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    VAV1 vav 1 guanine nucleotide exchange factor [ Homo sapiens ]

    Gene ID: 7409, updated on 21-Jan-2012
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    Summary

    Official Symbol
    VAV1provided by HGNC
    Official Full Name
    vav 1 guanine nucleotide exchange factorprovided by HGNC
    Primary source
    HGNC:12657
    See related
    Ensembl:ENSG00000141968; HPRD:01284; MIM:164875
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    VAV
    Summary
    The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    19p13.2
    Sequence :
    Chromosome: 19; NC_000019.9 (6772722..6857371)
    See VAV1 in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor interactor 10 Neighboring gene SH2 domain containing 3A Neighboring gene egf-like module containing, mucin-like, hormone receptor-like 1 Neighboring gene egf-like module containing, mucin-like, hormone receptor-like 4 pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The p.Arg63Trp polymorphism controls Vav1 functions and Foxp3 regulatory T cell development. Colacios C, et al. J Exp Med, 2011 Oct 24. PMID 21948080.
    2. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    3. EHD2 mediates trafficking from the plasma membrane by modulating Rac1 activity. Benjamin S, et al. Biochem J, 2011 Nov 1. PMID 21756249.
    4. Vav1 is a crucial molecule in monocytic/macrophagic differentiation of myeloid leukemia-derived cells. Bertagnolo V, et al. Cell Tissue Res, 2011 Jul. PMID 21647562.
    5. Integration of activating and inhibitory receptor signaling by regulated phosphorylation of Vav1 in immune cells. Mesecke S, et al. Sci Signal, 2011 May 31. PMID 21632469.

    See all (165) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data reveal a key role for Vav1-dependent T cell antigen receptor signaling in Foxp3 natural T(reg) cell development.
      Title: The p.Arg63Trp polymorphism controls Vav1 functions and Foxp3 regulatory T cell development.
    2. EHD2 associates in the plasma membrane with Vav1, a Nek3-regulated GEF (guanine-nucleotide-exchange factor) for Rho GTPases.
      Title: EHD2 mediates trafficking from the plasma membrane by modulating Rac1 activity.
    3. In tumoral promyelocytes, Vav1 is a component of lineage-specific transduction machineries that can be recruited by various differentiating agents.
      Title: Vav1 is a crucial molecule in monocytic/macrophagic differentiation of myeloid leukemia-derived cells.
    4. The integration of activating and inhibitory receptor signaling by regulated phosphorylation of Vav1 in NK cells.
      Title: Integration of activating and inhibitory receptor signaling by regulated phosphorylation of Vav1 in immune cells.
    5. CDC25A, VAV1, TP73, BRCA1 and ZAP70 may be novel markers for predicting the effectiveness of radiotherapy in CRC patients.
      Title: CDC25A, VAV1, TP73, BRCA1 and ZAP70 gene overexpression correlates with radiation response in colorectal cancer.
    6. Vav1-mediated scaffolding interactions stabilize SLP-76 microclusters and contribute to antigen-dependent T cell responses.
      Title: Vav1-mediated scaffolding interactions stabilize SLP-76 microclusters and contribute to antigen-dependent T cell responses.
    7. LFA-1-induced stabilization of ARE-containing mRNAs in T cells is dependent on HuR, and occurs through the Vav-1, Rac1/2, MKK3 and p38MAPK signaling cascade
      Title: T cell LFA-1 engagement induces HuR-dependent cytokine mRNA stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 signaling cascade.
    8. VAV1 protects Jurkat cells from apoptosis by promoting Bcl-2 transcription through its guanine nucleotide exchange factor activity.
      Title: The distinct role of guanine nucleotide exchange factor Vav1 in Bcl-2 transcription and apoptosis inhibition in Jurkat leukemia T cells.
    9. Vav-1 expression may be associated with activated B-cell DLBCL origin and higher proliferative activity, and indicate Vav-1 as a potential marker to identify tumours likely to respond to CD40-targeted therapies.
      Title: Vav-1 expression correlates with NFκB activation and CD40-mediated cell death in diffuse large B-cell lymphoma cell lines.
