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    SH3KBP1 SH3-domain kinase binding protein 1 [ Homo sapiens ]

    Gene ID: 30011, updated on 19-May-2012
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    Summary

    Official Symbol
    SH3KBP1provided by HGNC
    Official Full Name
    SH3-domain kinase binding protein 1provided by HGNC
    Primary source
    HGNC:13867
    Locus tag
    RP11-345L8.1
    See related
    Ensembl:ENSG00000147010; HPRD:02301; MIM:300374; Vega:OTTHUMG00000021227
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSB1; CIN85; GIG10; HSB-1; MIG18; CD2BP3
    Summary
    This gene encodes an adapter protein that contains three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
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    Genomic context

    Location :
    Xp22.1-p21.3
    Sequence :
    Chromosome: X; NC_000023.10 (19552083..19905744, complement)
    See SH3KBP1 in Epigenomics, MapViewer

    Chromosome X - NC_000023.10Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 15 Neighboring gene pyruvate dehydrogenase (lipoamide) alpha 1 Neighboring gene eukaryotic translation initiation factor 5 pseudogene Neighboring gene chromosome X open reading frame 23 Neighboring gene uncharacterized LOC729609

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    2. The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85. Oellerich T, et al. EMBO J, 2011 Aug 5. PMID 21822214.
    3. CIN85 regulates ubiquitination and degradative endosomal sorting of the EGF receptor. Rønning SB, et al. Exp Cell Res, 2011 Aug 1. PMID 21635887.
    4. Making ends meet: the importance of the N- and C-termini for the structure, stability, and function of the third SH3 domain of CIN85. Philippe D, et al. Biochemistry, 2011 May 10. PMID 21446695.
    5. CIN85 modulates the down-regulation of Fc gammaRIIa expression and function by c-Cbl in a PKC-dependent manner in human neutrophils. Marois L, et al. J Biol Chem, 2011 Apr 29. PMID 21372129.

