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MAPK3 mitogen-activated protein kinase 3 [ Homo sapiens (human) ]

Gene ID: 5595, updated on 14-Apr-2016
Official Symbol
MAPK3provided by HGNC
Official Full Name
mitogen-activated protein kinase 3provided by HGNC
Primary source
HGNC:HGNC:6877
See related
Ensembl:ENSG00000102882 HPRD:03479; MIM:601795; Vega:OTTHUMG00000132149
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERK1; ERT2; ERK-1; PRKM3; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; p44-ERK1; p44-MAPK
Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008]
Orthologs
Location:
16p11.2
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 16 NC_000016.10 (30114105..30123309, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30125426..30134630, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928595 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 3 Neighboring gene coronin 1A Neighboring gene bolA family member 2B Neighboring gene SLX1 homolog A, structure-specific endonuclease subunit

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 induces activation of the ERK1/2 MAPK signaling pathway in polarized oral epithelial cells PubMed
env HIV-1 gp120 activates AKT, ERK1/2, and p38 signaling in tonsil CD4+ T cells. Soluble CD4 inhibits AKT and ERK1/2 activation, but enhances phosphorylation of p38 PubMed
env HIV-1 gp120 induces nuclear localization of the phosphoinositide-specific phospholipase C (PI-PLC) beta 1 isozyme in MDMs, which requires activation of the MAPK ERK1/2 pathway PubMed
env HIV-1 gp120-induced phosphatidylcholine-specific phospholipase D (PLD) activity is dependent on the activation of ERK1/2 PubMed
env Treatment of cells with HIV-1 gp120 induces increased levels of endogenous c-fos and c-jun mRNA and proteins, an activation of both c-fos and c-jun promoters, and a very rapid stimulation of the MAPK/ERK pathway PubMed
env NHERF1 increases ERK1/2 phosphorylation levels following HIV-1 gp120 stimulation in cells PubMed
env HIV-1 X4-tropic gp120 upregulates alpha-SMA (ACTA2) and collagen I alpha 1 expression via the ERK1/2 pathway in a CXCR4-dependent manner in activated human hepatic stellate cells PubMed
env Stimulation of human monocyte-derived macrophages with HIV-1 gp120 results in the CCR5-mediated activation of Lyn and the concomitant Lyn-dependent activation of the mitogen-activated protein (MAP) kinase ERK-1/2, which leads to production of TNF-alpha PubMed
env HIV-1 gp120 induces IL-10 expression in monocyte-derived dendritic cells via a mannose C-type lectin receptor and an ERK signaling pathway PubMed
env Increased neurotoxicity mediated by cocaine and gp120 involves signaling pathways including c-jun N-terminal kinase (JNK), p38, extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinases (MAPK), and nuclear factor (NF)-kappaB PubMed
env HIV-1 gp120 activates c-Jun N-terminal kinase (JNK) and p42 extracellular-regulated kinase (ERK) in macrophages and primary human central nervous system (CNS) cells PubMed
env Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways PubMed
Envelope surface glycoprotein gp160, precursor env The activation of mitogen-activated protein kinases (MAPKs, including ERK, JNK, and p38MAPK) is induced by incubation of HIV-1 gp160 with CD4+complement receptor type 2 (CR2)+ cells PubMed
Envelope transmembrane glycoprotein gp41 env The HIV-1 gp41 transmembrane domain inhibits TLR2-induced activation of ERK1/2, and secretion of TNF-alpha, MCP-1, and IL-6 PubMed
env HIV-1 gp41 is able to activate the ERK/MAPK pathway by binding to CD74 PubMed
Nef nef HIV-1 Nef-induced strong activation of MAP kinases (p38/MAPK14, JNK/MAPK8, and ERK1/2) and NF-kappaB pathway (IKK alpha/beta) in M2-macrophages is mediated by TAK1 PubMed
nef HIV-1 Nef induces phosphorylation of MAPK3 (ERK1) in M2-type macrophages PubMed
nef The Nef/hnRNPK/PKC-delta/Hck protein complex increases paxillin phosphorylation at Y118 and activates and secretes TACE through Erk1/2 activation PubMed
