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    HSPA8 heat shock 70kDa protein 8 [ Homo sapiens ]

    Gene ID: 3312, updated on 19-May-2012
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    Summary

    Official Symbol
    HSPA8provided by HGNC
    Official Full Name
    heat shock 70kDa protein 8provided by HGNC
    Primary source
    HGNC:5241
    See related
    Ensembl:ENSG00000109971; HPRD:07205; MIM:600816; Vega:OTTHUMG00000166030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LAP1; HSC54; HSC70; HSC71; HSP71; HSP73; NIP71; HSPA10; MGC29929; MGC131511
    Summary
    This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
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    Genomic context

    Location :
    11q24.1
    Sequence :
    Chromosome: 11; NC_000011.9 (122928200..122932844, complement)
    See HSPA8 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100652787 Neighboring gene ribosomal protein S26 pseudogene 43 Neighboring gene ribosomal protein L31 pseudogene 47 Neighboring gene small nucleolar RNA, C/D box 14E Neighboring gene small nucleolar RNA, C/D box 14D Neighboring gene small nucleolar RNA, C/D box 14C Neighboring gene CXADR-like membrane protein Neighboring gene microRNA 4493

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). Lopitz-Otsoa F, et al. J Proteomics, 2012 Jun 6. PMID 22178446.
    2. The cellular chaperone hsc70 is specifically recruited to reovirus viral factories independently of its chaperone function. Kaufer S, et al. J Virol, 2012 Jan. PMID 22090113.
    3. Proteomic analysis of the 20S proteasome (PSMA3)-interacting proteins reveals a functional link between the proteasome and mRNA metabolism. Fedorova OA, et al. Biochem Biophys Res Commun, 2011 Dec 16. PMID 22079093.
    4. A small molecule that binds to an ATPase domain of Hsc70 promotes membrane trafficking of mutant cystic fibrosis transmembrane conductance regulator. Cho HJ, et al. J Am Chem Soc, 2011 Dec 21. PMID 22074182.
    5. Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport. Patterson KR, et al. Biochemistry, 2011 Nov 29. PMID 22039833.

