neighboring gene Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) Neighboring gene heat shock 70kDa protein 7 (HSP70B)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Aberrant expression of FcγRIIIA (CD16) contributes to the development of atherosclerosis. Huang Y, et al. Gene, 2012 Apr 25. PMID 22366371.
    2. Antibody-dependent anti-cytomegalovirus activity of human γδ T cells expressing CD16 (FcγRIIIa). Couzi L, et al. Blood, 2012 Feb 9. PMID 22180442.
    3. Genetic polymorphism of Fcγ-receptors IIa, IIIa and IIIb in South Indian patients with generalized aggressive periodontitis. Hans VM, et al. J Oral Sci, 2011 Dec. PMID 22167032.
    4. Differential inhibition of trastuzumab- and cetuximab-induced cytotoxicity of cancer cells by immunoglobulin G1 expressing different GM allotypes. Namboodiri AM, et al. Clin Exp Immunol, 2011 Dec. PMID 22059994.
    5. Polymorphism of the FcγRIIIa gene and post-treatment apical periodontitis. Siqueira JF Jr, et al. J Endod, 2011 Oct. PMID 21924179.

    See all (249) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. V/V genotype and/or V allele may be risk factors for generalized aggressive periodontitis in the population of South India
      Title: Genetic polymorphism of Fcγ-receptors IIa, IIIa and IIIb in South Indian patients with generalized aggressive periodontitis.
    2. FcgammaRIIIA (CD16)-mediated signaling orchestrated by interaction between monocytes and HUVECs, coupled with inflammatory cytokine stimulation and MMP activation, as a fundamental pathway linked to the development of atherosclerotic formation.
      Title: Aberrant expression of FcγRIIIA (CD16) contributes to the development of atherosclerosis.
    3. Data indicate that that CD16 could stimulate gammadelta T cells independently of T-cell receptor (TCR) engagement and provide them with an intrinsic antibody-dependent cell-mediated cytotoxic (ADCC) potential.
      Title: Antibody-dependent anti-cytomegalovirus activity of human γδ T cells expressing CD16 (FcγRIIIa).
    4. polymorphism does not influence the patient's response to endodontic treatment of teeth with apical periodontitis
      Title: Polymorphism of the FcγRIIIa gene and post-treatment apical periodontitis.
    5. In the presence of both FcgammaRIIIa-VV- and FcgammaRIIIa-FF-expressing NK cells, the inhibitory effect on trastuzumab-mediated ADCC was higher for the IgG1 expressing GM 3+,1-,2- allotypes than that for IgG1 expressing the GM 17 +,1 +,2 + allotypes.
      Title: Differential inhibition of trastuzumab- and cetuximab-induced cytotoxicity of cancer cells by immunoglobulin G1 expressing different GM allotypes.
    6. The interaction of R-CHOP, but not CHOP with FcgammaRIIIa polymorphisms, indicates a window of opportunity for CD20 antibodies designed to mediate enhanced antibody-dependent cellular cytotoxicity.
      Title: The impact of Fc-γ receptor polymorphisms in elderly patients with diffuse large B-cell lymphoma treated with CHOP with or without rituximab.
    7. under stimulation conditions known to induce NK cell proliferation, a subset of alpha-beta T-cell receptor CD16 T cells arises from antigen-experienced CD16 cells and from antigen-experienced CD16 T lymphocytes
      Title: FcγRIIIa (CD16) induction on human T lymphocytes and CD16pos T-lymphocyte amplification.
    8. Data show no statistically significant differences in OS and PFS according to genotypes of FcgammaRIIA and FcgammaRIIIA.
      Title: FcγRIIA and FcγRIIIA polymorphisms do not influence survival and response to rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone immunochemotherapy in patients with diffuse large B-cell lymphoma.
    9. The polymorphism FCGR3A V(176) is not associated with SLE or any of its manifestations in patients with SLE from the West of Mexico.
      Title: FCGR3A V(176) polymorphism for systemic lupus erythematosus susceptibility in Mexican population.
    10. we demonstrated that CD16 is necessary for human papillomavirus virus-like particles internalization by NK cells, as well as for degranulation and cytokine production.
      Title: Human papillomavirus entry into NK cells requires CD16 expression and triggers cytotoxic activity and cytokine secretion.
    Submit: New GeneRIF Correction See all (133)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Lupus erythematosus, systemic, susceptibility