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Live cell imaging and co-immunoprecipitation experiments confirmed that both SLP65 and CIN85 are both required for the onset and progression phases of B-cell antigen receptor signal transduction.
      Title: The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85.
    2. The CIN85 was constitutively associated with Hrs, and this strengthens the hypothesis of a functional role of CIN85 in endosomal EGFR sorting.
      Title: CIN85 regulates ubiquitination and degradative endosomal sorting of the EGF receptor.
    3. the ubiquitination and degradation of stimulated FcgammaRIIa mediated by c-Cbl are positively regulated by the adaptor protein CIN85 in a PKC-dependent manner and these events contribute to the termination of FcgammaRIIa signaling.
      Title: CIN85 modulates the down-regulation of Fc gammaRIIa expression and function by c-Cbl in a PKC-dependent manner in human neutrophils.
    4. the N- and C-termini are important for the structure, stability, and function of the third SH3 domain of CIN85
      Title: Making ends meet: the importance of the N- and C-termini for the structure, stability, and function of the third SH3 domain of CIN85.
    5. ARAP1 associated with CIN85 affects epidermal growth factor receptor endocytic trafficking.
      Title: ARAP1 association with CIN85 affects epidermal growth factor receptor endocytic trafficking.
    6. High CIN85 is associated with the development and progression of head and neck squamous cell carcinoma.
      Title: A critical role of c-Cbl-interacting protein of 85 kDa in the development and progression of head and neck squamous cell carcinomas through the ras-ERK pathway.
    7. CIN85 binding to a C-terminal motif within hTTP leads to the increased phosphorylation of hTTP, possibly through enhanced association with MEKK4
      Title: Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85.
    8. Ruk/CIN85 induces PAI-1 expression via modulation of HIF-1alpha stability
      Title: The adaptor protein Ruk/CIN85 activates plasminogen activator inhibitor-1 (PAI-1) expression via hypoxia-inducible factor-1alpha.
    9. Coexpression of CIN85/Ruk(L) with CD2AP led to a decreased binding of CIN85/Ruk(L) to nephrin and podocin, which indicates a functional competition between CD2AP and CIN85/Ruk(L).
      Title: CIN85/RukL is a novel binding partner of nephrin and podocin and mediates slit diaphragm turnover in podocytes.
    10. The ORF3 protein of hepatitis E virus was found to interact with CIN85 and compete with the formation of the growth factor receptor-Cbl-CIN85 complex, resulting in the reduced ubiquitination of CIN85.
      Title: The ORF3 protein of hepatitis E virus delays degradation of activated growth factor receptors by interacting with CIN85 and blocking formation of the Cbl-CIN85 complex.
    Submit: New GeneRIF Correction See all (33)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_114098.1 NP_060952.2 ASAP1    BIND  PubMed DDEF1 (AMAP1) interacts with SH3KBP1 (CIN85). 
    NP_114098.1 NP_003878.1 ASAP2    BIND  PubMed DDEF2 (AMAP2) interacts with SH3KBP1 (CIN85). 
    NP_114098.1 NP_005179.2 CBL    BIND  PubMed CIN85 interacts with Cbl. 
    NP_114098.1 NP_001758.1 CD2    BIND  PubMed SETA interacts with CD2. This interaction was modelled on a demonstrated interaction between rat SETA and human CD2. 
    NP_114098.1 NP_002077.1 GRB2    BIND  PubMed SETA interacts with Grb2. This interaction was modelled on a demonstrated interaction between rat SETA and human Grb2 
    NP_114098.1 NP_003016.1 SH3GL1    BIND  PubMed Endophilin A2 interacts with CIN85. This interaction was modeled on a demonstrated interaction between endophilin A2 from an unspecified species and human CIN85. 
    NP_114098.1 NP_003017.1 SH3GL2    BIND  PubMed CIN85 interacts with endophilin A1. This interaction was modeled on a demonstrated interaction between human CIN85 and mouse endophilin A1. 
    NP_114098.1 NP_003018.2 SH3GL3    BIND  PubMed Endophilin A3 interacts with CIN85. 
    Q96B97 Q9NYB9 ABI2    HPRD  PubMed  
    Q96B97 Rho GTPase activating protein 27 ARHGAP27    HPRD  PubMed  
    Q96B97 Q9ULH1 ASAP1    HPRD  PubMed  
    Q96B97 O43150 ASAP2    HPRD  PubMed  
    Q96B97 P56945 BCAR1    HPRD  PubMed  
    Q96B97 Q8WV28 BLNK    HPRD  PubMed  
    Q96B97 O00238 BMPR1B    HPRD  PubMed  
    Q96B97 P52907 CAPZA1    HPRD  PubMed  
    Q96B97 P22681 CBL    HPRD  PubMed  
    Q96B97 Q13191 CBLB    HPRD  PubMed  
    Q96B97 P06729 CD2    HPRD  PubMed  
    Q96B97 Q96EY5 FAM125A    HPRD  PubMed  
    Q96B97 P62993 GRB2    HPRD  PubMed  
    Q96B97 P08631 HCK    HPRD  PubMed  
    Q96B97 P46934 NEDD4    HPRD  PubMed  
    Q96B97 Q13177 PAK2    HPRD  PubMed  
    Q96B97 O75340 PDCD6    HPRD  PubMed  
    Q96B97 Q8WUM4 PDCD6IP    HPRD  PubMed  
    Q96B97 P42336 PIK3CA    HPRD  PubMed  
    Q96B97 P27986 PIK3R1    HPRD  PubMed  
    Q96B97 P78314 SH3BP2    HPRD  PubMed  
    Q96B97 Q99962 SH3GL2    HPRD  PubMed  
    Q96B97 Q99963 SH3GL3    HPRD  PubMed  
    Q96B97 Q96B97 SH3KBP1    HPRD  PubMed  
    Q96B97 Q8TBC3 SHKBP1    HPRD  PubMed  
    Q96B97 Q07889 SOS1    HPRD  PubMed  
    Q96B97 O43426 SYNJ1    HPRD  PubMed  
    Q96B97 P49848 TAF6    HPRD  PubMed  
    Q96B97 Q9UDY2 TJP2    HPRD  PubMed  
    Q96B97 Ubiquitin B UBB    HPRD  PubMed  
