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FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) [ Homo sapiens (human) ]

Gene ID: 2208, updated on 6-Jul-2014
Official Symbol
FCER2provided by HGNC
Official Full Name
Fc fragment of IgE, low affinity II, receptor for (CD23)provided by HGNC
Primary source
HGNC:3612
See related
Ensembl:ENSG00000104921; HPRD:01049; MIM:151445; Vega:OTTHUMG00000182517
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD23; FCE2; CD23A; IGEBF; CLEC4J; BLAST-2
Summary
The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
See FCER2 in Epigenomics, MapViewer
Location:
19p13.3
Exon count :
12
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (7688757..7702146, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (7753643..7767036, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene mast cell-expressed membrane protein 1 Neighboring gene trafficking protein particle complex 5 Neighboring gene C-type lectin domain family 4, member G Neighboring gene zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 pseudogene Neighboring gene CD209 molecule

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Env, gp160, envelope glycoprotein env Antibodies against cell surface molecules LFA-1, ICAM-1, HLA-DR, and CD28 inhibit the HIV-1 gp160-induced B cell differentiation response; gp160 also induces IL-6R and CD23 molecule expression on B cells PubMed
Envelope surface glycoprotein gp120 env CD23 protein membrane expression is upregulated by HIV-1 gp120 and this upregulation induces the production of nitric oxide (NO) and IL-1beta PubMed
Nef, p27 nef In macrophages, activation of CD40 or expression of HIV-1 Nef induces the release of sCD23 and sICAM, which mediate effects on T lymphocytes, rendering them permissive to HIV-1 infection PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
    Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
  • Epstein-Barr virus infection, conserved biosystem (from KEGG)
    Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
  • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
    Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hematopoietic cell lineage, conserved biosystem (from KEGG)
    Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
  • IL4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    IL4-mediated signaling events, organism-specific biosystem
    IL4-mediated signaling events
  • NOTCH2 intracellular domain regulates transcription, organism-specific biosystem (from REACTOME)
    NOTCH2 intracellular domain regulates transcription, organism-specific biosystemIn the nucleus, NICD2 forms a complex with RBPJ (CBF1, CSL) and MAML (mastermind). NICD2:RBPJ:MAML complex activates transcription from RBPJ-binding promoter elements (RBEs) (Wu et al. 2000). Besides...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by NOTCH, organism-specific biosystem (from REACTOME)
    Signaling by NOTCH, organism-specific biosystemThe Notch Signaling Pathway (NSP) is a highly conserved pathway for cell-cell communication. NSP is involved in the regulation of cellular differentiation, proliferation, and specification. For exam...
  • Signaling by NOTCH2, organism-specific biosystem (from REACTOME)
    Signaling by NOTCH2, organism-specific biosystemNOTCH2 is activated by binding Delta-like and Jagged ligands (DLL/JAG) expressed in trans on neighboring cells (Shimizu et al. 1999, Shimizu et al. 2000, Hicks et al. 2000, Ji et al. 2004). In trans ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
IgE binding IEA
Inferred from Electronic Annotation
more info
 
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
integrin binding TAS
Traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
low affinity immunoglobulin epsilon Fc receptor
Names
low affinity immunoglobulin epsilon Fc receptor
CD23 antigen
fc-epsilon-RII
lymphocyte IgE receptor
immunoglobulin E-binding factor
C-type lectin domain family 4, member J

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029554.1 

    Range
    5001..18390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001207019.2NP_001193948.2  low affinity immunoglobulin epsilon Fc receptor isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b, also known as CD23b) is shorter and has a distinct N-terminus, compared to isoform a. This variant is supported by data in PubMed IDs 12379312 and 15843555.
    Source sequence(s)
    AC008763, BC014108, DB333832
    UniProtKB/TrEMBL
    K3W4U1
    UniProtKB/Swiss-Prot
    P06734
    Related
    ENSP00000353178, ENST00000360067
    Conserved Domains (3) summary
    cd03590
    Location:162281
    Blast Score: 320
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam04156
    Location:60152
    Blast Score: 103
    IncA; IncA protein
    cl19113
    Location:47152
    Blast Score: 109
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  2. NM_001220500.1NP_001207429.1  low affinity immunoglobulin epsilon Fc receptor isoform a

    See proteins identical to NP_001207429.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate donor splice site in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (a, also known as CD23a).
    Source sequence(s)
    BC062591, DA957269, DB333832
    Consensus CDS
    CCDS12184.1
    UniProtKB/Swiss-Prot
    P06734
    Related
    ENSP00000471974, OTTHUMP00000269468, ENST00000597921, OTTHUMT00000461833
    Conserved Domains (3) summary
    cd03590
    Location:163282
    Blast Score: 319
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam04156
    Location:61153
    Blast Score: 102
    IncA; IncA protein
    cl19113
    Location:58153
    Blast Score: 106
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  3. NM_002002.4NP_001993.2  low affinity immunoglobulin epsilon Fc receptor isoform a

    See proteins identical to NP_001993.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a, also known as CD23a). Both variants 1 and 3 encode the same isoform.
    Source sequence(s)
    BC014108, DA957269, DB333832
    Consensus CDS
    CCDS12184.1
    UniProtKB/Swiss-Prot
    P06734
    Related
    ENSP00000264072, OTTHUMP00000269467, ENST00000346664, OTTHUMT00000461832
    Conserved Domains (3) summary
    cd03590
    Location:163282
    Blast Score: 319
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam04156
    Location:61153
    Blast Score: 102
    IncA; IncA protein
    cl19113
    Location:58153
    Blast Score: 106
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    7688757..7702146
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005272462.2XP_005272519.1  

    See proteins identical to XP_005272519.1

    UniProtKB/Swiss-Prot
    P06734
    Conserved Domains (3) summary
    cd03590
    Location:163282
    Blast Score: 319
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam04156
    Location:61153
    Blast Score: 102
    IncA; IncA protein
    cl19113
    Location:58153
    Blast Score: 106
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  2. XM_006722687.1XP_006722750.1  

    See proteins identical to XP_006722750.1

    UniProtKB/Swiss-Prot
    P06734
    Conserved Domains (3) summary
    cd03590
    Location:163282
    Blast Score: 319
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam04156
    Location:61153
    Blast Score: 102
    IncA; IncA protein
    cl19113
    Location:58153
    Blast Score: 106
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    7423283..7436591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    7753396..7766778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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