nef HIV-1 Nef-induced relocalization of LCK increases phosphorylated ERK1/2 induction in infected and trasduced primary T cells PubMed
nef Formation of the Nef-associated kinase complex (NAKC) is sufficient to activate LCK and ERK1/2 and causes a strong Tat-dependent increase of HIV-1 transcription in T cells PubMed
nef HIV-1 Nef and ALK are capable of cumulatively influencing the MAP-K phosphorylation in astrocytic glioma cells PubMed
nef HIV-1 Nef upregulates ICAM-1 expression on endothelial cells via Erk /Mapk signaling pathway PubMed
nef HIV-1 Nef myristoylation is required for the rapid and transient phosphorylation of the alpha- and beta- subunits of the Ikappa-B kinase complex and activation of JNK, ERK1/2 and p38 MAPK family members PubMed
Rev rev MAPK has been shown to phosphorylate Rev in vitro PubMed
Tat tat HIV-1 Tat increases phosphorylation of ERK1/2, JNK1/2, p38, AKT1, MEK-1, and STAT-1alpha in Muller glia and brain microvascular pericytes PubMed
tat Phospholipase C/protein kinase C signaling pathway-dependent phosphorylation of p44/42 and JNK MAP kinases participates partially in IL-1beta induction by HIV-1 Tat PubMed
tat Treatment with HIV-1 Tat induces phosphorylation of ERK1/2 and JNK in brain micro vascular endothelial cells (BMEC) and astrocytes, which mediates Tat-induced multidrug resistance-associated protein 1 (MRP1) expression PubMed
tat Blocking HIV-1 Tat and cocaine-mediated Erk activation reverses ZO-1 downregulation in human pulmonary artery endothelial cells PubMed
tat Treatment with HIV-1 Tat and cocaine activates Ras/Erk pathway in human pulmonary artery endothelial cells PubMed
tat Treatment with HIV-Tat and morphine activates extracellular signal-regulated kinase-1/2 (ERK1/2), upregulates p53 and p21 levels, and downregulates cyclin D1 and Akt levels in human fetal brain-derived neural precursor cells PubMed
tat The basic domain (49RKKRRQRRR57) of HIV-1 Tat is essential for enhancing the FGF-induced activation of ERK, Rho-A, and MLC2 and upregulates the expression of MMP-9 in human podocytes PubMed
tat HIV-1 Tat induces activation of the ERK1/2 MAPK signaling pathway in polarized oral epithelial cells PubMed
tat HIV-1 Tat- and oxovanadate-treated microglial cells synergistically induce release of TNF-alpha and IL-1beta proteins, which involves CD45 and ERK1/2 signaling pathways PubMed
tat HIV-1 Tat induces ERK phosphorylation by the activation of the small GTPase Ras, but not the small GTPase Rac, in human endothelial cells PubMed
tat HIV-1 Tat-induced upregulation of B7-H1 protein expression requires activation of the ERK/MAPK signaling pathway in human endothelial cells PubMed
tat HIV-1 Tat and morphine-induced apoptosis in human neuroblastoma cells involves ERK1/2 and JNK activation PubMed
tat Adhesion of endothelial cells to HIV-1 Tat triggers a signal transduction pathway, which leads to phosphorylation of VEGFR2 and pp60src and activation of ERK1/2 PubMed
tat HIV-1 Tat-linked intracellular third loop of the endothelin-1 type B receptor markedly enhances the endothelin-1 activation of ERK in the bone morphogenetic protein-2 receptor human pulmonary artery smooth muscle cells PubMed
tat The NADPH oxidase inhibitors DPI and apocynin abrogate HIV-1 Tat-stimulated ERK1/2 activation in human microglia-like cells PubMed
tat HIV-1 Tat inhibits the LPS-activation of ERK1/2 but not the p38 mitogen-activated protein kinases in primary blood monocytes/macrophages PubMed
tat Cell-permeable SOD inhibits the activation of MAP kinases including ERK, JNK and p38 and the upregulation of ICAM-1 and VCAM-1 by HIV-1 Tat PubMed
tat Tat-triggered PKCdelta and PKCtheta activation results in the downstream signaling through the apoptosis pathways mediated by both ERK1/2 and caspase-3 PubMed
tat Formation of the Nef-associated kinase complex (NAKC) is sufficient to activate LCK and ERK1/2 and causes a strong Tat-dependent increase of HIV-1 transcription in T cells PubMed
