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    GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 [ Homo sapiens (human) ]

    Gene ID: 10399, updated on 14-May-2013
    Official Symbol
    GNB2L1provided by HGNC
    Official Full Name
    guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1provided by HGNC
    Primary source
    HGNC:4399
    Locus tag
    HLC7
    See related
    Ensembl:ENSG00000204628; HPRD:01503; MIM:176981; Vega:OTTHUMG00000163380
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H12.3; HLC-7; PIG21; RACK1; Gnb2-rs1
    Location :
    5q35.3
    Sequence :
    Chromosome: 5; NC_000005.9 (180663928..180670906, complement)
    See GNB2L1 in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene microRNA 4638 Neighboring gene tripartite motif containing 41 Neighboring gene small nucleolar RNA, C/D box 96A Neighboring gene small nucleolar RNA, C/D box 95 Neighboring gene tripartite motif containing 52 Neighboring gene uncharacterized LOC100507602

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation. Xu Y, et al. Cell Rep, 2012 Dec 27. PMID 23246001.
    2. RACK1 identified as the PCBP1-interacting protein with a novel functional role on the regulation of human MOR gene expression. Nahar-Gohad P, et al. J Neurochem, 2013 Feb. PMID 23173782.
    3. Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6. Evsyukova I, et al. RNA, 2013 Jan. PMID 23151878.
    4. Localization and identification of sumoylated proteins in human sperm: excessive sumoylation is a marker of defective spermatozoa. Vigodner M, et al. Hum Reprod, 2013 Jan. PMID 23077236.
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, et al. Nat Cell Biol, 2012 Oct. PMID 23000965.

    See all (209) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. this study reports a novel role of RACK1, physically interacting with PCBP1 and participating in the regulation of human MOR gene expression in neuronal NMB cells.
      Title: RACK1 identified as the PCBP1-interacting protein with a novel functional role on the regulation of human MOR gene expression.
    2. Overexpressed RACK1 augments JNK activity and thereby promotes hepatocellular carcinoma growth through directly binding to MKK7 and enhancing MKK7 activity.
      Title: Receptor for activated C kinase 1 promotes hepatocellular carcinoma growth by enhancing mitogen-activated protein kinase kinase 7 activity.
    3. crystal structure of human receptor for activated C-kinase 1 (hRack1) protein is reported at 2.45 A resolution
      Title: Structure of human Rack1 protein at a resolution of 2.45 Å.
    4. our data demonstrate that the transmembrane receptor Trop-2 is a regulator of PrCa cell adhesion to fibronectin through activation of the beta(1) integrin-RACK1-FAK-Src signaling axis
      Title: Trop-2 inhibits prostate cancer cell adhesion to fibronectin through the β1 integrin-RACK1 axis.
    5. Rack1 is a Slo binding partner, the cell surface expression of which is upregulated by protein kinase C activation.
      Title: Hair cell BK channels interact with RACK1, and PKC increases its expression on the cell surface by indirect phosphorylation.
    6. integrin alphaLbeta2 engagement by its ligand ICAM-1 promotes the association of kindlin-3 with RACK1
      Title: Kindlin-3 mediates integrin αLβ2 outside-in signaling, and it interacts with scaffold protein receptor for activated-C kinase 1 (RACK1).
    7. RACK1 may function as an internal factor involved in the growth and survival of hepatocellular carcinoma
      Title: Ribosomal RACK1 promotes chemoresistance and growth in human hepatocellular carcinoma.
    8. Depletion of the M1-binding protein RACK1 also impairs virus release and RACK1 binding requires the proline residue at position 16 of M1.
      Title: Interaction of influenza A virus matrix protein with RACK1 is required for virus release.
    9. EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex
      Title: EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex.
    10. RACK1 was expressed in the neuroblastoma cells and positively regulated cell migration and proliferation probably via modulating the activation of Src on Tyr416 residue.
      Title: RACK1 downregulation suppresses migration and proliferation of neuroblastoma cell lines.
    Submit: New GeneRIF Correction See all (99)

