MRC1 mannose receptor, C type 1 [Homo sapiens] - Gene

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Summary

Official Symbol: MRC1provided by HGNC
Official Full Name: mannose receptor, C type 1provided by HGNC
Primary source: HGNC:7228
Locus tag: RP11-457D2.1
See related: Ensembl:ENSG00000120586; HPRD:01089; MIM:153618; Vega:OTTHUMG00000017757
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MMR; CD206; MRC1L1; CLEC13D; CLEC13DL; bA541I19.1; MGC181940
Summary: The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Apr 2011]
Annotation information: Note: In the NCBI Build 37.2 reference assembly, MRC1 and MRC1L1 are duplicate genes in close proximity to each other on chromosome 10. In July 2010, the Genome Reference Consortium determined that the region contains a duplication error. Two of the clones on which MRC1L1 was based (AL928580, BX255924) will be removed from the reference assembly and only MRC1 will be present in the assembly. [28 Apr 2011]

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Genomic context

Location :: 10p12.33

Sequence :: Chromosome: 10; NC_000010.10 (18098352..18200091)

See MRC1 in Epigenomics, MapViewer

Chromosome 10 - NC_000010.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

hMR expressed by vaginal epithelial cells has high affinity for HIV gp120 and this binding induces production of matrix metalloproteinases.
Title: HIV gp120 binds to mannose receptor on vaginal epithelial cells and induces production of matrix metalloproteinases.
MMR distribution in liver, spleen, lung, kidney, heart, diaphragm, quadriceps, and triceps in these animal models and compared them with MMR distribution in wild-type mice.
Title: Biotherapeutic target or sink: analysis of the macrophage mannose receptor tissue distribution in murine models of lysosomal storage diseases.
Studies show that tumoral mucin-mediated ligation of the MR on infiltrating TAM may contribute to their immune suppressive phenotype.
Title: Engagement of the mannose receptor by tumoral mucins activates an immune suppressive phenotype in human tumor-associated macrophages.
The studies provide the first demonstration of a significant role for mannose receptor, synergistic with TLR2, in activating a proinflammatory response to P. aeruginosa infection.
Title: Synergistic regulation of Pseudomonas aeruginosa-induced cytokine production in human monocytes by mannose receptor and TLR2.
These data suggest that in hepatitis B virus infected patients, mannose receptor-mediated interaction between HBsAg and dendritic cells and subsequent impairment of dendritic cells predominantly occurs at the main site of infection, the liver.
Title: The mannose receptor acts as hepatitis B virus surface antigen receptor mediating interaction with intrahepatic dendritic cells.
This is the first study to imply that genetic variants in MRC1, a major member of the C-type lectin, contribute to the development of sarcoidosis.
Title: Genetic variants in mannose receptor gene (MRC1) confer susceptibility to increased risk of sarcoidosis.
MR plays a key role in the T helper type (Th)2 cell polarization observed after dust mite glycoallergen Der p 1 exposure through regulation of indoleamine 2,3-dioxygenase activity.
Title: The mannose receptor mediates the uptake of diverse native allergens by dendritic cells and determines allergen-induced T cell polarization through modulation of IDO activity.
Data identify a new molecular pathway that links engagement of the mannose receptor, an important pattern recognition receptor for M. tuberculosis, with PPARgamma activation, which regulates the macrophage inflammatory response.
Title: Mycobacterium tuberculosis activates human macrophage peroxisome proliferator-activated receptor gamma linking mannose receptor recognition to regulation of immune responses.
The mannose receptor and hCG were colocalized on the surface of uterine natural killer cells.
Title: Proliferation of uterine natural killer cells is induced by human chorionic gonadotropin and mediated via the mannose receptor.
A significant association of exon 7 encoded amino acid haplotypes with leprosy per se (P = 0.012) and multibacillary leprosy (P = 0.004).
Title: Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibility.

Submit: New GeneRIF Correction See all (27)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genome-wide association study of hematological and biochemical traits in a Japanese population.

