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    ENO1 enolase 1, (alpha) [ Homo sapiens ]

    Gene ID: 2023, updated on 19-May-2012

    Summary

    Official Symbol
    ENO1provided by HGNC
    Official Full Name
    enolase 1, (alpha)provided by HGNC
    Primary source
    HGNC:3350
    See related
    Ensembl:ENSG00000074800; HPRD:01400; MIM:172430; Vega:OTTHUMG00000001773
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NNE; PPH; MPB1; ENO1L1
    Summary
    This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. [provided by RefSeq, Jan 2011]

    Genomic context

    Location :
    1p36.2
    Sequence :
    Chromosome: 1; NC_000001.10 (8921059..8939151, complement)
    See ENO1 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene arginine-glutamic acid dipeptide (RE) repeats Neighboring gene ribosomal protein L27 pseudogene Neighboring gene ribosomal protein L23a pseudogene 19 Neighboring gene ENO1 antisense RNA 1 (non-protein coding) Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 17 Neighboring gene carbonic anhydrase VI

    Genomic regions, transcripts, and products

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat MBP-1 suppresses transcription from the HIV-1 LTR promoter, an effect that is inhibited by HIV-1 Tat, suggesting an important role for MBP-1 in the regulation of HIV-1 replication in infected cells PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P06733 ATP/GTP binding protein 1 AGTPBP1    HPRD  PubMed  
    P06733 P19875 CXCL2    HPRD  PubMed  
    P06733 Q99972 MYOC    HPRD  PubMed  
    P06733 P00747 PLG    HPRD  PubMed  
    P06733 Q6EEV6 SUMO4    HPRD  PubMed  
    P06733 P63104 YWHAZ    HPRD  PubMed  
    BioGRID:108338 BioGRID:107358 CD4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108338 BioGRID:108472 FANCA    BioGRID  PubMed Two-hybrid 
    BioGRID:108338 BioGRID:109142 GRB2    BioGRID  PubMed Two-hybrid 
    BioGRID:108338 BioGRID:109268 H2AFX    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108338 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108338 BioGRID:119325 INSIG2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108338 BioGRID:114995 ISG15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108338 BioGRID:111593 MAP2K5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108338 BioGRID:204968 Mapk13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108338 BioGRID:111142 PCNA    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:108338 BioGRID:111356 PLG    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108338 BioGRID:111657 PSMA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108338 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108338 BioGRID:132223 SUMO4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108338 BioGRID:112299 TRAPPC2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108338 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:108338 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108338 BioGRID:113366 YWHAZ    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphopyruvate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
     
    sequence-specific DNA binding transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription corepressor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    carbohydrate metabolic process TAS
    Traceable Author Statement
    more info
     
    gluconeogenesis TAS
    Traceable Author Statement
    more info
     
    glucose metabolic process TAS
    Traceable Author Statement
    more info
     
    glycolysis TAS
    Traceable Author Statement
    more info
     
    negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to virus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    M band IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    nucleus IC
    Inferred by Curator
    more info
    PubMed 
    phosphopyruvate hydratase complex IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    alpha-enolase; c-myc promoter-binding protein-1
    Names
    alpha-enolase
    enolase-alpha
    tau-crystallin
    non-neural enolase
    alpha enolase like 1
    phosphopyruvate hydratase
    plasminogen-binding protein
    MYC promoter-binding protein 1
    2-phospho-D-glycerate hydro-lyase
    NP_001188412.1
    NP_001419.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029470.1 RefSeqGene

      Range
      5001..23093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201483.1NP_001188412.1  c-myc promoter-binding protein-1 isoform MBP-1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs at the 5' end compared to variant 1, and initiates translation from an in-frame downstream start codon, resulting in a shorter isoform (MBP-1). This isoform is localized to the nucleus, and functions as a transcriptional repressor of c-myc protooncogene by binding to its promoter (PMID:20849415).
      Source sequence(s)
      BC021166, GU170215
      UniProtKB/TrEMBL
      E2DRY6
      UniProtKB/Swiss-Prot
      P06733
      Conserved Domains (2) summary
      cd03313
      Location:1323
      Blast Score: 1420
      enolase; Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.
      pfam00113
      Location:49339
      Blast Score: 1486
      Enolase_C; Enolase, C-terminal TIM barrel domain
    2. NM_001428.3NP_001419.1  alpha-enolase isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1), which is localized to the cytosol, and has alpha-enolase activity. It has been reported that the monomeric form of this isoform functions as a structural lens protein (tau-crystallin), and the dimeric form as an enolase (PMID:2462567).
      Source sequence(s)
      AK309177, BC021166
      Consensus CDS
      CCDS97.1
      UniProtKB/Swiss-Prot
      P06733
      Related
      ENSP00000234590, OTTHUMP00000001706, ENST00000234590, OTTHUMT00000004945
      Conserved Domains (2) summary
      cd03313
      Location:5416
      Blast Score: 1793
      enolase; Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.
      PLN00191
      Location:2432
      Blast Score: 2069
      PLN00191; enolase

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      8921059..8939151, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      8070030..8088151, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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