    10. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    Submit: New GeneRIF Correction See all (64)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 alone or CD4/gp160 cross-linking induces tyrosine phosphorylation of intracellular substrates p59fyn, zap 70, and p95vav and also leads to ras activation PubMed
    Nef nef The C-terminal SH3 domain of Vav binds to the PXXP motif in HIV-1 Nef and this interaction activates Vav and its downstream effectors, leading to morphological changes, cytoskeletal rearrangements, and the activation of the JNK/SAPK cascade PubMed
    nef The interaction of HIV-1 Nef with Vav is detected by pull-down assays; mutations in the Nef PXXP motif maintain some residual binding capacity to Vav PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_005419.2 DNM2    BIND  PubMed An unspecified isoform of Dyn2 interacts with Vav1. 
    NP_005419.2 NP_002077.1 GRB2    BIND  PubMed Grb2 interacts with Vav 
    NP_005419.2 NP_002175.2 IL6ST    BIND  PubMed Vav interacts with gp130. 
    NP_005419.2 NP_002736.2 MAPK1    BIND  PubMed Vav interacts with ERK2. 
    NP_005419.2 NP_006248.1 PRKCQ    BIND  PubMed PRKCQ (PKC-theta) interacts with VAV1. This interaction was modelled on a demonstrated interaction between human PRKCQ and VAV1 from an unspecified species. 
    NP_005419.2 NP_003736.1 SOCS1    BIND  PubMed Socs1 interacts with Vav. This interaction was modeled on a demonstrated interaction between mouse Socs1 and Vav. 
    NP_005419.2     BIND  PubMed Vav1 interacts with EZH2-SUZ12-EED complex. 
    P15498 P68133 ACTA1    HPRD  PubMed  
    P15498 Q16853 AOC3    HPRD  PubMed  
    P15498 P52565 ARHGDIA    HPRD  PubMed  
    P15498 P52566 ARHGDIB    HPRD  PubMed  
    P15498 P11274 BCR    HPRD  PubMed  
    P15498 Q8WV28 BLNK    HPRD  PubMed  
    P15498 Q06187 BTK    HPRD  PubMed  
    P15498 P42574 CASP3    HPRD  PubMed  
    P15498 P22681 CBL    HPRD  PubMed  
    P15498 Q13191 CBLB    HPRD  PubMed  
    P15498 P15391 CD19    HPRD  PubMed  
    P15498 P60953 CDC42    HPRD  PubMed  
    P15498 P46108 CRK    HPRD  PubMed  
    P15498 P61073 CXCR4    HPRD  PubMed  
    P15498 P50570 DNM2    HPRD  PubMed  
    P15498 Q92608 DOCK2    HPRD  PubMed  
    P15498 P00533 EGFR    HPRD  PubMed  
    P15498 P19235 EPOR    HPRD  PubMed  
    P15498 Q15910 EZH2    HPRD  PubMed  
    P15498 P06241 FYN    HPRD  PubMed  
    P15498 P62993 GRB2    HPRD  PubMed  
    P15498 P08631 HCK    HPRD  PubMed  
    P15498 P61978 HNRNPK    HPRD  PubMed  
    P15498 P01112 HRAS    HPRD  PubMed  
    P15498 P40189 IL6ST    HPRD  PubMed  
    P15498 P06213 INSR    HPRD  PubMed  
    P15498 O60674 JAK2    HPRD  PubMed  
    P15498 O43561 LAT    HPRD  PubMed  
    P15498 P06239 LCK    HPRD  PubMed  
    P15498 Q13094 LCP2    HPRD  PubMed  
    P15498 P28482 MAPK1    HPRD  PubMed  
    P15498 Q12866 MERTK    HPRD  PubMed  
    P15498 P08581 MET    HPRD  PubMed  
    P15498 P51956 NEK3    HPRD  PubMed  
    P15498 Q9NWQ8 PAG1    HPRD  PubMed  
    P15498 P19174 PLCG1    HPRD  PubMed  
    P15498 Q04759 PRKCQ    HPRD  PubMed  
    P15498 P16471 PRLR    HPRD  PubMed  
    P15498 Q14289 PTK2B    HPRD  PubMed  
    P15498 Q9Y2R2 PTPN22    HPRD  PubMed  
    P15498 P29350 PTPN6    HPRD  PubMed  
    P15498 P63000 RAC1    HPRD  PubMed  
    P15498 Q9H0H5 RACGAP1    HPRD  PubMed  
    P15498 P04049 RAF1    HPRD  PubMed  
    P15498 P61586 RHOA    HPRD  PubMed  
    P15498 P84095 RHOG    HPRD  PubMed  
    P15498 P78314 SH3BP2    HPRD  PubMed  
    P15498 Q15464 SHB    HPRD  PubMed  
    P15498 P29353 SHC1    HPRD  PubMed  
    P15498 O43255 SIAH2    HPRD  PubMed  
    P15498 Q13239 SLA    HPRD  PubMed  
    P15498 O15524 SOCS1    HPRD  PubMed  
    P15498 P43405 SYK    HPRD  PubMed  
    P15498 P42680 TEC    HPRD  PubMed  
    P15498 P68366 TUBA4A    HPRD  PubMed  
    P15498 P07437 TUBB    HPRD  PubMed  
    P15498 P29597 TYK2    HPRD  PubMed  
    P15498 P13010 XRCC5    HPRD  PubMed  
    P15498 P12956 XRCC6    HPRD  PubMed  
    P15498 P43403 ZAP70    HPRD  PubMed  
    P15498 Q8N720 ZNF655    HPRD  PubMed  
    P15498 Q15942 ZYX    HPRD  PubMed  
    BioGRID:113252 BioGRID:106543 ABL1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:113252 BioGRID:106890 ARHGDIB    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113252 BioGRID:118894 BLNK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113252 BioGRID:107160 BTK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113252 BioGRID:107315 CBL    BioGRID  PubMed Affinity Capture-Western; Far Western; Reconstituted Complex 