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 binds to B cells through mannose C-type lectin receptors (MCLRs), such as DC-SIGN, mannose receptor, and langerin	PubMed
	env	HIV-1 gp120 interaction with human mannose receptor (hMR) results in increased production of matrix metalloproteinase-2 (MMP-2) in astrocytes	PubMed
Nef	nef	HIV-1 Nef downregulates mannose receptor (MR) on the surface of macrophages and dendritic cells (DC); both NTLY and SDXXXL motifs in the cytoplasmic tail of MR are critical for the cell surface reduction of MR	PubMed
Tat	tat	HIV-1 Tat interaction with cyclin T1 is required for the repression of mannose receptor (MR) and bone morphogenetic protein receptor-2 (BMPR2) promoters	PubMed
	tat	HIV-1 Tat represses transcription from the rat mannose receptor promoter, thereby downregulating expression of mannose receptor	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
P22897	O96017	CHEK2		HPRD	PubMed

Function	Evidence Code	Pubs
binding	IEA Inferred from Electronic Annotation more info
mannose binding	TAS Traceable Author Statement more info	PubMed
receptor activity	IDA Inferred from Direct Assay more info
sugar binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
receptor-mediated endocytosis	IDA Inferred from Direct Assay more info

Component	Evidence Code	Pubs
endosome	IEA Inferred from Electronic Annotation more info
endosome membrane	IDA Inferred from Direct Assay more info
integral to plasma membrane	TAS Traceable Author Statement more info	PubMed
plasma membrane	IDA Inferred from Direct Assay more info

General protein information

Preferred Names: macrophage mannose receptor 1

Names: macrophage mannose receptor 1; mannose receptor, C type 1-like 1; C-type lectin domain family 13 member D; macrophage mannose receptor 1-like protein 1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002438.2 → NP_002429.1 macrophage mannose receptor 1 precursor

Status: VALIDATED

Source sequence(s)

BU198859, J05550

Consensus CDS

CCDS7123.1

UniProtKB/Swiss-Prot

P22897

Related

ENSP00000239761, OTTHUMP00000019245, ENST00000239761, OTTHUMT00000047057

Conserved Domains (5) summary

cd00062
Location:162 – 209
Blast Score: 186

FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...

cd00161
Location:34 – 141
Blast Score: 147

RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

cd00037
Location:659 – 779
Blast Score: 290

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

smart00458
Location:27 – 142
Blast Score: 180

RICIN; Ricin-type beta-trefoil

cl02432
Location:1238 – 1357
Blast Score: 249

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000010.10 Reference GRCh37.p5 Primary Assembly

Range

18098352..18200091

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh37.p5 PATCHES

Genomic

NW_003315932.1 Reference GRCh37.p5 PATCHES

Range

238154..339953

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000142.1 Alternate HuRef

Range

17764100..17866209

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001009567.1: Suppressed sequence

Description

NM_001009567.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC069023.5 (52840..129344)	None
genomic	AL139238.13	CAH70872.1
genomic	AL928580.4	CAH71176.1
genomic	AL928729.2	CAH70733.1
genomic	BX255924.4	CAI15339.1
genomic	EF444997.1	ACA06020.1
genomic	M93192.1	AAA60389.1
genomic	M93193.1	AAA60389.1
genomic	M93194.1	AAA60389.1
genomic	M93195.1	AAA60389.1
genomic	M93196.1	AAA60389.1
genomic	M93197.1	AAA60389.1
genomic	M93198.1	AAA60389.1
genomic	M93199.1	AAA60389.1
genomic	M93200.1	AAA60389.1
genomic	M93201.1	AAA60389.1
genomic	M93202.1	AAA60389.1
genomic	M93203.1	AAA60389.1
genomic	M93204.1	AAA60389.1
genomic	M93205.1	AAA60389.1
genomic	M93206.1	AAA60389.1
genomic	M93207.1	AAA60389.1
genomic	M93208.1	AAA60389.1
genomic	M93209.1	AAA60389.1
genomic	M93210.1	AAA60389.1
genomic	M93211.1	AAA60389.1
genomic	M93212.1	AAA60389.1
genomic	M93213.1	AAA60389.1
genomic	M93214.1	AAA60389.1
genomic	M93215.1	AAA60389.1
genomic	M93216.1	AAA60389.1
genomic	M93217.1	AAA60389.1
genomic	M93218.1	AAA60389.1
genomic	M93219.1	AAA60389.1
genomic	M93220.1	AAA60389.1
genomic	M93221.1	AAA60389.1
mRNA	AK297044.1	BAG59571.1
mRNA	BC016003.1	None
mRNA	BC142642.1	AAI42643.1
mRNA	BC146838.1	AAI46839.1
mRNA	BU198859.1	None
mRNA	DQ663787.1	ABG47462.1
mRNA	J05550.1	AAA59868.1
mRNA	X55635.1	None