    BioGRID:119029 BioGRID:115454 ABI2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119029 BioGRID:125548 ARAP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:119029 BioGRID:128369 ARHGAP27    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:119029 BioGRID:114934 BCAR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119029 BioGRID:118894 BLNK    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:119029 BioGRID:107315 CBL    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:119029 BioGRID:107316 CBLB    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:119029 BioGRID:107352 CD2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119029 BioGRID:117140 CD2AP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119029 BioGRID:128126 CLYBL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119029 BioGRID:107788 CRK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119029 BioGRID:198477 Capza1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119029 BioGRID:198584 Cd2ap    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119029 BioGRID:108276 EGFR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119029 BioGRID:125018 FAM125A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119029 BioGRID:109142 GRB2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119029 BioGRID:114593 HGS    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119029 BioGRID:110015 KIT    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119029 BioGRID:110380 MAP3K4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:119029 BioGRID:110391 MET    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119029 BioGRID:110928 NPHS1    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:119029 BioGRID:113590 NPHS2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119029 BioGRID:111095 PAK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119029 BioGRID:111098 PAK2    BioGRID  PubMed Affinity Capture-Western; Far Western 
    BioGRID:119029 BioGRID:115333 PDCD6    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119029 BioGRID:115332 PDCD6IP    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:119029 BioGRID:111185 PDGFRB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119029 BioGRID:111313 PIK3R1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:119029 BioGRID:205072 Racgap1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119029 BioGRID:112353 SH3GL2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:119029 BioGRID:112354 SH3GL3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:119029 BioGRID:119289 SH3GLB1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119029 BioGRID:121234 SH3GLB2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:119029 BioGRID:119029 SH3KBP1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:119029 BioGRID:124979 SHKBP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119029 BioGRID:112537 SOS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119029 BioGRID:115546 SPRY1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119029 BioGRID:115547 SPRY2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:119029 BioGRID:114388 SYNJ1    BioGRID  PubMed Affinity Capture-Western; Far Western 
    BioGRID:119029 BioGRID:112741 TAF6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119029 BioGRID:114809 TJP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:119029 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:119029 BioGRID:119387 ZNF219    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen Activates B Cell Receptor Leading to Generation of Second Messengers, organism-specific biosystem (from REACTOME)
      Antigen Activates B Cell Receptor Leading to Generation of Second Messengers, organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, Fu et al. 1975, Kunkel e...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • EGFR downregulation, organism-specific biosystem (from REACTOME)
      EGFR downregulation, organism-specific biosystemRegulation of receptor tyrosine kinase (RTK) activity is implicated in the control of almost all cellular functions. One of the best understood RTKs is epidermal growth factor receptor (EGFR). Growth...
    • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Internalization of ErbB1, organism-specific biosystem (from Pathway Interaction Database)
      Internalization of ErbB1, organism-specific biosystem
      Internalization of ErbB1
    • Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Kit Receptor Signaling Pathway, organism-specific biosystemKit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    • Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by EGFR in Cancer, organism-specific biosystemThe pathway "Signaling by EGFR in Cancer" shows "Signaling by constitutively active EGFR" in parallel with "Signaling by EGFR". This allows users to compare signaling by constitutively active EGFR ca...
    • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
    • Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem
      Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		  
    cell-cell signaling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		  
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		  
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    synaptosome IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    SH3 domain-containing kinase-binding protein 1
    Names
    SH3 domain-containing kinase-binding protein 1
    CD2-binding protein 3
    c-Cbl-interacting protein
    migration-inducing gene 18
    cbl-interacting protein of 85 kDa
    Src family kinase-binding protein 1
    src-related kinase binding protein-1
    human Src family kinase-binding protein 1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021367.1 RefSeqGene