    BioGRID:113252 BioGRID:107316 CBLB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113252 BioGRID:107368 CD19    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113252 BioGRID:107433 CDC42    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113252 BioGRID:108129 DOCK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113252 BioGRID:114265 EED    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113252 BioGRID:108276 EGFR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113252 BioGRID:108325 EMD    BioGRID  PubMed Two-hybrid 
    BioGRID:113252 BioGRID:108371 EPOR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113252 BioGRID:108446 EZH2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113252 BioGRID:108499 FCER1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113252 BioGRID:108810 FYN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113252 BioGRID:109142 GRB2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113252 BioGRID:109431 HNRNPK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113252 BioGRID:109786 IL6ST    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113252 BioGRID:109854 INSR    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113252 BioGRID:109920 JAK2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113252 BioGRID:109928 JUN    BioGRID  PubMed Biochemical Activity 
    BioGRID:113252 BioGRID:117971 LAT    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113252 BioGRID:110129 LCP2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113252 BioGRID:111590 MAP2K1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113252 BioGRID:111580 MAPK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113252 BioGRID:120931 PAG1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113252 BioGRID:111185 PDGFRB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113252 BioGRID:119734 PHAX    BioGRID  PubMed Two-hybrid 
    BioGRID:113252 BioGRID:111313 PIK3R1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113252 BioGRID:111351 PLCG1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113252 BioGRID:111352 PLCG2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113252 BioGRID:111574 PRKCQ    BioGRID  PubMed Affinity Capture-Western; Phenotypic Enhancement 
    BioGRID:113252 BioGRID:111603 PRLR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113252 BioGRID:108480 PTK2B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113252 BioGRID:111742 PTPN6    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113252 BioGRID:111817 RAC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113252 BioGRID:118892 RACGAP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113252 BioGRID:111831 RAF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113252 BioGRID:112193 S100B    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113252 BioGRID:112350 SH3BP2    BioGRID  PubMed Affinity Capture-Western; Far Western 
    BioGRID:113252 BioGRID:112358 SHB    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113252 BioGRID:112372 SIAH1    BioGRID  PubMed Two-hybrid 
    BioGRID:113252 BioGRID:112373 SIAH2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113252 BioGRID:112394 SLA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113252 BioGRID:114203 SOCS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113252 BioGRID:117059 SUZ12    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113252 BioGRID:112717 SYK    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:113252 BioGRID:112865 TEC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113252 BioGRID:113603 TUBA1A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113252 BioGRID:128444 TUBB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113252 BioGRID:113148 TYK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113252 BioGRID:113353 XRCC5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113252 BioGRID:108822 XRCC6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113252 BioGRID:113367 ZAP70    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • B cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      B cell receptor signaling pathway, organism-specific biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • B cell receptor signaling pathway, conserved biosystem (from KEGG)
      B cell receptor signaling pathway, conserved biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • CD28 co-stimulation, organism-specific biosystem (from REACTOME)
      CD28 co-stimulation, organism-specific biosystemIn naive T cells, CD28 costimulation enhances cell cycle entry, potently stimulates expression of both the mitogenic lymphokine interleukin-2 (IL-2) and its receptor, and stimulates the activation o...
