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    CD46 CD46 molecule, complement regulatory protein [ Homo sapiens ]

    Gene ID: 4179, updated on 13-May-2012

    Summary

    Official Symbol
    CD46provided by HGNC
    Official Full Name
    CD46 molecule, complement regulatory proteinprovided by HGNC
    Primary source
    HGNC:6953
    See related
    Ensembl:ENSG00000117335; HPRD:00406; MIM:120920; Vega:OTTHUMG00000036397
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCP; TLX; AHUS2; MIC10; TRA2.10; MGC26544
    Summary
    The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]

    Genomic context

    Location :
    1q32
    Sequence :
    Chromosome: 1; NC_000001.10 (207925383..207968861)
    See CD46 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene cell division cycle associated 4 pseudogene Neighboring gene complement component (3b/4b) receptor 1-like Neighboring gene complement component (3b/4b) receptor 1 (Knops blood group) pseudogene Neighboring gene cell division cycle associated 4 pseudogene Neighboring gene microRNA 29b-2 Neighboring gene microRNA 29c

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    CAA68675.1 NP_042941.1 U62    BIND  PubMed Glycoprotein H of human herpesvirus 6 interacts with the human cellular receptor CD46. 
    P15529 P01024 C3    HPRD  PubMed  
    P15529 P15529 CD46    HPRD  PubMed  
    P15529 P78352 DLG4    HPRD  PubMed  
    P15529 P05556 ITGB1    HPRD  PubMed  
    P15529 Q15334 LLGL1    HPRD  PubMed  
    P15529 P26038 MSN    HPRD  PubMed  
    P15529 P12931 SRC    HPRD  PubMed  
    P15529 O14817 TSPAN4    HPRD  PubMed  
    P15529 P07947 YES1    HPRD  PubMed  
    P15529 Complement component 4B     HPRD  PubMed  
    BioGRID:110346 BioGRID:107415 CD151    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110346 BioGRID:107413 CD81    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110346 BioGRID:109935 CD82    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110346 BioGRID:107366 CD9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110346 BioGRID:108086 DLG4    BioGRID  PubMed Two-hybrid 
    BioGRID:110346 BioGRID:109880 ITGA2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110346 BioGRID:109894 ITGB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110346 BioGRID:110584 MSN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110346 BioGRID:112592 SRC    BioGRID  PubMed Biochemical Activity 
    BioGRID:110346 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110346 BioGRID:113357 YES1    BioGRID  PubMed Affinity Capture-Western 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    • Complement and Coagulation Cascades, organism-specific biosystem (from WikiPathways)
      Complement and Coagulation Cascades, organism-specific biosystemBlood coagulation is a series of coordinated and calcium-dependent proenzyme-to-serine protease conversions likely to be localized on the surfaces of activated cells in vivo. It culminates in the for...
    • Complement and coagulation cascades, organism-specific biosystem (from KEGG)
      Complement and coagulation cascades, organism-specific biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
    • Complement and coagulation cascades, conserved biosystem (from KEGG)
      Complement and coagulation cascades, conserved biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
    • Complement cascade, organism-specific biosystem (from REACTOME)
      Complement cascade, organism-specific biosystemThe complement system is a biochemical cascade, so named because it 'complements' the ability of antibodies to clear pathogens. It is part of the innate immune system. Complement system proteins circ...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Regulation of Complement cascade, organism-specific biosystem (from REACTOME)
      Regulation of Complement cascade, organism-specific biosystemTwo inherent features of complement activation make its regulation very important: 1. There is an inherent positive feedback loop because the product of C3 activation forms part of an enzyme that cau...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
     
    single fertilization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    inner acrosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    membrane cofactor protein
    Names
    membrane cofactor protein
    measles virus receptor
    complement membrane cofactor protein
    trophoblast leucocyte common antigen
    trophoblast leukocyte common antigen
    CD46 antigen, complement regulatory protein
    trophoblast-lymphocyte cross-reactive antigen
    antigen identified by monoclonal antibody TRA-2-10
    membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009296.1 RefSeqGene