    Review eQTL and phenotype association data in this region using PheGenI

    Protein Gene Interaction Pubs
    Nef, p27 nef The binding of HIV-1 Nef with Rack1 (receptor for activated C kinase 1) is mediated by amino acids 34-143 in Nef; Rack1 acts as a Nef intracellular docking site, bringing Nef and PKCs together PubMed
    Rev, p19 rev HIV-1 Rev interacting protein, guanine nucleotide binding protein, beta polypeptide 2-like 1 (GNB2L1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
    matrix gag Exposure of human acute monocytic leukemia cells THP-1 to HIV-1 MA activates the syndecan-2/RACK-1/Jak-1 signal pathway, leading to STAT-1 phosphorylation PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    NP_006089.1 NP_003905.1 CCNA1    BIND  PubMed Cyclin A1 interacts with RACK1. 
    NP_006089.1 NP_002203.1 EIF6    BIND  PubMed eIF6 interacts with RACK1 
    NP_006089.1 NP_000112.1 EPOR    BIND  PubMed EPOR interacts with RACK-1. This interaction was modelled on a demonstrated interaction between EPOR from an unspecified species and human RACK-1. 
    NP_006089.1 NP_004801.1 GRAP2    BIND  PubMed GRAP2 (GRID) interacts with GNB2L1 (RACK-1). 
    NP_006089.1 NP_055097.1 HABP4    BIND  PubMed HABP4 (Ki-1/57) interacts with GNB2L1 (RACK1). 
    NP_006089.1 NP_997468.1 IFNAR2    BIND  PubMed IFNR-beta-L interacts with RACK-1. 
    NP_006089.1 NP_000866.1 IGF1R    BIND  PubMed IGF-IR interacts with RACK1. 
    NP_006089.1 NP_000869.1 IL2RB    BIND  PubMed IL-2R-beta interacts with RACK-1. 
    NP_006089.1 NP_000409.1 IL4R    BIND  PubMed IL-4R-alpha interacts with RACK-1. This interaction was modelled on a demonstrated interaction between IL-4R-alpha from an unspecified species and human RACK-1. 
    NP_006089.1 ITGB1    BIND  PubMed beta-1 integrin interacts with RACK1. 
    NP_006089.1 ITGB1    BIND  PubMed An unspecified isoform of integrin-beta-1 interacts with RACK1. 
    NP_006089.1 NP_002218.1 JAK1    BIND  PubMed RACK-1 interacts with Jak1. 
    NP_006089.1 NP_003571.2 NSMAF    BIND  PubMed FAN interacts with RACK1. 
    NP_006089.1 AAC00069.1 PDE4D    BIND  PubMed RACK1 interacts with PDE4D5. 
    NP_006089.1 NP_006245.2 PRKCD    BIND  PubMed PKC-delta interacts with RACK1. 
    NP_006089.1 NP_002733.1 PRKD1    BIND  PubMed PKC-mu interacts with RACK1. 
    NP_006089.1 NP_002881.1 RASA1    BIND  PubMed RACK1 interacts with p120GAP.This interaction was modeled on a demonstrated interaction between RACK1 from mouse and rat, and human p120GAP. 
    NP_006089.1 NP_000312.1 RB1    BIND  PubMed RACK1 interacts with Rb 
    NP_006089.1 NP_001035.1 SLC6A3    BIND  PubMed DAT interacts with RACK1. 
    NP_006089.1 NP_009330.1 STAT1    BIND  PubMed RACK-1 interacts with STAT1-alpha. 
    NP_006089.1 NP_644671.1 STAT1    BIND  PubMed RACK-1 interacts with STAT1-beta. 
    NP_006089.1 NP_001056.1 TNFRSF1A    BIND  PubMed TNF-R55 interacts with RACK1. 
    NP_006089.1 NP_005418.1 TP73    BIND  PubMed RACK1 interacts with p73. 
    NP_006089.1 NP_003322.2 TYK2    BIND  PubMed RACK-1 interacts with Tyk2. 
    NP_006089.1 CAB63939.1     BIND  PubMed A73 interacts with RACK1. 
    P63244 Q6RW13 AGTRAP    HPRD  PubMed  
    P63244 P10275 AR    HPRD  PubMed  
    P63244 P78396 CCNA1    HPRD  PubMed  
    P63244 P38936 CDKN1A    HPRD  PubMed  
    P63244 P32927 CSF2RB    HPRD  PubMed  
    P63244 Q9UMR2 DDX19B    HPRD  PubMed  
    P63244 Q05193 DNM1    HPRD  PubMed  
    P63244 P56537 EIF6    HPRD  PubMed  
    P63244 P19235 EPOR    HPRD  PubMed  
    P63244 P06241 FYN    HPRD  PubMed  
    P63244 P28472 GABRB3    HPRD  PubMed  
    P63244 P62873 GNB1    HPRD  PubMed  
    P63244 P63244 GNB2L1    HPRD  PubMed  
    P63244 Q8NBJ4 GOLM1    HPRD  PubMed  
    P63244 O75791 GRAP2    HPRD  PubMed  
    P63244 Q13224 GRIN2B    HPRD  PubMed  
    P63244 Q5JVS0 HABP4    HPRD  PubMed  
    P63244 P17181 IFNAR1    HPRD  PubMed  
    P63244 P48551 IFNAR2    HPRD  PubMed  
    P63244 P08069 IGF1R    HPRD  PubMed  
    P63244 P14784 IL2RB    HPRD  PubMed  
    P63244 P24394 IL4R    HPRD  PubMed  
    P63244 P06213 INSR    HPRD  PubMed  
    P63244 P05556 ITGB1    HPRD  PubMed  
    P63244 P05107 ITGB2    HPRD  PubMed  
    P63244 P18084 ITGB5    HPRD  PubMed  
    P63244 P26010 ITGB7    HPRD  PubMed  
    P63244 P23458 JAK1    HPRD  PubMed  
    P63244 Q9Y561 LRP12    HPRD  PubMed  
    P63244 O95644 NFATC1    HPRD  PubMed  