    • CD28 dependent Vav1 pathway, organism-specific biosystem (from REACTOME)
      CD28 dependent Vav1 pathway, organism-specific biosystemCD28 binds to several intracellular proteins including PI3 kinase, Grb-2, Gads and ITK. Grb-2 specifically co-operates with Vav-1 in the up-regulation of NFAT/AP-1 transcription. CD28 costimulation r...
    • CXCR4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CXCR4-mediated signaling events, organism-specific biosystem
      CXCR4-mediated signaling events
    • Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem (from REACTOME)
      Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystemp75NTR is a key regulator of neuronal apoptosis, both during development and after injury. Apoptosis is triggered by binding of either mature neurotrophin or proneurotrophin (proNGF, proBDNF). ProNG...
    • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, conserved biosystem (from KEGG)
      Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Class I PI3K signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Class I PI3K signaling events, organism-specific biosystem
      Class I PI3K signaling events
    • Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
      Costimulation by the CD28 family, organism-specific biosystemOptimal activation of T-lymphocytes requires at least two signals. A primary one is delivered by the T-cell receptor (TCR) complex after antigen recognition and additional costimulatory signals are d...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Fc epsilon RI signaling pathway, organism-specific biosystem (from KEGG)
      Fc epsilon RI signaling pathway, organism-specific biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
    • Fc epsilon RI signaling pathway, conserved biosystem (from KEGG)
      Fc epsilon RI signaling pathway, conserved biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
    • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem (from Pathway Interaction Database)
      Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem
      Fc-epsilon receptor I signaling in mast cells
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • G alpha (12/13) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (12/13) signalling events, organism-specific biosystemThe G12/13 family is probably the least well characterized subtype, partly because G12/13 coupling is difficult to determine when compared with the other subtypes which predominantly rely on assay te...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPVI-mediated activation cascade, organism-specific biosystem (from REACTOME)
      GPVI-mediated activation cascade, organism-specific biosystemThe GPVI receptor is a complex of the GPVI protein with Fc epsilon R1 gamma (FcR). The Src family kinases Fyn and Lyn constitutively associate with the GPVI-FcR complex in platelets and initiate plat...
    • GPVI-mediated activation cascade, organism-specific biosystem (from REACTOME)
      GPVI-mediated activation cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • IL-2 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-2 Signaling Pathway, organism-specific biosystemInterleukin-2 belongs to a family of cytokines, which includes IL-4, IL-7, IL-9, IL-15 and IL-21. IL-2 signals through a receptor complex consisting of IL-2 specific IL-2 receptor alpha (CD25), IL-2 ...
    • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
    • IL-5 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-5 Signaling Pathway, organism-specific biosystemInterleukin-5 belongs to the family of cytokines, which includes IL-3 and GM-CSF. It signals through a receptor complex comprising of an IL-5 receptor alpha subunit (IL5RA), and a common beta chain w...
    • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-6 Signaling Pathway, organism-specific biosystemInterleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M...
    • IL6-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL6-mediated signaling events, organism-specific biosystem
      IL6-mediated signaling events
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystem (from REACTOME)
      Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystemThe Interleukin-3 (IL-3), IL-5 and Granulocyte-macrophage colony stimulating factor (GM-CSF) receptors form a family of heterodimeric receptors that have specific alpha chains but share a common beta...
    • Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Kit Receptor Signaling Pathway, organism-specific biosystemKit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets...
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • NRAGE signals death through JNK, organism-specific biosystem (from REACTOME)
      NRAGE signals death through JNK, organism-specific biosystemOnce bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pr...
    • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
      Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
    • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
      Platelet activation, signaling and aggregation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
      Regulation of Actin Cytoskeleton, organism-specific biosystem
      Regulation of Actin Cytoskeleton
    • Regulation of RAC1 activity, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of RAC1 activity, organism-specific biosystem
      Regulation of RAC1 activity
    • Regulation of RhoA activity, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of RhoA activity, organism-specific biosystem
      Regulation of RhoA activity
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton
    • Regulation of signaling by CBL, organism-specific biosystem (from REACTOME)
      Regulation of signaling by CBL, organism-specific biosystemCbl is an E3 ubiquitin-protein ligase that negatively regulates signaling pathways by targeting proteins for ubiquitination and proteasomal degradation (Rao et al. 2002). Cbl negatively regulates PI3...