tat HIV-1-Tat-mediated upregulation of platelet-derived growth factor (PDGF) B chain in astrocytes is regulated by activation of ERK1/2 and JNK MAPK signaling pathways and the downstream transcription factor early growth response 1 (Egr1) PubMed
tat Tat activates at least three signaling pathways concurrently, including NF-kappaB, PKC, ERK1/2 and p38 MAP kinases and IKKalpha pathways, to promote production of IL-10 PubMed
tat Sulfated polymannuroguluronate (SPMG) blocks the Tat-induced extracellular-signal regulated kinase 1/2- and c-jun amino-terminal kinase-mediated signalling pathways PubMed
tat HIV-1 Tat in combination with KSHV kaposin A activates the MEK/ERK, STAT3, and PI3K/Akt signals in NIH3T3 cells PubMed
tat HIV-1 Tat alters the properties of human neural precursor cells via attenuation of the cell cycle regulatory unit cyclin D1 and the mitogen-activated protein kinase (MAPK) pathway, particularly extracellular signal-related kinase 1/2 (ERK1/2) PubMed
tat HIV-1 Tat-induced glutamate release is mediated through p38 and p42/44 MAPK and through NADPH oxidase and the x(c)(-) cystine-glutamate antiporter (xCT) PubMed
tat HIV-1 Tat is phosphorylated by MAPK in vitro PubMed
tat HIV-1 Tat activates ERK1 and ERK2 through the activation of MEK1 and MEK2, leading to induction of IL-8, IL-10, IP-10, iNOS, superoxide and TNF-alpha, as well as suppression of p35 activator of cdk5, activation of CREB and increased albumin permeability PubMed
tat Expression of HIV-1 Tat in human SK-N-MC cells inhibits the NGF-signaling pathway leading to suppression of MAPK and reduction of Puralpha binding to the Egr-1 promoter PubMed
tat The interaction of HIV-1 Tat with KDR/VEGFR2 is implicated in the activation of ERK1 and ERK2 signaling pathways PubMed
Vif vif MAPK phosphorylates HIV-1 Vif on Thr96 and Ser165 and is important in the regulation of HIV-1 infectivity by Vif PubMed
Vpr vpr HIV-1 Vpr-induced caspase-8 activation causes cleavage of BID to tBID through ERK activation PubMed
matrix gag HIV-1 MA natural variant S75X-mediated proliferation of both Epstein-Barr virus (EBV)-infected primary and fully transformed B-lymphocytes requires AKT, ERK1/2, and STAT3 pathways PubMed
gag HIV-1 p17 variant S75X shows a similar activity to p17delta36 in modulating ERK1/2 signalling pathway in Raji and human primary B cells PubMed
gag Expression of Pokeweed antiviral protein (PAP), a plant-derived N-glycosidase, activates the ERK1/2 MAPK pathway to a limited extent, resulting in increased phosphorylation of HIV-1 MA PubMed
gag HIV-1 p17 induces phosphorylation of ERK1/ERK2 in human endothelial cells PubMed
gag HIV-1 p17 induces capillary-like structures in human endothelial cells by binding to CXCR1 and CXCR2, which requires activation of the Akt-dependent ERK signaling pathway PubMed
gag HIV-1 MA increases phosphorylation and the DNA-binding activity of CREB and c-Myc through activation of the cAMP/PKA and MEK/ERK signaling pathways. Both signaling pathways are synergistically activated upon co-stimulation through the CD19 receptor PubMed
gag Phosphorylation of HIV-1 Matrix on tyrosine and serine prior to and during virus infection facilitates dissociation of Matrix from the cellular membrane, thus allowing it to translocate to the nucleus and participate in HIV-1 nuclear import PubMed
gag Recombinant MAPK phosphorylates HIV-1 Matrix on serine and threonine residues, whereas immunoprecipitated MAPK predominantly phosphorylates HIV-1 Matrix on serine residues PubMed
p6 gag HIV-1 p6-Gag is phosphorylated by cellular kinases with ERK1 and ERK2 being the most likely kinases involved in p6 phosphorylation PubMed
reverse transcriptase gag-pol MEK1 in HIV-1 producer cells is able to activate virion-associated MAPK in trans, and the activated MAPK facilitates efficient disengagement of the HIV-1 reverse transcription complex from the cell membrane and subsequent nuclear translocation PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC20180