    See all (252) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. It is proposed that Az suppresses ubiquitination of DeltaF508-CFTR maybe by blocking interaction of the mutant with Hsc70 and CHIP, and, as a consequence, it enhances membrane trafficking of the mutant
      Title: A small molecule that binds to an ATPase domain of Hsc70 promotes membrane trafficking of mutant cystic fibrosis transmembrane conductance regulator.
    2. Partially unfolded states of AGXT strongly interact with Hsc70 and Hsp90 chaperones.
      Title: Role of low native state kinetic stability and interaction of partially unfolded states with molecular chaperones in the mitochondrial protein mistargeting associated with primary hyperoxaluria.
    3. Hsc70 is recruited to reovirus viral factories independently of its chaperone function.
      Title: The cellular chaperone hsc70 is specifically recruited to reovirus viral factories independently of its chaperone function.
    4. Addition of Hsp70 to a mixture of oligomeric and fibrillar tau aggregates prevents the toxic effect of these tau species on fast axonal transport.
      Title: Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport.
    5. The ability of the cytosolic cognate 70-kDa heat-shock protein (Hsc70) chaperone system to modulate cell surface expression of MC4R, was investigated.
      Title: The cytosolic chaperone Hsc70 promotes traffic to the cell surface of intracellular retained melanocortin-4 receptor mutants.
    6. Apoptin induced the translocation of endogenous Hsc70 from the cytoplasm to the nucleus, and both were co-localized in the nucleus.
      Title: A critical role of heat shock cognate protein 70 in Apoptin-induced phosphorylation of Akt.
    7. JB12 cooperates with cytosolic Hsc70 and the ubiquitin ligase RMA1 to target CFTR and CFTRDeltaF508 for degradation.
      Title: The endoplasmic reticulum-associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3-dependent degradation of nascent CFTRDeltaF508.
    8. The importance of Hsc70 in AtlE adhesin-mediated internalization was demonstrated by the inhibition of Staphylococcus aureus internalization with anti-Hsc70 antibodies.
      Title: A novel staphylococcal internalization mechanism involves the major autolysin Atl and heat shock cognate protein Hsc70 as host cell receptor.
    9. Immunocytochemical staining using this newly established antibody revealed that Hsc70 localizes predominantly in the cytoplasm in unstressed cells, whereas oxidative stress produced by H2O2 induces Hsc70 to translocate into the nucleus.
      Title: Generation of a rat monoclonal antibody specific for heat shock cognate protein 70.
    10. genetic variants in HSPA8 gene (especially promoter SNP rs2236659) contribute to the coronary heart disease susceptibility by affecting its expression level
      Title: Genetic variations in HSPA8 gene associated with coronary heart disease risk in a Chinese population.
    Submit: New GeneRIF Correction See all (74)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Over expression of hsp70 with a herpes viral amplicon vector protects cultured hippocampal rat neurons from gp120 neurotoxicity PubMed
    env The exposure of permissive CD4+ cells to HIV-1 gp120 increases the synthesis and nuclear translocation of 70kDa heat shock protein PubMed
    Pr55(Gag) gag Hsc70 is specifically incorporated into HIV-1 virions, similar to Hsp70 which is incorporated into virions through an interaction with HIV-1 Gag PubMed
    Tat tat Hsp70 and Hsp90 and Cdc37 regulate the stabilization and folding of CDK9 as well as the assembly of an active CDK9/cyclin T1 complex responsible for P-TEFb-mediated HIV-1 Tat transactivation PubMed
    Vpr vpr HIV-1 Vpr competes with Hsp70 for binding to karyopherin alpha PubMed
    matrix gag Hsp70 facilitates nuclear import of HIV-1 preintegration complexes by stimulating the binding of HIV-1 Matrix to karyopherin alpha PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_006588.1 NP_006136.1 DNAJB1    BIND  PubMed Hsp40 interacts with the carboxy-terminal region of Hsc70. 
    NP_006588.1 NP_005852.1 STUB1    BIND  PubMed The TPR and charged domains of CHIP interact with the carboxy-terminal region of Hsc70. 
    P11142 Q8IZP0 ABI1    HPRD  PubMed  
    P11142 P05062 ALDOB    HPRD  PubMed  
    P11142 P04114 APOB    HPRD  PubMed  
    P11142 Q99933 BAG1    HPRD  PubMed  
    P11142 O95816 BAG2    HPRD  PubMed  
    P11142 O95817 BAG3    HPRD  PubMed  
    P11142 P46379 BAG6    HPRD  PubMed  
    P11142 P49368 CCT3    HPRD  PubMed  
    P11142 P25942 CD40    HPRD  PubMed  
    P11142 Q99966 CITED1    HPRD  PubMed  
    P11142 P09496 CLTA    HPRD  PubMed  
    P11142 Q02388 COL7A1    HPRD  PubMed  
    P11142 P61073 CXCR4    HPRD  PubMed  
    P11142 P99999 CYCS    HPRD  PubMed  
    P11142 P31689 DNAJA1    HPRD  PubMed  
    P11142 Q96EY1 DNAJA3    HPRD  PubMed  
    P11142 Q9NY33 DPP3    HPRD  PubMed  
    P11142 P63167 DYNLL1    HPRD  PubMed  