    • Rho GTPase cycle, organism-specific biosystem (from REACTOME)
      Rho GTPase cycle, organism-specific biosystemThe cycling of Rho GTPases is tightly controlled by three classes of protein. These are (1) guanine nucleotide dissociation inhibitors or GDIs, which maintain Rho proteins in an inactive state in the...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
      Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
    • Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by Stem cell factor receptor (c-Kit), organism-specific biosystem
      Signaling events mediated by Stem cell factor receptor (c-Kit)
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • T Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      T Cell Receptor Signaling Pathway, organism-specific biosystem
      T Cell Receptor Signaling Pathway
    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
      T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • TCR signaling in naive CD4+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD4+ T cells, organism-specific biosystem
      TCR signaling in naive CD4+ T cells
    • TCR signaling in naive CD8+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD8+ T cells, organism-specific biosystem
      TCR signaling in naive CD8+ T cells
    • p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
      p75 NTR receptor-mediated signalling, organism-specific biosystemBesides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a ...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Rac guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    sequence-specific DNA binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    T cell activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    T cell costimulation TAS
    Traceable Author Statement
    more info
    		  
    apoptotic process TAS
    Traceable Author Statement
    more info
    		  
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    induction of apoptosis by extracellular signals TAS
    Traceable Author Statement
    more info
    		  
    integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    nerve growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    platelet activation TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		  
    regulation of transcription, DNA-dependent TAS
    Traceable Author Statement
    more info
    		 PubMed 
    small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    proto-oncogene vav
    Names
    proto-oncogene vav
    oncogene vav
    vav 1 oncogene
    vav proto-oncogene
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005428.2 → NP_005419.2  proto-oncogene vav

      Status: REVIEWED

      Source sequence(s)
      AH006196
      Consensus CDS
      CCDS12174.1
      UniProtKB/Swiss-Prot
      P15498
      Related
      ENSP00000302269, ENST00000304076
      Conserved Domains (6) summary
      cd00014
      Location:2 – 116
      Blast Score: 112
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00029
      Location:516 – 563
      Blast Score: 129
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:195 – 352
      Blast Score: 331
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00174
      Location:786 – 839
      Blast Score: 177
      SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...
      cd10405
      Location:665 – 767
      Blast Score: 543
      SH2_Vav1; Src homology 2 (SH2) domain found in the Vav1 proteins
      cl00273
      Location:400 – 508
      Blast Score: 310
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      6772722..6857371
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      6535196..6619802
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC010647.5 (4113..40101) None
    genomic AC020895.8 (5947..16657) None
    genomic AC020954.8 (23072..39854) None
    genomic AC022156.8 (12764..33930) None
    genomic AF030201.1 AAC25011.1
    genomic AF030202.1 AAC25011.1
    genomic AF030203.1 AAC25011.1
    genomic AF030204.1 AAC25011.1
    genomic AF030205.1 AAC25011.1
    genomic AF030206.1 AAC25011.1
    genomic AF030207.1 AAC25011.1
    genomic AF030208.1 AAC25011.1
    genomic AF030209.1 AAC25011.1
    genomic AF030210.1 AAC25011.1
    genomic AF030211.1 AAC25011.1
    genomic AF030212.1 AAC25011.1
    genomic AF030213.1 AAC25011.1
    genomic AF030214.1 AAC25011.1
    genomic AF030215.1 AAC25011.1
    genomic AF030216.1 AAC25011.1
    genomic AF030217.1 AAC25011.1
    genomic AF030218.1 AAC25011.1
    genomic AF030219.1 AAC25011.1
    genomic AF030220.1 AAC25011.1
    genomic AF030221.1 AAC25011.1
    genomic AF030222.1 AAC25011.1
    genomic AF030223.1 AAC25011.1
    genomic AF030224.1 AAC25011.1
    genomic AF030225.1 AAC25011.1
    genomic AF030226.1 AAC25011.1
    genomic AF030227.1 AAC25011.1
    genomic AF216848.1 None
    genomic AF216849.1 None
    genomic AF216850.1 None
    genomic AF216851.1 None
    genomic CH471139.2 EAW69057.1
      EAW69058.1
    genomic M59834.1 AAA63267.1
    mRNA AK225710.1 None
    mRNA AK301128.1 BAG62721.1
    mRNA AK313307.1 BAG36112.1
    mRNA BC013361.2 AAH13361.2
    mRNA X16316.1 CAA34383.1
    mRNA X83931.1 CAA58783.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    P15498.4 GenPept UniProtKB/Swiss-Prot:P15498
    Q96D37 GenPept UniProtKB/TrEMBL:Q96D37
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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