    P63244 Q92636 NSMAF    HPRD  PubMed  
    P63244 P11940 PABPC1    HPRD  PubMed  
    P63244 Q08499 PDE4D    HPRD  PubMed  
    P63244 P19174 PLCG1    HPRD  PubMed  
    P63244 Q15149 PLEC    HPRD  PubMed  
    P63244 P17252 PRKCA    HPRD  PubMed  
    P63244 P05771 PRKCB    HPRD  PubMed  
    P63244 Q05655 PRKCD    HPRD  PubMed  
    P63244 Q02156 PRKCE    HPRD  PubMed  
    P63244 Q15139 PRKD1    HPRD  PubMed  
    P63244 P21246 PTN    HPRD  PubMed  
    P63244 P28827 PTPRM    HPRD  PubMed  
    P63244 P20936 RASA1    HPRD  PubMed  
    P63244 Q14644 RASA3    HPRD  PubMed  
    P63244 P06400 RB1    HPRD  PubMed  
    P63244 Q9Y2P4 SLC27A6    HPRD  PubMed  
    P63244 Q01959 SLC6A3    HPRD  PubMed  
    P63244 P12931 SRC    HPRD  PubMed  
    P63244 Q8WXA9 SREK1    HPRD  PubMed  
    P63244 Suppression of tumorigenicity 7 ST7    HPRD  PubMed  
    P63244 P42224 STAT1    HPRD  PubMed  
    P63244 P40763 STAT3    HPRD  PubMed  
    P63244 Q6EEV6 SUMO4    HPRD  PubMed  
    P63244 P21579 SYT1    HPRD  PubMed  
    P63244 P19438 TNFRSF1A    HPRD  PubMed  
    P63244 O15350 TP73    HPRD  PubMed  
    P63244 Q9Y3Q8 TSC22D4    HPRD  PubMed  
    P63244 P07437 TUBB    HPRD  PubMed  
    P63244 P29597 TYK2    HPRD  PubMed  
    BioGRID:115671 BioGRID:106637 ADH1B    BioGRID  PubMed Two-hybrid 
    BioGRID:115671 BioGRID:121356 AGTRAP    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:115671 BioGRID:223223 AI837181    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:106799 ANXA2    BioGRID  PubMed Co-fractionation 
    BioGRID:115671 BioGRID:106862 AR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:115671 BioGRID:114646 AURKB    BioGRID  PubMed Two-hybrid 
    BioGRID:115671 BioGRID:115335 BCL2L11    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:115671 BioGRID:107140 BRCA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:120937 CAND1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:121487 CBX8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:114417 CCNA1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:115671 BioGRID:107452 CDK2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:107460 CDKN1A    BioGRID  PubMed Two-hybrid 
    BioGRID:115671 BioGRID:107506 CFTR    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:115778 CHERP    BioGRID  PubMed Two-hybrid 
    BioGRID:115671 BioGRID:107574 CISH    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115671 BioGRID:116183 COPS5    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:115671 BioGRID:107826 CSF2RB    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:115671 BioGRID:114032 CUL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:114031 CUL2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115671 BioGRID:114030 CUL3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:216498 Cep55    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:116426 DDX19B    BioGRID  PubMed Two-hybrid 
    BioGRID:115671 BioGRID:113855 DGCR14    BioGRID  PubMed Two-hybrid 
    BioGRID:115671 BioGRID:108120 DYNC1LI2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:114206 DYNLL1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:115671 BioGRID:108223 ECT2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:109857 EIF3E    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:118148 EIF3K    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:109898 EIF6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:115671 BioGRID:108371 EPOR    BioGRID  PubMed Reconstituted Complex 
    BioGRID:115671 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:120581 FBXW7    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:115671 BioGRID:115421 FEM1B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115671 BioGRID:108621 FN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:108810 FYN    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:115671 BioGRID:109044 GNB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115671 BioGRID:115671 GNB2L1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115671 BioGRID:119933 GNG2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115671 BioGRID:119432 GOLM1    BioGRID  PubMed Two-hybrid 