      Range
      4982..48460
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_155

    mRNA and Protein(s)

    1. NM_002389.4NP_002380.3  membrane cofactor protein isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AI589224, BC030594, DB078198, X59410
      Consensus CDS
      CCDS1485.1
      UniProtKB/Swiss-Prot
      P15529
      Related
      ENSP00000350893, OTTHUMP00000034577, ENST00000358170, OTTHUMT00000088588
      Conserved Domains (2) summary
      cd00033
      Location:99158
      Blast Score: 143
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cl00043
      Location:3588
      Blast Score: 85
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    2. NM_153826.3NP_722548.1  membrane cofactor protein isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (d) lacks an alternate in-frame exon and an exon containing the stop codon as compared to variant a. The resulting isoform (4) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AI589224, BC030594, DB078198
      Consensus CDS
      CCDS1480.1
      UniProtKB/Swiss-Prot
      P15529
      Related
      ENSP00000346912, OTTHUMP00000034622, ENST00000354848, OTTHUMT00000088683
      Conserved Domains (2) summary
      cd00033
      Location:99158
      Blast Score: 142
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cl00043
      Location:3588
      Blast Score: 84
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    3. NM_172350.2NP_758860.1  membrane cofactor protein isoform 14 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (n) lacks three alternate in-frame exons as well as an alternate segment compared to variant a, which causes a frameshift. The resulting isoform (14) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AI589224, BC030594, D84105, DB078198
      Consensus CDS
      CCDS1479.1
      UniProtKB/Swiss-Prot
      P15529
      Related
      ENSP00000314664, OTTHUMP00000034623, ENST00000322918, OTTHUMT00000088684
      Conserved Domains (2) summary
      cd00033
      Location:99158
      Blast Score: 143
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cl00043
      Location:3588
      Blast Score: 86
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    4. NM_172351.2NP_758861.1  membrane cofactor protein isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (c) lacks an alternate in-frame exon compared to variant a, resulting in a shorter isoform (3) compared to isoform 1.
      Source sequence(s)
      AI589224, DB078198, X59405
      Consensus CDS
      CCDS31008.1
      UniProtKB/Swiss-Prot
      P15529
      Related
      ENSP00000356009, OTTHUMP00000034624, ENST00000367042, OTTHUMT00000088685
      Conserved Domains (2) summary
      cd00033
      Location:99158
      Blast Score: 143
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cl00043
      Location:3588
      Blast Score: 85
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    5. NM_172352.2NP_758862.1  membrane cofactor protein isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (e) lacks an alternate in-frame segment compared to variant a, resulting in a shorter isoform (5) compared to isoform 1.
      Source sequence(s)
      AI589224, BC030594, DB078198, X59406
      Consensus CDS
      CCDS31009.1
      UniProtKB/Swiss-Prot
      P15529
      Related
      ENSP00000356008, OTTHUMP00000034625, ENST00000367041, OTTHUMT00000088686
      Conserved Domains (2) summary
      cd00033
      Location:99158
      Blast Score: 142
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cl00043
      Location:3588
      Blast Score: 85
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    6. NM_172353.2NP_758863.1  membrane cofactor protein isoform 6 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (f) lacks an alternate in-frame exon and an exon containing the stop codon compared to variant a. The resulting isoform (6) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AI589224, BC030594, DB078198, X59407
      Consensus CDS
      CCDS1481.1
      UniProtKB/Swiss-Prot
      P15529
      Related
      ENSP00000350346, OTTHUMP00000034626, ENST00000357714, OTTHUMT00000088687
      Conserved Domains (2) summary
      cd00033
      Location:99158
      Blast Score: 142
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cl00043
      Location:3588
      Blast Score: 84
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    7. NM_172359.2NP_758869.1  membrane cofactor protein isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b) lacks an alternate exon containing the stop codon compared to variant a. The resulting isoform (2) is longer and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AI589224, AK222822, BC030594, DB078198, X59410
      Consensus CDS
      CCDS1482.1
      UniProtKB/Swiss-Prot
      P15529
      Related
      ENSP00000313875, OTTHUMP00000034706, ENST00000322875, OTTHUMT00000088893
      Conserved Domains (2) summary
      cd00033
      Location:99158
      Blast Score: 142
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cl00043
      Location:3588
      Blast Score: 85
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    8. NM_172361.2NP_758871.1  membrane cofactor protein isoform 12 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (l) lacks an alternate in-frame segment and an exon containing the stop codon as compared to variant a. The resulting isoform (12) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AI589224, BC030594, DB078198, EF076057
      Consensus CDS
      CCDS1484.1
      UniProtKB/Swiss-Prot
      P15529
      Related
      ENSP00000353342, OTTHUMP00000216786, ENST00000360212, OTTHUMT00000357800
      Conserved Domains (2) summary
      cd00033
      Location:99158
      Blast Score: 142
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cl00043
      Location:3588
      Blast Score: 85
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      207925383..207968861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      178599655..178643144
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_172354.1: Suppressed sequence