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
MAP kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
MAP kinase activity TAS
Traceable Author Statement
more info
 
kinase activity TAS
Traceable Author Statement
more info
 
phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphotyrosine binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
scaffold protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Bergmann glial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
DNA damage induced protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
JAK-STAT cascade involved in growth hormone signaling pathway TAS
Traceable Author Statement
more info
 
MAPK cascade NAS
Non-traceable Author Statement
more info
PubMed 
MAPK cascade TAS
Traceable Author Statement
more info
 
MAPK import into nucleus IEA
Inferred from Electronic Annotation
more info
 
activation of MAPK activity TAS
Traceable Author Statement
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
arachidonic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
axon guidance TAS
Traceable Author Statement
more info
 
cardiac neural crest cell development involved in heart development IEA
Inferred from Electronic Annotation
more info
 
cartilage development IEA
Inferred from Electronic Annotation
more info
 
caveolin-mediated endocytosis TAS
Traceable Author Statement
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
face development IEA
Inferred from Electronic Annotation
more info
 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-1-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipopolysaccharide-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
lung morphogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apolipoprotein binding IEA
Inferred from Electronic Annotation
more info
 
outer ear morphogenesis IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
platelet activation TAS
Traceable Author Statement
more info
 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cyclase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of histone acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of histone phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of telomerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of telomere capping IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of translation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of xenophagy IEA
Inferred from Electronic Annotation
more info
 
protein complex assembly IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of Golgi inheritance TAS
Traceable Author Statement
more info
PubMed 
regulation of cellular response to heat TAS
Traceable Author Statement
more info
 
regulation of cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
regulation of early endosome to late endosome transport TAS
Traceable Author Statement
more info
PubMed 
regulation of phosphatidylinositol 3-kinase signaling TAS
Traceable Author Statement
more info
 
regulation of sequence-specific DNA binding transcription factor activity TAS
Traceable Author Statement
more info
 
regulation of stress-activated MAPK cascade TAS
Traceable Author Statement
more info
PubMed 
response to epidermal growth factor IDA
Inferred from Direct Assay
more info
PubMed 
response to exogenous dsRNA IEA
Inferred from Electronic Annotation
more info
 
response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
thymus development IEA
Inferred from Electronic Annotation
more info
 
thyroid gland development IEA
Inferred from Electronic Annotation
more info
 
trachea formation IEA
Inferred from Electronic Annotation
more info
 
transcription initiation from RNA polymerase I promoter TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
caveola TAS
Traceable Author Statement
more info
PubMed 
cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
PubMed 
early endosome TAS
Traceable Author Statement
more info
PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion TAS
Traceable Author Statement
more info
PubMed 
late endosome TAS
Traceable Author Statement
more info
PubMed 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
mitochondrion TAS
Traceable Author Statement
more info
PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
protein complex IEA
Inferred from Electronic Annotation
more info
 
pseudopodium IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
mitogen-activated protein kinase 3
Names
MAP kinase isoform p44
MAPK 1
extracellular signal-regulated kinase 1
extracellular signal-related kinase 1
insulin-stimulated MAP2 kinase
microtubule-associated protein 2 kinase
NP_001035145.1
NP_001103361.1
NP_002737.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029936.1 RefSeqGene

    Range
    5001..14205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001040056.2NP_001035145.1  mitogen-activated protein kinase 3 isoform 2

    See identical proteins and their annotated locations for NP_001035145.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as ERK1c) lacks several exons and its 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AY033607, DA351318, DQ399291
    Consensus CDS
    CCDS42149.1
    UniProtKB/Swiss-Prot
    P27361
    Related
    ENSP00000378625, OTTHUMP00000174540, ENST00000395199, OTTHUMT00000268286
    Conserved Domains (2) summary
    smart00220
    Location:42330
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07849
    Location:36344
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
  2. NM_001109891.1NP_001103361.1  mitogen-activated protein kinase 3 isoform 3

    See identical proteins and their annotated locations for NP_001103361.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    BC000205, BC013992, DA351318, DQ399291
    Consensus CDS
    CCDS42148.1
    UniProtKB/Swiss-Prot
    P27361
    UniProtKB/TrEMBL
    Q9BWJ1
    Related
    ENSP00000327293, ENST00000322266
    Conserved Domains (2) summary
    smart00220
    Location:42286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07849
    Location:36326
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
  3. NM_002746.2NP_002737.2  mitogen-activated protein kinase 3 isoform 1

    See identical proteins and their annotated locations for NP_002737.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the most common transcript and encodes isoform 1.
    Source sequence(s)
    AC012645, BC013992, DA351318
    Consensus CDS
    CCDS10672.1
    UniProtKB/Swiss-Prot
    P27361
    UniProtKB/TrEMBL
    L7RXH5
    Related
    ENSP00000263025, OTTHUMP00000163018, ENST00000263025, OTTHUMT00000255196
    Conserved Domains (2) summary
    smart00220
    Location:42330
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07849
    Location:36370
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p2 Primary Assembly

    Range
    30114105..30123309 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_243293.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    31341181..31350385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)