      Range
      5001..358662
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001024666.2 → NP_001019837.1  SH3 domain-containing kinase-binding protein 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AF542051, AL732423, DC409010
      Consensus CDS
      CCDS35213.1
      UniProtKB/TrEMBL
      Q5JPT5
      UniProtKB/Swiss-Prot
      Q96B97
      Related
      ENSP00000369020, OTTHUMP00000023024, ENST00000379698, OTTHUMT00000055994
      Conserved Domains (1) summary
      cd00174
      Location:234 – 288
      Blast Score: 180
      SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...

    2. NM_001184960.1 → NP_001171889.1  SH3 domain-containing kinase-binding protein 1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK293237, AL732327, AL732423, BP224209, DC359739
      Consensus CDS
      CCDS55383.1
      UniProtKB/TrEMBL
      B7Z1D5
      UniProtKB/TrEMBL
      Q5JPT4
      Related
      ENSP00000369039, OTTHUMP00000023028, ENST00000379716, OTTHUMT00000055999
      Conserved Domains (1) summary
      cd00174
      Location:33 – 87
      Blast Score: 179
      SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...

    3. NM_031892.2 → NP_114098.1  SH3 domain-containing kinase-binding protein 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AF230904, AL732423, DR000949
      Consensus CDS
      CCDS14193.1
      UniProtKB/TrEMBL
      Q5JPT6
      UniProtKB/Swiss-Prot
      Q96B97
      Related
      ENSP00000380921, OTTHUMP00000023022, ENST00000397821, OTTHUMT00000055992
      Conserved Domains (1) summary
      cd00174
      Location:4 – 55
      Blast Score: 180
      SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000023.10 Reference GRCh37.p5 Primary Assembly

      Range
      19552083..19905744, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000155.1 Alternate HuRef

      Range
      17300128..17674889, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL732325.6 CAI41253.1
      CAI41254.1
    genomic AL732327.6 CAI40509.1
      CAI40510.1
      CAI40511.1
      CAI40512.1
      CAI40513.1
      CAI40514.1
      CAI40515.1
    genomic AL732327.6 CAI40509.1
      CAI40510.1
      CAI40511.1
      CAI40512.1
      CAI40513.1
      CAI40514.1
      CAI40515.1
    genomic AL732409.6 (2000..16764) None
    genomic AL732423.12 CAI40276.1
      CAI40277.1
      CAI40278.1
      CAI40280.1
    genomic AL772197.12 CAH71710.1
    genomic CH471074.1 EAW98964.1
      EAW98965.1
      EAW98966.1
      EAW98967.1
    genomic CS300518.1 CAK32182.1
    mRNA AF230904.1 AAF37854.1
    mRNA AF329267.1 AAK95587.1
    mRNA AF329268.1 AAO13348.1
    mRNA AF542051.1 AAN77231.1
    mRNA AK293234.1 BAH11470.1
    mRNA AK293237.1 BAH11471.1
    mRNA AK300189.1 BAH13234.1
    mRNA AK307276.1 None
    mRNA AK313308.1 BAG36113.1
    mRNA AY423734.1 AAS00497.1
    mRNA AY542305.1 AAT08174.1
    mRNA BC015806.1 AAH15806.1
    mRNA BC041055.1 None
    mRNA BC050663.2 AAH50663.1
    mRNA BP224209.1 None
    mRNA DC359739.1 None
    mRNA DC409010.1 None
    mRNA DR000949.1 None
    other-genetic DQ892387.2 ABM83313.1
    other-genetic DQ895600.2 ABM86526.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5JPT1 GenPept UniProtKB/TrEMBL:Q5JPT1
    Q5JPT3 GenPept UniProtKB/TrEMBL:Q5JPT3
    Q5JPT5 GenPept UniProtKB/TrEMBL:Q5JPT5
    Q5JPT6 GenPept UniProtKB/TrEMBL:Q5JPT6
    Q96B97.2 GenPept UniProtKB/Swiss-Prot:Q96B97
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    Additional Links

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