      Description
      NM_172354.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    2. NM_172355.1: Suppressed sequence

      Description
      NM_172355.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    3. NM_172356.1: Suppressed sequence

      Description
      NM_172356.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    4. NM_172357.1: Suppressed sequence

      Description
      NM_172357.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    5. NM_172358.1: Suppressed sequence

      Description
      NM_172358.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    6. NM_172360.1: Suppressed sequence

      Description
      NM_172360.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL035209.1 CAI18804.1
      CAI18805.1
      CAI18806.1
      CAI18807.1
      CAI18808.1
      CAI18809.1
      CAI18810.1
      CAI18811.1
    genomic AL365178.10 CAH73947.1
      CAH73948.1
      CAH73949.1
      CAH73950.1
      CAH73951.1
      CAH73952.1
      CAH73953.1
      CAH73954.1
    genomic AY916779.1 AAW82433.1
    genomic CH471100.2 EAW93463.1
      EAW93464.1
      EAW93465.1
      EAW93466.1
      EAW93467.1
      EAW93468.1
      EAW93469.1
      EAW93470.1
      EAW93471.1
      EAW93472.1
      EAW93473.1
      EAW93474.1
      EAW93475.1
      EAW93476.1
      EAW93477.1
    genomic S65879.1 AAD13968.1
    mRNA AF209712.1 AAF73844.1
    mRNA AF209713.1 AAF73845.1
    mRNA AF209714.1 AAF73846.1
    mRNA AI589224.1 None
    mRNA AK129560.1 None
    mRNA AK222822.1 BAD96542.1
    mRNA AK291227.1 BAF83916.1
    mRNA AK296819.1 BAG59392.1
    mRNA AU131238.2 None
    mRNA BC007046.1 None
    mRNA BC026273.1 None
    mRNA BC030594.2 AAH30594.1
    mRNA BX537451.1 CAD97694.1
    mRNA BX640613.1 CAE45719.1
    mRNA BX649050.1 CAI45983.1
    mRNA D84105.1 BAA12224.1
    mRNA DB078198.1 None
    mRNA EF076055.1 ABK81635.1
    mRNA EF076056.1 ABK81636.1
    mRNA EF076057.1 ABK81637.1
    mRNA EF076058.1 ABK81638.1
    mRNA M58050.1 AAA62833.1
    mRNA S51940.1 AAB24802.1
    mRNA X59405.1 None
    mRNA X59406.1 None
    mRNA X59407.1 None
    mRNA X59408.1 None
    mRNA X59409.1 None
    mRNA X59410.1 None
    mRNA Y00651.1 CAA68675.1
    mRNA Y07713.1 CAA68985.1
    mRNA A18585.1 CAA01400.1
    other-genetic DQ890901.2 ABM81827.1
    other-genetic DQ894054.2 ABM84980.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15529.3 GenPept UniProtKB/Swiss-Prot:P15529
    Q06C42 GenPept UniProtKB/TrEMBL:Q06C42
    Q92494 GenPept UniProtKB/TrEMBL:Q92494

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