    P11142 P84090 ERH    HPRD  PubMed  
    P11142 P09467 FBP1    HPRD  PubMed  
    P11142 O14976 GAK    HPRD  PubMed  
    P11142 P30793 GCH1    HPRD  PubMed  
    P11142 P00505 GOT2    HPRD  PubMed  
    P11142 O15379 HDAC3    HPRD  PubMed  
    P11142 Q00613 HSF1    HPRD  PubMed  
    P11142 P07900 HSP90AA1    HPRD  PubMed  
    P11142 Heat shock 70 KD protein 1A HSPA1A    HPRD  PubMed  
    P11142 P11142 HSPA8    HPRD  PubMed  
    P11142 HSPBP1 HSPBP1    HPRD  PubMed  
    P11142 Q92598 HSPH1    HPRD  PubMed  
    P11142 O60674 JAK2    HPRD  PubMed  
    P11142 P10636 MAPT    HPRD  PubMed  
    P11142 Q8NC60 NOA1    HPRD  PubMed  
    P11142 P78364 PHC1    HPRD  PubMed  
    P11142 Q08752 PPID    HPRD  PubMed  
    P11142 P04049 RAF1    HPRD  PubMed  
    P11142 P06400 RB1    HPRD  PubMed  
    P11142 Q04864 REL    HPRD  PubMed  
    P11142 P41220 RGS2    HPRD  PubMed  
    P11142 P08047 SP1    HPRD  PubMed  
    P11142 P16949 STMN1    HPRD  PubMed  
    P11142 Q9UNE7 STUB1    HPRD  PubMed  
    P11142 Q6EEV6 SUMO4    HPRD  PubMed  
    P11142 O75528 TADA3    HPRD  PubMed  
    P11142 O14776 TCERG1    HPRD  PubMed  
    P11142 P30408 TM4SF1    HPRD  PubMed  
    P11142 Q9BXA6 TSSK6    HPRD  PubMed  
    P11142 P62988 UBB    HPRD  PubMed  
    P11142 P09936 UCHL1    HPRD  PubMed  
    P11142 P61981 YWHAG    HPRD  PubMed  
    P11142 P27348 YWHAQ    HPRD  PubMed  
    BioGRID:109544 BioGRID:106543 ABL1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109544 BioGRID:107049 BAG1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:109544 BioGRID:114908 BAG2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:109544 BioGRID:114907 BAG3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:109544 BioGRID:114906 BAG4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109544 BioGRID:107083 BCR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109544 BioGRID:107140 BRCA1    BioGRID  PubMed Two-hybrid 
    BioGRID:109544 BioGRID:107067 CCND1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109544 BioGRID:107358 CD4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:107424 CDC5L    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:109544 BioGRID:107421 CDK11B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:107454 CDK4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109544 BioGRID:123213 CDK5RAP3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:107463 CDKN2A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:107487 CENPA    BioGRID  PubMed Co-purification 
    BioGRID:109544 BioGRID:107506 CFTR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109544 BioGRID:110572 CITED1    BioGRID  PubMed Affinity Capture-Western; Phenotypic Suppression 
    BioGRID:109544 BioGRID:107621 CLTA    BioGRID  PubMed Protein-peptide 
    BioGRID:109544 BioGRID:119922 CYCS    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109544 BioGRID:119986 DGCR8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:109534 DNAJA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109544 BioGRID:114547 DNAJA3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109544 BioGRID:109569 DNAJB1    BioGRID  PubMed Reconstituted Complex 
    CAA66913.1 DNAJC2    BIND  PubMed Mpp11 interacts with an unspecified isoform of Hsc70. 
    BioGRID:109544 BioGRID:111597 DNAJC3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109544 BioGRID:114023 DYRK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:971788 EBNA-LP    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-purification 
    BioGRID:109544 BioGRID:108276 EGFR    BioGRID  PubMed PCA 
    BioGRID:109544 BioGRID:128178 EIF2C4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:108389 ERG    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109544 BioGRID:108390 ERH    BioGRID  PubMed Two-hybrid 
    BioGRID:109544 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:109544 BioGRID:108473 FANCC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:109544 BioGRID:108497 FBP1    BioGRID  PubMed Two-hybrid 
    BioGRID:109544 BioGRID:108552 FGFR3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:109068 GOT2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109544 BioGRID:116452 GPN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:109119 GPR37    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109544 BioGRID:109304 HCFC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:123818 HDAC10    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109544 BioGRID:114368 HDAC3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109544 BioGRID:114593 HGS    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109544 BioGRID:113895 HIST3H3    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:109544 BioGRID:109367 HLA-DRA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:109368 HLA-DRB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:109370 HLA-DRB3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:109371 HLA-DRB4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:109372 HLA-DRB5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:109389 HMGB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109544 BioGRID:109425 HNRNPD    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109544 BioGRID:109530 HSF1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109544 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109544 BioGRID:117168 HSPBP1    BioGRID  PubMed Two-hybrid 
