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SRP72 signal recognition particle 72kDa [ Homo sapiens (human) ]

Gene ID: 6731, updated on 8-May-2016
Official Symbol
SRP72provided by HGNC
Official Full Name
signal recognition particle 72kDaprovided by HGNC
Primary source
HGNC:HGNC:11303
See related
Ensembl:ENSG00000174780 HPRD:03671; MIM:602122
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BMFF; BMFS1; HEL103
Summary
This gene encodes the 72 kDa subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the targeting of secretory proteins to the endoplasmic reticulum (ER). The SRP complex consists of a 7S RNA and 6 protein subunits: SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72, that are bound to the 7S RNA as monomers or heterodimers. SRP has at least 3 distinct functions that can be associated with the protein subunits: signal recognition, translational arrest, and ER membrane targeting by interaction with the docking protein. Mutations in this gene are associated with familial bone marrow failure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
Orthologs
Location:
4q11
Exon count:
20
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (56467596..56503681)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (57333370..57369847)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100506514 Neighboring gene phosphoribosyl pyrophosphate amidotransferase Neighboring gene phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase Neighboring gene uncharacterized LOC105377665 Neighboring gene ADP ribosylation factor like GTPase 9 Neighboring gene theg spermatid protein-like Neighboring gene glycine dehydrogenase (decarboxylase) pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Bone marrow failure, familial
MedGen: C3808553 OMIM: 614675 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify signal recognition particle 72kDa protein (SRP72), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify signal recognition particle 72kDa protein (SRP72), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify signal recognition particle 72kDa protein (SRP72), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify signal recognition particle 72kDa protein (SRP72), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human signal recognition particle 72kDa (SRP72) at amino acid residues 519-520 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Protein export, organism-specific biosystem (from KEGG)
    Protein export, organism-specific biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
  • Protein export, conserved biosystem (from KEGG)
    Protein export, conserved biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
  • SRP-dependent cotranslational protein targeting to membrane, organism-specific biosystem (from REACTOME)
    SRP-dependent cotranslational protein targeting to membrane, organism-specific biosystemThe process for translation of a protein destined for the endoplasmic reticulum (ER) branches from the canonical cytoslic translation process at the point when a nascent polypeptide containing a hydr...
  • Translation, organism-specific biosystem (from REACTOME)
    Translation, organism-specific biosystemProtein synthesis is accomplished through the process of translation of an mRNA sequence into a polypeptide chain. This process can be divided into three distinct stages: initiation, elongation and ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
7S RNA binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signal recognition particle binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
response to drug IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
signal recognition particle, endoplasmic reticulum targeting IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
signal recognition particle subunit SRP72
Names
epididymis luminal protein 103
signal recognition particle 72 kDa protein
signal recognition particle 72kD

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032796.1 RefSeqGene

    Range
    5001..41086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267722.1NP_001254651.1  signal recognition particle subunit SRP72 isoform 2

    See identical proteins and their annotated locations for NP_001254651.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks 2 consecutive in-frame coding exons in the 5' region compared to variant 1, which results in a shorter isoform (2) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AF069765, AK023480, BM985263, BM985419, BX537991, DB487204
    Consensus CDS
    CCDS58898.1
    UniProtKB/Swiss-Prot
    O76094
    Related
    ENSP00000424576, OTTHUMP00000218925, ENST00000510663, OTTHUMT00000362152
    Conserved Domains (4) summary
    cd05804
    Location:23209
    StaR_like; StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been ...
    pfam08492
    Location:465523
    SRP72; SRP72 RNA-binding domain
    pfam12895
    Location:57135
    Apc3; Anaphase-promoting complex, cyclosome, subunit 3
    sd00006
    Location:4474
    TPR; TPR repeat [structural motif]
  2. NM_006947.3NP_008878.3  signal recognition particle subunit SRP72 isoform 1

    See identical proteins and their annotated locations for NP_008878.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1).
    Source sequence(s)
    AC114766, AF069765, BM985419, BX537991, CN270014, DB487204
    Consensus CDS
    CCDS3506.1
    UniProtKB/Swiss-Prot
    O76094
    UniProtKB/TrEMBL
    V9HWK0
    Related
    ENSP00000342181, OTTHUMP00000159063, ENST00000342756, OTTHUMT00000250782
    Conserved Domains (6) summary
    cd05804
    Location:23209
    StaR_like; StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been ...
    pfam00515
    Location:226259
    TPR_1; Tetratricopeptide repeat
    pfam08492
    Location:526584
    SRP72; SRP72 RNA-binding domain
    pfam12895
    Location:57135
    Apc3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13424
    Location:180255
    TPR_12; Tetratricopeptide repeat
    sd00006
    Location:176204
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

    Range
    56467596..56503681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005265765.3XP_005265822.2  

    Conserved Domains (5) summary
    cd05804
    Location:23209
    StaR_like; StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been ...
    pfam12895
    Location:57135
    Apc3; Anaphase-promoting complex, cyclosome, subunit 3
    pfam13424
    Location:180255
    TPR_12; Tetratricopeptide repeat
    sd00006
    Location:176204
    TPR; TPR repeat [structural motif]
    sd00004
    Location:341367
    PPR; PPR repeat [structural motif]

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 Alternate CHM1_1.1

    Range
    57368898..57404983
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)