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VAV1 vav 1 guanine nucleotide exchange factor [ Homo sapiens (human) ]

Gene ID: 7409, updated on 29-Oct-2014
Official Symbol
VAV1provided by HGNC
Official Full Name
vav 1 guanine nucleotide exchange factorprovided by HGNC
Primary source
HGNC:HGNC:12657
See related
Ensembl:ENSG00000141968; HPRD:01284; MIM:164875; Vega:OTTHUMG00000181965
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VAV
Summary
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
See VAV1 in Epigenomics, MapViewer
Location:
19p13.2
Exon count:
27
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (6772668..6857366)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6772679..6857377)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor interactor 10 Neighboring gene SH2 domain containing 3A Neighboring gene egf-like module containing, mucin-like, hormone receptor-like 1 Neighboring gene egf-like module containing, mucin-like, hormone receptor-like 4 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 alone or CD4/gp160 cross-linking induces tyrosine phosphorylation of intracellular substrates p59fyn, zap 70, and p95vav and also leads to ras activation PubMed
Nef nef The association of HIV-1 Nef with Vav1, Pak2, and Nck1 is greatly reduced in SLP76-deficient T cells PubMed
nef Nef-mediated microdomain recruitment of Vav1 is associated with the Nef-p21-activated kinase 2 (PAK2) signalosome. Nef residue F195 is identified as critical for Nef-mediated raft recruitment of Vav1 PubMed
nef The interaction of HIV-1 Nef with Vav is detected by pull-down assays; mutations in the Nef PXXP motif maintain some residual binding capacity to Vav PubMed
nef The C-terminal SH3 domain of Vav binds to the PXXP motif in HIV-1 Nef and this interaction activates Vav and its downstream effectors, leading to morphological changes, cytoskeletal rearrangements, and the activation of the JNK/SAPK cascade PubMed

Go to the HIV-1, Human Interaction Database

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    Downstream signal transduction, organism-specific biosystemThe role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of aro...
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  • FCERI mediated MAPK activation, organism-specific biosystem (from REACTOME)
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  • Fc epsilon RI signaling pathway, organism-specific biosystem (from KEGG)
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  • Fc epsilon RI signaling pathway, conserved biosystem (from KEGG)
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  • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
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  • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
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  • Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem (from Pathway Interaction Database)
    Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem
    Fc-epsilon receptor I signaling in mast cells
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  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
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  • Focal adhesion, conserved biosystem (from KEGG)
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  • G alpha (12/13) signalling events, organism-specific biosystem (from REACTOME)
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  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
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  • GPVI-mediated activation cascade, organism-specific biosystem (from REACTOME)
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  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
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  • IL-5 Signaling Pathway, organism-specific biosystem (from WikiPathways)
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  • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
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  • IL6-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    IL6-mediated signaling events, organism-specific biosystem
    IL6-mediated signaling events
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
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  • Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
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  • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
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  • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
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  • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
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  • PI-3K cascade, organism-specific biosystem (from REACTOME)
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  • PI3K events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
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  • PI3K/AKT Signaling in Cancer, organism-specific biosystem (from REACTOME)
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  • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
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  • Regulation of RAC1 activity, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of RAC1 activity, organism-specific biosystem
    Regulation of RAC1 activity
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    Regulation of RhoA activity, organism-specific biosystem
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    Regulation of actin cytoskeleton, organism-specific biosystem
    Regulation of actin cytoskeleton
  • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
    Regulation of actin cytoskeleton, conserved biosystem
    Regulation of actin cytoskeleton
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  • Signaling by EGFR, organism-specific biosystem (from REACTOME)
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  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
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  • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
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  • Signaling by VEGF, organism-specific biosystem (from REACTOME)
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  • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
    Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
  • Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem
    Signaling events mediated by Stem cell factor receptor (c-Kit)
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
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  • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
    T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
  • T cell receptor signaling pathway, conserved biosystem (from KEGG)
    T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
  • TCR Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TCR Signaling Pathway, organism-specific biosystemThe T-cell antigen receptor (TCR) complex is composed of a ligand-binding subunit, the ? and ? chains, and a signaling subunit, namely the CD3?, ? and ? chains and the TCR? chain. This complex partic...
  • TCR signaling in naive CD4+ T cells, organism-specific biosystem (from Pathway Interaction Database)
    TCR signaling in naive CD4+ T cells, organism-specific biosystem
    TCR signaling in naive CD4+ T cells
  • TCR signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
    TCR signaling in naive CD8+ T cells, organism-specific biosystem
    TCR signaling in naive CD8+ T cells
  • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
    VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
  • VEGFR2 mediated vascular permeability, organism-specific biosystem (from REACTOME)
    VEGFR2 mediated vascular permeability, organism-specific biosystemThe free radical nitric oxide (NO), produced by endothelial NO synthase (eNOS), is an important vasoactive substance in normal vascular biology and pathophysiology. It plays an important role in vasc...
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
    p75 NTR receptor-mediated signalling, organism-specific biosystemBesides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rac guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
guanyl-nucleotide exchange factor activity EXP
Inferred from Experiment
more info
 
guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
T cell activation IEA
Inferred from Electronic Annotation
more info
 
T cell costimulation TAS
Traceable Author Statement
more info
 
apoptotic signaling pathway TAS
Traceable Author Statement
more info
 
blood coagulation TAS
Traceable Author Statement
more info
 
epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
innate immune response TAS
Traceable Author Statement
more info
 
integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
neurotrophin TRK receptor signaling pathway TAS
Traceable Author Statement
more info
 
neutrophil chemotaxis IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-mediated signaling TAS
Traceable Author Statement
more info
 
platelet activation TAS
Traceable Author Statement
more info
 
positive regulation of Rac GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process TAS
Traceable Author Statement
more info
 
positive regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 
reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of Rac GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
proto-oncogene vav
Names
proto-oncogene vav
vav 1 oncogene

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258206.1NP_001245135.1  proto-oncogene vav isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK225710, AW105491, BC013361, DC408645
    Consensus CDS
    CCDS59341.1
    UniProtKB/TrEMBL
    Q96D37
    Related
    ENSP00000302269, OTTHUMP00000267988, ENST00000304076, OTTHUMT00000458474
    Conserved Domains (7) summary
    cd10405
    Location:643745
    SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
    cd11976
    Location:764817
    SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
    cd00029
    Location:516563
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:195371
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:385508
    PH_Vav; Vav pleckstrin homology (PH) domain
    cl00030
    Location:18102
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl17036
    Location:596639
    SH3; Src Homology 3 domain superfamily
  2. NM_001258207.1NP_001245136.1  proto-oncogene vav isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AK301128, AW105491, BC013361, DC408645
    Consensus CDS
    CCDS59342.1
    UniProtKB/Swiss-Prot
    P15498
    UniProtKB/TrEMBL
    Q96D37
    Related
    ENSP00000469450, OTTHUMP00000267990, ENST00000596764, OTTHUMT00000458476
    Conserved Domains (7) summary
    cd10405
    Location:633735
    SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
    cd11976
    Location:754807
    SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
    cd11979
    Location:564626
    SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
    cd00029
    Location:484531
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:187339
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:353476
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam11971
    Location:18102
    CAMSAP_CH; CAMSAP CH domain
  3. NM_005428.3NP_005419.2  proto-oncogene vav isoform 1

    See proteins identical to NP_005419.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK313307, AW105491, BC013361, DC408645
    Consensus CDS
    CCDS12174.1
    UniProtKB/TrEMBL
    B2R8B5
    UniProtKB/Swiss-Prot
    P15498
    UniProtKB/TrEMBL
    Q96D37
    Related
    ENSP00000472929, OTTHUMP00000267989, ENST00000602142, OTTHUMT00000458475
    Conserved Domains (7) summary
    cd10405
    Location:665767
    SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
    cd11976
    Location:786839
    SH3_VAV1_2; C-terminal (or second) Src homology 3 domain of VAV1 protein
    cd11979
    Location:596658
    SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
    cd00029
    Location:516563
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:195371
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:385508
    PH_Vav; Vav pleckstrin homology (PH) domain
    cl00030
    Location:18102
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    6772668..6857366
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259642.1XP_005259699.1  

    Conserved Domains (6) summary
    cd11979
    Location:596658
    SH3_VAV1_1; First Src homology 3 domain of VAV1 protein
    cd00029
    Location:516563
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd00160
    Location:195371
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:385508
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam11971
    Location:18102
    CAMSAP_CH; CAMSAP CH domain
    cl15255
    Location:665739
    SH2; Src homology 2 (SH2) domain

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    6535153..6619808
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    6772530..6857195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)