    BioGRID:109544 BioGRID:109314 HTT    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109544 BioGRID:109816 IL16    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109544 BioGRID:119325 INSIG2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:109920 JAK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109544 BioGRID:110101 LALBA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109544 BioGRID:111585 MAPK8    BioGRID  PubMed Two-hybrid 
    BioGRID:109544 BioGRID:110308 MAPT    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:109544 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109544 BioGRID:110384 MEN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:110455 MME    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:110592 MST1R    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109544 BioGRID:124000 NOA1    BioGRID  PubMed Two-hybrid 
    BioGRID:109544 BioGRID:248286 P2rx7    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:109544 BioGRID:119018 PACSIN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:116413 PACSIN2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:118896 PACSIN3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:111105 PARK2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109544 BioGRID:107129 POLR3D    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:111477 PPID    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109544 BioGRID:111493 PPP1CA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109544 BioGRID:110743 PPP1R12B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109544 BioGRID:117172 PPP1R15A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109544 BioGRID:111657 PSMA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:202416 Psma2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:111831 RAF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109544 BioGRID:115301 RBX1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:122136 RFWD2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:111929 RGS2    BioGRID  PubMed Two-hybrid 
    BioGRID:109544 BioGRID:117487 RPAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:114166 RUVBL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:116152 SEC61B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:118079 SERP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:112530 SOD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:110119 STMN1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109544 BioGRID:115563 STUB1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:109544 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:132223 SUMO4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:115737 TADA3    BioGRID  PubMed Two-hybrid 
    BioGRID:109544 BioGRID:116120 TCERG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:112810 TCP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:109544 BioGRID:112954 TLR4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109544 BioGRID:119902 TLR9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109544 BioGRID:110249 TM4SF1    BioGRID  PubMed Two-hybrid 
    BioGRID:109544 BioGRID:112986 TNFRSF1A    BioGRID  PubMed Reconstituted Complex 
    NP_000537.2 TP53    BIND  PubMed Hsc70 interacts with p53. 
    NP_000537.2 TP53    BIND  PubMed p53 interacts with an unspecified isoform of Hsc70. This interaction was modeled on a demonstrated interaction between human p53 and bovine Hsc70. 
    BioGRID:109544 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:109544 BioGRID:123835 TSSK6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:109544 BioGRID:113185 UBE3A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109544 BioGRID:131884 USP50    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:113258 VCP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109544 BioGRID:113269 VHL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:123245 WDR82    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:109544 BioGRID:592058 clint1-a    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:109544 BioGRID:64283 lqf    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Antigen processing and presentation, organism-specific biosystem (from KEGG)
      Antigen processing and presentation, organism-specific biosystem
      Antigen processing and presentation
    • Antigen processing and presentation, conserved biosystem (from KEGG)
      Antigen processing and presentation, conserved biosystem
      Antigen processing and presentation
    • C-MYB transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      C-MYB transcription factor network, organism-specific biosystem