    BioGRID:115671 BioGRID:114799 GRAP2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:115671 BioGRID:109161 GRIN2B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115671 BioGRID:116587 HABP4    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:115671 BioGRID:109338 HIF1A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:115671 BioGRID:113946 HIST1H3A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115671 BioGRID:113955 HIST1H4A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115671 BioGRID:109429 HNRNPH2    BioGRID  PubMed Two-hybrid 
    BioGRID:115671 BioGRID:109528 HSD17B4    BioGRID  PubMed Co-fractionation 
    BioGRID:115671 BioGRID:113036 HSP90B1    BioGRID  PubMed Co-fractionation 
    BioGRID:115671 BioGRID:200268 Htt    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:109677 IFNAR2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:115671 BioGRID:109688 IFNR    BioGRID  PubMed Reconstituted Complex 
    BioGRID:115671 BioGRID:109701 IGF1R    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115671 BioGRID:109766 IK    BioGRID  PubMed Two-hybrid 
    BioGRID:115671 BioGRID:109775 IL2RB    BioGRID  PubMed Reconstituted Complex 
    BioGRID:115671 BioGRID:109780 IL4R    BioGRID  PubMed Reconstituted Complex 
    BioGRID:115671 BioGRID:109789 IL7R    BioGRID  PubMed Protein-RNA 
    BioGRID:115671 BioGRID:114995 ISG15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:109894 ITGB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115671 BioGRID:109895 ITGB2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:115671 BioGRID:109919 JAK1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:115671 BioGRID:109928 JUN    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115671 BioGRID:109943 KCNA5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115671 BioGRID:113626 KCNAB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115671 BioGRID:109962 KCNJ3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115671 BioGRID:116795 LARP4B    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:115671 BioGRID:111583 MAPK6    BioGRID  PubMed Two-hybrid 
    BioGRID:115671 BioGRID:115014 MDC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:110427 MID1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115671 BioGRID:109165 NR3C1    BioGRID  PubMed Two-hybrid 
    BioGRID:115671 BioGRID:114019 NSMAF    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:115671 BioGRID:120751 OTUB1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:115671 BioGRID:117939 PABPC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:116625 PAXIP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:111170 PDE4D    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:115671 BioGRID:111351 PLCG1    BioGRID  PubMed Far Western 
    BioGRID:115671 BioGRID:111510 PPP2R1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:111552 PRKAB2    BioGRID  PubMed Two-hybrid 
    BioGRID:115671 BioGRID:111564 PRKCA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115671 BioGRID:111565 PRKCB    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:115671 BioGRID:111567 PRKCE    BioGRID  PubMed Affinity Capture-Western; Far Western; Reconstituted Complex 
    BioGRID:115671 BioGRID:117563 PRPF31    BioGRID  PubMed Two-hybrid 
    BioGRID:115671 BioGRID:111731 PTN    BioGRID  PubMed Two-hybrid 
    BioGRID:115671 BioGRID:111761 PTPRM    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:115671 BioGRID:111856 RASA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:115671 BioGRID:116497 RASA3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115671 BioGRID:111860 RB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115671 BioGRID:106880 RHOA    BioGRID  PubMed Two-hybrid 
    BioGRID:115671 BioGRID:124834 RNF185    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:112057 RPL13    BioGRID  PubMed Co-fractionation 
    BioGRID:115671 BioGRID:112058 RPL15    BioGRID  PubMed Co-fractionation 
    BioGRID:115671 BioGRID:112063 RPL19    BioGRID  PubMed Co-fractionation 
    BioGRID:115671 BioGRID:112064 RPL21    BioGRID  PubMed Co-fractionation 
    BioGRID:115671 BioGRID:112076 RPL27A    BioGRID  PubMed Co-fractionation 
    BioGRID:115671 BioGRID:112087 RPL37A    BioGRID  PubMed Co-fractionation 
    BioGRID:115671 BioGRID:112044 RPL4    BioGRID  PubMed Co-fractionation 
    BioGRID:115671 BioGRID:112050 RPL7A    BioGRID  PubMed Co-fractionation 
    BioGRID:115671 BioGRID:112120 RPS12    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:112121 RPS13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:112131 RPS16    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:112136 RPS18    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:112101 RPS2    BioGRID  PubMed Co-fractionation 