    Neutropenia, alloimmune neonatal

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat inhibits the rise in intracellular free calcium concentration in Natural Killer (NK) cells upon cross-linking of the adhesion molecule CD11a and the activation molecule CD16, indicating Tat is involved in the impairment of NK cell function PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P08637 P02743 APCS    HPRD  PubMed  
    P08637 P20963 CD247    HPRD  PubMed  
    P08637 P28907 CD38    HPRD  PubMed  
    P08637 P01730 CD4    HPRD  PubMed  
    P08637 P30273 FCER1G    HPRD  PubMed  
    P08637 P12314 FCGR1A    HPRD  PubMed  
    P08637 Q9HCN6 GP6    HPRD  PubMed  
    P08637 P01857 IGHG1    HPRD  PubMed  
    P08637 P06239 LCK    HPRD  PubMed  
    P08637 P08575 PTPRC    HPRD  PubMed  
    P08637 P29353 SHC1    HPRD  PubMed  
    P08637 P43403 ZAP70    HPRD  PubMed  
    BioGRID:108508 BioGRID:106822 APCS    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108508 BioGRID:107390 CD38    BioGRID  PubMed FRET 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
    • Leishmaniasis, organism-specific biosystem (from KEGG)
      Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Leishmaniasis, conserved biosystem (from KEGG)
      Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
    • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Staphylococcus aureus infection, organism-specific biosystem (from KEGG)
      Staphylococcus aureus infection, organism-specific biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Staphylococcus aureus infection, conserved biosystem (from KEGG)
      Staphylococcus aureus infection, conserved biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
    • Systemic lupus erythematosus, organism-specific biosystem (from KEGG)
      Systemic lupus erythematosus, organism-specific biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
    • Systemic lupus erythematosus, conserved biosystem (from KEGG)
      Systemic lupus erythematosus, conserved biosystemSystemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and cert...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    IgG binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of immune response TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    low affinity immunoglobulin gamma Fc region receptor III-A
    Names
    low affinity immunoglobulin gamma Fc region receptor III-A
    FcgammaRIIIA
    CD16a antigen
    fc-gamma RIII
    Fc-gamma RIIIa
    Fc-gamma RIII-alpha
    igG Fc receptor III-2
    Fc gamma receptor III-A
    Fc-gamma receptor IIIb (CD16)
    neutrophil-specific antigen NA
    Fc-gamma receptor III-2 (CD 16)
    immunoglobulin G Fc receptor III
    Fc fragment of IgG, low affinity III, receptor for (CD16)
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009066.1 RefSeqGene

      Range
      5001..13865
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_60

    mRNA and Protein(s)

    1. NM_000569.6 → NP_000560.5  low affinity immunoglobulin gamma Fc region receptor III-A isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      BC017865, BC033678, BC036723, X52645
      Consensus CDS
      CCDS1232.1
      UniProtKB/Swiss-Prot
      P08637
      Related
      ENSP00000356946, OTTHUMP00000032374, ENST00000367969, OTTHUMT00000083313
      Conserved Domains (2) summary
      cd05752
      Location:62 – 140
      Blast Score: 296
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:144 – 226
      Blast Score: 362
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

    2. NM_001127592.1 → NP_001121064.1  low affinity immunoglobulin gamma Fc region receptor III-A isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a.
      Source sequence(s)
      BC036723, BI768140, DA944383, M24853
      Consensus CDS
      CCDS44265.1
      UniProtKB/TrEMBL
      E9PG94
      UniProtKB/Swiss-Prot
      P08637
      Related
      ENSP00000392047, ENST00000443193
      Conserved Domains (2) summary
      cd05752
      Location:61 – 139
      Blast Score: 296
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:143 – 225
      Blast Score: 361
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

    3. NM_001127593.1 → NP_001121065.1  low affinity immunoglobulin gamma Fc region receptor III-A isoform c precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (c) is shorter at the N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform.
      Source sequence(s)
      AL590385, BC036723, DA957430, M24853
      Consensus CDS
      CCDS44266.1
      UniProtKB/Swiss-Prot
      P08637
      Related
      ENSP00000416607, ENST00000436743
      Conserved Domains (2) summary
      cd05752
      Location:26 – 104
      Blast Score: 292
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:108 – 190
      Blast Score: 356
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

    4. NM_001127595.1 → NP_001121067.1  low affinity immunoglobulin gamma Fc region receptor III-A isoform c precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (c) is shorter at the N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform.
      Source sequence(s)
      AL590385, BC036723, DA933259, DA957430, M24853
      Consensus CDS
      CCDS44266.1
      UniProtKB/Swiss-Prot
      P08637
      Related
      ENSP00000356944, OTTHUMP00000040694, ENST00000367967, OTTHUMT00000102169
      Conserved Domains (2) summary
      cd05752
      Location:26 – 104
      Blast Score: 292
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:108 – 190
      Blast Score: 356
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

    5. NM_001127596.1 → NP_001121068.1  low affinity immunoglobulin gamma Fc region receptor III-A isoform d precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks an in-frame portion of the 5' coding region, and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (d) is shorter at the N-terminus and lacks an internal residue, compared to isoform a.
      Source sequence(s)
      AL590385, BC036723, DA674960, DA957430, M24853
      UniProtKB/Swiss-Prot
      P08637
      Conserved Domains (2) summary
      cd05752
      Location:25 – 103
      Blast Score: 292
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:107 – 189
      Blast Score: 355
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      161511549..161520413, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1

      Range
      132836942..132863694, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    2. NW_001840690.1 

      Range
      5233..7447
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XP_003403761.1 Peptide Sequence

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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AB032414.1 BAA86888.1
    genomic AF162790.1 AAD48438.1
    genomic AL590385.23 CAI16122.1
      CAI16123.2
      CAO03439.1
      CAO03440.1
    genomic HC728087.1 CBL93996.1
    genomic Z46222.1 CAA86295.1
    mRNA AK223268.1 BAD96988.1
    mRNA AK223295.1 BAD97015.1
    mRNA AK302126.1 BAG63503.1
    mRNA BC017865.1 AAH17865.1
    mRNA BC033678.1 AAH33678.1
    mRNA BC036723.1 AAH36723.1
    mRNA BI768140.1 None
    mRNA DA674960.1 None
    mRNA DA933259.1 None
    mRNA DA944383.1 None
    mRNA DA957430.1 None
    mRNA M24853.1 AAA53506.1
    mRNA S62490.1 None
    mRNA S76824.1 AAB33925.2
    mRNA X52645.1 CAA36870.1
    other-genetic HQ447137.1 ADQ31624.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08637.2 GenPept UniProtKB/Swiss-Prot:P08637
    Q9ULV2 GenPept UniProtKB/TrEMBL:Q9ULV2
    Q9UN20 GenPept UniProtKB/TrEMBL:Q9UN20
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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