      C-MYB transcription factor network
    • Clathrin derived vesicle budding, organism-specific biosystem (from REACTOME)
      Clathrin derived vesicle budding, organism-specific biosystemThere at least two classes of clathrin coated vesicles in cells, one predominantly Golgi-associated, involved in budding from the trans-Golgi network and the other at the plasma membrane. Here the cl...
    • Destabilization of mRNA by AUF1 (hnRNP D0), organism-specific biosystem (from REACTOME)
      Destabilization of mRNA by AUF1 (hnRNP D0), organism-specific biosystemAUF1 (hnRNP D0) dimers bind U-rich regions of AU-rich elements (AREs) in the 3' untranslated regions of mRNAs. The binding causes AUF1 dimers to assemble into higher order tetrameric complexes. Dipho...
    • Diurnally regulated genes with circadian orthologs, organism-specific biosystem (from WikiPathways)
      Diurnally regulated genes with circadian orthologs, organism-specific biosystemHuman genes regulated in the diurnal comparison with orthologues that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regu...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • GABA synthesis, release, reuptake and degradation, organism-specific biosystem (from REACTOME)
      GABA synthesis, release, reuptake and degradation, organism-specific biosystemGABA is a major inhibitory neurotransmitter in the mammalian central nervous system. GABA modulates neuronal excitability throughout the nervous system. Disruption of GABA neurotransmission leads to ...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Golgi Associated Vesicle Biogenesis, organism-specific biosystem (from REACTOME)
      Golgi Associated Vesicle Biogenesis, organism-specific biosystemProteins that have been synthesized, processed and sorted eventually reach the final steps of the secretory pathway. This pathway is responsible not only for proteins that are secreted from the cell ...
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Legionellosis, organism-specific biosystem (from KEGG)
      Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Legionellosis, conserved biosystem (from KEGG)
      Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Lysosome Vesicle Biogenesis, organism-specific biosystem (from REACTOME)
      Lysosome Vesicle Biogenesis, organism-specific biosystemProteins that have been synthesized, processed and sorted eventually reach the final steps of the secretory pathway. This pathway is responsible not only for proteins that are secreted from the cell ...
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Neuronal System, organism-specific biosystem (from REACTOME)
      Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
    • Neurotransmitter Release Cycle, organism-specific biosystem (from REACTOME)
      Neurotransmitter Release Cycle, organism-specific biosystemNeurotransmitter is stored in the synaptic vesicle in the pre-synaptic terminal prior to its release in the synaptic cleft upon depolarization of the pre-synaptic membrane. The release of the neurotr...
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Regulation of mRNA Stability by Proteins that Bind AU-rich Elements, organism-specific biosystem (from REACTOME)
      Regulation of mRNA Stability by Proteins that Bind AU-rich Elements, organism-specific biosystemRNA elements rich in adenine and uracil residues (AU-rich elements) bind specific proteins which either target the RNA for degradation or, more rarely, stabilize the RNA. The activity of the AU-eleme...
    • Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem
      Regulation of nuclear SMAD2/3 signaling
    • Spliceosome, organism-specific biosystem (from KEGG)
      Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, conserved biosystem (from KEGG)
      Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, 35S U5-snRNP, organism-specific biosystem (from KEGG)
      Spliceosome, 35S U5-snRNP, organism-specific biosystemStructural complex; Genetic information processing; Spliceosome
    • Spliceosome, Prp19/CDC5L complex, organism-specific biosystem (from KEGG)
      Spliceosome, Prp19/CDC5L complex, organism-specific biosystemStructural complex; Genetic information processing; Spliceosome
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
      Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...
    • trans-Golgi Network Vesicle Budding, organism-specific biosystem (from REACTOME)
      trans-Golgi Network Vesicle Budding, organism-specific biosystemAfter passing through the Golgi complex, secretory cargo is packaged into post-Golgi transport intermediates (post-Golgi), which translocate plus-end directed along microtubules to the plasma membran...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    ATPase activity, coupled NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    RNA metabolic process TAS
    Traceable Author Statement
    more info
    		  