    BioGRID:115671 BioGRID:112138 RPS20    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:112141 RPS21    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:112144 RPS25    BioGRID  PubMed Co-fractionation 
    BioGRID:115671 BioGRID:112146 RPS27    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:119256 RPS27L    BioGRID  PubMed Affinity Capture-MS; Co-fractionation 
    BioGRID:115671 BioGRID:112102 RPS3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:112103 RPS3A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:112107 RPS5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:112116 RPS8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:112117 RPS9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:110115 RPSA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:941018 SAP25    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:112210 SAT1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:115671 BioGRID:119602 SIRT7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:118790 SLC27A6    BioGRID  PubMed Two-hybrid 
    BioGRID:115671 BioGRID:114769 SLC9A3R1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:115671 BioGRID:112592 SRC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:115671 BioGRID:126754 SREK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:113695 ST7    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:115671 BioGRID:112649 STAT1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:115671 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:132223 SUMO4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:115755 SYNCRIP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:112783 TCEB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:115671 BioGRID:112785 TCEB2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:115671 BioGRID:112929 TIAL1    BioGRID  PubMed Co-fractionation 
    BioGRID:115671 BioGRID:113011 TP53BP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:114181 TP63    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:115671 BioGRID:113014 TP73    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:115671 BioGRID:123563 TSC22D4    BioGRID  PubMed Two-hybrid 
    BioGRID:115671 BioGRID:113148 TYK2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:115671 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:115791 UBD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:113885 UBL4A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:113255 VCAM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:113269 VHL    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:115671 BioGRID:124019 WDR83    BioGRID  PubMed Two-hybrid 
    BioGRID:115671 BioGRID:113366 YWHAZ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:1205542 rev    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:115671 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    SH2 domain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cysteine-type endopeptidase activator activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    ion channel inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase C binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein tyrosine kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    receptor binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    receptor tyrosine kinase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    gastrulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of Wnt receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		  
    negative regulation of protein kinase B signaling cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    		  
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		  
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    		  
    positive regulation of gastrulation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    		  
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of establishment of cell polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    regulation of establishment of protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    virus-host interaction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    phagocytic cup IDA
    Inferred from Direct Assay
    more info
    		  
    small ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Preferred Names
    guanine nucleotide-binding protein subunit beta-2-like 1
    Names
    guanine nucleotide-binding protein subunit beta-2-like 1
    lung cancer oncogene 7
    proliferation-inducing gene 21
    receptor for activated C kinase 1
    human lung cancer oncogene 7 protein
    receptor of activated protein kinase C 1
    cell proliferation-inducing gene 21 protein
    guanine nucleotide-binding protein subunit beta-like protein 12.3
    protein homologous to chicken B complex protein, guanine nucleotide binding

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006098.4 → NP_006089.1  guanine nucleotide-binding protein subunit beta-2-like 1

      Status: VALIDATED

      Source sequence(s)
      AK222488, BC029996, M24194
      Consensus CDS
      CCDS34324.1
      UniProtKB/TrEMBL
      E9KL35
      UniProtKB/Swiss-Prot
      P63244
      Related
      ENSP00000366013, OTTHUMP00000223930, ENST00000376817, OTTHUMT00000373429
      Conserved Domains (2) summary
      COG2319
      Location:2 – 310
      Blast Score: 357
      COG2319; FOG: WD40 repeat [General function prediction only]
      cd00200
      Location:7 – 311
      Blast Score: 714
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p10 Primary Assembly

      Range
      180663928..180670906, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      175390873..175397848, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018916.1 Alternate CHM1_1.0

      Range
      180881184..180888162, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01010097.1 (8654..15629) None
    genomic AC008443.10 (57489..64434) None
    genomic AMYH01015977.1 (132677..139655) None
    genomic CH471165.2 EAW53692.1
      EAW53693.1
      EAW53694.1
      EAW53695.1
      EAW53696.1
      EAW53697.1
      EAW53698.1
      EAW53699.1
      EAW53700.1
      EAW53701.1
      EAW53702.1
    mRNA AK095666.1 BAG53102.1
    mRNA AK222488.1 BAD96208.1
    mRNA AK301029.1 BAG62644.1
    mRNA AK301468.1 BAG62988.1
    mRNA AK303316.1 BAG64385.1
    mRNA AK310916.1 None
    mRNA AY336089.1 AAR24619.1
    mRNA BC000214.1 AAH00214.1
    mRNA BC000366.2 AAH00366.1
    mRNA BC010119.2 AAH10119.1
    mRNA BC014256.1 AAH14256.1
    mRNA BC014582.1 None
    mRNA BC014788.1 AAH14788.1
    mRNA BC017287.2 AAH17287.1
    mRNA BC019093.2 AAH19093.1
    mRNA BC019362.1 AAH19362.1
    mRNA BC021993.1 AAH21993.1
    mRNA BC029996.1 None
    mRNA BC032006.1 AAH32006.1
    mRNA BC035460.1 None
    mRNA CR456978.1 CAG33259.1
    mRNA CR541909.1 CAG46707.1
    mRNA D28398.1 BAA05764.1
    mRNA GU727632.1 ADU87634.1
    mRNA M24194.1 AAA59626.1
    other-genetic AM393661.1 CAL38537.1
    other-genetic DQ891422.2 ABM82348.1
    other-genetic DQ894596.2 ABM85522.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63244.3 GenPept UniProtKB/Swiss-Prot:P63244

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

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