    cellular membrane organization TAS
    Traceable Author Statement
    more info
    		  
    gene expression TAS
    Traceable Author Statement
    more info
    		  
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    mRNA metabolic process TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    neurotransmitter secretion TAS
    Traceable Author Statement
    more info
    		  
    post-Golgi vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    		  
    protein folding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    response to stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to unfolded protein NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    synaptic transmission TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    clathrin sculpted gamma-aminobutyric acid transport vesicle membrane TAS
    Traceable Author Statement
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    intracellular NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    melanosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    heat shock cognate 71 kDa protein
    Names
    heat shock cognate 71 kDa protein
    LPS-associated protein 1
    heat shock 70kd protein 10
    heat shock cognate protein 54
    constitutive heat shock protein 70
    lipopolysaccharide-associated protein 1
    N-myristoyltransferase inhibitor protein 71
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029473.1 RefSeqGene

      Range
      4944..9645
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_006597.4 → NP_006588.1  heat shock cognate 71 kDa protein isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1).
      Source sequence(s)
      AK222628, AK310467, BC019816
      Consensus CDS
      CCDS8440.1
      UniProtKB/Swiss-Prot
      P11142
      UniProtKB/TrEMBL
      Q53HF2
      Related
      ENSP00000432083, OTTHUMP00000231745, ENST00000534624, OTTHUMT00000387518
      Conserved Domains (1) summary
      PTZ00009
      Location:1 – 612
      Blast Score: 2749
      PTZ00009; heat shock 70 kDa protein; Provisional

    2. NM_153201.2 → NP_694881.1  heat shock cognate 71 kDa protein isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses alternate splice sites, and is missing an exon in the 3' coding region compared to variant 1. However, it maintains the reading frame, and encodes a shorter isoform (2) missing an internal protein segment compared to isoform 1.
      Source sequence(s)
      AK222628, AK310467, BC019816
      Consensus CDS
      CCDS44754.1
      UniProtKB/Swiss-Prot
      P11142
      UniProtKB/TrEMBL
      Q53HF2
      Related
      ENSP00000404372, OTTHUMP00000231746, ENST00000453788, OTTHUMT00000387519
      Conserved Domains (1) summary
      PTZ00009
      Location:1 – 462
      Blast Score: 2089
      PTZ00009; heat shock 70 kDa protein; Provisional

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      122928200..122932844, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      118870278..118874923, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AP000926.6 (35401..40045) None
    genomic CH471065.1 EAW67539.1
      EAW67540.1
      EAW67541.1
      EAW67542.1
    genomic Y00371.1 CAA68445.1
    mRNA AB034951.1 BAB18615.1
    mRNA AB073886.1 None
    mRNA AF217511.1 AAF67622.1
    mRNA AF352832.1 AAK17898.1
    mRNA AK000571.1 BAA91262.1
    mRNA AK096100.1 BAG53212.1
    mRNA AK129885.1 None
    mRNA AK222628.1 BAD96348.1
    mRNA AK222785.1 BAD96505.1
    mRNA AK292067.1 BAF84756.1
    mRNA AK300404.1 BAG62134.1
    mRNA AK303935.1 BAG64863.1
    mRNA AK310467.1 None
    mRNA BC007276.1 AAH07276.2
    mRNA BC008907.2 AAH08907.2
    mRNA BC015699.1 AAH15699.1
    mRNA BC016179.1 AAH16179.1
    mRNA BC016660.1 AAH16660.1
    mRNA BC019816.2 AAH19816.1
    mRNA BC042163.1 None
    other-genetic DQ891145.2 ABM82071.1
    other-genetic DQ894325.2 ABM85251.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P11142.1 GenPept UniProtKB/Swiss-Prot:P11142
    Q53GZ6 GenPept UniProtKB/TrEMBL:Q53GZ6
    Q53HF2 GenPept UniProtKB/TrEMBL:Q53HF2
    Q96BE0 GenPept UniProtKB/TrEMBL:Q96BE0
    Q96H53 GenPept UniProtKB/TrEMBL:Q96H53
    Q96IS6 GenPept UniProtKB/TrEMBL:Q96IS6
    Q9NWW3 GenPept UniProtKB/TrEMBL:Q9NWW3
    Q9NZ87 GenPept UniProtKB/TrEMBL:Q9NZ87
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
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